Rangap1 (RAN GTPase activating protein 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Rangap1 (RAN GTPase activating protein 1) Rattus norvegicus
Analyze
Symbol: Rangap1
Name: RAN GTPase activating protein 1
RGD ID: 1310380
Description: Enables small GTPase binding activity and ubiquitin protein ligase binding activity. Involved in cellular response to vasopressin and response to axon injury. Located in several cellular components, including axon cytoplasm; cytoplasmic periphery of the nuclear pore complex; and mitotic spindle. Part of nuclear pore cytoplasmic filaments. Biomarker of sciatic neuropathy. Orthologous to human RANGAP1 (Ran GTPase activating protein 1); PARTICIPATES IN CRM1 export pathway; RNA transport pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC362965; ran GTPase-activating protein 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87115,104,820 - 115,130,564 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7115,104,823 - 115,130,564 (-)EnsemblGRCr8
mRatBN7.27113,224,695 - 113,250,441 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7113,224,703 - 113,250,438 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7114,987,321 - 115,013,059 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07117,210,820 - 117,236,558 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07117,180,248 - 117,205,987 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07122,939,266 - 122,967,178 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7122,940,376 - 122,967,178 (-)Ensemblrn6Rnor6.0
Rnor_5.07122,913,894 - 122,942,464 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47120,056,065 - 120,080,018 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7109,543,716 - 109,569,417 (-)NCBICelera
RGSC_v3.17120,090,297 - 120,114,248 (-)NCBI
Cytogenetic Map7q34NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dinitrotoluene  (EXP)
2,6-dimethoxyphenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-amino-14,16-dimethyloctadecan-3-ol  (ISO)
2-bromohexadecanoic acid  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-chloropropane-1,2-diol  (EXP)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
amphetamine  (EXP)
azoxystrobin  (EXP)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
buspirone  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (EXP)
chromium(6+)  (ISO)
cobalt dichloride  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
Dibutyl phosphate  (ISO)
diuron  (EXP)
dopamine  (EXP)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
ethanol  (ISO)
fenoldopam  (EXP)
flutamide  (EXP)
folic acid  (ISO)
FR900359  (ISO)
furfural  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glyphosate  (EXP)
imidacloprid  (EXP)
isoprenaline  (ISO)
ivermectin  (ISO)
lead(0)  (ISO)
lithocholic acid  (ISO)
methimazole  (EXP)
naphthalene  (ISO)
nefazodone  (EXP)
nickel atom  (ISO)
nocodazole  (ISO)
okadaic acid  (ISO)
oridonin  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
parathion  (ISO)
phenobarbital  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (ISO)
propiconazole  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
retinyl acetate  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
selenium atom  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (EXP,ISO)
thiabendazole  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tremolite asbestos  (ISO)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
trovafloxacin  (EXP)
valproic acid  (ISO)
vitamin E  (ISO)
zinc atom  (ISO)
zinc dichloride  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Vasopressin V1a receptor is required for nucleocytoplasmic transport of mineralocorticoid receptor. Hori K, etal., Am J Physiol Renal Physiol. 2012 Oct;303(7):F1080-8. doi: 10.1152/ajprenal.00052.2012. Epub 2012 Jul 18.
4. Modification of Ran GTPase-activating protein by the small ubiquitin-related modifier SUMO-1 requires Ubc9, an E2-type ubiquitin-conjugating enzyme homologue. Lee GW, etal., J Biol Chem. 1998 Mar 13;273(11):6503-7.
5. A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2. Mahajan R, etal., Cell. 1997 Jan 10;88(1):97-107.
6. A novel ubiquitin-like modification modulates the partitioning of the Ran-GTPase-activating protein RanGAP1 between the cytosol and the nuclear pore complex. Matunis MJ, etal., J Cell Biol. 1996 Dec;135(6 Pt 1):1457-70.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Postage for the messenger: designating routes for nuclear mRNA export. Natalizio BJ and Wente SR, Trends Cell Biol. 2013 Aug;23(8):365-73. doi: 10.1016/j.tcb.2013.03.006. Epub 2013 Apr 11.
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. The Ran GTPase-activating protein (RanGAP1) is critically involved in smooth muscle cell differentiation, proliferation and migration following vascular injury: implications for neointima formation and restenosis. Vorpahl M, etal., PLoS One. 2014 Jul 2;9(7):e101519. doi: 10.1371/journal.pone.0101519. eCollection 2014.
14. Localized regulation of axonal RanGTPase controls retrograde injury signaling in peripheral nerve. Yudin D, etal., Neuron. 2008 Jul 31;59(2):241-52. doi: 10.1016/j.neuron.2008.05.029.
Additional References at PubMed
PMID:8889548   PMID:12477932   PMID:15923632   PMID:16428860   PMID:16449645   PMID:16903783   PMID:17363900   PMID:18794800   PMID:22082260   PMID:25468996   PMID:26308891  


Genomics

Comparative Map Data
Rangap1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87115,104,820 - 115,130,564 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7115,104,823 - 115,130,564 (-)EnsemblGRCr8
mRatBN7.27113,224,695 - 113,250,441 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7113,224,703 - 113,250,438 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7114,987,321 - 115,013,059 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07117,210,820 - 117,236,558 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07117,180,248 - 117,205,987 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07122,939,266 - 122,967,178 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7122,940,376 - 122,967,178 (-)Ensemblrn6Rnor6.0
Rnor_5.07122,913,894 - 122,942,464 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47120,056,065 - 120,080,018 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7109,543,716 - 109,569,417 (-)NCBICelera
RGSC_v3.17120,090,297 - 120,114,248 (-)NCBI
Cytogenetic Map7q34NCBI
RANGAP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382241,244,779 - 41,302,369 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2241,244,779 - 41,286,272 (-)Ensemblhg38GRCh38
GRCh372241,640,783 - 41,698,373 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362239,971,561 - 40,012,162 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342239,966,115 - 40,006,716NCBI
Celera2225,447,987 - 25,488,613 (-)NCBICelera
Cytogenetic Map22q13.2NCBI
HuRef2224,605,244 - 24,646,120 (-)NCBIHuRef
CHM1_12241,600,469 - 41,641,957 (-)NCBICHM1_1
T2T-CHM13v2.02241,719,708 - 41,781,201 (-)NCBIT2T-CHM13v2.0
Rangap1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391581,588,449 - 81,614,120 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1581,588,449 - 81,629,731 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381581,704,248 - 81,730,798 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1581,704,248 - 81,745,530 (-)Ensemblmm10GRCm38
MGSCv371581,534,678 - 81,560,349 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361581,531,508 - 81,557,156 (-)NCBIMGSCv36mm8
Celera1583,823,354 - 83,848,746 (-)NCBICelera
Cytogenetic Map15E1NCBI
cM Map1538.21NCBI
Rangap1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541326,867,812 - 26,890,284 (-)Ensembl
ChiLan1.0NW_00495541326,869,487 - 26,894,192 (-)NCBIChiLan1.0ChiLan1.0
RANGAP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22351,078,320 - 51,135,017 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12253,778,242 - 53,834,871 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02222,142,644 - 22,199,268 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12240,233,357 - 40,286,677 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2240,233,357 - 40,272,671 (-)EnsemblpanPan2panpan1.1
RANGAP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11023,953,877 - 23,985,622 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1023,953,912 - 24,003,162 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1023,886,012 - 23,917,770 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01024,698,293 - 24,730,051 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1024,698,297 - 24,747,502 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11024,414,746 - 24,446,498 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01024,735,632 - 24,767,361 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01024,910,123 - 24,941,882 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Rangap1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049457,585,629 - 7,615,805 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936492595,938 - 626,213 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936492595,905 - 626,219 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RANGAP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl57,211,010 - 7,241,003 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.157,210,974 - 7,240,965 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.254,545,694 - 4,555,008 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RANGAP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11923,789,839 - 23,829,653 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1923,788,241 - 23,829,631 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666045101,593,587 - 101,634,522 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rangap1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247527,246,193 - 7,277,701 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247527,246,161 - 7,277,702 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Rangap1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11251,451,177 - 251,471,813 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Rangap1
181 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:336
Count of miRNA genes:207
Interacting mature miRNAs:238
Transcripts:ENSRNOT00000052098
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)792388565119280177Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)782111245123048330Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7104186212135371468Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)773618702118618702Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)793302009131686183Rat
61397Bw17Body weight QTL 176.3body mass (VT:0001259)body weight (CMO:0000012)795485047137014596Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)746307490127866166Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)785043242130043242Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)785497398130497398Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)792362341137014596Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)783626689128626689Rat
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)782111382132099989Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)798549867137014596Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
631201Panci1Pancreas inflammation QTL 100.001pancreas integrity trait (VT:0010560)percentage of study population displaying chronic pancreatitis at a point in time (CMO:0001214)773557047118557047Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)782111245123048330Rat
2313102Bmd79Bone mineral density QTL 792.30.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)796700404118618702Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)740540077123682549Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7110725024135371468Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)749682832115766396Rat
10450862Kidm55Kidney mass QTL 554.9kidney mass (VT:0002707)kidney weight (CMO:0000081)772725037117725037Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)7100548246137014596Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)782111245134948181Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
10450856Livw4Liver weight QTL 43.8liver mass (VT:0003402)liver weight (CMO:0000092)772725037117725037Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)749682832115766396Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)778682549123682549Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)749682832115766396Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)771621154119349044Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)771827901136544683Rat

Markers in Region
RH137102  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27113,224,817 - 113,225,004 (+)MAPPERmRatBN7.2
Rnor_6.07122,940,496 - 122,940,682NCBIRnor6.0
Rnor_5.07122,915,123 - 122,915,309UniSTSRnor5.0
RGSC_v3.47120,055,738 - 120,055,924UniSTSRGSC3.4
Celera7109,543,839 - 109,544,025UniSTS
RH 3.4 Map7880.6UniSTS
Cytogenetic Map7q34UniSTS
RH138266  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27113,225,208 - 113,225,329 (+)MAPPERmRatBN7.2
Rnor_6.07122,940,887 - 122,941,007NCBIRnor6.0
Rnor_5.07122,915,514 - 122,915,634UniSTSRnor5.0
RGSC_v3.47120,056,129 - 120,056,249UniSTSRGSC3.4
Celera7109,544,230 - 109,544,350UniSTS
RH 3.4 Map7877.5UniSTS
Cytogenetic Map7q34UniSTS
RH139938  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27113,251,501 - 113,251,698 (+)MAPPERmRatBN7.2
Rnor_6.07122,968,239 - 122,968,435NCBIRnor6.0
Rnor_5.07122,943,525 - 122,943,721UniSTSRnor5.0
RGSC_v3.47120,084,958 - 120,085,154UniSTSRGSC3.4
Celera7109,570,474 - 109,570,670UniSTS
RH 3.4 Map7878.4UniSTS
Cytogenetic Map7q34UniSTS
AI228735  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27113,242,759 - 113,242,921 (+)MAPPERmRatBN7.2
Rnor_6.07122,959,498 - 122,959,659NCBIRnor6.0
Rnor_5.07122,934,784 - 122,934,945UniSTSRnor5.0
RGSC_v3.47120,076,217 - 120,076,378UniSTSRGSC3.4
Celera7109,561,737 - 109,561,898UniSTS
RH 3.4 Map7880.4UniSTS
Cytogenetic Map7q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 92 59 6 356 192 11 142 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000052098   ⟹   ENSRNOP00000050029
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7115,104,823 - 115,130,564 (-)Ensembl
mRatBN7.2 Ensembl7113,224,710 - 113,250,438 (-)Ensembl
Rnor_6.0 Ensembl7122,940,376 - 122,967,178 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000090208   ⟹   ENSRNOP00000073525
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7115,105,273 - 115,126,685 (-)Ensembl
mRatBN7.2 Ensembl7113,225,148 - 113,246,562 (-)Ensembl
Rnor_6.0 Ensembl7122,940,826 - 122,963,299 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000106829   ⟹   ENSRNOP00000094275
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7115,108,274 - 115,130,564 (-)Ensembl
mRatBN7.2 Ensembl7113,224,703 - 113,250,427 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000107227   ⟹   ENSRNOP00000095665
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7115,104,823 - 115,130,564 (-)Ensembl
mRatBN7.2 Ensembl7113,224,703 - 113,250,427 (-)Ensembl
RefSeq Acc Id: NM_001244855   ⟹   NP_001231784
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87115,104,820 - 115,130,564 (-)NCBI
mRatBN7.27113,224,695 - 113,250,441 (-)NCBI
Rnor_6.07122,940,373 - 122,967,178 (-)NCBI
Rnor_5.07122,913,894 - 122,942,464 (-)NCBI
Celera7109,543,716 - 109,569,417 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006242100   ⟹   XP_006242162
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87115,104,828 - 115,126,777 (-)NCBI
mRatBN7.27113,224,695 - 113,246,595 (-)NCBI
Rnor_6.07122,939,266 - 122,963,808 (-)NCBI
Rnor_5.07122,913,894 - 122,942,464 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006242101   ⟹   XP_006242163
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87115,104,828 - 115,130,315 (-)NCBI
mRatBN7.27113,224,695 - 113,249,988 (-)NCBI
Rnor_6.07122,939,266 - 122,966,964 (-)NCBI
Rnor_5.07122,913,894 - 122,942,464 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039079597   ⟹   XP_038935525
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87115,107,411 - 115,126,777 (-)NCBI
mRatBN7.27113,227,286 - 113,246,597 (-)NCBI
RefSeq Acc Id: XR_005486677
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87115,106,074 - 115,126,777 (-)NCBI
mRatBN7.27113,224,695 - 113,246,596 (-)NCBI
RefSeq Acc Id: XR_010053010
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87115,106,074 - 115,126,777 (-)NCBI
RefSeq Acc Id: NP_001231784   ⟸   NM_001244855
- UniProtKB: F1MAA5 (UniProtKB/TrEMBL),   A0A8I6AMS6 (UniProtKB/TrEMBL),   A6HT14 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242163   ⟸   XM_006242101
- Peptide Label: isoform X2
- UniProtKB: F1MAA5 (UniProtKB/TrEMBL),   A0A8I6AMS6 (UniProtKB/TrEMBL),   A6HT14 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242162   ⟸   XM_006242100
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K5R3 (UniProtKB/TrEMBL),   F1MAA5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073525   ⟸   ENSRNOT00000090208
Ensembl Acc Id: ENSRNOP00000050029   ⟸   ENSRNOT00000052098
RefSeq Acc Id: XP_038935525   ⟸   XM_039079597
- Peptide Label: isoform X3
Ensembl Acc Id: ENSRNOP00000095665   ⟸   ENSRNOT00000107227
Ensembl Acc Id: ENSRNOP00000094275   ⟸   ENSRNOT00000106829
Protein Domains
Ran-GTPase activating protein 1 C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1MAA5-F1-model_v2 AlphaFold F1MAA5 1-586 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695522
Promoter ID:EPDNEW_R6038
Type:initiation region
Name:Rangap1_2
Description:RAN GTPase activating protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R6039  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07122,963,298 - 122,963,358EPDNEW
RGD ID:13695515
Promoter ID:EPDNEW_R6039
Type:multiple initiation site
Name:Rangap1_1
Description:RAN GTPase activating protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R6038  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07122,967,194 - 122,967,254EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310380 AgrOrtholog
BioCyc Gene G2FUF-32664 BioCyc
Ensembl Genes ENSRNOG00000031789 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000052098 ENTREZGENE
  ENSRNOT00000052098.7 UniProtKB/TrEMBL
  ENSRNOT00000090208 ENTREZGENE
  ENSRNOT00000090208.3 UniProtKB/TrEMBL
  ENSRNOT00000106829 ENTREZGENE
  ENSRNOT00000106829.2 UniProtKB/TrEMBL
  ENSRNOT00000107227.2 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.200 UniProtKB/TrEMBL
  3.80.10.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7132303 IMAGE-MGC_LOAD
InterPro L_dom-like UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/TrEMBL
  Ran_GTPase_activating_1_C UniProtKB/TrEMBL
  RanGap UniProtKB/TrEMBL
  RanGAP1_C_sf UniProtKB/TrEMBL
KEGG Report rno:362965 UniProtKB/TrEMBL
MGC_CLONE MGC:95209 IMAGE-MGC_LOAD
NCBI Gene 362965 ENTREZGENE
PANTHER RAN GTPASE-ACTIVATING PROTEIN 1 UniProtKB/TrEMBL
  RAN GTPASE-ACTIVATING PROTEIN 1 UniProtKB/TrEMBL
Pfam LRR_6 UniProtKB/TrEMBL
  RanGAP1_C UniProtKB/TrEMBL
PhenoGen Rangap1 PhenoGen
RatGTEx ENSRNOG00000031789 RatGTEx
SMART LRR_RI UniProtKB/TrEMBL
Superfamily-SCOP RanGAP1_C UniProtKB/TrEMBL
  RNI-like UniProtKB/TrEMBL
UniProt A0A0G2K5R3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AMS6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GL89_RAT UniProtKB/TrEMBL
  A6HT14 ENTREZGENE, UniProtKB/TrEMBL
  F1MAA5 ENTREZGENE, UniProtKB/TrEMBL
  Q66H32_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Rangap1  RAN GTPase activating protein 1  Rangap1_predicted  RAN GTPase activating protein 1 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Rangap1_predicted  RAN GTPase activating protein 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED