Emc8 (ER membrane protein complex subunit 8)

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Gene: Emc8 (ER membrane protein complex subunit 8) Rattus norvegicus

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Symbol:

Emc8

Name:

ER membrane protein complex subunit 8

RGD ID:

1311219

Description:

Predicted to contribute to membrane insertase activity. Predicted to be involved in protein insertion into ER membrane by stop-transfer membrane-anchor sequence and tail-anchored membrane protein insertion into ER membrane. Predicted to be located in Golgi apparatus and endoplasmic reticulum. Predicted to be part of EMC complex. Orthologous to human EMC8 (ER membrane protein complex subunit 8); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 3H-1,2-dithiole-3-thione.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

COX4 neighbor; Cox4nb; DD6A4-2(5); LOC361425; MGC109187; neighbor of Cox4; Noc4

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	EMC8 (ER membrane protein complex subunit 8)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Emc8 (ER membrane protein complex subunit 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Emc8 (ER membrane protein complex subunit 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	EMC8 (ER membrane protein complex subunit 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	EMC8 (ER membrane protein complex subunit 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Emc8 (ER membrane protein complex subunit 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	EMC8 (ER membrane protein complex subunit 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	EMC8 (ER membrane protein complex subunit 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Emc8 (ER membrane protein complex subunit 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	EMC8 (ER membrane protein complex subunit 8)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Emc8 (ER membrane protein complex subunit 8)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	emc8 (ER membrane protein complex subunit 8)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	F25H2.4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	EMC8-9	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	emc8	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	19	65,620,365 - 65,630,328 (-)	NCBI		GRCr8
mRatBN7.2	19	48,708,304 - 48,721,626 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	19	48,582,574 - 48,721,543 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	19	55,506,023 - 55,515,898 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	19	56,186,676 - 56,196,537 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	19	58,401,260 - 58,411,245 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	19	54,235,949 - 54,245,810 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	19	54,235,936 - 54,245,855 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	19	64,955,327 - 64,965,187 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	19	51,013,951 - 51,023,812 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	19	51,018,832 - 51,028,693 (-)	NCBI
Celera	19	47,963,545 - 47,973,406 (-)	NCBI		Celera
Cytogenetic Map	19	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

persistent fetal circulation syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

2,3',4,4',5-Pentachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (ISO)

2,4-dinitrotoluene (EXP)

2-hydroxypropanoic acid (ISO)

2-palmitoylglycerol (ISO)

3H-1,2-dithiole-3-thione (EXP)

4,4'-sulfonyldiphenol (ISO)

5-aza-2'-deoxycytidine (ISO)

aflatoxin B1 (ISO)

Aflatoxin B2 alpha (ISO)

arsenite(3-) (ISO)

atrazine (ISO)

bisphenol A (EXP,ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

carbon nanotube (ISO)

cisplatin (ISO)

cyclosporin A (ISO)

Dibutyl phosphate (ISO)

disodium selenite (ISO)

doxorubicin (ISO)

ethanol (ISO)

fenthion (ISO)

finasteride (EXP)

flutamide (EXP)

folic acid (ISO)

furan (EXP)

inulin (ISO)

ivermectin (ISO)

leflunomide (EXP)

methidathion (ISO)

nefazodone (EXP)

nickel sulfate (ISO)

nimesulide (EXP)

ozone (EXP,ISO)

paracetamol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenobarbital (ISO)

pirinixic acid (EXP,ISO)

rac-lactic acid (ISO)

resveratrol (ISO)

sevoflurane (ISO)

sodium arsenite (ISO)

thalidomide (ISO)

thiram (ISO)

titanium dioxide (ISO)

triphenyl phosphate (ISO)

Triptolide (EXP)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

protein insertion into ER membrane by stop-transfer membrane-anchor sequence (ISO,ISS)

tail-anchored membrane protein insertion into ER membrane (ISO,ISS)

Cellular Component

cytoplasm (ISO,ISS)

EMC complex (IBA,IEA,ISO,ISS)

endoplasmic reticulum (ISO)

Golgi apparatus (IEA,ISO)

Molecular Function

membrane insertase activity (ISO,ISS)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:14651853	PMID:19946888	PMID:22119785

Genomics

Comparative Map Data

Emc8
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	19	65,620,365 - 65,630,328 (-)	NCBI		GRCr8
mRatBN7.2	19	48,708,304 - 48,721,626 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	19	48,582,574 - 48,721,543 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	19	55,506,023 - 55,515,898 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	19	56,186,676 - 56,196,537 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	19	58,401,260 - 58,411,245 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	19	54,235,949 - 54,245,810 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	19	54,235,936 - 54,245,855 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	19	64,955,327 - 64,965,187 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	19	51,013,951 - 51,023,812 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	19	51,018,832 - 51,028,693 (-)	NCBI
Celera	19	47,963,545 - 47,973,406 (-)	NCBI		Celera
Cytogenetic Map	19	q12	NCBI

EMC8
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	16	85,778,624 - 85,799,544 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	16	85,771,758 - 85,799,608 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	16	85,812,230 - 85,833,150 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	16	84,369,736 - 84,390,601 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	16	84,369,736 - 84,390,601	NCBI
Celera	16	70,115,308 - 70,136,230 (-)	NCBI		Celera
Cytogenetic Map	16	q24.1	NCBI
HuRef	16	71,553,743 - 71,574,663 (-)	NCBI		HuRef
CHM1_1	16	87,223,771 - 87,244,692 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	16	91,844,143 - 91,865,064 (-)	NCBI		T2T-CHM13v2.0

Emc8
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	121,380,653 - 121,394,826 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	121,380,653 - 121,395,312 (-)	Ensembl		GRCm39 Ensembl
GRCm38	8	120,653,914 - 120,668,087 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	120,653,914 - 120,668,573 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	123,177,814 - 123,192,012 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	8	123,539,891 - 123,554,089 (-)	NCBI		MGSCv36	mm8
Celera	8	124,869,770 - 124,883,970 (-)	NCBI		Celera
Cytogenetic Map	8	E1	NCBI
cM Map	8	69.98	NCBI

Emc8
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955541	871,657 - 884,247 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955541	873,354 - 884,247 (-)	NCBI	ChiLan1.0	ChiLan1.0

EMC8
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	18	95,529,572 - 95,550,273 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	16	101,447,630 - 101,467,586 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	16	66,446,272 - 66,467,191 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	16	85,784,653 - 85,805,465 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	16	85,784,653 - 85,805,465 (-)	Ensembl	panpan1.1		panPan2

EMC8
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	66,891,619 - 66,910,628 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	66,890,224 - 66,911,451 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	66,907,805 - 66,926,307 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	67,120,265 - 67,138,690 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	5	67,119,475 - 67,141,206 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	5	67,141,708 - 67,160,178 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	66,975,784 - 66,994,009 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	67,390,736 - 67,409,228 (+)	NCBI		UU_Cfam_GSD_1.0

Emc8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	26,942,637 - 26,956,594 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936641	2,696,178 - 2,710,180 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936641	2,696,184 - 2,710,141 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

EMC8
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	6	3,137,630 - 3,152,291 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	3,460,323 - 3,474,934 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

EMC8
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	5	71,185,407 - 71,207,478 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	5	71,186,424 - 71,207,238 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666047	4,530,584 - 4,552,734 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Emc8
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624746	2,173,578 - 2,187,440 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624746	2,173,578 - 2,187,354 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Emc8
96 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	33
Count of miRNA genes:	30
Interacting mature miRNAs:	33
Transcripts:	ENSRNOT00000023855
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1578764	Stresp19	Stress response QTL 19	3.6	0.001	blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	19	15630201	57337602	Rat
61350	Bp32	Blood pressure QTL 32		0.012	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	19	20483575	57337602	Rat
5135224	Leukc1	Leukocyte quantity QTL 1			eosinophil quantity (VT:0002602)	blood eosinophil count (CMO:0000033)	19	44340214	55283277	Rat
724546	Kidm3	Kidney mass QTL 3	3.1		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	19	29322490	57337602	Rat
7411549	Bw130	Body weight QTL 130	5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	19	15455860	57337602	Rat
1358200	Insglur2	Insulin/glucose ratio QTL 2	4.1		blood glucose amount (VT:0000188)	serum glucose level (CMO:0000543)	19	33838214	55283146	Rat
724566	Uae12	Urinary albumin excretion QTL 12	5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	19	2187927	56457239	Rat
1331737	Uae29	Urinary albumin excretion QTL 29	5.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	19	4096155	55283277	Rat
2298478	Eau8	Experimental allergic uveoretinitis QTL 8		0.0163	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	19	17154433	57337602	Rat

Markers in Region

AA800179

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	19	48,711,766 - 48,711,979 (+)	MAPPER	mRatBN7.2
Rnor_6.0	19	54,236,045 - 54,236,257	NCBI	Rnor6.0
Rnor_5.0	19	64,955,423 - 64,955,635	UniSTS	Rnor5.0
RGSC_v3.4	19	51,014,047 - 51,014,259	UniSTS	RGSC3.4
Celera	19	47,963,641 - 47,963,853	UniSTS
RH 3.4 Map	19	659.1	UniSTS
Cytogenetic Map	19	q12	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001012165	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063278149	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063278150	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010060016	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC118833	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF034239	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC089914	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473972	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000019	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000023855 ⟹ ENSRNOP00000023855

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	19	48,582,574 - 48,721,543 (-)	Ensembl
Rnor_6.0 Ensembl	19	54,235,936 - 54,245,855 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000102818 ⟹ ENSRNOP00000086027

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	19	48,582,574 - 48,721,441 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000111906 ⟹ ENSRNOP00000085333

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	19	48,712,088 - 48,721,441 (-)	Ensembl

RefSeq Acc Id:

NM_001012165 ⟹ NP_001012165

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	19	65,620,374 - 65,630,235 (-)	NCBI
mRatBN7.2	19	48,711,671 - 48,721,532 (-)	NCBI
Rnor_6.0	19	54,235,949 - 54,245,810 (-)	NCBI
Rnor_5.0	19	64,955,327 - 64,965,187 (-)	NCBI
RGSC_v3.4	19	51,013,951 - 51,023,812 (-)	RGD
Celera	19	47,963,545 - 47,973,406 (-)	RGD

Sequence:

show sequence

GGCGGACTGAGGCGGGAGGCTGTAGCTGGTGGTGGGAGCTCATCTTAGCGTGCAGTGGGGTCGT
GTTTCGTACTGTGGTGCGTTGGTCGCGACGCGACCAGCTAGGCTCAGCATGCCTGGCGTGAAGC
TGACCACCCAGGCCTACTGCAAGATGGTGCTACACGGCGCCAAGTACCCGCACTGCGCCGTCAA
CGGGCTTCTGGTGGCAGAGAGGCAGAGGCCGCGCAAGGAACATCCTCCCGGCGCGGGCAACCAC
ACTCTCTTCGTGGACTGCATCCCGCTCTTCCACGGCACGCTGGCTCTGACGCCCATGCTGGAGG
TGGCGCTCACCCTAATTGACTCATGGTGCAAAGACAACAGCTATGTGATCGCCGGCTATTACCA
AGCTAATGAACGTGTGAAGGATGCCAGCCCAAACCAGGTGGCAGAGAAGGTGGCCTCCAGGATC
GCAGAGGGCTTCAGTGATGCTGCACTCATCATGGTGGACAACGCCAAGTTCACGATGGACTGTG
CAGCGCCCACGATCCACGTGTATGAGCAACACGAGAACAGGTGGCGGTGCCGAGACCCACATCA
CGACTACTGTGAAGATTGGCCGGAGGCTCAGAGGATCTCCGCTTCGCTCCTGGACAGCCGCTCC
TATGAGACACTTGTAGATTTTGATAATCACCTGGATGACATTCGGAGCGACTGGACAAACCCAG
AGATCAACAAAGCAGTTCTACACCTGTGCTAGACAAGGACCACGACTGGAGACTCCACTACAGA
GAAGATGAAAGCGTATTTTTAAATGTAGAGGCATAGTGGGTTAGCCCATGGGAAGCTGCAAGTC
TGTAATGTGTGCCTTGGAACGGGTGCAGCCGGCATCCTTCAGGGCGGGGCTGTGGAGAGAGAGC
TGTGGGCTATCTGGGCTTTGGGTTCTTAGTCCTGTGCTGCCCAACCCTGCCCATCAAAGCTCTT
TCTGCTTGTCCCAGGTTATTCCCATTAAACAGTTGTAGCCTTTTAAAAAAAAAAAAAAAAAAAA
AAAAA

hide sequence

RefSeq Acc Id:

XM_063278149 ⟹ XP_063134219

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	19	65,620,365 - 65,623,398 (-)	NCBI

RefSeq Acc Id:

XM_063278150 ⟹ XP_063134220

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	19	65,621,630 - 65,630,328 (-)	NCBI

RefSeq Acc Id:

XR_010060016

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	19	65,621,104 - 65,630,326 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001012165	(Get FASTA)	NCBI Sequence Viewer
	XP_063134219	(Get FASTA)	NCBI Sequence Viewer
	XP_063134220	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH89914	(Get FASTA)	NCBI Sequence Viewer
	EDL92705	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000023855.2
	ENSRNOP00000085333.1
	ENSRNOP00000086027.1
	ENSRNOP00055030770
	ENSRNOP00060024906
	ENSRNOP00065007732
GenBank Protein	Q5FVL2	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001012165 ⟸ NM_001012165

- UniProtKB:

Q5FVL2 (UniProtKB/Swiss-Prot), A6IZM7 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MPGVKLTTQAYCKMVLHGAKYPHCAVNGLLVAERQRPRKEHPPGAGNHTLFVDCIPLFHGTLAL
TPMLEVALTLIDSWCKDNSYVIAGYYQANERVKDASPNQVAEKVASRIAEGFSDAALIMVDNAK
FTMDCAAPTIHVYEQHENRWRCRDPHHDYCEDWPEAQRISASLLDSRSYETLVDFDNHLDDIRS
DWTNPEINKAVLHLC

hide sequence

Ensembl Acc Id:

ENSRNOP00000023855 ⟸ ENSRNOT00000023855

Ensembl Acc Id:

ENSRNOP00000085333 ⟸ ENSRNOT00000111906

Ensembl Acc Id:

ENSRNOP00000086027 ⟸ ENSRNOT00000102818

RefSeq Acc Id:	XP_063134219 ⟸ XM_063278149
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_063134220 ⟸ XM_063278150
- Peptide Label:	isoform X2

Protein Domains

MPN

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q5FVL2-F1-model_v2	AlphaFold	Q5FVL2	1-207	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13701196

Promoter ID:

EPDNEW_R11719

Type:

initiation region

Name:

Emc8_1

Description:

ER membrane protein complex subunit 8

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	19	54,245,821 - 54,245,881	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1311219	AgrOrtholog
BioCyc Gene	G2FUF-5474	BioCyc
Ensembl Genes	ENSRNOG00000017654	Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ENSRNOG00055021979	UniProtKB/Swiss-Prot
	ENSRNOG00060017924	UniProtKB/Swiss-Prot
	ENSRNOG00065006759	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000023855.5	UniProtKB/Swiss-Prot
	ENSRNOT00000102818.1	UniProtKB/Swiss-Prot
	ENSRNOT00000111906.1	UniProtKB/TrEMBL
	ENSRNOT00055037727	UniProtKB/Swiss-Prot
	ENSRNOT00060030760	UniProtKB/Swiss-Prot
	ENSRNOT00065010509	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7305045	IMAGE-MGC_LOAD
InterPro	EMC8/9	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	MPN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:361425	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE	MGC:109187	IMAGE-MGC_LOAD
NCBI Gene	361425	ENTREZGENE
PANTHER	ER MEMBRANE PROTEIN COMPLEX SUBUNIT 8	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR12941	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	UPF0172	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Emc8	PhenoGen
PROSITE	MPN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000017654	RatGTEx
	ENSRNOG00055021979	RatGTEx
	ENSRNOG00060017924	RatGTEx
	ENSRNOG00065006759	RatGTEx
UniProt	A0A8I6A3P3_RAT	UniProtKB/TrEMBL
	A6IZM7	ENTREZGENE, UniProtKB/TrEMBL
	EMC8_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2013-07-16	Emc8	ER membrane protein complex subunit 8	Cox4nb	COX4 neighbor	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	Cox4nb	COX4 neighbor	Noc4	neighbor of Cox4	Symbol and Name updated	1299863	APPROVED
2005-12-06	Noc4	neighbor of Cox4	Noc4_predicted	neighbor of Cox4 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Noc4_predicted	neighbor of Cox4 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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