Emc8 (ER membrane protein complex subunit 8) - Rat Genome Database

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Gene: Emc8 (ER membrane protein complex subunit 8) Rattus norvegicus
Analyze
Symbol: Emc8
Name: ER membrane protein complex subunit 8
RGD ID: 1311219
Description: Predicted to contribute to membrane insertase activity. Predicted to be involved in protein insertion into ER membrane by stop-transfer membrane-anchor sequence and tail-anchored membrane protein insertion into ER membrane. Predicted to be located in cytoplasm. Predicted to be part of EMC complex. Orthologous to human EMC8 (ER membrane protein complex subunit 8); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 3H-1,2-dithiole-3-thione.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: COX4 neighbor; Cox4nb; DD6A4-2(5); LOC361425; MGC109187; neighbor of Cox4; Noc4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81965,620,365 - 65,630,328 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1965,620,375 - 65,630,235 (-)EnsemblGRCr8
mRatBN7.21948,708,304 - 48,721,626 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1948,582,574 - 48,721,543 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1955,506,023 - 55,515,898 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01956,186,676 - 56,196,537 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01958,401,260 - 58,411,245 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01954,235,949 - 54,245,810 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1954,235,936 - 54,245,855 (-)Ensemblrn6Rnor6.0
Rnor_5.01964,955,327 - 64,965,187 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41951,013,951 - 51,023,812 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1947,963,545 - 47,973,406 (-)NCBICelera
RGSC_v3.11951,018,832 - 51,028,693 (-)NCBI
Cytogenetic Map19q12NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA,ISO,ISS)
EMC complex  (IBA,IEA,ISO,ISS)
endoplasmic reticulum  (IEA,ISO)
endoplasmic reticulum membrane  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:14651853   PMID:19946888   PMID:22119785  


Genomics

Comparative Map Data
Emc8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81965,620,365 - 65,630,328 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1965,620,375 - 65,630,235 (-)EnsemblGRCr8
mRatBN7.21948,708,304 - 48,721,626 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1948,582,574 - 48,721,543 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1955,506,023 - 55,515,898 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01956,186,676 - 56,196,537 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01958,401,260 - 58,411,245 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01954,235,949 - 54,245,810 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1954,235,936 - 54,245,855 (-)Ensemblrn6Rnor6.0
Rnor_5.01964,955,327 - 64,965,187 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41951,013,951 - 51,023,812 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1947,963,545 - 47,973,406 (-)NCBICelera
RGSC_v3.11951,018,832 - 51,028,693 (-)NCBI
Cytogenetic Map19q12NCBI
EMC8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381685,778,624 - 85,799,544 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1685,771,758 - 85,799,625 (-)Ensemblhg38GRCh38
GRCh371685,812,230 - 85,833,150 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361684,369,736 - 84,390,601 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341684,369,736 - 84,390,601NCBI
Celera1670,115,308 - 70,136,230 (-)NCBICelera
Cytogenetic Map16q24.1NCBI
HuRef1671,553,743 - 71,574,663 (-)NCBIHuRef
CHM1_11687,223,771 - 87,244,692 (-)NCBICHM1_1
T2T-CHM13v2.01691,844,143 - 91,865,064 (-)NCBIT2T-CHM13v2.0
Emc8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398121,380,653 - 121,394,826 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8121,380,653 - 121,395,312 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm388120,653,914 - 120,668,087 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8120,653,914 - 120,668,573 (-)Ensemblmm10GRCm38
MGSCv378123,177,814 - 123,192,012 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv368123,539,891 - 123,554,089 (-)NCBIMGSCv36mm8
Celera8124,869,770 - 124,883,970 (-)NCBICelera
Cytogenetic Map8E1NCBI
cM Map869.98NCBI
Emc8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955541871,657 - 884,247 (-)Ensembl
ChiLan1.0NW_004955541873,354 - 884,247 (-)NCBIChiLan1.0ChiLan1.0
EMC8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21895,529,572 - 95,550,273 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan116101,447,630 - 101,467,586 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01666,446,272 - 66,467,191 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11685,784,653 - 85,805,465 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1685,784,653 - 85,805,465 (-)EnsemblpanPan2panpan1.1
EMC8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1566,891,619 - 66,910,628 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl566,890,224 - 66,911,451 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha566,907,805 - 66,926,307 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0567,120,265 - 67,138,690 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl567,119,475 - 67,141,206 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1567,141,708 - 67,160,178 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0566,975,784 - 66,994,009 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0567,390,736 - 67,409,228 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Emc8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934926,942,637 - 26,956,594 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366412,696,178 - 2,710,180 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366412,696,184 - 2,710,141 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EMC8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.163,137,630 - 3,152,291 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.263,460,323 - 3,474,934 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EMC8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1571,185,407 - 71,207,478 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl571,186,424 - 71,207,238 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660474,530,584 - 4,552,734 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Emc8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247462,173,578 - 2,187,440 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247462,173,578 - 2,187,354 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Emc8
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11740,301,345 - 40,311,130 (-)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:33
Count of miRNA genes:30
Interacting mature miRNAs:33
Transcripts:ENSRNOT00000023855
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631840Niddm38Non-insulin dependent diabetes mellitus QTL 383.86blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)191032907674246245Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)194622677874246245Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)193236531174246245Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)193628974246245Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)192409397369093973Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191083361874246245Rat
2303628Vencon9Ventilatory control QTL 90.005respiration trait (VT:0001943)minute ventilation (CMO:0000132)192318858668188586Rat
2313395Anxrr26Anxiety related response QTL 26aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)194438513474246245Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)193253961574246245Rat
5135224Leukc1Leukocyte quantity QTL 1eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)196124916174246245Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)193177788874246245Rat
1554318Bmd5Bone mineral density QTL 512.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)192318858668188586Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19219431774246245Rat
1549835Tcas7Tongue tumor susceptibility QTL 70.001tongue integrity trait (VT:0010553)squamous cell carcinoma of the head and neck tumor number (CMO:0001876)194172254674246245Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19219431774246245Rat

Markers in Region
AA800179  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21948,711,766 - 48,711,979 (+)MAPPERmRatBN7.2
Rnor_6.01954,236,045 - 54,236,257NCBIRnor6.0
Rnor_5.01964,955,423 - 64,955,635UniSTSRnor5.0
RGSC_v3.41951,014,047 - 51,014,259UniSTSRGSC3.4
Celera1947,963,641 - 47,963,853UniSTS
RH 3.4 Map19659.1UniSTS
Cytogenetic Map19q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000023855   ⟹   ENSRNOP00000023855
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1965,620,375 - 65,630,235 (-)Ensembl
mRatBN7.2 Ensembl1948,582,574 - 48,721,543 (-)Ensembl
Rnor_6.0 Ensembl1954,235,936 - 54,245,855 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000102818   ⟹   ENSRNOP00000086027
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1965,620,375 - 65,630,235 (-)Ensembl
mRatBN7.2 Ensembl1948,582,574 - 48,721,441 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000111906   ⟹   ENSRNOP00000085333
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1948,712,088 - 48,721,441 (-)Ensembl
RefSeq Acc Id: NM_001012165   ⟹   NP_001012165
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81965,620,374 - 65,630,235 (-)NCBI
mRatBN7.21948,711,671 - 48,721,532 (-)NCBI
Rnor_6.01954,235,949 - 54,245,810 (-)NCBI
Rnor_5.01964,955,327 - 64,965,187 (-)NCBI
RGSC_v3.41951,013,951 - 51,023,812 (-)RGD
Celera1947,963,545 - 47,973,406 (-)RGD
Sequence:
RefSeq Acc Id: XM_063278149   ⟹   XP_063134219
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81965,620,365 - 65,623,398 (-)NCBI
RefSeq Acc Id: XM_063278150   ⟹   XP_063134220
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81965,621,630 - 65,630,328 (-)NCBI
RefSeq Acc Id: XR_010060016
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81965,621,104 - 65,630,326 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001012165 (Get FASTA)   NCBI Sequence Viewer  
  XP_063134219 (Get FASTA)   NCBI Sequence Viewer  
  XP_063134220 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH89914 (Get FASTA)   NCBI Sequence Viewer  
  EDL92705 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000023855
  ENSRNOP00000023855.2
  ENSRNOP00000086027.1
GenBank Protein Q5FVL2 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001012165   ⟸   NM_001012165
- UniProtKB: Q5FVL2 (UniProtKB/Swiss-Prot),   A6IZM7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000023855   ⟸   ENSRNOT00000023855
Ensembl Acc Id: ENSRNOP00000085333   ⟸   ENSRNOT00000111906
Ensembl Acc Id: ENSRNOP00000086027   ⟸   ENSRNOT00000102818
RefSeq Acc Id: XP_063134219   ⟸   XM_063278149
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063134220   ⟸   XM_063278150
- Peptide Label: isoform X2
Protein Domains
MPN

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5FVL2-F1-model_v2 AlphaFold Q5FVL2 1-207 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701196
Promoter ID:EPDNEW_R11719
Type:initiation region
Name:Emc8_1
Description:ER membrane protein complex subunit 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01954,245,821 - 54,245,881EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311219 AgrOrtholog
BioCyc Gene G2FUF-5474 BioCyc
Ensembl Genes ENSRNOG00000017654 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000023855 ENTREZGENE
  ENSRNOT00000023855.5 UniProtKB/Swiss-Prot
  ENSRNOT00000102818.1 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7305045 IMAGE-MGC_LOAD
InterPro EMC8/9 UniProtKB/Swiss-Prot
  MPN UniProtKB/Swiss-Prot
KEGG Report rno:361425 UniProtKB/Swiss-Prot
MGC_CLONE MGC:109187 IMAGE-MGC_LOAD
NCBI Gene 361425 ENTREZGENE
PANTHER ER MEMBRANE PROTEIN COMPLEX SUBUNIT 8 UniProtKB/Swiss-Prot
  PTHR12941 UniProtKB/Swiss-Prot
Pfam UPF0172 UniProtKB/Swiss-Prot
PhenoGen Emc8 PhenoGen
PROSITE MPN UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000017654 RatGTEx
UniProt A6IZM7 ENTREZGENE, UniProtKB/TrEMBL
  EMC8_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-07-16 Emc8  ER membrane protein complex subunit 8  Cox4nb  COX4 neighbor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Cox4nb  COX4 neighbor  Noc4  neighbor of Cox4  Symbol and Name updated 1299863 APPROVED
2005-12-06 Noc4  neighbor of Cox4  Noc4_predicted  neighbor of Cox4 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Noc4_predicted  neighbor of Cox4 (predicted)      Symbol and Name status set to approved 70820 APPROVED