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Gene: Med17 (mediator complex subunit 17) Rattus norvegicus

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Symbol:

Med17

Name:

mediator complex subunit 17

RGD ID:

1311120

Description:

Contributes to ubiquitin protein ligase activity. Involved in protein ubiquitination. Part of ubiquitin ligase complex. Human ortholog(s) of this gene implicated in infantile cerebral and cerebellar atrophy with postnatal progressive microcephaly. Orthologous to human MED17 (mediator complex subunit 17); PARTICIPATES IN RNA polymerase II transcription pathway; INTERACTS WITH 2,4-dinitrotoluene; 2,6-dinitrotoluene; bisphenol A.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

cofactor required for Sp1 transcriptional activation, subunit 6; Crsp6; LOC300367; mediator of RNA polymerase II transcription subunit 17

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	MED17 (mediator complex subunit 17)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Med17 (mediator complex subunit 17)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Med17 (mediator complex subunit 17)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	MED17 (mediator complex subunit 17)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	MED17 (mediator complex subunit 17)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Med17 (mediator complex subunit 17)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	MED17 (mediator complex subunit 17)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	MED17 (mediator complex subunit 17)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Med17 (mediator complex subunit 17)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Med17 (mediator complex subunit 17)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	IGF2R (insulin like growth factor 2 receptor)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	MED17 (mediator complex subunit 17)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Med17 (mediator complex subunit 17)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	med17 (mediator complex subunit 17)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	mdt-17	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	MED17	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	SRB4	Alliance	DIOPT (Hieranoid\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	med17	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	20,382,995 - 20,401,993 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	8	20,382,995 - 20,401,993 (-)	Ensembl				GRCr8
mRatBN7.2	8	12,101,594 - 12,120,592 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	12,101,594 - 12,120,592 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	8	16,083,107 - 16,102,171 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	14,380,857 - 14,399,921 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	12,364,550 - 12,383,548 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	13,522,257 - 13,835,302 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	13,819,563 - 13,835,168 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	8	13,465,155 - 13,466,922 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
Rnor_5.0	8	13,756,806 - 13,774,832 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	8	12,062,713 - 12,081,709 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	8	13,569,315 - 13,588,313 (-)	NCBI		Celera
RGSC_v3.1	8	12,064,449 - 12,083,299 (-)	NCBI
Cytogenetic Map	8	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

endometriosis (ISO)

genetic disease (ISO)

infantile cerebral and cerebellar atrophy with postnatal progressive microcephaly (ISO)

intellectual disability (ISO)

microcephaly (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-demecolcine (ISO)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

beta-lapachone (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP)

caffeine (ISO)

carbamazepine (ISO)

cobalt dichloride (ISO)

copper(II) sulfate (ISO)

crocidolite asbestos (ISO)

cyclosporin A (ISO)

Dibutyl phosphate (ISO)

dibutyl phthalate (ISO)

diclofenac (ISO)

dioxygen (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

folic acid (ISO)

formaldehyde (ISO)

lead(0) (ISO)

methylmercury chloride (ISO)

perfluorooctanoic acid (ISO)

resveratrol (ISO)

rotenone (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

Soman (EXP)

thimerosal (ISO)

thioacetamide (EXP)

trichostatin A (ISO)

valproic acid (ISO)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

positive regulation of DNA-templated transcription (IEA,ISO)

positive regulation of transcription by RNA polymerase II (ISO)

positive regulation of transcription initiation by RNA polymerase II (IEA,ISO)

protein ubiquitination (IDA)

regulation of transcription by RNA polymerase II (IBA,IEA,ISO)

stem cell population maintenance (ISO)

Cellular Component

core mediator complex (IBA,IEA,ISO)

mediator complex (IBA,IEA,ISO)

nucleus (IEA,ISO)

transcription regulator complex (IEA,ISO)

ubiquitin ligase complex (IDA)

Molecular Function

nuclear thyroid hormone receptor binding (IEA,ISO)

protein binding (ISO)

transcription coactivator activity (IEA,ISO)

transcription coregulator activity (IBA,IEA,ISO)

ubiquitin protein ligase activity (IDA)

Molecular Pathway Annotations Click to see Annotation Detail View

RNA polymerase II transcription pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase.	Brower CS, etal., Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10353-8. Epub 2002 Jul 29.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
5.	The Mediator complex and transcription regulation.	Poss ZC, etal., Crit Rev Biochem Mol Biol. 2013 Nov-Dec;48(6):575-608. doi: 10.3109/10409238.2013.840259. Epub 2013 Oct 3.
6.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
8.	Comprehensive gene review and curation	RGD comprehensive gene curation

Additional References at PubMed

PMID:9989412	PMID:10198638	PMID:10235267	PMID:11867769	PMID:12037571	PMID:12218053	PMID:12477932	PMID:14638676	PMID:15340084	PMID:19946888	PMID:20508642	PMID:20720539

Genomics

Comparative Map Data

Med17
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	20,382,995 - 20,401,993 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	8	20,382,995 - 20,401,993 (-)	Ensembl				GRCr8
mRatBN7.2	8	12,101,594 - 12,120,592 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	12,101,594 - 12,120,592 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	8	16,083,107 - 16,102,171 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	14,380,857 - 14,399,921 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	12,364,550 - 12,383,548 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	13,522,257 - 13,835,302 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	13,819,563 - 13,835,168 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	8	13,465,155 - 13,466,922 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
Rnor_5.0	8	13,756,806 - 13,774,832 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	8	12,062,713 - 12,081,709 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	8	13,569,315 - 13,588,313 (-)	NCBI		Celera
RGSC_v3.1	8	12,064,449 - 12,083,299 (-)	NCBI
Cytogenetic Map	8	q12	NCBI

MED17
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	93,784,282 - 93,814,963 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	93,784,227 - 93,814,963 (+)	Ensembl			hg38	GRCh38
GRCh37	11	93,517,448 - 93,548,129 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	93,157,053 - 93,186,144 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	11	93,157,095 - 93,186,102	NCBI
Celera	11	90,808,857 - 90,837,937 (+)	NCBI		Celera
Cytogenetic Map	11	q21	NCBI
HuRef	11	89,594,312 - 89,623,193 (+)	NCBI		HuRef
CHM1_1	11	93,400,364 - 93,429,449 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	11	93,700,614 - 93,731,285 (+)	NCBI		T2T-CHM13v2.0

Med17
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	15,171,647 - 15,194,576 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	15,171,647 - 15,191,227 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	9	15,260,351 - 15,279,906 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	15,260,351 - 15,279,931 (-)	Ensembl			mm10	GRCm38
MGSCv37	9	15,064,795 - 15,084,311 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	9	15,010,744 - 15,030,260 (-)	NCBI		MGSCv36	mm8
Celera	9	12,539,617 - 12,559,133 (-)	NCBI		Celera
Cytogenetic Map	9	A2	NCBI
cM Map	9	4.74	NCBI

Med17
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955414	755,975 - 777,480 (-)	Ensembl
ChiLan1.0	NW_004955414	755,975 - 779,934 (-)	NCBI	ChiLan1.0	ChiLan1.0

MED17
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	94,644,306 - 94,675,541 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	95,738,225 - 95,767,135 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	88,806,209 - 88,835,138 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	92,292,947 - 92,321,913 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	92,292,947 - 92,321,913 (+)	Ensembl			panPan2	panpan1.1

MED17
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	21	6,967,304 - 6,990,542 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	21	6,967,481 - 6,990,547 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	21	6,982,685 - 7,005,952 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	21	7,147,946 - 7,171,189 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	21	7,118,059 - 7,171,135 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	21	6,934,113 - 6,957,371 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	21	6,998,521 - 7,021,778 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	21	7,047,357 - 7,070,630 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Med17
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	78,871,484 - 78,893,390 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936674	997,259 - 1,019,953 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936674	998,036 - 1,019,937 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MED17
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	26,192,201 - 26,228,612 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	9	26,192,206 - 26,214,177 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	29,825,463 - 29,847,759 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MED17
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	85,031,407 - 85,060,562 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	85,031,716 - 85,059,285 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666043	40,737,891 - 40,768,990 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Med17
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624735	38,427,918 - 38,451,198 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624735	38,427,854 - 38,450,625 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Med17
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	8	11,059,446 - 11,076,761 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Med17
50 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	37
Count of miRNA genes:	37
Interacting mature miRNAs:	37
Transcripts:	ENSRNOT00000014435
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1357398	Slep3	Serum leptin concentration QTL 3	3.43		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	8	17994105	50763951	Rat
2317030	Wbc5	White blood cell count QTL 5	3.21	0.005	leukocyte quantity (VT:0000217)	white blood cell count (CMO:0000027)	8	16994642	61994642	Rat
12880044	Am9	Aortic mass QTL 9		0.007	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	8	10382540	55382540	Rat
2317032	Ginf2	Gastrointestinal inflammation QTL 2	3.21	0.005	liver integrity trait (VT:0010547)	liver granuloma severity score (CMO:0002157)	8	12964165	57964165	Rat
2301416	Bp315	Blood pressure QTL 315		0.008	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	15952279	60952279	Rat
2317036	Livw3	Liver weight QTL 3	2.43	0.01	liver mass (VT:0003402)	liver weight to body weight ratio (CMO:0000633)	8	12964165	57964165	Rat
1598824	Memor4	Memory QTL 4	2.5		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	8	17993862	62252873	Rat
12880023	Bw184	Body weight QTL 184		0.001	body mass (VT:0001259)	body weight (CMO:0000012)	8	10382540	55382540	Rat
9590084	Insglur5	Insulin/glucose ratio QTL 5	18.54	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	8	1	32882639	Rat
12880028	Cm103	Cardiac mass QTL 103		0.02	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	8	10382540	55382540	Rat
2317051	Aia18	Adjuvant induced arthritis QTL 18	2.42		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	8	16994642	61994642	Rat
2317048	Ginf1	Gastrointestinal inflammation QTL 1	3.52	0.005	cecum mucosa thickness (VT:0010234)	enterocolitis severity score (CMO:0002138)	8	12964165	57964165	Rat
2302367	Slep5	Serum leptin concentration QTL 5	3.43		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	8	17994105	50763951	Rat
12880025	Cm102	Cardiac mass QTL 102		0.044	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	8	10382540	55382540	Rat

Markers in Region

RH130708

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	12,122,627 - 12,122,839 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	13,837,338 - 13,837,549	NCBI	Rnor6.0
Rnor_5.0	8	13,776,868 - 13,777,079	UniSTS	Rnor5.0
RGSC_v3.4	8	12,083,745 - 12,083,956	UniSTS	RGSC3.4
Celera	8	13,590,349 - 13,590,560	UniSTS
RH 3.4 Map	8	109.8	UniSTS
Cytogenetic Map	8	q12	UniSTS

RH140967

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	12,103,380 - 12,103,570 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	13,524,066 - 13,524,255	NCBI	Rnor6.0
Rnor_5.0	8	13,465,282 - 13,465,471	UniSTS	Rnor5.0
RGSC_v3.4	8	12,064,500 - 12,064,689	UniSTS	RGSC3.4
Celera	8	13,571,102 - 13,571,291	UniSTS
RH 3.4 Map	8	106.9	UniSTS
Cytogenetic Map	8	q12	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	163	91	90	59	92	59	6	356	192	11	142	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001106801	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC083809	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473993	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ232111	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000014435 ⟹ ENSRNOP00000014435

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	8	20,382,995 - 20,401,993 (-)	Ensembl
mRatBN7.2 Ensembl	8	12,101,594 - 12,120,592 (-)	Ensembl
Rnor_6.0 Ensembl	8	13,819,563 - 13,835,168 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000148759 ⟹ ENSRNOP00000108544

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	8	20,382,995 - 20,401,993 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000158566 ⟹ ENSRNOP00000104996

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	8	20,384,500 - 20,401,993 (-)	Ensembl

RefSeq Acc Id:

NM_001106801 ⟹ NP_001100271

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	20,382,995 - 20,401,993 (-)	NCBI
mRatBN7.2	8	12,101,594 - 12,120,592 (-)	NCBI
Rnor_6.0	8	13,522,257 - 13,835,302 (-)	NCBI
Rnor_5.0	8	13,465,155 - 13,466,922 (-)	NCBI
Rnor_5.0	8	13,756,806 - 13,774,832 (-)	NCBI
RGSC_v3.4	8	12,062,713 - 12,081,709 (-)	RGD
Celera	8	13,569,315 - 13,588,313 (-)	RGD

Sequence:

show sequence

ATTGTGGGACAGCGGTGGGTGGTTGGCTTCCGCCGGGTCCGCCGCGTCGGGCTTTCGGAGAGAT
TGGTGTCCAGCCTTCCGTGTCCGTGCTCGTTTCTGAGTCTCTGGCAAGTCACCCGCAGGCTGCC
GCCAGGATGTCGGGCGTGCGAGCTGTGCGCATCAGCATCGAGTCGGCCTGCGAGAAGCAGGTGC
AGGAGGTGGGCCTTGATGGCACCGAGACGTACCTGCAGCCGCTGTCTATGTCGCAGAACCTGGC
GCGTCTGGCGCAGCGCATCGACTTCAGCCAGGGCTCCGGCTCCGAGGAGGAGGAGGCGGCGGGG
CCTGACGGCGACGCGCCGGACTGGGCGGGCGCGGGGGCCGACCAGGACGACGAAGAGGGGTTGG
TAAAATTCCAACCTTCTCTGTGGCCTTGGGACTCTGTGAGGAACAATTTGCGAAGTGCCCTTAC
AGAGATGTGTGTTCTCTATGATGTCCTCAGTATTGTCAGGGACAAAAAGTTCATGACTCTGGAC
CCCGTCTCTCAGGATGCGCTTCCTCCCAAACAGAGCCCACAGACGCTGCAGCTGATCTCTAAGA
AGAAGTCCCTTGCTGGAGCAGCTCAGATCCTATTGAAGGGGGCGGAAAGACTGACCAAGTCGGT
GACTGAGAACCAGGAAAACAAGCTTCAGCGAGACTTCAATTCTGAGCTCTTGAGACTACGGCAA
CACTGGAAACTGAGGAAGGTGGGAGACAAGATCCTGGGTGACCTAAGCTACAGAAGTGCAGGCT
CTCTTTTTCCCCACCATGGTACCTTTGAAGTGATAAAGAATACAGACATTGACTTGGATAAAAA
GATACCAGAAGATTACTGTCCTCTAGATGTCCAGATTCCTAGTGACTTAGAGGGGTCTGCATAT
ATCAAGGTTTCTATTCAGAAACAGGCTCCAGACATTGGTGATCTTGGTACAGTTAACCTTTTTA
AGAGACCTTTGCCCAAATCCAAGCCAGGTTCCCCACACTGGCAGACAAAATTAGAAGCAGCACA
AAATGTTCTTCTTTGTAAGGAAATTTTTGCACAGCTCTCTCGGGAAGCCGTTCAGATTAAGTCT
CAGATCCCTCACATTGTGGTGAAAAACCAGATCATCTCTCAGCCCTTTCCAAGCTTGCAGTTGT
CTATTTCTCTGTGCCACTCCTCAGATGATAAGAAGTCCCAGAAATGTGCCCCAGAGAAGCCTGG
TCAGGAGGGTCACCTCTACGTCCTGGAGCACAACTTGCACCTGCTGATCAGAGAGTTTCATAAA
CAGACCTTGAGCTCCATCGTGATGCCACACCCAGCGAGTGCTCCTTTTGGGCACAAGAGAATGA
GACTCTCAGGTCCTCAAGCTTTTGATAAGAATGAAATTAATTCAATACAGTCCACAGAAGGACT
CCTAGAAAAAATAATTAAACAAGCAAAGCATATTTTTCTAAGGAGCAGAACTGCTGCGACCATT
GACAGCTTGGCAAGTCGCATTGAGGACCCCCAGATCCAGGCCCACTGGTCGAACATCAACGATG
TGTATGAGTCTAGTGTAAAAGTTTTAATCACATCGCAGGGTTATGAACAGATCTGCAAGTCCAT
CCAGCTGCAGCTGAACATTGGCGTTGAGCAGGTCCGTGTCGTGCACAGAGATGGGCGGGTGATC
ACGCTGTCTCACCAGGAACAGGAACTACAGGACTTCCTTCTGTCTCAGATGTCCCAGCACCAGG
TGCATGCGGTTCAGCAGCTTGCCAAGGTCATGGGCTGGCAGGTCCTCAGCTTCAGCAATCACGT
GGGACTCGGGCCCATAGAGAGTATTGGCAATGCCTCCGCCATCACAGTGGCCTCGCCAAGTGGT
GACTATGCTATTTCAGTTCGTAACGGACCCGAGAGTGGCAGCAAGATCATGGTTCAGTTTCCCC
GTAACCAGTGCAAAGACCTTCCGAAAAGTGATGTTTTACAAGATAGCAAGTGGAGCCATCTCCG
AGGACCGTTCAAGGAGGTTCAGTGGAACAAGATGGAGGGCCGAAACTTCGTTTATAAAATGGAG
CTGCTTATGTCTGCCCTGAGTCCCTGTCTCCTGTGATTTTCTCCAGAACAAGTTGCAGAAATTC
TGACCTGCGTGTTTGCAGATCAGTTATAAGCACAAGGGAGCGATGGCCTCCGTATGAGTACTGA
GCACAGACTCGTGCACTGGCGCTCTAGCCTTTCGCGGGAGTCCTGTTTAAAAGTGACATGTTTA
CCCTGCGTTTGAATTCTCTCACGTTATAAGTGACGAGTACTTTGGAATGGAAAAATGTATGTAC
AGTTTTAGTATGCAGTATGGGGAGATGTAAAATAGTACATTTTTATACAGCTCACCTGAAAATA
TTACTAACTTAAGGGCTTGAATTTGCTTTTTTTTAAATTACATCTTTAATGTTAACATAAACTT
TGTGTTTAAAAATCTCCAAGTATTTTGTGAATTTCTCATAACCTATATGAGCTGCGTCTCAAAT
CAGCCACTCCTGCTGTTTCTTTAAAAATCACTGAAGACCGTCTTACAGCACAGATTCACTGACC
ACACCAGGCCCTGTCCCTGAAGTTCACCGAGATCACTCACAGGAGTAGTCTTCCCTAGCACCTG
GGGCTCTCGGGGTGTGGGGACATGAAGTGCCTTTGTAGCCATCTTCTTCCTCACCTGGGTCAAC
ATGAATGAACAGGGTAAGAACTTCCTCAAAAAGCAGTGGAAACCAAAAAATGTACCATGATAGT
CTGTTTTCCCTGTTAGTGCTCACTGTTTCTGGCTGTGTAGAAACTTCCACAGAGCCGCATCTCG
CTTGAATTTTGACAAGCTGAGGTAAATATAAAGGAGATGCACCAAGTGTGATGGCTCATGCCGG
TGATTGGAGGACTAGGGAGTTGAAGACAGGAAGACAAAGAGTTCAAGTTCAGCCTGATCTGCAT
GAGTTCCAGGCCATCTGGGGCTACGTAGGGCGAGCCTTGTCTCAAAGTTTAAAGATTTATTTAT
TTTATGTATATAGTACACAATAATCTTTAGACACACCAGAAGGTAGAGCATCAGATCCCATGAC
AGATGGCTGTGAGCCACCATTTGGTTGCTGGGAATTGAACTGAGGACCTTGGGAAGAGCAGCCA
GTGCTCTTAACCACTGCGCCATCTCTCCAGTCCTCTAAGTTTAAAAGAAAAGAAAGGGGGTTTT
AGTAAACAAACTGTATTCATACTATGGGTTATGTTTTCCAAGGAGGAAGAGTGAAATTTAATAG
GGAGAGATGTGAAGTGAGAGAATGCATCAGGAAAAGCAGACAGGCCATGGGTACAGTGGCATCC
GTGGGCTGCCATGTCGCCTAGCGGGAAAATGCCTAGTATGCTCCAGGATTACAGAGAAGAGGGG
CGGGTGCATTCGGTTGTCAGAGTGTGTACTGTAATGTAGAGACCTGTTTATGTGTGTGTCCAGA
AAGATACTGTGCCCTCTGAGAAGTAAGGTTGAGGAGAGAGAACTTTCAGTGTATTGGGTTCCTG
TGTATCTTTTGACTTTTCAAGAAGCATTTTTTATTTTTGCAATTAGAGATTCTTGAAAGGTAAG
AGAAATGAGGACTCCAGCTGTCCTTGAGGATTGGCAGCTGAGATGGTGGTCACATGCAGAAGCA
CACACGTGGACAGTCCATCCCTCTTCTGAGTGAAACTTGATGTAGCTGTGGTAACAATAGTTTC
TCAGTTAACTCTAGAGGTGTTTGATATCAGGAAACAGCATAATAAGCCGATCTGATCCATGAAT
CTGGAGGGAAGAGCCTTTACTACCCTGGTATCACTCAAGGCAACTGCGACTGAGACAGGTGCCT
GAAGGTCACTTCAGGCTTTGAGTGTAATTGGCCCCCATAGACCCATAGAGAGTGGCACCATTAG
GAGGTGTGGCCTTGCTGGAGGAAGTGAGTCACTGTGGGGGTGGGCCTTGAGGTCTCATATGCTC
ATGGTACACCCAGTGTGGTACAGTTTCTCCTTGCTGCCTGCAGATCAAGAAGTAGAACTGTAAA
CTCCACGTCCAACATGTCTGCCCATACGCTGCCATGTTATCCGCCATGATGATACTGGACTAAA
CCTCTGAAAGTGTAAGCCAGCCCCACTCAGTGTTTTACTTCGTGGGAGTTGCCTTGGTCCTGCT
GTTTCTTCACAGCAATAGAAC

hide sequence

Protein Sequences


Protein RefSeqs	NP_001100271	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL78452	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000014435
	ENSRNOP00000014435.6
	ENSRNOP00000104996.1
	ENSRNOP00000108544.1

RefSeq Acc Id:

NP_001100271 ⟸ NM_001106801

- UniProtKB:

D4ABU0 (UniProtKB/TrEMBL), A6JNB4 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSGVRAVRISIESACEKQVQEVGLDGTETYLQPLSMSQNLARLAQRIDFSQGSGSEEEEAAGPD
GDAPDWAGAGADQDDEEGLVKFQPSLWPWDSVRNNLRSALTEMCVLYDVLSIVRDKKFMTLDPV
SQDALPPKQSPQTLQLISKKKSLAGAAQILLKGAERLTKSVTENQENKLQRDFNSELLRLRQHW
KLRKVGDKILGDLSYRSAGSLFPHHGTFEVIKNTDIDLDKKIPEDYCPLDVQIPSDLEGSAYIK
VSIQKQAPDIGDLGTVNLFKRPLPKSKPGSPHWQTKLEAAQNVLLCKEIFAQLSREAVQIKSQI
PHIVVKNQIISQPFPSLQLSISLCHSSDDKKSQKCAPEKPGQEGHLYVLEHNLHLLIREFHKQT
LSSIVMPHPASAPFGHKRMRLSGPQAFDKNEINSIQSTEGLLEKIIKQAKHIFLRSRTAATIDS
LASRIEDPQIQAHWSNINDVYESSVKVLITSQGYEQICKSIQLQLNIGVEQVRVVHRDGRVITL
SHQEQELQDFLLSQMSQHQVHAVQQLAKVMGWQVLSFSNHVGLGPIESIGNASAITVASPSGDY
AISVRNGPESGSKIMVQFPRNQCKDLPKSDVLQDSKWSHLRGPFKEVQWNKMEGRNFVYKMELL
MSALSPCLL

hide sequence

Ensembl Acc Id:

ENSRNOP00000014435 ⟸ ENSRNOT00000014435

Ensembl Acc Id:

ENSRNOP00000104996 ⟸ ENSRNOT00000158566

Ensembl Acc Id:

ENSRNOP00000108544 ⟸ ENSRNOT00000148759

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D4ABU0-F1-model_v2	AlphaFold	D4ABU0	1-579	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13695752

Promoter ID:

EPDNEW_R6275

Type:

initiation region

Name:

Med17_1

Description:

mediator complex subunit 17

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	8	13,835,264 - 13,835,324	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1311120	AgrOrtholog
BioCyc Gene	G2FUF-31668	BioCyc
Ensembl Genes	ENSRNOG00000010496	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000014435	ENTREZGENE
	ENSRNOT00000014435.9	UniProtKB/TrEMBL
	ENSRNOT00000148759.1	UniProtKB/TrEMBL
	ENSRNOT00000158566.1	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7109944	IMAGE-MGC_LOAD
InterPro	Mediator_Med17	UniProtKB/TrEMBL
KEGG Report	rno:300367	UniProtKB/TrEMBL
MGC_CLONE	MGC:94861	IMAGE-MGC_LOAD
NCBI Gene	300367	ENTREZGENE
PANTHER	MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17	UniProtKB/TrEMBL
	PTHR13114	UniProtKB/TrEMBL
Pfam	DUF2364	UniProtKB/TrEMBL
PhenoGen	Med17	PhenoGen
RatGTEx	ENSRNOG00000010496	RatGTEx
UniProt	A0ABK0L5H6_RAT	UniProtKB/TrEMBL
	A0ABK0M0M8_RAT	UniProtKB/TrEMBL
	A6JNB4	ENTREZGENE, UniProtKB/TrEMBL
	D4ABU0	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-03-03	Med17	mediator complex subunit 17	Crsp6	cofactor required for Sp1 transcriptional activation, subunit 6	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	Crsp6	cofactor required for Sp1 transcriptional activation, subunit 6	Crsp6_predicted	cofactor required for Sp1 transcriptional activation, subunit 6 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Crsp6_predicted	cofactor required for Sp1 transcriptional activation, subunit 6 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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