Map3k4 (mitogen activated protein kinase kinase kinase 4) - Rat Genome Database

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Gene: Map3k4 (mitogen activated protein kinase kinase kinase 4) Rattus norvegicus
Analyze
Symbol: Map3k4
Name: mitogen activated protein kinase kinase kinase 4
RGD ID: 1311192
Description: Predicted to enable MAP kinase kinase kinase activity. Predicted to be involved in p38MAPK cascade; positive regulation of p38MAPK cascade; and response to UV-C. Predicted to act upstream of or within several processes, including chorionic trophoblast cell differentiation; male germ-line sex determination; and regulation of macromolecule metabolic process. Predicted to be located in cytoplasm. Orthologous to human MAP3K4 (mitogen-activated protein kinase kinase kinase 4); PARTICIPATES IN adenosine signaling pathway; c-Jun N-terminal kinases MAPK signaling pathway; p38 MAPK signaling pathway; INTERACTS WITH 2,6-dinitrotoluene; 4,4'-sulfonyldiphenol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC308106; mitogen-activated protein kinase kinase kinase 4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8150,977,870 - 51,067,117 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl150,979,586 - 51,067,117 (+)EnsemblGRCr8
mRatBN7.2148,431,801 - 48,519,358 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl148,431,830 - 48,519,358 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx149,123,422 - 49,210,946 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0155,108,862 - 55,196,008 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0149,198,915 - 49,286,447 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0148,625,714 - 48,711,642 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl148,625,743 - 48,711,642 (+)Ensemblrn6Rnor6.0
Rnor_5.0151,043,920 - 51,129,819 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4142,891,172 - 42,978,862 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera144,222,636 - 44,308,690 (+)NCBICelera
RGSC_v3.1142,894,086 - 42,981,804 (+)NCBI
Cytogenetic Map1q11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-tribromophenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-methylcholine  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP)
6-propyl-2-thiouracil  (EXP)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
amphetamine  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
C60 fullerene  (EXP)
cadmium dichloride  (EXP)
caffeine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
cypermethrin  (EXP)
D-glucose  (ISO)
decabromodiphenyl ether  (ISO)
dibutyl phthalate  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
enzyme inhibitor  (ISO)
flutamide  (EXP)
formaldehyde  (ISO)
FR900359  (ISO)
gentamycin  (EXP)
glucose  (ISO)
glyphosate  (EXP)
ivermectin  (ISO)
josamycin  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nitrates  (ISO)
paracetamol  (EXP,ISO)
phenytoin  (EXP)
pirinixic acid  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
sodium arsenate  (ISO)
tetrachloromethane  (EXP,ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Mechanisms and functions of p38 MAPK signalling. Cuadrado A and Nebreda AR, Biochem J. 2010 Aug 1;429(3):403-17. doi: 10.1042/BJ20100323.
2. MEK kinases are regulated by EGF and selectively interact with Rac/Cdc42. Fanger GR, etal., EMBO J. 1997 Aug 15;16(16):4961-72.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. The c-jun kinase/stress-activated pathway: regulation, function and role in human disease. Johnson GL and Nakamura K, Biochim Biophys Acta. 2007 Aug;1773(8):1341-8. Epub 2007 Jan 4.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
9. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
10. GOA pipeline RGD automated data pipeline
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:6855886   PMID:9305639   PMID:9827804   PMID:12878610   PMID:16157600   PMID:17015265   PMID:19289495   PMID:21531765   PMID:31602666  


Genomics

Comparative Map Data
Map3k4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8150,977,870 - 51,067,117 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl150,979,586 - 51,067,117 (+)EnsemblGRCr8
mRatBN7.2148,431,801 - 48,519,358 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl148,431,830 - 48,519,358 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx149,123,422 - 49,210,946 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0155,108,862 - 55,196,008 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0149,198,915 - 49,286,447 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0148,625,714 - 48,711,642 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl148,625,743 - 48,711,642 (+)Ensemblrn6Rnor6.0
Rnor_5.0151,043,920 - 51,129,819 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4142,891,172 - 42,978,862 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera144,222,636 - 44,308,690 (+)NCBICelera
RGSC_v3.1142,894,086 - 42,981,804 (+)NCBI
Cytogenetic Map1q11NCBI
MAP3K4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386160,991,769 - 161,117,380 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6160,991,473 - 161,117,385 (+)Ensemblhg38GRCh38
GRCh376161,412,801 - 161,538,412 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366161,332,812 - 161,458,407 (+)NCBIBuild 36Build 36hg18NCBI36
Build 346161,383,232 - 161,508,827NCBI
Celera6162,142,470 - 162,267,820 (+)NCBICelera
Cytogenetic Map6q26NCBI
HuRef6158,868,162 - 158,993,547 (+)NCBIHuRef
CHM1_16161,675,694 - 161,801,069 (+)NCBICHM1_1
T2T-CHM13v2.06162,350,255 - 162,475,786 (+)NCBIT2T-CHM13v2.0
Map3k4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391712,446,508 - 12,537,683 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1712,446,508 - 12,537,683 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381712,227,621 - 12,318,796 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1712,227,621 - 12,318,796 (-)Ensemblmm10GRCm38
MGSCv371712,420,487 - 12,511,526 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361712,070,979 - 12,162,106 (-)NCBIMGSCv36mm8
Celera1712,261,355 - 12,347,211 (-)NCBICelera
Cytogenetic Map17A1NCBI
cM Map178.42NCBI
Map3k4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543920,144,059 - 20,263,879 (-)Ensembl
ChiLan1.0NW_00495543920,144,059 - 20,263,885 (-)NCBIChiLan1.0ChiLan1.0
MAP3K4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25181,166,613 - 181,292,313 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16179,070,978 - 179,197,841 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06158,937,424 - 159,062,550 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16163,948,643 - 164,073,264 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6163,948,122 - 164,073,264 (+)EnsemblpanPan2panpan1.1
MAP3K4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1149,590,615 - 49,702,289 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl149,548,274 - 49,702,289 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha150,433,855 - 50,545,486 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0149,776,134 - 49,887,469 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl149,776,184 - 49,887,472 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1149,658,474 - 49,769,746 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0149,530,210 - 49,640,896 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0150,145,324 - 50,257,061 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Map3k4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946144,657,957 - 144,720,199 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648911,909,922 - 11,975,715 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648911,908,083 - 11,972,186 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAP3K4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl16,891,265 - 7,049,775 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.116,891,255 - 7,049,784 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.218,304,293 - 8,322,833 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MAP3K4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11388,489,835 - 88,621,504 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1388,490,200 - 88,620,992 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604060,826,355 - 60,952,511 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Map3k4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248552,174,097 - 2,298,259 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248552,174,141 - 2,298,219 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Map3k4
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12190,970,127 - 191,058,956 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Map3k4
473 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:301
Count of miRNA genes:179
Interacting mature miRNAs:206
Transcripts:ENSRNOT00000064018
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)14345783787558729Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1774611852746118Rat
1357397Bw41Body weight QTL 414.190.0001body mass (VT:0001259)body weight (CMO:0000012)12940927974409279Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14630261591302615Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)14345783787558729Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)14630261591302615Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)14212296887122968Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1694102251941022Rat
1357401Bw43Body weight QTL 433.75body mass (VT:0001259)body weight (CMO:0000012)1690935351909353Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
631494Bp95Blood pressure QTL 95400.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)11731537851816258Rat
5684998Bss101Bone structure and strength QTL 1013.6tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)1690935351909353Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)14630261591302615Rat
5684999Bss102Bone structure and strength QTL 1025.57e-07tibia strength trait (VT:1000284)tibia stiffness (CMO:0001735)1690935351909353Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
1331778Rf28Renal function QTL 284.66urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)14345783787558729Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)14630261591302615Rat
1578756Iddm22Insulin dependent diabetes mellitus QTL 222.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12050832665508326Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)11168446456684464Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)13070837587558729Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13456572679565726Rat
4889451Eae29Experimental allergic encephalomyelitis QTL 295.51nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1774612152746121Rat
1558642Prcr2Prostate cancer resistance QTL 24.3prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)11037949255379492Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)14630261591302615Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)14350995288509952Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)14212296887122968Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11282049457820494Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)14630261591302615Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat
634353Rends2Renal damage susceptibility QTL 20.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)12065642065656420Rat

Markers in Region
BF418077  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2148,430,853 - 48,430,953 (+)MAPPERmRatBN7.2
Rnor_6.0148,624,724 - 48,624,823NCBIRnor6.0
Rnor_5.0151,130,739 - 51,130,838UniSTSRnor5.0
RGSC_v3.4142,890,153 - 42,890,252UniSTSRGSC3.4
Celera144,221,617 - 44,221,716UniSTS
RH 3.4 Map1570.8UniSTS
Cytogenetic Map1q11UniSTS
PMC148819P7  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2148,475,974 - 48,476,206 (+)MAPPERmRatBN7.2
Rnor_6.0148,668,810 - 48,669,041NCBIRnor6.0
Rnor_5.0151,086,521 - 51,086,752UniSTSRnor5.0
RGSC_v3.4142,935,040 - 42,935,271UniSTSRGSC3.4
Celera144,265,309 - 44,265,540UniSTS
Cytogenetic Map1q11UniSTS
SHGC-59862  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.0151,106,241 - 51,107,504UniSTSRnor5.0
Cytogenetic Map1q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000064018   ⟹   ENSRNOP00000062453
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl150,979,600 - 51,067,117 (+)Ensembl
mRatBN7.2 Ensembl148,431,873 - 48,519,358 (+)Ensembl
Rnor_6.0 Ensembl148,625,743 - 48,711,642 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000084317   ⟹   ENSRNOP00000072741
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl150,979,588 - 51,067,115 (+)Ensembl
mRatBN7.2 Ensembl148,431,841 - 48,519,353 (+)Ensembl
Rnor_6.0 Ensembl148,625,754 - 48,711,634 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000094132   ⟹   ENSRNOP00000081978
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl150,990,116 - 51,067,117 (+)Ensembl
mRatBN7.2 Ensembl148,442,339 - 48,519,353 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000112094   ⟹   ENSRNOP00000083079
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl150,979,588 - 51,065,637 (+)Ensembl
mRatBN7.2 Ensembl148,431,830 - 48,517,878 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000116657   ⟹   ENSRNOP00000096435
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl150,979,596 - 51,067,114 (+)Ensembl
mRatBN7.2 Ensembl148,431,841 - 48,519,353 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000171818   ⟹   ENSRNOP00000106526
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl150,979,586 - 51,067,114 (+)Ensembl
RefSeq Acc Id: NM_001107456   ⟹   NP_001100926
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8150,979,600 - 51,067,117 (+)NCBI
mRatBN7.2148,431,840 - 48,519,358 (+)NCBI
Rnor_6.0148,625,743 - 48,711,642 (+)NCBI
Rnor_5.0151,043,920 - 51,129,819 (-)NCBI
RGSC_v3.4142,891,172 - 42,978,862 (+)RGD
Celera144,222,636 - 44,308,690 (+)RGD
Sequence:
RefSeq Acc Id: NM_001401453   ⟹   NP_001388382
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8150,979,600 - 51,067,117 (+)NCBI
mRatBN7.2148,431,840 - 48,519,358 (+)NCBI
RefSeq Acc Id: NM_001415845   ⟹   NP_001402774
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8150,979,600 - 51,067,117 (+)NCBI
mRatBN7.2148,431,840 - 48,519,358 (+)NCBI
RefSeq Acc Id: XM_039110561   ⟹   XP_038966489
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8150,981,552 - 51,067,117 (+)NCBI
mRatBN7.2148,437,537 - 48,519,358 (+)NCBI
RefSeq Acc Id: XM_039110574   ⟹   XP_038966502
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8150,979,556 - 51,067,117 (+)NCBI
mRatBN7.2148,431,801 - 48,519,358 (+)NCBI
RefSeq Acc Id: XM_063288432   ⟹   XP_063144502
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8150,977,870 - 51,055,128 (+)NCBI
RefSeq Acc Id: XM_063288437   ⟹   XP_063144507
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8151,035,999 - 51,067,117 (+)NCBI
RefSeq Acc Id: NP_001100926   ⟸   NM_001107456
- Peptide Label: isoform 2
- UniProtKB: D3ZGU6 (UniProtKB/TrEMBL),   A6KJY7 (UniProtKB/TrEMBL),   A0A8I5ZTM8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000072741   ⟸   ENSRNOT00000084317
Ensembl Acc Id: ENSRNOP00000062453   ⟸   ENSRNOT00000064018
RefSeq Acc Id: XP_038966502   ⟸   XM_039110574
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZUS1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038966489   ⟸   XM_039110561
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZTM8 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000083079   ⟸   ENSRNOT00000112094
Ensembl Acc Id: ENSRNOP00000096435   ⟸   ENSRNOT00000116657
Ensembl Acc Id: ENSRNOP00000081978   ⟸   ENSRNOT00000094132
RefSeq Acc Id: NP_001388382   ⟸   NM_001401453
- Peptide Label: isoform 1
- UniProtKB: A0A0G2K3R1 (UniProtKB/TrEMBL),   A0A8I5ZUS1 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001402774   ⟸   NM_001415845
- Peptide Label: isoform 3
- UniProtKB: A0A8I6GLL3 (UniProtKB/TrEMBL),   A0A8I5ZUS1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063144502   ⟸   XM_063288432
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063144507   ⟸   XM_063288437
- Peptide Label: isoform X4
Ensembl Acc Id: ENSRNOP00000106526   ⟸   ENSRNOT00000171818
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K3R1-F1-model_v2 AlphaFold A0A0G2K3R1 1-1599 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689622
Promoter ID:EPDNEW_R147
Type:multiple initiation site
Name:Map3k4_1
Description:mitogen activated protein kinase kinase kinase 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0148,625,710 - 48,625,770EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311192 AgrOrtholog
BioCyc Gene G2FUF-61560 BioCyc
Ensembl Genes ENSRNOG00000017419 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000064018 ENTREZGENE
  ENSRNOT00000064018.5 UniProtKB/TrEMBL
  ENSRNOT00000084317 ENTREZGENE
  ENSRNOT00000084317.3 UniProtKB/TrEMBL
  ENSRNOT00000094132 ENTREZGENE
  ENSRNOT00000094132.2 UniProtKB/TrEMBL
  ENSRNOT00000112094.2 UniProtKB/TrEMBL
  ENSRNOT00000116657 ENTREZGENE
  ENSRNOT00000116657.2 UniProtKB/TrEMBL
  ENSRNOT00000171818 ENTREZGENE
  ENSRNOT00000171818.1 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom UniProtKB/TrEMBL
  MAP_kinase_kinase_kinase UniProtKB/TrEMBL
  MEKK4_N UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
KEGG Report rno:308106 UniProtKB/TrEMBL
NCBI Gene 308106 ENTREZGENE
PANTHER MAP KINASE KINASE KINASE SSK2-RELATED-RELATED UniProtKB/TrEMBL
  MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4 UniProtKB/TrEMBL
Pfam MEKK4_N UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
PhenoGen Map3k4 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
RatGTEx ENSRNOG00000017419 RatGTEx
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
UniProt A0A0G2K3R1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZTM8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZUS1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GLL3 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LXI2_RAT UniProtKB/TrEMBL
  A6KJY7 ENTREZGENE, UniProtKB/TrEMBL
  D3ZGU6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Map3k4  mitogen activated protein kinase kinase kinase 4   Map3k4_predicted  mitogen activated protein kinase kinase kinase 4 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Map3k4_predicted  mitogen activated protein kinase kinase kinase 4 (predicted)      Symbol and Name status set to approved 70820 APPROVED