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Gene: Abhd2 (abhydrolase domain containing 2, acylglycerol lipase) Rattus norvegicus

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Symbol:

Abhd2

Name:

abhydrolase domain containing 2, acylglycerol lipase

RGD ID:

1311389

Description:

Predicted to enable several functions, including acetylesterase activity; lipase activity; and nuclear steroid receptor activity. Predicted to be involved in several processes, including medium-chain fatty acid metabolic process; response to progesterone; and sperm capacitation. Predicted to act upstream of or within negative regulation of smooth muscle cell migration and response to wounding. Predicted to be located in acrosomal vesicle. Predicted to be active in sperm flagellum and sperm plasma membrane. Orthologous to human ABHD2 (abhydrolase domain containing 2, acylglycerol lipase); INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 17beta-estradiol.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

abhydrolase domain containing 2; abhydrolase domain-containing protein 2; LOC293050; monoacylglycerol lipase ABHD2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	142,626,748 - 142,707,892 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	142,626,732 - 142,712,674 (+)	Ensembl				GRCr8
mRatBN7.2	1	133,217,403 - 133,298,564 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	133,217,375 - 133,299,061 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	1	141,126,872 - 141,207,609 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	148,296,304 - 148,377,032 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	141,213,989 - 141,294,729 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	140,998,240 - 141,087,405 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	140,998,240 - 141,087,405 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	1	141,965,576 - 142,049,687 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	135,025,144 - 135,111,792 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	125,281,300 - 125,361,782 (+)	NCBI		Celera
RGSC_v3.1	1	135,103,531 - 135,191,046 (+)	NCBI
Cytogenetic Map	1	q31	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (EXP,ISO)

17beta-estradiol (EXP,ISO)

17beta-hydroxy-5alpha-androstan-3-one (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

3-chloropropane-1,2-diol (EXP)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

aflatoxin B1 (EXP,ISO)

all-trans-retinoic acid (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

atrazine (EXP)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol AF (EXP)

bisphenol F (ISO)

bortezomib (ISO)

butanal (ISO)

Butylbenzyl phthalate (ISO)

cadmium dichloride (EXP,ISO)

caffeine (ISO)

carbofuran (EXP)

carbon nanotube (ISO)

CGP 52608 (ISO)

chlordecone (ISO)

choline (ISO)

cisplatin (ISO)

clomiphene (ISO)

cobalt dichloride (EXP)

copper(II) sulfate (ISO)

crocidolite asbestos (ISO)

cyclosporin A (ISO)

decabromodiphenyl ether (EXP)

dexamethasone (ISO)

diazinon (ISO)

Dibutyl phosphate (ISO)

diethylstilbestrol (ISO)

dimethylarsinous acid (ISO)

dioxygen (EXP)

doxorubicin (EXP)

elemental selenium (ISO)

Enterolactone (ISO)

estrone (ISO)

ethanol (ISO)

ethyl methanesulfonate (ISO)

flutamide (EXP)

folic acid (ISO)

formaldehyde (ISO)

fulvestrant (ISO)

furan (EXP,ISO)

genistein (ISO)

gentamycin (EXP)

glafenine (EXP)

glyphosate (ISO)

hexestrol (ISO)

indole-3-methanol (EXP)

indometacin (ISO)

inulin (ISO)

isoprenaline (EXP)

L-methionine (ISO)

lead(0) (ISO)

leflunomide (EXP)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

mestranol (ISO)

methotrexate (ISO)

methoxychlor (EXP)

methyl methanesulfonate (ISO)

N-nitrosodiethylamine (ISO)

nefazodone (EXP)

nitrofen (EXP)

O-methyleugenol (ISO)

paracetamol (EXP,ISO)

paraquat (EXP)

parathion (ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenobarbital (ISO)

phenylephrine (EXP)

picene (ISO)

pirinixic acid (ISO)

poly(I:C) (EXP)

potassium chromate (ISO)

raloxifene (ISO)

rotenone (EXP)

selenium atom (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

streptozocin (ISO)

sunitinib (ISO)

tamoxifen (ISO)

testosterone enanthate (ISO)

tetrachloromethane (EXP,ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

trichostatin A (ISO)

trimellitic anhydride (ISO)

Triptolide (ISO)

valproic acid (ISO)

vinclozolin (EXP)

vitamin E (ISO)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

acrosome reaction (IEA,ISO)

acylglycerol catabolic process (IBA,IEA,ISO)

lipid catabolic process (IEA)

lipid metabolic process (IEA)

medium-chain fatty acid biosynthetic process (IBA)

medium-chain fatty acid catabolic process (IBA)

negative regulation of cell migration (ISO)

nuclear receptor-mediated steroid hormone signaling pathway (IEA)

response to progesterone (IEA,ISO)

response to wounding (ISO)

sperm capacitation (IBA,IEA,ISO)

steroid hormone receptor signaling pathway (IBA,IEA,ISO)

Cellular Component

acrosomal vesicle (IEA,ISO)

plasma membrane (IEA)

sperm flagellum (IBA,IEA,ISO)

sperm plasma membrane (IBA,IEA,ISO)

Molecular Function

acetylesterase activity (IBA,IEA,ISO)

carboxylic ester hydrolase activity (IEA)

diacylglycerol lipase activity (IEA,ISO)

hormone binding (IEA,ISO)

hydrolase activity (IEA)

monoacylglycerol lipase activity (IBA,IEA,ISO)

nuclear steroid receptor activity (IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:15721306	PMID:26989199	PMID:27247428

Genomics

Comparative Map Data

Abhd2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	142,626,748 - 142,707,892 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	142,626,732 - 142,712,674 (+)	Ensembl				GRCr8
mRatBN7.2	1	133,217,403 - 133,298,564 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	133,217,375 - 133,299,061 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	1	141,126,872 - 141,207,609 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	148,296,304 - 148,377,032 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	141,213,989 - 141,294,729 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	140,998,240 - 141,087,405 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	140,998,240 - 141,087,405 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	1	141,965,576 - 142,049,687 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	135,025,144 - 135,111,792 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	125,281,300 - 125,361,782 (+)	NCBI		Celera
RGSC_v3.1	1	135,103,531 - 135,191,046 (+)	NCBI
Cytogenetic Map	1	q31	NCBI

ABHD2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	15	89,040,998 - 89,202,355 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	15	89,087,459 - 89,202,355 (+)	Ensembl			hg38	GRCh38
GRCh37	15	89,584,229 - 89,745,586 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	15	87,432,429 - 87,546,591 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	15	87,432,627 - 87,541,199	NCBI
Celera	15	66,032,695 - 66,146,881 (+)	NCBI		Celera
Cytogenetic Map	15	q26.1	NCBI
HuRef	15	65,743,212 - 65,857,546 (+)	NCBI		HuRef
CHM1_1	15	89,472,357 - 89,586,578 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	15	86,795,895 - 86,957,178 (+)	NCBI		T2T-CHM13v2.0

Abhd2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	78,923,002 - 79,015,257 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	78,922,947 - 79,015,256 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	7	79,273,266 - 79,361,601 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	79,273,199 - 79,365,508 (+)	Ensembl			mm10	GRCm38
MGSCv37	7	86,418,152 - 86,506,487 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	7	79,146,779 - 79,235,114 (+)	NCBI		MGSCv36	mm8
Celera	7	76,673,721 - 76,758,716 (+)	NCBI		Celera
Cytogenetic Map	7	D2	NCBI
cM Map	7	44.96	NCBI

Abhd2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955416	15,884,624 - 15,983,322 (-)	Ensembl
ChiLan1.0	NW_004955416	15,878,972 - 15,983,322 (-)	NCBI	ChiLan1.0	ChiLan1.0

ABHD2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	16	78,635,699 - 78,750,091 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	15	82,338,167 - 82,454,579 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	15	67,780,453 - 67,891,454 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	15	86,987,070 - 87,095,823 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	15	86,987,070 - 87,095,818 (+)	Ensembl			panPan2	panpan1.1

ABHD2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	3	52,151,500 - 52,255,024 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	3	52,151,535 - 52,249,612 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	3	54,787,785 - 54,891,049 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	3	52,570,316 - 52,673,869 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	3	52,570,371 - 52,673,867 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	3	52,092,905 - 52,196,309 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	3	52,303,690 - 52,406,947 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	3	52,642,383 - 52,745,916 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Abhd2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	131,254,659 - 131,360,435 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936483	14,974,035 - 15,074,154 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936483	14,974,053 - 15,079,824 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ABHD2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	54,655,804 - 54,770,131 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	7	54,655,694 - 54,776,140 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	59,630,969 - 59,746,589 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ABHD2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	29	7,631,436 - 7,742,209 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	29	7,631,412 - 7,740,394 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666059	39,085,426 - 39,196,977 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Abhd2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624768	16,297,464 - 16,402,624 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624768	16,283,369 - 16,404,476 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Abhd2
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	2	120,886,942 - 120,944,564 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Abhd2
690 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	313
Count of miRNA genes:	180
Interacting mature miRNAs:	204
Transcripts:	ENSRNOT00000023506
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
61442	Strs1	Sensitivity to stroke QTL 1	7.4		cerebrum integrity trait (VT:0010549)	post-insult time to onset of cerebrovascular lesion (CMO:0002343)	1	131179947	176179947	Rat
1578780	Cm52	Cardiac mass QTL 52	3.3	0.0001	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	1	137611478	182611478	Rat
1578654	Bss10	Bone structure and strength QTL 10	4		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	1	51940904	168768703	Rat
1554320	Bmd1	Bone mineral density QTL 1	12.2	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	1	101228864	146228864	Rat
1598866	Bp287	Blood pressure QTL 287	5.1		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	130419227	175419227	Rat
1578770	Stresp23	Stress response QTL 23			kidney sympathetic nerve activity (VT:0004050)	stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)	1	132760429	191848948	Rat
631684	Bp117	Blood pressure QTL 117	8.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	120082258	165082258	Rat
9590300	Scort16	Serum corticosterone level QTL 16	4.39	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	1	112521556	157521556	Rat
2298545	Neuinf8	Neuroinflammation QTL 8	4.6		nervous system integrity trait (VT:0010566)	spinal cord beta-2 microglobulin mRNA level (CMO:0002125)	1	66009857	160501508	Rat
631199	Cm23	Cardiac mass QTL 23	4.6	0.0004	heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	1	142582336	182383862	Rat
2313402	Anxrr24	Anxiety related response QTL 24			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	1	51511344	153680016	Rat
1598850	Bp297	Blood pressure QTL 297	2.1		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	130419227	175419227	Rat
631570	Bp94	Blood pressure QTL 94		0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	132889797	152403053	Rat
152025235	Bw194	Body weight QTL 194	4.86		body mass (VT:0001259)		1	132966869	252856240	Rat
61341	Bp26	Blood pressure QTL 26			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	139442053	223964440	Rat
152025232	Bw192	Body weight QTL 192	3.93		body mass (VT:0001259)		1	127329268	206393015	Rat
724521	Uae1	Urinary albumin excretion QTL 1	3.8	0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	99645382	182701046	Rat
1358902	Bw47	Body weight QTL 47	1.67		body mass (VT:0001259)	body weight (CMO:0000012)	1	99645382	221502378	Rat
61346	Rf2	Renal disease susceptibility QTL 2	3.7		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	1	142582180	153680016	Rat
8655649	Arrd1	Age-related retinal degeneration QTL 1	4.89		retinal layer morphology trait (VT:0003727)	percentage of study population developing retinopathy during a period of time (CMO:0002453)	1	109493780	193400781	Rat
2317833	Alcrsp19	Alcohol response QTL 19	12.4	0.001	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	1	110389869	155389869	Rat
1300153	Bp171	Blood pressure QTL 171	3.37		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	1	124975316	152612788	Rat
631202	Gluco13	Glucose level QTL 13		0.0001	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	141173126	169168317	Rat
731168	Bp154	Blood pressure QTL 154	3.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	103779152	223964440	Rat
631205	Bp196	Blood pressure QTL 196	4	0.0001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	98879955	208479939	Rat
631206	Niddm40	Non-insulin dependent diabetes mellitus QTL 40			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	1	140833106	185833106	Rat
1641897	Alcrsp1	Alcohol response QTL 1			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	1	110389869	155389869	Rat
1331751	Bp199	Blood pressure QTL 199	3.60022		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	1	116099376	191260518	Rat
2293142	Bp314	Blood pressure QTL 314			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	101594089	146594089	Rat
2293140	Bp313	Blood pressure QTL 313			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	131243790	176243790	Rat
724529	Cm16	Cardiac mass QTL 16	2.7		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	1	96717367	160111531	Rat
737974	Bp161	Blood pressure QTL 161		0.002	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	129182274	174182274	Rat
1641895	Bp298	Blood pressure QTL 298			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	132760429	191848948	Rat
631496	Bp97	Blood pressure QTL 97	3.08		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	115183611	176289080	Rat
634314	Niddm44	Non-insulin dependent diabetes mellitus QTL 44			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	51941022	208479811	Rat
1331793	Bp200	Blood pressure QTL 200	3.71601		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	102780511	182384005	Rat
1354591	Cm36	Cardiac mass QTL 36	4.1		heart left ventricle mass (VT:0007031)	calculated heart weight (CMO:0000073)	1	111949780	210707719	Rat
7421630	Bp362	Blood pressure QTL 362		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	128019551	173019551	Rat
70225	Bp58	Blood pressure QTL 58	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	34184556	172281316	Rat
10059597	Bp377	Blood pressure QTL 377	3.42	0.025	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	34565911	208798288	Rat
631519	Pia11	Pristane induced arthritis QTL 11	5.3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	1	93903998	191260518	Rat
61399	Tcat1	Tongue tumor resistance QTL 1	3.3		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 5 mm (CMO:0001879)	1	108680016	153680016	Rat
724562	Rends1	Renal damage susceptibility QTL 1		0.05	kidney glomerulus integrity trait (VT:0010546)	index of glomerular damage (CMO:0001135)	1	139442053	223964440	Rat
724567	Tcas6	Tongue tumor susceptibility QTL 6	6.85		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	1	102359314	153680016	Rat
738006	Anxrr14	Anxiety related response QTL 14	4	0.00035	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	1	140048073	185048073	Rat
1354615	Cm32	Cardiac mass QTL 32	5.2		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	1	111949780	210707719	Rat
634348	Bp138	Blood pressure QTL 138			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	135021436	178317588	Rat
8694370	Bw154	Body weight QTL 154	8.91	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	1	112521556	157521556	Rat
738028	Anxrr12	Anxiety related response QTL 12	4.9	0.00001	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	1	140048073	185048073	Rat
1354623	Rf46	Renal function QTL 46	3.8		blood creatinine amount (VT:0005328)	plasma creatinine level (CMO:0000537)	1	111949780	160574007	Rat
631654	Bp107	Blood pressure QTL 107			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	135021436	180021436	Rat
631544	Bp84	Blood pressure QTL 84	5.6		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	132760429	191190115	Rat
152025212	Bw190	Body weight QTL 190	5.7		body mass (VT:0001259)		1	132966869	206393015	Rat
631549	Bp89	Blood pressure QTL 89	5.7		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	132760429	152404087	Rat
631548	Bp88	Blood pressure QTL 88	5	0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	140915717	185915717	Rat
61433	Cia2	Collagen induced arthritis QTL 2	5		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	1	100345976	145345976	Rat
1358189	Cstrr1	Cold stress response QTL 1		0.0001	catecholamine amount (VT:0010543)	urine norepinephrine level (CMO:0001629)	1	132760429	191848948	Rat
1354606	Bp246	Blood pressure QTL 246	3.6		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	1	111949780	228180370	Rat

Markers in Region

BF413329

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	133,215,894 - 133,215,984 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	140,996,732 - 140,996,821	NCBI	Rnor6.0
Rnor_5.0	1	141,964,068 - 141,964,157	UniSTS	Rnor5.0
RGSC_v3.4	1	135,023,636 - 135,023,725	UniSTS	RGSC3.4
Celera	1	125,279,792 - 125,279,881	UniSTS
RH 3.4 Map	1	1058.8	UniSTS
Cytogenetic Map	1	q31	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	161	91	90	59	92	59	6	356	192	11	140	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001106275	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC106909	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473980	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000023506 ⟹ ENSRNOP00000023506

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	142,626,755 - 142,712,674 (+)	Ensembl
mRatBN7.2 Ensembl	1	133,217,439 - 133,299,061 (+)	Ensembl
Rnor_6.0 Ensembl	1	140,998,240 - 141,087,405 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000090897 ⟹ ENSRNOP00000072489

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	142,626,732 - 142,712,674 (+)	Ensembl
mRatBN7.2 Ensembl	1	133,217,375 - 133,299,061 (+)	Ensembl
Rnor_6.0 Ensembl	1	140,998,260 - 141,087,084 (+)	Ensembl

RefSeq Acc Id:

NM_001106275 ⟹ NP_001099745

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	142,626,748 - 142,707,892 (+)	NCBI
mRatBN7.2	1	133,217,403 - 133,298,564 (+)	NCBI
Rnor_6.0	1	140,998,240 - 141,087,405 (+)	NCBI
Rnor_5.0	1	141,965,576 - 142,049,687 (+)	NCBI
RGSC_v3.4	1	135,025,144 - 135,111,792 (+)	RGD
Celera	1	125,281,300 - 125,361,782 (+)	RGD

Sequence:

show sequence

GCGGCGGGAGCTGCGCTGGCCAGGGGTTCCGGCTGTATTTCTATGAGCGCAGCCGGCAGCTGCG
GAGCTGCGGGAACCGGACTCCGGGCGGGCTGGACCGCGGGAGTCACCGAGCAAAGCTTTTAGGT
TACTTTGAATACAAGATCAGATCTGATTGGCCCACCTGTATACCTCTTCAAGGAAAGCCGGTCT
TCTCCGTGGGAGGAGTAAGCGACATAGAATCAAGATGAATGCCATGTTGGAGACCCCCGAGCTC
CCCGCCGTGTTTGACGGGGTGAAGCTGGCTGCCGTAGCTGCCGTTCTCTACGTCATCGTGCGGT
GTTTGAACCTGAAGAGCCCTACTGCCCCTCCTGACCTCTACTTCCAGGACTCCGGGCTCTCACG
TTTCCTGCTCAAATCCTGTCCTCTTCTGACCAAAGAATACATTCCACCACTAATCTGGGGAAAG
AGTGGACATATCCAGACAGCCTTGTATGGGAAGATGGGGAGGGTGAGGTCGCCACACCCTTACG
GGCACCGCAAGTTCATCACCATGTCAGATGGTGCCACTTCTACATTCGACCTCTTCGAGCCCCT
GGCTGAGCACTGTGTTGGAGATGACGTCACCATGGTCATCTGTCCTGGAATTGCCAATCACAGC
GAGAAGCAGTATATCCGAACCTTTGTTGACTATGCACAGAAAAATGGCTACCGGTGCGCAGTGC
TAAACCACCTGGGGGCCCTCCCCAACATTGAGCTGACCTCCCCACGCATGTTCACCTATGGCTG
CACGTGGGAATTTGGAGCCATGGTGAACTACATCAAGAAGACATATCCCCAGACTCAGCTGGTC
GTCGTGGGCTTCAGCCTGGGTGGTAACATCGTGTGCAAATACTTGGGGGAGACGCAGGCCAACC
AGGAAAAGGTCCTATGCTGTGTCAGTGTTTGCCAGGGGTACAGTGCACTGAGGGCCCAGGAGAC
CTTCATGCAGTGGGACCAGTGTCGCCGGTTCTACAACTTCCTCATGGCTGACAACATGAAGAAG
ATCATCCTGTCTCACAGACAAGCTCTCTTTGGAGACCATGTTAAGAAACCCCAGAGCCTGGAGG
ACACGGACTTGAGCCGGCTCTACACAGCAACGTCCCTGATGCAGATCGATGACAATGTGATGAG
AAAGTTCCATGGCTATAACTCCCTGAAGGAATATTATGAGGAAGAGAGCTGCATGAGGTACCTG
CACAGGATATACGTGCCTCTCATGCTGGTCAATGCTGCTGACGACCCCTTGGTGCACGAAAGCC
TTCTAACCATTCCAAAGTCTCTCTCAGAGAAACGGGAAAATGTCATGTTTGTGCTGCCTCTGCA
TGGGGGCCACCTGGGCTTCTTCGAGGGCTCCGTGCTGTTCCCAGAGCCGCTGACATGGATGGAT
AAGCTGGTGGTGGAGTACGCCAATGCCATTTGCCAATGGGAAAGGAATAAGTCCCAGTGCTCAG
ACACGGAGCAGATGGAGGCCGAGTTAGAATGAGGCCTCCGGACTCTGGCGTGCTCCAGCGGCCC
TCCTCTGGAACCCACGCTTTGACGGCTGTTTCAGGTCTCTCAGTGACCTGGATCTGACCTCATA
CCATCAGTGGGGGGTTACCCATCATGCAACCTGTCTAAAGTAGGCGGCTCTCCCTGGGAGCTCC
AGGCTATTTTTGTGCTTAGTTACGGGTTTTCTCCATTGCATTGTTAGCCATGGTGACAAGCTAC
AAGATTCTCACCCTTCTGTCCAGTTTCAGTGTCTGATTGCTTTCACAGCCAGTAACATCTAGTT
TTCCTACTAAGGAGCTAGTCTGAACTACAGTTTTGCTTTGCCAGTCAAAGGCCTTTCCCTGAGA
ACAGTGAAGGATGTACGTCACTTTGTGATGGTTGTAGGCGCCCTACCAGAGTCCCCACCAAGAA
GTCATATCTCTAGTGCTGAAGACATCACTCAGCTTGGGAGTCCGAGGACCTGGGGCTTCCTGGG
CCTGAACTTTGCCTGTGAAGCAAAGGAAGTTCTCTGATC

hide sequence

Protein Sequences


Protein RefSeqs	NP_001099745	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM08574	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000023506
	ENSRNOP00000023506.4
	ENSRNOP00000072489.1

RefSeq Acc Id:

NP_001099745 ⟸ NM_001106275

- UniProtKB:

D4A7W1 (UniProtKB/TrEMBL), A6JC47 (UniProtKB/TrEMBL), A0A0G2K337 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MNAMLETPELPAVFDGVKLAAVAAVLYVIVRCLNLKSPTAPPDLYFQDSGLSRFLLKSCPLLTK
EYIPPLIWGKSGHIQTALYGKMGRVRSPHPYGHRKFITMSDGATSTFDLFEPLAEHCVGDDVTM
VICPGIANHSEKQYIRTFVDYAQKNGYRCAVLNHLGALPNIELTSPRMFTYGCTWEFGAMVNYI
KKTYPQTQLVVVGFSLGGNIVCKYLGETQANQEKVLCCVSVCQGYSALRAQETFMQWDQCRRFY
NFLMADNMKKIILSHRQALFGDHVKKPQSLEDTDLSRLYTATSLMQIDDNVMRKFHGYNSLKEY
YEEESCMRYLHRIYVPLMLVNAADDPLVHESLLTIPKSLSEKRENVMFVLPLHGGHLGFFEGSV
LFPEPLTWMDKLVVEYANAICQWERNKSQCSDTEQMEAELE

hide sequence

Ensembl Acc Id:

ENSRNOP00000023506 ⟸ ENSRNOT00000023506

Ensembl Acc Id:

ENSRNOP00000072489 ⟸ ENSRNOT00000090897

Protein Domains

AB hydrolase-1

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-A0A0G2K337-F1-model_v2	AlphaFold	A0A0G2K337	1-453	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13690129

Promoter ID:

EPDNEW_R652

Type:

initiation region

Name:

Abhd2_1

Description:

abhydrolase domain containing 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	1	140,998,274 - 140,998,334	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1311389	AgrOrtholog
BioCyc Gene	G2FUF-58810	BioCyc
BioCyc Pathway	LIPAS-PWY [triacylglycerol degradation]	BioCyc
	PWY-7420 [monoacylglycerol metabolism (yeast)]	BioCyc
BioCyc Pathway Image	LIPAS-PWY	BioCyc
	PWY-7420	BioCyc
Ensembl Genes	ENSRNOG00000017120	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000023506	ENTREZGENE
	ENSRNOT00000023506.8	UniProtKB/TrEMBL
	ENSRNOT00000090897.3	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.1820	UniProtKB/TrEMBL
InterPro	AB-Hydro_YheT	UniProtKB/TrEMBL
	AB_hydrolase	UniProtKB/TrEMBL
	AB_hydrolase_1	UniProtKB/TrEMBL
	AB_hydrolase_4_sf	UniProtKB/TrEMBL
	UPF0017_hydro-like_CS	UniProtKB/TrEMBL
KEGG Report	rno:293050	UniProtKB/TrEMBL
NCBI Gene	293050	ENTREZGENE
PANTHER	ABHYDROLASE DOMAIN-CONTAINING PROTEIN	UniProtKB/TrEMBL
	MONOACYLGLYCEROL LIPASE ABHD2	UniProtKB/TrEMBL
Pfam	Abhydrolase_1	UniProtKB/TrEMBL
PharmGKB	ABHD2	RGD
PhenoGen	Abhd2	PhenoGen
PIRSF	Ab_hydro_YheT	UniProtKB/TrEMBL
PROSITE	UPF0017	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000017120	RatGTEx
Superfamily-SCOP	SSF53474	UniProtKB/TrEMBL
UniProt	A0A0G2K337	ENTREZGENE, UniProtKB/TrEMBL
	A6JC47	ENTREZGENE, UniProtKB/TrEMBL
	D4A7W1	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2020-02-13	Abhd2	abhydrolase domain containing 2, acylglycerol lipase	Abhd2	abhydrolase domain containing 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Abhd2	abhydrolase domain containing 2	Abhd2_predicted	abhydrolase domain containing 2 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Abhd2_predicted	abhydrolase domain containing 2 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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