Sorcs2 (sortilin-related VPS10 domain containing receptor 2) - Rat Genome Database

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Pathways
Gene: Sorcs2 (sortilin-related VPS10 domain containing receptor 2) Rattus norvegicus
Analyze
Symbol: Sorcs2
Name: sortilin-related VPS10 domain containing receptor 2
RGD ID: 1310621
Description: Predicted to be involved in intracellular protein transport and long-term synaptic depression. Predicted to be located in endosome membrane; plasma membrane; and postsynaptic density. Predicted to be active in membrane. Orthologous to human SORCS2 (sortilin related VPS10 domain containing receptor 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 3,7-dihydropurine-6-thione.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC305438; VPS10 domain receptor protein SORCS 2; VPS10 domain-containing receptor SorCS2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Sorcs2em4Mcwi ; Sorcs2em1Mcwi ; Sorcs2em7Mcwi ; Sorcs2em9Mcwi
Genetic Models: SS-Sorcs2em4Mcwi ; SS-Sorcs2em9Mcwi ; SS-Sorcs2em7Mcwi ; SS-Sorcs2em1Mcwi
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81478,592,290 - 78,960,582 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1478,596,087 - 78,960,582 (+)EnsemblGRCr8
mRatBN7.21474,371,089 - 74,735,943 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1474,371,415 - 74,735,943 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1478,813,341 - 79,177,234 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01480,054,214 - 80,418,108 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01476,499,206 - 76,863,105 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01479,538,911 - 79,912,333 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1479,538,911 - 79,912,333 (+)Ensemblrn6Rnor6.0
Rnor_5.01479,176,694 - 79,547,823 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41479,968,072 - 80,344,330 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1473,307,871 - 73,668,512 (+)NCBICelera
RGSC_v3.11480,096,523 - 80,344,581 (+)NCBI
Cytogenetic Map14q21NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,7-dihydropurine-6-thione  (EXP)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (EXP)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
Brodifacoum  (EXP)
butane-2,3-dione  (ISO)
Butylbenzyl phthalate  (ISO)
cantharidin  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
choline  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
endosulfan  (EXP)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fenvalerate  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glyphosate  (EXP)
hydrogen peroxide  (ISO)
iron dichloride  (ISO)
isoprenaline  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
manganese(II) chloride  (EXP)
mercaptopurine  (EXP)
methapyrilene  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
panobinostat  (ISO)
paraquat  (EXP)
pentane-2,3-dione  (ISO)
phenylmercury acetate  (ISO)
purine-6-thiol  (EXP)
SB 431542  (ISO)
sodium arsenite  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
testosterone  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
tungsten  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:27457814   PMID:30840898  


Genomics

Comparative Map Data
Sorcs2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81478,592,290 - 78,960,582 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1478,596,087 - 78,960,582 (+)EnsemblGRCr8
mRatBN7.21474,371,089 - 74,735,943 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1474,371,415 - 74,735,943 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1478,813,341 - 79,177,234 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01480,054,214 - 80,418,108 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01476,499,206 - 76,863,105 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01479,538,911 - 79,912,333 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1479,538,911 - 79,912,333 (+)Ensemblrn6Rnor6.0
Rnor_5.01479,176,694 - 79,547,823 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41479,968,072 - 80,344,330 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1473,307,871 - 73,668,512 (+)NCBICelera
RGSC_v3.11480,096,523 - 80,344,581 (+)NCBI
Cytogenetic Map14q21NCBI
SORCS2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3847,192,538 - 7,742,827 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl47,192,538 - 7,742,827 (+)Ensemblhg38GRCh38
GRCh3747,194,265 - 7,744,554 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3647,245,373 - 7,795,464 (+)NCBIBuild 36Build 36hg18NCBI36
Build 3447,312,543 - 7,862,634NCBI
Celera47,098,892 - 7,646,499 (+)NCBICelera
Cytogenetic Map4p16.1NCBI
HuRef47,121,365 - 7,666,825 (+)NCBIHuRef
CHM1_147,192,978 - 7,742,776 (+)NCBICHM1_1
T2T-CHM13v2.047,165,091 - 7,714,720 (+)NCBIT2T-CHM13v2.0
Sorcs2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39536,174,524 - 36,555,541 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl536,174,524 - 36,555,483 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38536,017,180 - 36,398,197 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl536,017,180 - 36,398,139 (-)Ensemblmm10GRCm38
MGSCv37536,359,829 - 36,740,788 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36536,334,092 - 36,715,203 (-)NCBIMGSCv36mm8
Celera533,494,787 - 33,878,421 (-)NCBICelera
Cytogenetic Map5B3NCBI
cM Map519.14NCBI
Sorcs2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555143,053,071 - 3,390,125 (-)Ensembl
ChiLan1.0NW_0049555143,053,127 - 3,390,125 (-)NCBIChiLan1.0ChiLan1.0
SORCS2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v237,461,355 - 8,018,926 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan147,390,923 - 7,947,395 (+)NCBINHGRI_mPanPan1
PanPan1.147,259,342 - 7,805,275 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl47,259,337 - 7,803,594 (+)EnsemblpanPan2panpan1.1
SORCS2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1359,319,707 - 59,679,071 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl359,255,848 - 59,679,049 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha361,869,645 - 62,328,037 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0359,694,699 - 60,150,946 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl359,693,881 - 60,150,928 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1359,190,682 - 59,647,586 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0359,393,438 - 59,850,032 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0359,749,003 - 60,208,135 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Sorcs2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528565,251,269 - 65,577,361 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647718,952,959 - 19,279,198 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647718,952,965 - 19,279,053 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SORCS2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl83,207,098 - 3,760,393 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.183,207,087 - 3,715,002 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.283,962,102 - 4,004,672 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SORCS2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12743,629,273 - 43,700,888 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666113202,336 - 351,788 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sorcs2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475523,479,893 - 23,659,370 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475523,346,247 - 23,657,637 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Sorcs2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11168,705,836 - 69,067,935 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Sorcs2
2001 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:939
Count of miRNA genes:310
Interacting mature miRNAs:378
Transcripts:ENSRNOT00000009960
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313089Bss81Bone structure and strength QTL 813.40.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)143802371083023710Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1459848686104848686Rat
1582236Gluco22Glucose level QTL 223.30.0164blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147764007196755654Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1477914838104348525Rat
70214Niddm28Non-insulin dependent diabetes mellitus QTL 284.06blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)143900944484009444Rat
70153Bp59Blood pressure QTL 593.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)147297021087582095Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143067446985041098Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1433424686102238540Rat
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1474255551109089856Rat
1582197Gluco27Glucose level QTL 273.40.0006blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)147764007196755654Rat
2313100Bss82Bone structure and strength QTL 8230.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143802371083023710Rat
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1462398852107398852Rat
1582250Gluco26Glucose level QTL 263.30.0009blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1477640071100078267Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1460854936105854936Rat
1641900Alcrsp11Alcohol response QTL 11alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)1474255551109089856Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1411334716100078267Rat
1582255Gluco29Glucose level QTL 293.10.0025blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)147764007196755654Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1459848686104848686Rat
1582209Gluco20Glucose level QTL 203.80.0005blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147764007196755654Rat
2313048Bss84Bone structure and strength QTL 843.10.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143802371083023710Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)144261625899224555Rat
1549834Scl45Serum cholesterol level QTL 455.8blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)146592028399224555Rat
738037Hcas6Hepatocarcinoma susceptibility QTL 62.93liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)143941117087582095Rat
2313084Bss83Bone structure and strength QTL 832.90.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143802371083023710Rat

Markers in Region
D14Rat127  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81478,652,848 - 78,653,078 (+)Marker Load Pipeline
mRatBN7.21474,428,179 - 74,428,411 (+)MAPPERmRatBN7.2
Rnor_6.01479,596,105 - 79,596,334NCBIRnor6.0
Rnor_5.01479,233,168 - 79,233,397UniSTSRnor5.0
RGSC_v3.41480,026,543 - 80,026,772UniSTSRGSC3.4
RGSC_v3.41480,026,542 - 80,026,772RGDRGSC3.4
Celera1473,363,714 - 73,363,943UniSTS
RGSC_v3.11480,028,934 - 80,029,163RGD
RH 3.4 Map14452.44RGD
RH 3.4 Map14452.44UniSTS
SHRSP x BN Map1440.7199RGD
SHRSP x BN Map1440.7199UniSTS
Cytogenetic Map14q21UniSTS
D14Got140  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21474,674,873 - 74,675,072 (+)MAPPERmRatBN7.2
Rnor_6.01479,851,270 - 79,851,468NCBIRnor6.0
Rnor_5.01479,486,998 - 79,487,196UniSTSRnor5.0
RGSC_v3.41480,281,544 - 80,281,742UniSTSRGSC3.4
Cytogenetic Map14q21UniSTS
RH144526  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21474,544,818 - 74,545,030 (+)MAPPERmRatBN7.2
Rnor_6.01479,711,867 - 79,712,078NCBIRnor6.0
Rnor_5.01479,348,058 - 79,348,269UniSTSRnor5.0
RGSC_v3.41480,141,917 - 80,142,128UniSTSRGSC3.4
Celera1473,479,865 - 73,480,076UniSTS
Cytogenetic Map14q21UniSTS
UniSTS:478869  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81478,746,344 - 78,746,493 (+)Marker Load Pipeline
mRatBN7.21474,521,686 - 74,521,834 (+)MAPPERmRatBN7.2
Rnor_6.01479,688,704 - 79,688,851NCBIRnor6.0
Rnor_5.01479,325,231 - 79,325,378UniSTSRnor5.0
RGSC_v3.41480,117,357 - 80,117,504UniSTSRGSC3.4
Celera1473,457,010 - 73,457,157UniSTS
Cytogenetic Map14q21UniSTS
UniSTS:478870  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21474,503,080 - 74,503,223 (+)MAPPERmRatBN7.2
Rnor_6.01479,670,072 - 79,670,214NCBIRnor6.0
Rnor_5.01479,306,599 - 79,306,741UniSTSRnor5.0
RGSC_v3.41480,098,752 - 80,098,894UniSTSRGSC3.4
Celera1473,438,421 - 73,438,555UniSTS
Cytogenetic Map14q21UniSTS


Genetic Models
This gene Sorcs2 is modified in the following models/strains:


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 161 91 90 59 57 59 6 321 157 10 140 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000009960   ⟹   ENSRNOP00000009960
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1478,596,087 - 78,960,582 (+)Ensembl
mRatBN7.2 Ensembl1474,371,415 - 74,735,943 (+)Ensembl
Rnor_6.0 Ensembl1479,538,911 - 79,912,333 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000089334   ⟹   ENSRNOP00000074805
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1479,540,235 - 79,912,290 (+)Ensembl
RefSeq Acc Id: NM_001107225   ⟹   NP_001100695
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81478,596,087 - 78,960,582 (+)NCBI
mRatBN7.21474,371,415 - 74,735,943 (+)NCBI
Rnor_6.01479,538,911 - 79,912,333 (+)NCBI
Rnor_5.01479,176,694 - 79,547,823 (+)NCBI
RGSC_v3.41479,968,072 - 80,344,330 (+)RGD
Celera1473,307,871 - 73,668,512 (+)RGD
Sequence:
RefSeq Acc Id: XM_039091954   ⟹   XP_038947882
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81478,592,295 - 78,960,569 (+)NCBI
mRatBN7.21474,371,091 - 74,735,937 (+)NCBI
RefSeq Acc Id: XM_039091956   ⟹   XP_038947884
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81478,598,222 - 78,960,569 (+)NCBI
mRatBN7.21474,373,548 - 74,735,937 (+)NCBI
RefSeq Acc Id: XM_039091957   ⟹   XP_038947885
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81478,596,690 - 78,960,569 (+)NCBI
mRatBN7.21474,372,023 - 74,735,937 (+)NCBI
RefSeq Acc Id: XM_039091958   ⟹   XP_038947886
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81478,592,290 - 78,941,078 (+)NCBI
mRatBN7.21474,371,089 - 74,716,311 (+)NCBI
RefSeq Acc Id: NP_001100695   ⟸   NM_001107225
- Peptide Label: precursor
- UniProtKB: A6IJY5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000074805   ⟸   ENSRNOT00000089334
Ensembl Acc Id: ENSRNOP00000009960   ⟸   ENSRNOT00000009960
RefSeq Acc Id: XP_038947886   ⟸   XM_039091958
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038947882   ⟸   XM_039091954
- Peptide Label: isoform X1
- UniProtKB: D3ZW09 (UniProtKB/TrEMBL),   A6IJY5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038947885   ⟸   XM_039091957
- Peptide Label: isoform X3
- UniProtKB: A6IJY5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038947884   ⟸   XM_039091956
- Peptide Label: isoform X2
- UniProtKB: A6IJY5 (UniProtKB/TrEMBL)
Protein Domains
PKD

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZW09-F1-model_v2 AlphaFold D3ZW09 1-1158 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699385
Promoter ID:EPDNEW_R9910
Type:single initiation site
Name:Sorcs2_1
Description:sortilin-related VPS10 domain containing receptor 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01479,538,911 - 79,538,971EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310621 AgrOrtholog
BioCyc Gene G2FUF-15332 BioCyc
Ensembl Genes ENSRNOG00000007033 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000009960 ENTREZGENE
  ENSRNOT00000009960.9 UniProtKB/TrEMBL
Gene3D-CATH 2.10.70.80 UniProtKB/TrEMBL
  2.130.10.10 UniProtKB/TrEMBL
  2.60.40.10 UniProtKB/TrEMBL
  3.30.60.270 UniProtKB/TrEMBL
InterPro Ig-like_fold UniProtKB/TrEMBL
  PKD_dom UniProtKB/TrEMBL
  PKD_dom_sf UniProtKB/TrEMBL
  Sortilin_C UniProtKB/TrEMBL
  Sortilin_N UniProtKB/TrEMBL
  VPS10 UniProtKB/TrEMBL
  VPS10-sortilin UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom UniProtKB/TrEMBL
NCBI Gene 305438 ENTREZGENE
PANTHER SORTILIN RELATED UniProtKB/TrEMBL
  VPS10 DOMAIN-CONTAINING RECEPTOR SORCS2 UniProtKB/TrEMBL
Pfam PKD UniProtKB/TrEMBL
  Sortilin-Vps10 UniProtKB/TrEMBL
  Sortilin_C UniProtKB/TrEMBL
PhenoGen Sorcs2 PhenoGen
PROSITE PKD UniProtKB/TrEMBL
RatGTEx ENSRNOG00000007033 RatGTEx
SMART VPS10 UniProtKB/TrEMBL
Superfamily-SCOP Oligoxyloglucan reducing end-specific cellobiohydrolase UniProtKB/TrEMBL
  PKD UniProtKB/TrEMBL
UniProt A6IJY5 ENTREZGENE, UniProtKB/TrEMBL
  D3ZW09 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Sorcs2  sortilin-related VPS10 domain containing receptor 2   Sorcs2_predicted  sortilin-related VPS10 domain containing receptor 2 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Sorcs2_predicted  sortilin-related VPS10 domain containing receptor 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED