MAP3K4 (mitogen-activated protein kinase kinase kinase 4) - Rat Genome Database

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Gene: MAP3K4 (mitogen-activated protein kinase kinase kinase 4) Pan paniscus
Analyze
Symbol: MAP3K4
Name: mitogen-activated protein kinase kinase kinase 4
RGD ID: 11718771
Description: ENCODES a protein that exhibits ATP binding (inferred); kinase activity (inferred); MAP kinase kinase kinase activity (inferred); INVOLVED IN chorionic trophoblast cell differentiation (ortholog); intracellular signal transduction (ortholog); male germ-line sex determination (ortholog); PARTICIPATES IN adenosine signaling pathway; c-Jun N-terminal kinases MAPK signaling pathway; p38 MAPK signaling pathway; ASSOCIATED WITH 3-methylglutaconic aciduria with deafness, encephalopathy, and Leigh-like syndrome (ortholog); Endometrial Neoplasms (ortholog); genetic disease (ortholog); FOUND IN cytoplasm (inferred)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25181,166,613 - 181,292,313 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16179,070,978 - 179,197,841 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06158,937,424 - 159,062,550 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16163,948,643 - 164,073,264 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6163,948,122 - 164,073,264 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
MAP3K4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25181,166,613 - 181,292,313 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16179,070,978 - 179,197,841 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06158,937,424 - 159,062,550 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16163,948,643 - 164,073,264 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6163,948,122 - 164,073,264 (+)Ensemblpanpan1.1panPan2
MAP3K4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386160,991,769 - 161,117,380 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6160,991,727 - 161,117,385 (+)EnsemblGRCh38hg38GRCh38
GRCh376161,412,801 - 161,538,412 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366161,332,812 - 161,458,407 (+)NCBINCBI36Build 36hg18NCBI36
Build 346161,383,232 - 161,508,827NCBI
Celera6162,142,470 - 162,267,820 (+)NCBICelera
Cytogenetic Map6q26NCBI
HuRef6158,868,162 - 158,993,547 (+)NCBIHuRef
CHM1_16161,675,694 - 161,801,069 (+)NCBICHM1_1
T2T-CHM13v2.06162,350,255 - 162,475,786 (+)NCBIT2T-CHM13v2.0
Map3k4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391712,446,508 - 12,537,683 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1712,446,508 - 12,537,683 (-)EnsemblGRCm39 Ensembl
GRCm381712,227,621 - 12,318,796 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1712,227,621 - 12,318,796 (-)EnsemblGRCm38mm10GRCm38
MGSCv371712,420,487 - 12,511,526 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361712,070,979 - 12,162,106 (-)NCBIMGSCv36mm8
Celera1712,261,355 - 12,347,211 (-)NCBICelera
Cytogenetic Map17A1NCBI
cM Map178.42NCBI
Map3k4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8150,977,870 - 51,067,117 (+)NCBIGRCr8
mRatBN7.2148,431,801 - 48,519,358 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl148,431,830 - 48,519,358 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx149,123,422 - 49,210,946 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0155,108,862 - 55,196,008 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0149,198,915 - 49,286,447 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0148,625,714 - 48,711,642 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl148,625,743 - 48,711,642 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0151,043,920 - 51,129,819 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4142,891,172 - 42,978,862 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1142,894,086 - 42,981,804 (+)NCBI
Celera144,222,636 - 44,308,690 (+)NCBICelera
Cytogenetic Map1q11NCBI
Map3k4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543920,144,059 - 20,263,879 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543920,144,059 - 20,263,885 (-)NCBIChiLan1.0ChiLan1.0
MAP3K4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1149,590,615 - 49,702,289 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl149,548,274 - 49,702,289 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha150,433,855 - 50,545,486 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0149,776,134 - 49,887,469 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl149,776,184 - 49,887,472 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1149,658,474 - 49,769,746 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0149,530,210 - 49,640,896 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0150,145,324 - 50,257,061 (+)NCBIUU_Cfam_GSD_1.0
Map3k4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946144,657,957 - 144,720,199 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648911,909,922 - 11,975,715 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648911,908,083 - 11,972,186 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAP3K4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl16,891,265 - 7,049,775 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.116,891,255 - 7,049,784 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.218,304,293 - 8,322,833 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MAP3K4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11388,489,835 - 88,621,504 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1388,490,200 - 88,620,992 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604060,826,355 - 60,952,511 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Map3k4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248552,174,097 - 2,298,259 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248552,174,141 - 2,298,219 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000052708   ⟹   ENSPPAP00000029856
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl6163,948,122 - 164,073,264 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000052718   ⟹   ENSPPAP00000029866
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl6163,948,122 - 164,065,640 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000052733   ⟹   ENSPPAP00000029881
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl6163,948,643 - 164,073,264 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000052742   ⟹   ENSPPAP00000029889
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl6163,987,353 - 164,072,749 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000052750   ⟹   ENSPPAP00000029897
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl6163,988,652 - 164,072,749 (+)Ensembl
RefSeq Acc Id: XM_003820240   ⟹   XP_003820288
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v25181,166,613 - 181,292,313 (+)NCBI
NHGRI_mPanPan16179,070,978 - 179,197,841 (+)NCBI
Mhudiblu_PPA_v06158,937,465 - 159,062,550 (+)NCBI
PanPan1.16163,948,643 - 164,073,264 (+)NCBI
Sequence:
RefSeq Acc Id: XM_003820241   ⟹   XP_003820289
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v25181,166,766 - 181,292,313 (+)NCBI
NHGRI_mPanPan16179,072,106 - 179,197,841 (+)NCBI
Mhudiblu_PPA_v06158,937,424 - 159,062,550 (+)NCBI
PanPan1.16163,948,643 - 164,073,264 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008973635   ⟹   XP_008971883
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v25181,166,766 - 181,292,313 (+)NCBI
NHGRI_mPanPan16179,072,106 - 179,197,841 (+)NCBI
Mhudiblu_PPA_v06158,937,424 - 159,062,550 (+)NCBI
PanPan1.16163,948,643 - 164,073,264 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008973636   ⟹   XP_008971884
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v25181,166,766 - 181,292,313 (+)NCBI
NHGRI_mPanPan16179,072,106 - 179,197,841 (+)NCBI
Mhudiblu_PPA_v06158,937,424 - 159,062,550 (+)NCBI
PanPan1.16163,948,643 - 164,073,264 (+)NCBI
Sequence:
RefSeq Acc Id: XM_034963205   ⟹   XP_034819096
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v25181,242,537 - 181,292,313 (+)NCBI
NHGRI_mPanPan16179,148,071 - 179,197,841 (+)NCBI
Mhudiblu_PPA_v06159,012,808 - 159,062,550 (+)NCBI
RefSeq Acc Id: XM_055114293   ⟹   XP_054970268
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v25181,166,766 - 181,284,819 (+)NCBI
NHGRI_mPanPan16179,072,379 - 179,190,353 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_003820288   ⟸   XM_003820240
- Peptide Label: isoform X1
- UniProtKB: A0A2R9BTE8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_003820289   ⟸   XM_003820241
- Peptide Label: isoform X3
- UniProtKB: A0A2R9BTH4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008971883   ⟸   XM_008973635
- Peptide Label: isoform X2
- UniProtKB: A0A2R9BTE8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008971884   ⟸   XM_008973636
- Peptide Label: isoform X4
- UniProtKB: A0A2R9BTH4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_034819096   ⟸   XM_034963205
- Peptide Label: isoform X6
RefSeq Acc Id: ENSPPAP00000029856   ⟸   ENSPPAT00000052708
RefSeq Acc Id: ENSPPAP00000029866   ⟸   ENSPPAT00000052718
RefSeq Acc Id: ENSPPAP00000029881   ⟸   ENSPPAT00000052733
RefSeq Acc Id: ENSPPAP00000029889   ⟸   ENSPPAT00000052742
RefSeq Acc Id: ENSPPAP00000029897   ⟸   ENSPPAT00000052750
RefSeq Acc Id: XP_054970268   ⟸   XM_055114293
- Peptide Label: isoform X5
- UniProtKB: A0A2R9BTF9 (UniProtKB/TrEMBL)
Protein Domains
Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000037745 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000052708.1 UniProtKB/TrEMBL
  ENSPPAT00000052718.1 UniProtKB/TrEMBL
  ENSPPAT00000052733.1 UniProtKB/TrEMBL
  ENSPPAT00000052742.1 UniProtKB/TrEMBL
  ENSPPAT00000052750.1 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  MEKK4_N UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
NCBI Gene MAP3K4 ENTREZGENE
PANTHER MAP KINASE KINASE KINASE SSK2-RELATED-RELATED UniProtKB/TrEMBL
  MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4 UniProtKB/TrEMBL
Pfam MEKK4_N UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A2R9BJN1_PANPA UniProtKB/TrEMBL
  A0A2R9BN89_PANPA UniProtKB/TrEMBL
  A0A2R9BTE8 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9BTF9 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9BTH4 ENTREZGENE, UniProtKB/TrEMBL