Inhca (inhibitor of carbonic anhydrase) - Rat Genome Database

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Gene: Inhca (inhibitor of carbonic anhydrase) Rattus norvegicus
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Symbol: Inhca
Name: inhibitor of carbonic anhydrase
RGD ID: 1310507
Description: Predicted to enable enzyme inhibitor activity. Predicted to be involved in antibacterial humoral response and iron ion transport. Predicted to be located in extracellular region. Predicted to be active in endosome; extracellular space; and plasma membrane; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetamide; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Aa2-001; hypothetical protein LOC315963; Inhibitor of carbonic anhydrase-like; LOC315963; LRRGT00077; LRRGT00161; RGD1310507; similar to RIKEN cDNA 1300017J02; uncharacterized protein LOC315963
RGD Orthologs
Mouse
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88112,715,733 - 112,753,950 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8112,702,085 - 112,766,829 (-)EnsemblGRCr8
mRatBN7.28103,836,846 - 103,874,980 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8103,823,196 - 103,874,985 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx8109,496,309 - 109,534,665 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08107,695,474 - 107,733,828 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08105,538,149 - 105,576,503 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.08111,742,987 - 111,762,747 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8111,727,984 - 111,777,677 (-)Ensemblrn6Rnor6.0
Rnor_5.08111,134,566 - 111,154,326 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.48108,266,263 - 108,286,026 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera8103,215,750 - 103,235,502 (-)NCBICelera
RGSC_v3.18108,284,364 - 108,323,074 (-)NCBI
Cytogenetic Map8q32NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Inhca
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88112,715,733 - 112,753,950 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8112,702,085 - 112,766,829 (-)EnsemblGRCr8
mRatBN7.28103,836,846 - 103,874,980 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8103,823,196 - 103,874,985 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx8109,496,309 - 109,534,665 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08107,695,474 - 107,733,828 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08105,538,149 - 105,576,503 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.08111,742,987 - 111,762,747 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8111,727,984 - 111,777,677 (-)Ensemblrn6Rnor6.0
Rnor_5.08111,134,566 - 111,154,326 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.48108,266,263 - 108,286,026 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera8103,215,750 - 103,235,502 (-)NCBICelera
RGSC_v3.18108,284,364 - 108,323,074 (-)NCBI
Cytogenetic Map8q32NCBI
Inhca
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399103,127,722 - 103,165,496 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9103,127,720 - 103,182,281 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm389103,250,523 - 103,288,297 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9103,250,521 - 103,305,082 (-)Ensemblmm10GRCm38
MGSCv379103,152,860 - 103,190,627 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv369103,108,680 - 103,146,447 (-)NCBIMGSCv36mm8
Celera9102,801,073 - 102,839,460 (-)NCBICelera
Cytogenetic Map9F1NCBI
cM Map955.1NCBI

Variants

.
Variants in Inhca
197 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:32
Count of miRNA genes:29
Interacting mature miRNAs:32
Transcripts:ENSRNOT00000056483
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)8105462581132782436Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)882352698127352698Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)861019838121662124Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)849849908118871671Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)880768445125768445Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)880768445125768445Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)870041301121080908Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)868690349119799881Rat
10450865Bw175Body weight QTL 1754.1total fat pad mass (VT:0015008)adipose tissue molecular composition measurement (CMO:0000484)884192326129192326Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)8102413464132782436Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8103375781129871912Rat
8693654Alc32Alcohol consumption QTL 3220.755drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)897492344116428905Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)855428333127966348Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)839106363114525825Rat
634332Pia18Pristane induced arthritis QTL 184joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)884192326132782436Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)885348065130348065Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)879394435132782436Rat
631217Activ1Activity QTL 115.9voluntary movement trait (VT:0003491)number of photobeam interruptions in an experimental apparatus (CMO:0001517)8111249511117802327Rat
2313400Anxrr25Anxiety related response QTL 25aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)898145073122898010Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)880768445125768445Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)880768445125768445Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)891340911131690273Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 158 91 90 59 89 59 6 349 189 11 137 77 90 31 15 15

Sequence


Ensembl Acc Id: ENSRNOT00000052317   ⟹   ENSRNOP00000049614
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8112,702,085 - 112,753,867 (-)Ensembl
mRatBN7.2 Ensembl8103,823,196 - 103,874,924 (-)Ensembl
Rnor_6.0 Ensembl8111,727,984 - 111,777,602 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000056483   ⟹   ENSRNOP00000053319
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8112,717,061 - 112,735,972 (-)Ensembl
mRatBN7.2 Ensembl8103,838,174 - 103,857,085 (-)Ensembl
Rnor_6.0 Ensembl8111,742,987 - 111,761,871 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000083855   ⟹   ENSRNOP00000074521
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8112,715,733 - 112,753,867 (-)Ensembl
mRatBN7.2 Ensembl8103,836,882 - 103,874,985 (-)Ensembl
Rnor_6.0 Ensembl8111,741,678 - 111,777,677 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000108282   ⟹   ENSRNOP00000090502
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8112,715,733 - 112,754,052 (-)Ensembl
mRatBN7.2 Ensembl8103,836,882 - 103,874,924 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000110690   ⟹   ENSRNOP00000092784
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8112,715,733 - 112,753,867 (-)Ensembl
mRatBN7.2 Ensembl8103,836,882 - 103,874,924 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000125238   ⟹   ENSRNOP00000107557
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8112,715,733 - 112,766,829 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000137567   ⟹   ENSRNOP00000098816
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8112,717,740 - 112,766,693 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000138054   ⟹   ENSRNOP00000108990
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8112,715,733 - 112,766,693 (-)Ensembl
RefSeq Acc Id: NM_001047891   ⟹   NP_001041356
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88112,715,733 - 112,753,867 (-)NCBI
mRatBN7.28103,836,846 - 103,874,980 (-)NCBI
Rnor_6.08111,742,987 - 111,762,747 (-)NCBI
Rnor_5.08111,134,566 - 111,154,326 (-)NCBI
RGSC_v3.48108,266,263 - 108,286,026 (-)RGD
Celera8103,215,750 - 103,235,502 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039081555   ⟹   XP_038937483
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88112,715,783 - 112,753,912 (-)NCBI
mRatBN7.28103,836,890 - 103,874,973 (-)NCBI
RefSeq Acc Id: XM_039081556   ⟹   XP_038937484
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88112,715,783 - 112,753,863 (-)NCBI
mRatBN7.28103,836,890 - 103,874,976 (-)NCBI
RefSeq Acc Id: XM_063265605   ⟹   XP_063121675
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88112,715,783 - 112,753,950 (-)NCBI
RefSeq Acc Id: NP_001041356   ⟸   NM_001047891
- Peptide Label: precursor
- UniProtKB: A0A8I6AEF9 (UniProtKB/TrEMBL),   A0A8I6AHP0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000053319   ⟸   ENSRNOT00000056483
Ensembl Acc Id: ENSRNOP00000074521   ⟸   ENSRNOT00000083855
Ensembl Acc Id: ENSRNOP00000049614   ⟸   ENSRNOT00000052317
RefSeq Acc Id: XP_038937484   ⟸   XM_039081556
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AHP0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038937483   ⟸   XM_039081555
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K896 (UniProtKB/TrEMBL),   A0A8I6AHP0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000092784   ⟸   ENSRNOT00000110690
Ensembl Acc Id: ENSRNOP00000090502   ⟸   ENSRNOT00000108282
RefSeq Acc Id: XP_063121675   ⟸   XM_063265605
- Peptide Label: isoform X3
- UniProtKB: A0A8I6AHP0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000107557   ⟸   ENSRNOT00000125238
Ensembl Acc Id: ENSRNOP00000108990   ⟸   ENSRNOT00000138054
Ensembl Acc Id: ENSRNOP00000098816   ⟸   ENSRNOT00000137567
Protein Domains
Transferrin-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K896-F1-model_v2 AlphaFold A0A0G2K896 1-700 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310507 AgrOrtholog
BioCyc Gene G2FUF-29327 BioCyc
Ensembl Genes ENSRNOG00000009434 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000052317.6 UniProtKB/TrEMBL
  ENSRNOT00000056483.6 UniProtKB/TrEMBL
  ENSRNOT00000083855 ENTREZGENE
  ENSRNOT00000083855.3 UniProtKB/TrEMBL
  ENSRNOT00000108282 ENTREZGENE
  ENSRNOT00000108282.2 UniProtKB/TrEMBL
  ENSRNOT00000110690.2 UniProtKB/TrEMBL
  ENSRNOT00000125238.1 UniProtKB/TrEMBL
  ENSRNOT00000137567.1 UniProtKB/TrEMBL
  ENSRNOT00000138054.1 UniProtKB/TrEMBL
Gene3D-CATH Periplasmic binding protein-like II UniProtKB/TrEMBL
InterPro Peptidase_S60 UniProtKB/TrEMBL
  Transferrin UniProtKB/TrEMBL
  Transferrin_Fe_BS UniProtKB/TrEMBL
KEGG Report rno:315963 UniProtKB/TrEMBL
NCBI Gene 315963 ENTREZGENE
PANTHER PTHR11485:SF20 UniProtKB/TrEMBL
  TRANSFERRIN UniProtKB/TrEMBL
Pfam Transferrin UniProtKB/TrEMBL
PhenoGen Inhca PhenoGen
PIRSF Transferrin UniProtKB/TrEMBL
PRINTS TRANSFERRIN UniProtKB/TrEMBL
PROSITE TRANSFERRIN_LIKE_1 UniProtKB/TrEMBL
  TRANSFERRIN_LIKE_3 UniProtKB/TrEMBL
  TRANSFERRIN_LIKE_4 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000009434 RatGTEx
SMART TR_FER UniProtKB/TrEMBL
Superfamily-SCOP Periplasmic binding protein-like II UniProtKB/TrEMBL
UniProt A0A0G2K896 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AEF9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AHP0 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0KWK6_RAT UniProtKB/TrEMBL
  A0ABK0LAH9_RAT UniProtKB/TrEMBL
  A0ABK0LXQ3_RAT UniProtKB/TrEMBL
  E9PST1_RAT UniProtKB/TrEMBL
  Q6QI47_RAT UniProtKB/TrEMBL
  Q6TUG7_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-10-21 Inhca  inhibitor of carbonic anhydrase  RGD1310507  similar to RIKEN cDNA 1300017J02  Name and Symbol changed 629549 APPROVED
2005-12-06 RGD1310507  similar to RIKEN cDNA 1300017J02  RGD1310507_predicted  similar to RIKEN cDNA 1300017J02 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1310507_predicted  similar to RIKEN cDNA 1300017J02 (predicted)  LOC315963_predicted    Symbol and Name status set to approved 1331353 APPROVED