Serpinb6b (serine (or cysteine) peptidase inhibitor, clade B, member 6b) - Rat Genome Database

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Gene: Serpinb6b (serine (or cysteine) peptidase inhibitor, clade B, member 6b) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Serpinb6b
Name: serine (or cysteine) peptidase inhibitor, clade B, member 6b
RGD ID: 1310452
Description: Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be located in nucleus. Predicted to be active in cytoplasm and extracellular space. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 91. Orthologous to human SERPINB6 (serpin family B member 6); PARTICIPATES IN Entamoebiasis pathway; INTERACTS WITH 1,3-dinitrobenzene; 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC364705; serine (or cysteine) proteinase inhibitor, clade B, member 6b
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81731,666,587 - 31,684,222 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1731,666,594 - 31,683,934 (-)EnsemblGRCr8
mRatBN7.21731,455,092 - 31,475,460 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1731,457,834 - 31,475,176 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1731,293,094 - 31,311,814 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01732,896,865 - 32,915,583 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01731,288,855 - 31,307,575 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01732,770,488 - 32,787,835 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1732,770,739 - 32,783,427 (-)Ensemblrn6Rnor6.0
Rnor_5.01734,662,694 - 34,680,041 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41737,816,548 - 37,834,299 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1731,020,008 - 31,037,355 (-)NCBICelera
RGSC_v3.11737,819,393 - 37,837,140 (-)NCBI
Cytogenetic Map17p12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA)
extracellular space  (IBA,IEA)
nucleus  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:16778019  


Genomics

Variants

.
Variants in Serpinb6b
64 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:134
Count of miRNA genes:111
Interacting mature miRNAs:126
Transcripts:ENSRNOT00000059921
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17143999106Rat
2300002Iddm36Insulin dependent diabetes mellitus QTL 361.98blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)17926675540968173Rat
70210Cm15Cardiac mass QTL 156.5heart right ventricle mass (VT:0007033)heart right ventricle wet weight (CMO:0000072)173006647275066472Rat
8552966Pigfal18Plasma insulin-like growth factor 1 level QTL 188.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)171286094257860942Rat
152023626Bp403Blood pressure QTL 4033.86arterial blood pressure trait (VT:2000000)172413612784432719Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17212084342054133Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)17622199858177198Rat
70157Niddm32Non-insulin dependent diabetes mellitus QTL 324.34blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)172266079955604694Rat
9589151Insul30Insulin level QTL 308.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)171286094257860942Rat
1354628Stl13Serum triglyceride level QTL 133.8blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)172149899450592236Rat
1581512Cm55Cardiac mass QTL 552.80.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172723344583975845Rat
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17131706603Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17473353449733534Rat
61394Bp8Blood pressure QTL 82.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172328632264246472Rat
9589057Scfw6Subcutaneous fat weight QTL 68.620.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)171286094257860942Rat
2317045Aia11Adjuvant induced arthritis QTL 114.06joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)172652205171522051Rat
9590154Scort9Serum corticosterone level QTL 923.570.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)171286094257860942Rat
10450503Bp386Blood pressure QTL 3860.28arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172201970567019705Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172385892668858926Rat
152025238Slep14Serum leptin concentration QTL 144.62blood leptin amount (VT:0005667)172439059584432719Rat
9590088Insglur7Insulin/glucose ratio QTL 720.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)171286094257860942Rat
2317053Aia25Adjuvant induced arthritis QTL 252.69joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)171060469455604694Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17136045694Rat
1331765Hrtrt15Heart rate QTL 154.094heart pumping trait (VT:2000009)heart rate (CMO:0000002)171553702560531414Rat
7411666Foco31Food consumption QTL 3111.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)171286094257860942Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17473353449733534Rat
12903980Cm120Cardiac mass QTL 1200.002heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)172385892668858926Rat
70184BpQTLcluster14Blood pressure QTL cluster 143.38arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)17857434232199534Rat
12903981Am17Aortic mass QTL 170.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)172385892668858926Rat
4889955Bss93Bone structure and strength QTL 934.4tibia size trait (VT:0100001)tibia cortical bone volume to tibia total bone volume ratio (CMO:0001727)172723344565155015Rat
4889891Eae32Experimental allergic encephalomyelitis QTL 324.80.0002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)172723344572233445Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172385892668858926Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17138037084Rat
12903978Cm118Cardiac mass QTL 1180.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)172385892668858926Rat
12903979Cm119Cardiac mass QTL 1190.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172385892668858926Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17143999106Rat
152023740Bp406Blood pressure QTL 4066.06arterial blood pressure trait (VT:2000000)172413612784432719Rat
7488966Bp370Blood pressure QTL 3700.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172385892668858926Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17143999106Rat
152023737Bp405Blood pressure QTL 4055.06arterial blood pressure trait (VT:2000000)2413612784432719Rat
152023736Bp404Blood pressure QTL 4043.78arterial blood pressure trait (VT:2000000)172413612784432719Rat

Markers in Region
D17Got43  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81731,671,943 - 31,672,066 (+)Marker Load Pipeline
mRatBN7.21731,463,183 - 31,463,308 (+)MAPPERmRatBN7.2
Rnor_6.01732,775,845 - 32,775,967NCBIRnor6.0
Rnor_5.01734,668,051 - 34,668,173UniSTSRnor5.0
RGSC_v3.41737,821,904 - 37,822,027RGDRGSC3.4
RGSC_v3.41737,821,905 - 37,822,027UniSTSRGSC3.4
Celera1731,025,365 - 31,025,487UniSTS
RGSC_v3.11737,824,745 - 37,824,868RGD
RH 3.4 Map17363.9RGD
RH 3.4 Map17363.9UniSTS
RH 2.0 Map17253.5RGD
Cytogenetic Map17p12UniSTS
RH141133  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21731,458,033 - 31,458,245 (+)MAPPERmRatBN7.2
Rnor_6.01732,770,695 - 32,770,906NCBIRnor6.0
Rnor_5.01734,662,901 - 34,663,112UniSTSRnor5.0
RGSC_v3.41737,816,755 - 37,816,966UniSTSRGSC3.4
Celera1731,020,215 - 31,020,426UniSTS
RH 3.4 Map17359.3UniSTS
Cytogenetic Map17p12UniSTS
Serpinb6c  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21730,978,000 - 30,978,060 (+)MAPPERmRatBN7.2
Rnor_6.01732,197,843 - 32,197,902NCBIRnor6.0
Rnor_5.01734,091,165 - 34,091,224UniSTSRnor5.0
RGSC_v3.41737,323,431 - 37,323,490UniSTSRGSC3.4
RGSC_v3.41737,826,272 - 37,826,332UniSTSRGSC3.4
Celera1731,029,328 - 31,029,388UniSTS
Celera1730,542,150 - 30,542,209UniSTS
Cytogenetic Map17p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 161 91 90 59 92 59 6 356 192 11 133 81 92 31 13 13

Sequence


Ensembl Acc Id: ENSRNOT00000059921   ⟹   ENSRNOP00000056665
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1731,666,594 - 31,683,934 (-)Ensembl
mRatBN7.2 Ensembl1731,457,834 - 31,475,176 (-)Ensembl
Rnor_6.0 Ensembl1732,770,739 - 32,783,427 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000094444   ⟹   ENSRNOP00000080262
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1731,666,594 - 31,683,934 (-)Ensembl
mRatBN7.2 Ensembl1731,457,834 - 31,475,176 (-)Ensembl
RefSeq Acc Id: NM_001012214   ⟹   NP_001012214
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81731,666,587 - 31,683,934 (-)NCBI
mRatBN7.21731,457,827 - 31,475,176 (-)NCBI
Rnor_6.01732,770,488 - 32,787,835 (-)NCBI
Rnor_5.01734,662,694 - 34,680,041 (-)NCBI
RGSC_v3.41737,816,548 - 37,834,299 (-)RGD
Celera1731,020,008 - 31,037,355 (-)RGD
Sequence:
RefSeq Acc Id: XM_039095971   ⟹   XP_038951899
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81731,666,751 - 31,684,222 (-)NCBI
mRatBN7.21731,455,092 - 31,475,460 (-)NCBI
RefSeq Acc Id: XM_039095972   ⟹   XP_038951900
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81731,666,751 - 31,680,683 (-)NCBI
mRatBN7.21731,455,092 - 31,471,925 (-)NCBI
RefSeq Acc Id: XM_039095973   ⟹   XP_038951901
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81731,666,751 - 31,679,498 (-)NCBI
mRatBN7.21731,455,092 - 31,470,744 (-)NCBI
RefSeq Acc Id: XM_039095974   ⟹   XP_038951902
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81731,666,751 - 31,674,032 (-)NCBI
mRatBN7.21731,455,092 - 31,465,269 (-)NCBI
RefSeq Acc Id: NP_001012214   ⟸   NM_001012214
- UniProtKB: Q68FX2 (UniProtKB/TrEMBL),   F7F6T5 (UniProtKB/TrEMBL),   A0A9K3Y788 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000056665   ⟸   ENSRNOT00000059921
RefSeq Acc Id: XP_038951899   ⟸   XM_039095971
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZQA7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038951900   ⟸   XM_039095972
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZQA7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038951901   ⟸   XM_039095973
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038951902   ⟸   XM_039095974
- Peptide Label: isoform X3
Ensembl Acc Id: ENSRNOP00000080262   ⟸   ENSRNOT00000094444
Protein Domains
SERPIN

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F7F6T5-F1-model_v2 AlphaFold F7F6T5 1-376 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310452 AgrOrtholog
BioCyc Gene G2FUF-9577 BioCyc
Ensembl Genes ENSRNOG00000016420 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000059921 ENTREZGENE
  ENSRNOT00000059921.6 UniProtKB/TrEMBL
  ENSRNOT00000094444 ENTREZGENE
  ENSRNOT00000094444.2 UniProtKB/TrEMBL
Gene3D-CATH 2.30.39.10 UniProtKB/TrEMBL
  3.30.497.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7125468 IMAGE-MGC_LOAD
InterPro Protease_inhib_I4_serpin UniProtKB/TrEMBL
  Protease_inhib_I4_serpin_CS UniProtKB/TrEMBL
  Sepin_dom UniProtKB/TrEMBL
  Serpin_sf UniProtKB/TrEMBL
  Serpin_sf_1 UniProtKB/TrEMBL
  Serpin_sf_2 UniProtKB/TrEMBL
KEGG Report rno:364705 UniProtKB/TrEMBL
MGC_CLONE MGC:94100 IMAGE-MGC_LOAD
NCBI Gene 364705 ENTREZGENE
PANTHER NK13-RELATED UniProtKB/TrEMBL
  Prot_inh_serpin UniProtKB/TrEMBL
Pfam Serpin UniProtKB/TrEMBL
PhenoGen Serpinb6b PhenoGen
PROSITE SERPIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016420 RatGTEx
SMART SERPIN UniProtKB/TrEMBL
Superfamily-SCOP Prot_inh_serpin UniProtKB/TrEMBL
UniProt A0A8I5ZQA7 ENTREZGENE, UniProtKB/TrEMBL
  A0A9K3Y788 ENTREZGENE, UniProtKB/TrEMBL
  F7F6T5 ENTREZGENE
  Q68FX2 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary F7F6T5 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-07 Serpinb6b  serine (or cysteine) peptidase inhibitor, clade B, member 6b  Serpinb6b  serine (or cysteine) proteinase inhibitor, clade B, member 6b  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Serpinb6b  serine (or cysteine) proteinase inhibitor, clade B, member 6b  Serpinb6b_predicted  serine (or cysteine) proteinase inhibitor, clade B, member 6b (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Serpinb6b_predicted  serine (or cysteine) proteinase inhibitor, clade B, member 6b (predicted)      Symbol and Name status set to approved 70820 APPROVED