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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1310389
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pik3c2a
Name: phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pik3c2adecreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of PIK3C2A mRNAPMID:32109520 PMID:33387578
Pik3c2aincreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of PIK3C2A mRNAPMID:34747641
Pik3c2aaffects expressionISOPik3c2a (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of PIK3C2A mRNAPMID:21570461
Pik3c2aincreases expressionISOPik3c2a (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of PIK3C2A mRNAPMID:15034205
Pik3c2amultiple interactionsISOPik3c2a (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PIK3C2A mRNA; AHR protein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PIK3C2A mRNA]PMID:15034205 PMID:17942748
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