EMC8 (ER membrane protein complex subunit 8)

Gene: EMC8 (ER membrane protein complex subunit 8) Pan paniscus

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Symbol:

EMC8

Name:

ER membrane protein complex subunit 8

RGD ID:

11990388

Description:

ENCODES a protein that exhibits membrane insertase activity (ortholog); INVOLVED IN protein insertion into ER membrane by stop-transfer membrane-anchor sequence (inferred); tail-anchored membrane protein insertion into ER membrane (inferred); ASSOCIATED WITH genetic disease (ortholog); persistent fetal circulation syndrome (ortholog); FOUND IN EMC complex (ortholog)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	18	95,529,572 - 95,550,273 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	16	101,447,630 - 101,467,586 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	16	66,446,272 - 66,467,191 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	16	85,784,653 - 85,805,465 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	16	85,784,653 - 85,805,465 (-)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

persistent fetal circulation syndrome (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

protein insertion into ER membrane by stop-transfer membrane-anchor sequence (IEA)

tail-anchored membrane protein insertion into ER membrane (IEA)

Cellular Component

cytoplasm (IEA)

EMC complex (IEA,ISO)

endoplasmic reticulum (IEA)

Golgi apparatus (IEA)

Molecular Function

membrane insertase activity (IEA,ISO)

protein binding (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

EMC8
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	18	95,529,572 - 95,550,273 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	16	101,447,630 - 101,467,586 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	16	66,446,272 - 66,467,191 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	16	85,784,653 - 85,805,465 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	16	85,784,653 - 85,805,465 (-)	Ensembl	panpan1.1		panPan2

EMC8
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	16	85,778,624 - 85,799,544 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	16	85,771,758 - 85,799,608 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	16	85,812,230 - 85,833,150 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	16	84,369,736 - 84,390,601 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	16	84,369,736 - 84,390,601	NCBI
Celera	16	70,115,308 - 70,136,230 (-)	NCBI		Celera
Cytogenetic Map	16	q24.1	NCBI
HuRef	16	71,553,743 - 71,574,663 (-)	NCBI		HuRef
CHM1_1	16	87,223,771 - 87,244,692 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	16	91,844,143 - 91,865,064 (-)	NCBI		T2T-CHM13v2.0

Emc8
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	121,380,653 - 121,394,826 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	121,380,653 - 121,395,312 (-)	Ensembl		GRCm39 Ensembl
GRCm38	8	120,653,914 - 120,668,087 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	120,653,914 - 120,668,573 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	123,177,814 - 123,192,012 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	8	123,539,891 - 123,554,089 (-)	NCBI		MGSCv36	mm8
Celera	8	124,869,770 - 124,883,970 (-)	NCBI		Celera
Cytogenetic Map	8	E1	NCBI
cM Map	8	69.98	NCBI

Emc8
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	19	65,620,365 - 65,630,328 (-)	NCBI		GRCr8
mRatBN7.2	19	48,708,304 - 48,721,626 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	19	48,582,574 - 48,721,543 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	19	55,506,023 - 55,515,898 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	19	56,186,676 - 56,196,537 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	19	58,401,260 - 58,411,245 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	19	54,235,949 - 54,245,810 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	19	54,235,936 - 54,245,855 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	19	64,955,327 - 64,965,187 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	19	51,013,951 - 51,023,812 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	19	51,018,832 - 51,028,693 (-)	NCBI
Celera	19	47,963,545 - 47,973,406 (-)	NCBI		Celera
Cytogenetic Map	19	q12	NCBI

Emc8
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955541	871,657 - 884,247 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955541	873,354 - 884,247 (-)	NCBI	ChiLan1.0	ChiLan1.0

EMC8
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	66,891,619 - 66,910,628 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	66,890,224 - 66,911,451 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	66,907,805 - 66,926,307 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	67,120,265 - 67,138,690 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	5	67,119,475 - 67,141,206 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	5	67,141,708 - 67,160,178 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	66,975,784 - 66,994,009 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	67,390,736 - 67,409,228 (+)	NCBI		UU_Cfam_GSD_1.0

Emc8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	26,942,637 - 26,956,594 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936641	2,696,178 - 2,710,180 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936641	2,696,184 - 2,710,141 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

EMC8
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	6	3,137,630 - 3,152,291 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	3,460,323 - 3,474,934 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

EMC8
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	5	71,185,407 - 71,207,478 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	5	71,186,424 - 71,207,238 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666047	4,530,584 - 4,552,734 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Emc8
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624746	2,173,578 - 2,187,440 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624746	2,173,578 - 2,187,354 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003820845	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_024925790	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_055100772	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_057300169	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000018	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSPPAT00000062266 ⟹ ENSPPAP00000039356

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	16	85,784,653 - 85,805,465 (-)	Ensembl

RefSeq Acc Id:

ENSPPAT00000062269 ⟹ ENSPPAP00000039359

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	16	85,785,890 - 85,805,308 (-)	Ensembl

RefSeq Acc Id:

XM_003820845 ⟹ XP_003820893

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	18	95,529,572 - 95,550,273 (-)	NCBI
NHGRI_mPanPan1	16	101,447,630 - 101,467,586 (-)	NCBI
Mhudiblu_PPA_v0	16	66,446,272 - 66,467,191 (-)	NCBI
PanPan1.1	16	85,784,653 - 85,805,465 (-)	NCBI

Sequence:

show sequence

AAACGGGGCCGGGCCTGAGGGGTCCCCCGCCAGCCGCGGCCGCGCCATCAATCGCCGCCGCCTC
GTCCCGCTTCTCGGCTGAGGCGCCGCGCGGCCAGGCAGCGGGTCCAGGCCTCAGCCGCGCGCCC
AGGGGCCTCCGGGGCCCTCCCGGGTCAGCATGCCCGGGGTGAAGCTGACCACCCAGGCCTACTG
CAAGATGGTGCTGCACGGCGCCAAGTACCCGCACTGCGCCGTCAACGGGCTCCTGGTGGCCGAG
AAGCAGAAGCCGCGTAAGGAGCACCTCCCCCTGGGCGGCCCGGGCGCCCACCACACCCTCTTCG
TGGACTGCATCCCCCTCTTCCACGGCACCCTGGCCCTAGCCCCCATGCTGGAGGTGGCCCTCAC
CCTGATTGATTCATGGTGCAAAGATCATAGCTACGTGATTGCTGGTTATTATCAAGCTAATGAG
CGAGTAAAGGATGCCAGTCCAAACCAGGTTGCAGAGAAGGTGGCCTCCAGAATCGCCGAGGGCT
TCAGTGACACTGCACTCATCATGGTAGACAACACCAAGTTTACGATGGACTGCGTAGCGCCTAC
GATCCACGTGTACGAGCACCACGAGAACAGATGGCGGTGCAGAGACCCACACCATGACTACTGT
GAAGACTGGCCAGAGGCACAGAGGATCTCAGCCTCGCTCCTGGACAGCCGGTCCTACGAGACGC
TCGTGGATTTCGATAACCACCTGGATGACATTCGGAATGACTGGACAAACCCAGAGATCAATAA
AGCTGTCCTGCACTTGTGCTAGGCAGGCACCGCTGTGACTGGGCTCCGGGCCTTTCCACTACGT
TGAAGAAGAAAACCTATTTTTAAATGTAAATAAAATATCTCGTAGCCTGTGTGGAAAGCTGACC
GTTTTAAGAAGTGGCATGTGCCTTGAAAGGGGGCAGAATGTTCAGTCGGTCGTGGTTTTAACAC
AGAGTCTCTAGAAGAGGTGCAGACATCCCGTCTGACTGTCCCTGTGGACTCTGTCAGTTGTATG
TTGCTATAATCCTCCACATCAAAGCTCTTTCTGCTTGTGCAAGATTGTTCCTATTAAACACTTT
TAACTAACCTTTTATAATCTGGAGAGAATACTTTTTAAGGCTTTTGAACTATCTTTTTTTAAAA
AAAAAAAAGCCCACATCTTATACTCCAATGAGTGTGTTTGTGAGTTTTTATCCTGTTTGAATTT
TGATGTCGTCCAGGTGTCCTGGGATCAGGGTAGACACGTGGAGTGCTGGTGCTGTGCTGTTTGA
GAAGCTCTGTGTGGGTGTTTCTGTGGTCAGGTGGGCTGGGCTGTGAACAGCACTGCTCCACACG
GTGTCGGCTCCCAGAGCCACCGCAGCTCTGCCCAGCGGGAGTGACACCACTGATGCCACAGGAG
CCTTTATCGTTACGGGCAAAAGCAGACATCTCTGGTAGTAGGAGCTCAGTGTGGTGCTCTTCAG
CCACCCAGAAACCTCACATGCCTGCAGGGCCAGGAAAGGGAAATGATCATTTCTTTTGTATTAG
GAAAAACAAGACTTAGACTTCCCGAGTTGTGCAGAGTGACGTCTGTACTTTTTATACTTAGAAC
ATTTGGTCAAGTTTTCTAACCAAACCTTAGGAAATTGAGAGGGAAACTTTGTGGTATGTTTACC
TTTTTTCCTTTTTATATGAATTATTTTGTACAAAGTTCAGAGAGCGGTACCTTTCCTACTGTCT
TTTCTTTGACTCCATGGAGGAATTTGTAACGATCGGTGTGACCTGAAAAGGTTTGTGATACAGC
GGTCACTATTTTCTCTTAACACATAGGAAAAAAGTTCAGACATCGCTACAATAAATGTGCTTTA
TTTGATCCACCAAA

hide sequence

RefSeq Acc Id:

XM_055100772 ⟹ XP_054956747

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	18	95,529,572 - 95,550,273 (-)	NCBI
NHGRI_mPanPan1	16	101,447,630 - 101,467,586 (-)	NCBI

RefSeq Acc Id:

XM_057300169 ⟹ XP_057156152

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	18	95,529,572 - 95,550,273 (-)	NCBI
NHGRI_mPanPan1	16	101,447,630 - 101,467,586 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_003820893	(Get FASTA)	NCBI Sequence Viewer
	XP_054956747	(Get FASTA)	NCBI Sequence Viewer
	XP_057156152	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000039356
	ENSPPAP00000039356.1
	ENSPPAP00000039359.1

RefSeq Acc Id:	XP_003820893 ⟸ XM_003820845
- Peptide Label:	isoform X2
- UniProtKB:	A0A2R9CBP9 (UniProtKB/TrEMBL)
- Sequence:	show sequence MPGVKLTTQAYCKMVLHGAKYPHCAVNGLLVAEKQKPRKEHLPLGGPGAHHTLFVDCIPLFHGT LALAPMLEVALTLIDSWCKDHSYVIAGYYQANERVKDASPNQVAEKVASRIAEGFSDTALIMVD NTKFTMDCVAPTIHVYEHHENRWRCRDPHHDYCEDWPEAQRISASLLDSRSYETLVDFDNHLDD IRNDWTNPEINKAVLHLC hide sequence

RefSeq Acc Id:

ENSPPAP00000039359 ⟸ ENSPPAT00000062269

RefSeq Acc Id:

ENSPPAP00000039356 ⟸ ENSPPAT00000062266

RefSeq Acc Id:	XP_054956747 ⟸ XM_055100772
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_057156152 ⟸ XM_057300169
- Peptide Label:	isoform X3
- UniProtKB:	A0A2R9CBV7 (UniProtKB/TrEMBL)

Protein Domains

MPN

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000042383	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000062266.1	UniProtKB/TrEMBL
	ENSPPAT00000062269.1	UniProtKB/TrEMBL
InterPro	EMC8/9	UniProtKB/TrEMBL
	MPN	UniProtKB/TrEMBL
KEGG Report	pps:100969540	UniProtKB/TrEMBL
NCBI Gene	EMC8	ENTREZGENE
PANTHER	ER MEMBRANE PROTEIN COMPLEX SUBUNIT 8	UniProtKB/TrEMBL
	PTHR12941	UniProtKB/TrEMBL
Pfam	UPF0172	UniProtKB/TrEMBL
PROSITE	MPN	UniProtKB/TrEMBL
UniProt	A0A2R9CBP9	ENTREZGENE, UniProtKB/TrEMBL
	A0A2R9CBV7	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar