Eci3 (enoyl-Coenzyme A delta isomerase 3) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Eci3 (enoyl-Coenzyme A delta isomerase 3) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Eci3 (Ensembl: Eci2)
Name: enoyl-Coenzyme A delta isomerase 3 (Ensembl:enoyl-CoA delta isomerase 2)
RGD ID: 1310224
Description: ENCODES a protein that exhibits delta(3)-delta(2)-enoyl-CoA isomerase activity (inferred); fatty-acyl-CoA binding (inferred); isomerase activity (inferred); FOUND IN peroxisome (inferred); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: hypothetical protein LOC291076; LOC291076; MGC108813; RGD1310224; similar to RIKEN cDNA 1810022C23
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81730,127,425 - 30,149,249 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1730,128,588 - 30,149,137 (+)EnsemblGRCr8
mRatBN7.21729,921,962 - 29,943,864 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1729,921,977 - 29,943,862 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1729,742,730 - 29,764,519 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01731,346,474 - 31,368,263 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01729,738,453 - 29,760,242 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01730,617,382 - 30,639,068 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1730,556,884 - 30,639,040 (+)Ensemblrn6Rnor6.0
Rnor_5.01732,517,301 - 32,539,061 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41736,253,004 - 36,274,899 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1729,492,074 - 29,513,890 (+)NCBICelera
RGSC_v3.11736,255,844 - 36,277,739 (+)NCBI
Cytogenetic Map17p12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
peroxisome  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:24344334  


Genomics

Variants

.
Variants in Eci3
141 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:39
Count of miRNA genes:38
Interacting mature miRNAs:39
Transcripts:ENSRNOT00000048923
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17143999106Rat
2300002Iddm36Insulin dependent diabetes mellitus QTL 361.98blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)17926675540968173Rat
70210Cm15Cardiac mass QTL 156.5heart right ventricle mass (VT:0007033)heart right ventricle wet weight (CMO:0000072)173006647275066472Rat
8552966Pigfal18Plasma insulin-like growth factor 1 level QTL 188.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)171286094257860942Rat
152023626Bp403Blood pressure QTL 4033.86arterial blood pressure trait (VT:2000000)172413612784432719Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17212084342054133Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)17622199858177198Rat
70157Niddm32Non-insulin dependent diabetes mellitus QTL 324.34blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)172266079955604694Rat
9589151Insul30Insulin level QTL 308.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)171286094257860942Rat
1354628Stl13Serum triglyceride level QTL 133.8blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)172149899450592236Rat
1581512Cm55Cardiac mass QTL 552.80.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172723344583975845Rat
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17131706603Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17473353449733534Rat
61394Bp8Blood pressure QTL 82.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172328632264246472Rat
9589057Scfw6Subcutaneous fat weight QTL 68.620.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)171286094257860942Rat
2317045Aia11Adjuvant induced arthritis QTL 114.06joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)172652205171522051Rat
9590154Scort9Serum corticosterone level QTL 923.570.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)171286094257860942Rat
10450503Bp386Blood pressure QTL 3860.28arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172201970567019705Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172385892668858926Rat
152025238Slep14Serum leptin concentration QTL 144.62blood leptin amount (VT:0005667)172439059584432719Rat
9590088Insglur7Insulin/glucose ratio QTL 720.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)171286094257860942Rat
2317053Aia25Adjuvant induced arthritis QTL 252.69joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)171060469455604694Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17136045694Rat
1331765Hrtrt15Heart rate QTL 154.094heart pumping trait (VT:2000009)heart rate (CMO:0000002)171553702560531414Rat
7411666Foco31Food consumption QTL 3111.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)171286094257860942Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17473353449733534Rat
12903980Cm120Cardiac mass QTL 1200.002heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)172385892668858926Rat
70184BpQTLcluster14Blood pressure QTL cluster 143.38arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)17857434232199534Rat
12903981Am17Aortic mass QTL 170.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)172385892668858926Rat
4889955Bss93Bone structure and strength QTL 934.4tibia size trait (VT:0100001)tibia cortical bone volume to tibia total bone volume ratio (CMO:0001727)172723344565155015Rat
4889891Eae32Experimental allergic encephalomyelitis QTL 324.80.0002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)172723344572233445Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172385892668858926Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17138037084Rat
12903978Cm118Cardiac mass QTL 1180.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)172385892668858926Rat
12903979Cm119Cardiac mass QTL 1190.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172385892668858926Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17143999106Rat
152023740Bp406Blood pressure QTL 4066.06arterial blood pressure trait (VT:2000000)172413612784432719Rat
7488966Bp370Blood pressure QTL 3700.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172385892668858926Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17143999106Rat
152023737Bp405Blood pressure QTL 4055.06arterial blood pressure trait (VT:2000000)2413612784432719Rat
152023736Bp404Blood pressure QTL 4043.78arterial blood pressure trait (VT:2000000)172413612784432719Rat

Markers in Region
RH141084  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21729,942,533 - 29,943,712 (+)MAPPERmRatBN7.2
Rnor_6.01730,637,739 - 30,638,917NCBIRnor6.0
Rnor_5.01732,537,732 - 32,538,910UniSTSRnor5.0
RGSC_v3.41736,273,570 - 36,274,748UniSTSRGSC3.4
Celera1729,512,561 - 29,513,739UniSTS
RH 3.4 Map17372.4UniSTS
Cytogenetic Map17p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 89 59 6 353 189 11 142 81 92 31 15 15

Sequence


RefSeq Acc Id: NM_001009275   ⟹   NP_001009275
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81730,127,425 - 30,149,249 (+)NCBI
mRatBN7.21729,922,037 - 29,943,863 (+)NCBI
Rnor_6.01730,617,382 - 30,639,068 (+)NCBI
Rnor_5.01732,517,301 - 32,539,061 (+)NCBI
RGSC_v3.41736,253,004 - 36,274,899 (+)RGD
Celera1729,492,074 - 29,513,890 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001009275 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH88178 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000050206
  ENSRNOP00000050206.2
  ENSRNOP00000072135.2
RefSeq Acc Id: NP_001009275   ⟸   NM_001009275
- UniProtKB: Q5M884 (UniProtKB/TrEMBL),   A0A0G2K277 (UniProtKB/TrEMBL)
- Sequence:
Protein Domains
ACB

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700406
Promoter ID:EPDNEW_R10929
Type:initiation region
Name:Eci2_2
Description:enoyl-CoA delta isomerase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R10928  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01730,617,376 - 30,617,436EPDNEW

Additional Information

Database Acc Id Source(s)
BioCyc Gene G2FUF-9620 BioCyc
Ensembl Genes ENSRNOG00000029549 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000048923 ENTREZGENE
  ENSRNOT00000048923.6 UniProtKB/TrEMBL
  ENSRNOT00000080929.3 UniProtKB/TrEMBL
Gene3D-CATH 1.10.12.10 UniProtKB/TrEMBL
  1.20.80.10 UniProtKB/TrEMBL
  2-enoyl-CoA Hydratase, Chain A, domain 1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7324966 IMAGE-MGC_LOAD
InterPro Acyl-CoA-binding_protein UniProtKB/TrEMBL
  Acyl-CoA-binding_sf UniProtKB/TrEMBL
  ClpP/crotonase-like_dom UniProtKB/TrEMBL
  Crontonase_C UniProtKB/TrEMBL
  Crotonase_core UniProtKB/TrEMBL
  ECH/Chromodomain_protein UniProtKB/TrEMBL
  FERM/acyl-CoA-bd_prot_3-hlx UniProtKB/TrEMBL
KEGG Report rno:291076 UniProtKB/TrEMBL
MGC_CLONE MGC:108813 IMAGE-MGC_LOAD
NCBI Gene 291076 ENTREZGENE
PANTHER ENOYL-COA DELTA ISOMERASE 2 UniProtKB/TrEMBL
  PTHR43684 UniProtKB/TrEMBL
Pfam ACBP UniProtKB/TrEMBL
  ECH UniProtKB/TrEMBL
PhenoGen Eci3 PhenoGen
RatGTEx ENSRNOG00000029549 RatGTEx
Superfamily-SCOP SSF47027 UniProtKB/TrEMBL
  SSF52096 UniProtKB/TrEMBL
UniProt A0A0G2K277 ENTREZGENE, UniProtKB/TrEMBL
  Q5M884 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-03-17 Eci3  enoyl-Coenzyme A delta isomerase 3  RGD1310224  similar to RIKEN cDNA 1810022C23  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 RGD1310224  similar to RIKEN cDNA 1810022C23  RGD1310224_predicted  similar to RIKEN cDNA 1810022C23 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1310224_predicted  similar to RIKEN cDNA 1810022C23 (predicted)  LOC291076_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC291076_predicted  similar to RIKEN cDNA 1810022C23 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL