Pik3c2a (phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha) - Rat Genome Database

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Gene: Pik3c2a (phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha) Rattus norvegicus
Analyze
Symbol: Pik3c2a
Name: phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
RGD ID: 1310389
Description: Predicted to enable clathrin binding activity and phosphatidylinositol kinase activity. Predicted to be involved in several processes, including intracellular signal transduction; phosphatidylinositol-3-phosphate biosynthetic process; and positive regulation of cell migration involved in sprouting angiogenesis. Predicted to act upstream of or within autophagosome organization; cellular response to starvation; and negative regulation of zinc ion transmembrane transport. Predicted to be located in clathrin-coated vesicle and trans-Golgi network. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human PIK3C2A (phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha); PARTICIPATES IN phosphoinositide metabolic pathway; inositol phosphate metabolic pathway; phosphatidylinositol 3-kinase signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; DDT.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC361632; phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha; phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit alpha; phosphoinositide-3-kinase, class 2 alpha polypeptide; phosphoinositide-3-kinase, class 2, alpha polypeptide
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81180,012,248 - 180,117,786 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1180,012,248 - 180,117,773 (-)EnsemblGRCr8
mRatBN7.21170,577,942 - 170,684,353 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1170,577,942 - 170,683,472 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1178,895,808 - 179,001,695 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01186,082,327 - 186,188,218 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01178,795,249 - 178,900,740 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01185,210,922 - 185,326,314 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1185,210,922 - 185,326,314 (+)Ensemblrn6Rnor6.0
Rnor_5.01192,182,647 - 192,297,034 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41174,430,831 - 174,537,706 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1168,399,225 - 168,504,593 (-)NCBICelera
RGSC_v3.11174,572,538 - 174,676,951 (-)NCBI
Cytogenetic Map1q35NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1-nitropyrene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrobenzenesulfonic acid  (ISO)
2-hydroxypropanoic acid  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-vinylcyclohexene dioxide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
acetylsalicylic acid  (ISO)
aflatoxin B1  (ISO)
aflatoxin M1  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
avobenzone  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbamazepine  (ISO)
celastrol  (ISO)
chenodeoxycholic acid  (ISO)
chlorpyrifos  (ISO)
clorgyline  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
DDT  (EXP)
deoxycholic acid  (ISO)
Dibutyl phosphate  (ISO)
diclofenac  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
gentamycin  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
GSK-J4  (ISO)
heptanal  (ISO)
hexadecanoic acid  (ISO)
hexanal  (ISO)
hypochlorous acid  (ISO)
inulin  (ISO)
isoflavones  (ISO)
methidathion  (ISO)
methoxychlor  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
Monobutylphthalate  (ISO)
nonanal  (ISO)
octanal  (ISO)
oleic acid  (ISO)
oxaliplatin  (EXP)
p-chloromercuribenzoic acid  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenylmercury acetate  (ISO)
phlorizin  (ISO)
propanal  (ISO)
quercitrin  (ISO)
rac-lactic acid  (ISO)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sorafenib  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
Sunset Yellow FCF  (ISO)
tamoxifen  (ISO)
tartrazine  (ISO)
tetracycline  (ISO)
thimerosal  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
clathrin-coated vesicle  (IEA,ISO)
cytoplasm  (IBA,ISO,ISS)
cytoplasmic vesicle  (IEA)
Golgi apparatus  (IEA)
nucleoplasm  (ISO)
nucleus  (IEA)
plasma membrane  (IBA,IEA,ISO,ISS)
trans-Golgi network  (ISO)
vesicle  (ISO,ISS)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Class II phosphoinositide 3-kinase regulates exocytosis of insulin granules in pancreatic beta cells. Dominguez V, etal., J Biol Chem. 2011 Feb 11;286(6):4216-25. doi: 10.1074/jbc.M110.200295. Epub 2010 Dec 2.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:8663140   PMID:16336212   PMID:17179444   PMID:19056867   PMID:19946888   PMID:21081650   PMID:23823722   PMID:24098492   PMID:25357130   PMID:26175229   PMID:28910396   PMID:33999393  
PMID:36132983  


Genomics

Comparative Map Data
Pik3c2a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81180,012,248 - 180,117,786 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1180,012,248 - 180,117,773 (-)EnsemblGRCr8
mRatBN7.21170,577,942 - 170,684,353 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1170,577,942 - 170,683,472 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1178,895,808 - 179,001,695 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01186,082,327 - 186,188,218 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01178,795,249 - 178,900,740 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01185,210,922 - 185,326,314 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1185,210,922 - 185,326,314 (+)Ensemblrn6Rnor6.0
Rnor_5.01192,182,647 - 192,297,034 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41174,430,831 - 174,537,706 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1168,399,225 - 168,504,593 (-)NCBICelera
RGSC_v3.11174,572,538 - 174,676,951 (-)NCBI
Cytogenetic Map1q35NCBI
PIK3C2A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381117,086,575 - 17,207,986 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1117,077,730 - 17,207,986 (-)Ensemblhg38GRCh38
GRCh371117,108,122 - 17,229,533 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361117,064,698 - 17,147,930 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341117,067,860 - 17,147,864NCBI
Celera1117,236,314 - 17,320,701 (-)NCBICelera
Cytogenetic Map11p15.1NCBI
HuRef1116,791,536 - 16,875,065 (-)NCBIHuRef
CHM1_11117,107,728 - 17,190,971 (-)NCBICHM1_1
T2T-CHM13v2.01117,184,463 - 17,305,651 (-)NCBIT2T-CHM13v2.0
Pik3c2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397115,936,500 - 116,042,693 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7115,936,500 - 116,042,684 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm387116,337,265 - 116,443,465 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7116,337,265 - 116,443,449 (-)Ensemblmm10GRCm38
MGSCv377123,480,790 - 123,586,972 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv367116,130,710 - 116,209,201 (-)NCBIMGSCv36mm8
Celera7116,275,791 - 116,376,830 (-)NCBICelera
Cytogenetic Map7F1NCBI
cM Map761.62NCBI
Pik3c2a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541431,896,161 - 31,999,730 (-)Ensembl
ChiLan1.0NW_00495541431,896,161 - 31,999,730 (-)NCBIChiLan1.0ChiLan1.0
PIK3C2A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2919,421,635 - 19,542,611 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11119,382,544 - 19,503,423 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01117,143,024 - 17,263,920 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11116,828,959 - 16,949,891 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1116,828,966 - 16,949,856 (-)EnsemblpanPan2panpan1.1
PIK3C2A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12139,693,211 - 39,868,603 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2139,695,520 - 39,784,639 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2139,193,753 - 39,309,848 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02140,798,394 - 40,914,802 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2140,799,161 - 40,914,780 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12139,813,119 - 39,927,798 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02140,018,167 - 40,133,971 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02140,357,482 - 40,473,688 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pik3c2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494745,811,389 - 45,932,425 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365281,869,527 - 1,964,183 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365281,845,372 - 1,964,908 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PIK3C2A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl241,829,916 - 42,024,362 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1241,829,969 - 42,024,062 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2244,958,962 - 45,079,401 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PIK3C2A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1147,759,850 - 47,874,458 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl147,795,954 - 47,877,028 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666038145,200,659 - 145,318,077 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pik3c2a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247668,701,642 - 8,776,578 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247668,698,836 - 8,834,928 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Pik3c2a
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1285,134,954 - 85,241,585 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Pik3c2a
760 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:548
Count of miRNA genes:272
Interacting mature miRNAs:346
Transcripts:ENSRNOT00000055120
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)1137611478182611478Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1153679879198679879Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1177339686222339686Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1132760429191848948Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1153679879205813246Rat
8694166Bw147Body weight QTL 1476.830.001body mass (VT:0001259)body weight gain (CMO:0000420)1153788989198788989Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1142582336182383862Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1160573753210707719Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1139442053223964440Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1160573753210707719Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1165278545210278545Rat
152025232Bw192Body weight QTL 1923.93body mass (VT:0001259)1127329268206393015Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1161077990206077990Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)199645382182701046Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1168063662213063662Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1159894717207261263Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1109493780193400781Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1163992710208992710Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1155359438194575574Rat
631206Niddm40Non-insulin dependent diabetes mellitus QTL 40blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1140833106185833106Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1153679879232414077Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1160574007235238518Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1116099376191260518Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1132760429191848948Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1162753891207753891Rat
634315Niddm45Non-insulin dependent diabetes mellitus QTL 457.16blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1153680016182383862Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
61379Bp44Blood pressure QTL 4419.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1153680016183564652Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1102780511182384005Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1172718770228180370Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1111949780210707719Rat
2312558Glom17Glomerulus QTL 173.90.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1175967553200707874Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1178547286206690557Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1139442053223964440Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1140048073185048073Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1111949780210707719Rat
1582204Livw1Liver weight QTL 13.60.0003liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)1170078537182384005Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1140048073185048073Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753210707719Rat
1576310Schws2Schwannoma susceptibility QTL 20.029nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1153788989198788989Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1165707719210707719Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1173363824227535316Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1135021436180021436Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1132760429191190115Rat
152025212Bw190Body weight QTL 1905.7body mass (VT:0001259)1132966869206393015Rat
631548Bp88Blood pressure QTL 8850.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1140915717185915717Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1132760429191848948Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat
7411599Foco11Food consumption QTL 1118.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)1153788989198788989Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1160573753210707719Rat

Markers in Region
RH136965  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21170,578,275 - 170,578,459 (-)MAPPERmRatBN7.2
Rnor_6.01185,325,797 - 185,325,980NCBIRnor6.0
Rnor_5.01192,296,517 - 192,296,700UniSTSRnor5.0
RGSC_v3.41174,431,165 - 174,431,348UniSTSRGSC3.4
Celera1168,399,559 - 168,399,742UniSTS
RH 3.4 Map11562.2UniSTS
Cytogenetic Map1q34-q35UniSTS
RH140296  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21170,611,306 - 170,611,490 (-)MAPPERmRatBN7.2
Rnor_6.01185,292,766 - 185,292,949NCBIRnor6.0
Rnor_5.01192,263,486 - 192,263,669UniSTSRnor5.0
RGSC_v3.41174,464,196 - 174,464,379UniSTSRGSC3.4
Celera1168,432,590 - 168,432,773UniSTS
Cytogenetic Map1q34-q35UniSTS
AI236381  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21170,598,205 - 170,598,421 (-)MAPPERmRatBN7.2
Rnor_6.01185,305,835 - 185,306,050NCBIRnor6.0
Rnor_5.01192,276,555 - 192,276,770UniSTSRnor5.0
RGSC_v3.41174,451,095 - 174,451,310UniSTSRGSC3.4
Celera1168,419,489 - 168,419,704UniSTS
Cytogenetic Map1q34-q35UniSTS
BM387076  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21170,580,147 - 170,580,355 (-)MAPPERmRatBN7.2
Rnor_6.01185,323,901 - 185,324,108NCBIRnor6.0
Rnor_5.01192,294,621 - 192,294,828UniSTSRnor5.0
RGSC_v3.41174,433,037 - 174,433,244UniSTSRGSC3.4
Celera1168,401,431 - 168,401,638UniSTS
RH 3.4 Map11562.91UniSTS
Cytogenetic Map1q34-q35UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000055120   ⟹   ENSRNOP00000051993
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1180,012,248 - 180,117,773 (-)Ensembl
mRatBN7.2 Ensembl1170,577,942 - 170,683,472 (-)Ensembl
Rnor_6.0 Ensembl1185,210,922 - 185,326,314 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000126321   ⟹   ENSRNOP00000112453
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1180,012,248 - 180,117,773 (-)Ensembl
RefSeq Acc Id: NM_001108500   ⟹   NP_001101970
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81180,012,248 - 180,117,773 (-)NCBI
mRatBN7.21170,577,942 - 170,683,472 (-)NCBI
Rnor_6.01185,210,922 - 185,326,314 (+)NCBI
Rnor_5.01192,182,647 - 192,297,034 (+)NCBI
RGSC_v3.41174,430,831 - 174,537,706 (-)RGD
Celera1168,399,225 - 168,504,593 (-)RGD
Sequence:
RefSeq Acc Id: XM_039082801   ⟹   XP_038938729
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81180,028,140 - 180,117,786 (-)NCBI
mRatBN7.21170,594,837 - 170,684,353 (-)NCBI
RefSeq Acc Id: XM_063267503   ⟹   XP_063123573
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81180,012,428 - 180,117,786 (-)NCBI
RefSeq Acc Id: XM_063267507   ⟹   XP_063123577
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81180,012,428 - 180,117,786 (-)NCBI
RefSeq Acc Id: XM_063267510   ⟹   XP_063123580
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81180,012,428 - 180,094,274 (-)NCBI
RefSeq Acc Id: XM_063267512   ⟹   XP_063123582
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81180,012,428 - 180,066,552 (-)NCBI
RefSeq Acc Id: NP_001101970   ⟸   NM_001108500
- UniProtKB: D3ZTF6 (UniProtKB/TrEMBL),   A6I8E5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000051993   ⟸   ENSRNOT00000055120
RefSeq Acc Id: XP_038938729   ⟸   XM_039082801
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063123577   ⟸   XM_063267507
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063123573   ⟸   XM_063267503
- Peptide Label: isoform X1
- UniProtKB: A6I8E5 (UniProtKB/TrEMBL),   D3ZTF6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063123580   ⟸   XM_063267510
- Peptide Label: isoform X3
- UniProtKB: A6I8E7 (UniProtKB/TrEMBL),   A6I8E6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063123582   ⟸   XM_063267512
- Peptide Label: isoform X4
- UniProtKB: A6I8E6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000112453   ⟸   ENSRNOT00000126321
Protein Domains
C2   C2 PI3K-type   PI3K-RBD   PI3K/PI4K catalytic   PIK helical   PX

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZTF6-F1-model_v2 AlphaFold D3ZTF6 1-1687 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690335
Promoter ID:EPDNEW_R860
Type:initiation region
Name:Pik3c2a_1
Description:phosphatidylinositol-4-phosphate 3-kinase, catalytic subunittype 2 alpha
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01185,210,949 - 185,211,009EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310389 AgrOrtholog
BioCyc Gene G2FUF-57715 BioCyc
Ensembl Genes ENSRNOG00000020479 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000055120 ENTREZGENE
  ENSRNOT00000055120.4 UniProtKB/TrEMBL
  ENSRNOT00000126321.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1070.11 UniProtKB/TrEMBL
  1.25.40.70 UniProtKB/TrEMBL
  2.60.40.150 UniProtKB/TrEMBL
  3.30.1520.10 UniProtKB/TrEMBL
  Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1 UniProtKB/TrEMBL
  Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4 UniProtKB/TrEMBL
InterPro ARM-type_fold UniProtKB/TrEMBL
  C2_Ca-dep UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/TrEMBL
  IPR001683 UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  PI3/4_kinase_cat UniProtKB/TrEMBL
  PI3/4_kinase_cat_sf UniProtKB/TrEMBL
  PI3/4_kinase_CS UniProtKB/TrEMBL
  PI3K-C2-alpha_dom UniProtKB/TrEMBL
  PI3K_accessory_sf UniProtKB/TrEMBL
  PI3K_C2 UniProtKB/TrEMBL
  PI3K_ras-bd UniProtKB/TrEMBL
  PI_Kinase UniProtKB/TrEMBL
  PInositide-3_kin_accessory_dom UniProtKB/TrEMBL
  PX_dom_sf UniProtKB/TrEMBL
  PX_PI3K_C2_alpha UniProtKB/TrEMBL
  Ubiquitin-rel_dom UniProtKB/TrEMBL
KEGG Report rno:361632 UniProtKB/TrEMBL
NCBI Gene 361632 ENTREZGENE
PANTHER PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA UniProtKB/TrEMBL
  PI_Kinase UniProtKB/TrEMBL
Pfam PF00168 UniProtKB/TrEMBL
  PF00787 UniProtKB/TrEMBL
  PI3_PI4_kinase UniProtKB/TrEMBL
  PI3K_C2 UniProtKB/TrEMBL
  PI3K_rbd UniProtKB/TrEMBL
  PI3Ka UniProtKB/TrEMBL
PhenoGen Pik3c2a PhenoGen
PROSITE PI3_4_KINASE_1 UniProtKB/TrEMBL
  PI3_4_KINASE_2 UniProtKB/TrEMBL
  PI3_4_KINASE_3 UniProtKB/TrEMBL
  PI3K_C2 UniProtKB/TrEMBL
  PI3K_RBD UniProtKB/TrEMBL
  PIK_HELICAL UniProtKB/TrEMBL
  PS50004 UniProtKB/TrEMBL
  PS50195 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000020479 RatGTEx
SMART PI3K_C2 UniProtKB/TrEMBL
  PI3K_rbd UniProtKB/TrEMBL
  PI3Ka UniProtKB/TrEMBL
  PI3Kc UniProtKB/TrEMBL
  SM00239 UniProtKB/TrEMBL
  SM00312 UniProtKB/TrEMBL
Superfamily-SCOP 64268 UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/TrEMBL
  Kinase_like UniProtKB/TrEMBL
  SSF49562 UniProtKB/TrEMBL
  SSF54236 UniProtKB/TrEMBL
UniProt A0ABK0M9B4_RAT UniProtKB/TrEMBL
  A6I8E5 ENTREZGENE, UniProtKB/TrEMBL
  A6I8E6 ENTREZGENE, UniProtKB/TrEMBL
  A6I8E7 ENTREZGENE, UniProtKB/TrEMBL
  D3ZTF6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-10-10 Pik3c2a  phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha  Pik3c2a  phosphoinositide-3-kinase, class 2, alpha polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-09 Pik3c2a  phosphoinositide-3-kinase, class 2, alpha polypeptide  Pik3c2a  phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Pik3c2a  phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide   Pik3c2a_predicted  phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Pik3c2a_predicted  phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide (predicted)      Symbol and Name status set to approved 70820 APPROVED