Dtnb (dystrobrevin, beta) - Rat Genome Database

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Gene: Dtnb (dystrobrevin, beta) Rattus norvegicus
Analyze
Symbol: Dtnb
Name: dystrobrevin, beta
RGD ID: 1309579
Description: Enables phosphatase binding activity. Predicted to be involved in neuron differentiation and synaptic signaling. Located in postsynaptic density. Orthologous to human DTNB (dystrobrevin beta); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: beta-dystrobrevin; DTN-B; dystrobrevin beta; LOC362715
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8632,286,022 - 32,483,007 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl632,285,941 - 32,485,872 (+)EnsemblGRCr8
mRatBN7.2626,566,418 - 26,763,467 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl626,566,925 - 26,766,335 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx626,859,268 - 27,055,798 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0627,175,183 - 27,371,711 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0626,653,548 - 26,850,392 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0627,975,302 - 28,177,236 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl627,975,417 - 28,177,214 (+)Ensemblrn6Rnor6.0
Rnor_5.0637,787,793 - 37,986,165 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4626,542,148 - 26,742,199 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera626,042,938 - 26,238,448 (+)NCBICelera
RGSC_v3.1626,545,100 - 26,745,151 (+)NCBI
Cytogenetic Map6q14NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2,4-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
4,4'-sulfonyldiphenol  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
alpha-Zearalanol  (EXP)
amphetamine  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-naphthoflavone  (EXP)
bezafibrate  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Butylbenzyl phthalate  (EXP,ISO)
C60 fullerene  (EXP)
cadmium dichloride  (ISO)
calcitriol  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (EXP)
clofibrate  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (ISO)
diuron  (EXP)
enzyme inhibitor  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
furan  (EXP)
hypochlorous acid  (ISO)
inulin  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methidathion  (ISO)
methoxychlor  (EXP)
N-nitrosodiethylamine  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (ISO)
PCB138  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
pirinixic acid  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
tamoxifen  (ISO)
testosterone  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
triptonide  (ISO)
trovafloxacin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
basal plasma membrane  (IEA)
cytoplasm  (IEA,ISO,ISS)
dendrite  (IEA)
GABA-ergic synapse  (ISO)
inhibitory synapse  (ISO,ISS)
nucleus  (IEA,ISO,ISS)
plasma membrane  (IBA,IEA)
postsynapse  (IEA,ISO)
postsynaptic density  (IDA,IEA)
synapse  (IBA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Different dystrophin-like complexes are expressed in neurons and glia. Blake DJ, etal., J Cell Biol. 1999 Nov 1;147(3):645-58. doi: 10.1083/jcb.147.3.645.
2. Association of dystrobrevin and regulatory subunit of protein kinase A: a new role for dystrobrevin as a scaffold for signaling proteins. Ceccarini M, etal., J Mol Biol. 2007 Aug 31;371(5):1174-87. doi: 10.1016/j.jmb.2007.06.019. Epub 2007 Jun 14.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Beta-dystrobrevin interacts directly with kinesin heavy chain in brain. Macioce P, etal., J Cell Sci 2003 Dec 1;116(Pt 23):4847-56.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. beta-dystrobrevin, a kinesin-binding receptor, interacts with the extracellular matrix components pancortins. Veroni C, etal., J Neurosci Res. 2007 Sep;85(12):2631-9. doi: 10.1002/jnr.21186.
Additional References at PubMed
PMID:8889548   PMID:10995443   PMID:11316798   PMID:12477932   PMID:15489334   PMID:16448387   PMID:17728463   PMID:19931615   PMID:20530487   PMID:25931508   PMID:39160285  


Genomics

Comparative Map Data
Dtnb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8632,286,022 - 32,483,007 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl632,285,941 - 32,485,872 (+)EnsemblGRCr8
mRatBN7.2626,566,418 - 26,763,467 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl626,566,925 - 26,766,335 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx626,859,268 - 27,055,798 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0627,175,183 - 27,371,711 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0626,653,548 - 26,850,392 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0627,975,302 - 28,177,236 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl627,975,417 - 28,177,214 (+)Ensemblrn6Rnor6.0
Rnor_5.0637,787,793 - 37,986,165 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4626,542,148 - 26,742,199 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera626,042,938 - 26,238,448 (+)NCBICelera
RGSC_v3.1626,545,100 - 26,745,151 (+)NCBI
Cytogenetic Map6q14NCBI
DTNB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38225,377,243 - 25,673,577 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl225,377,028 - 25,673,717 (-)Ensemblhg38GRCh38
GRCh37225,600,112 - 25,896,446 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36225,453,616 - 25,750,007 (-)NCBIBuild 36Build 36hg18NCBI36
Celera225,440,455 - 25,736,846 (-)NCBICelera
Cytogenetic Map2p23.3NCBI
HuRef225,337,463 - 25,633,574 (-)NCBIHuRef
CHM1_1225,529,919 - 25,826,226 (-)NCBICHM1_1
T2T-CHM13v2.0225,412,572 - 25,708,881 (-)NCBIT2T-CHM13v2.0
Dtnb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39123,622,372 - 3,834,070 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl123,622,381 - 3,831,796 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38123,572,372 - 3,785,486 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl123,572,381 - 3,781,796 (+)Ensemblmm10GRCm38
MGSCv37123,572,391 - 3,781,398 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36123,572,523 - 3,781,505 (+)NCBIMGSCv36mm8
Celera123,500,288 - 3,709,433 (+)NCBICelera
Cytogenetic Map12A1.1NCBI
cM Map121.88NCBI
Dtnb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554697,398,127 - 7,671,899 (-)Ensembl
ChiLan1.0NW_0049554697,402,777 - 7,771,767 (-)NCBIChiLan1.0ChiLan1.0
DTNB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v212100,843,189 - 101,139,871 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A100,847,159 - 101,143,635 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A25,378,862 - 25,675,556 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A25,476,274 - 25,749,937 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A25,476,274 - 25,749,937 (-)EnsemblpanPan2panpan1.1
DTNB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11719,619,745 - 19,863,697 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1719,516,792 - 19,761,595 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01719,895,403 - 20,187,150 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1719,895,340 - 20,185,797 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11719,629,332 - 19,874,605 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01719,639,273 - 19,884,237 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01719,685,630 - 19,930,471 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Dtnb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629263,958,040 - 64,188,819 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364936,676,037 - 6,881,626 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364936,676,146 - 6,881,112 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DTNB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.13113,229,161 - 113,477,009 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23120,246,444 - 120,451,748 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DTNB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11481,978,427 - 82,282,849 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604529,877,198 - 30,178,986 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dtnb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247387,603,252 - 8,100,369 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247387,607,885 - 7,941,335 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Dtnb
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1724,255,710 - 24,448,503 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Dtnb
932 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:291
Count of miRNA genes:182
Interacting mature miRNAs:222
Transcripts:ENSRNOT00000060810
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6197587946975879Rat
10401812Kidm54Kidney mass QTL 54kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)62009763565097635Rat
8552910Pigfal5Plasma insulin-like growth factor 1 level QTL 54.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)62265388967653889Rat
10401800Kidm49Kidney mass QTL 49kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)62009763565097635Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6323998948239989Rat
1331779Rf38Renal function QTL 382.876kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)63118500276185002Rat
9589129Insul24Insulin level QTL 2419.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)6197587946975879Rat
7411603Foco13Food consumption QTL 135.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6197587946975879Rat
1598843Cm63Cardiac mass QTL 632.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)6144788383Rat
7411542Bw127Body weight QTL 1275.50.001body mass (VT:0001259)body weight gain (CMO:0000420)6197587946975879Rat
2292616Ept15Estrogen-induced pituitary tumorigenesis QTL 154.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)6144788383Rat
9589048Scfw3Subcutaneous fat weight QTL 34.570.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)6197587946975879Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62661831486868070Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)620859430113082285Rat
2301964Bp323Blood pressure QTL 3234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6186868070Rat
2293709Bss23Bone structure and strength QTL 235.180.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)6323998948239989Rat
2293650Bss31Bone structure and strength QTL 315.050.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)6323998948239989Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62661831486868070Rat
1300128Rf16Renal function QTL 163.89renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6140163351Rat
1641898Colcr4Colorectal carcinoma resistance QTL43.710.0007intestine integrity trait (VT:0010554)well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)63093763275937632Rat
70199Coreg1Compensatory renal growth QTL 111.8kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)61459947363457687Rat
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)61608937261967788Rat
1358190Ept1Estrogen-induced pituitary tumorigenesis QTL 14.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)6144788383Rat
2293656Bss28Bone structure and strength QTL 286.790.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)6323998948239989Rat
1359023Bp272Blood pressure QTL 2722.5arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)62228825732981219Rat
1354664Slep2Serum leptin concentration QTL 24.49blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)62228825767288257Rat

Markers in Region
D6Got16  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2626,711,269 - 26,711,406 (+)MAPPERmRatBN7.2
Rnor_6.0628,125,661 - 28,125,797NCBIRnor6.0
Rnor_5.0637,934,823 - 37,934,959UniSTSRnor5.0
RGSC_v3.4626,689,395 - 26,689,532RGDRGSC3.4
RGSC_v3.4626,689,396 - 26,689,532UniSTSRGSC3.4
Celera626,186,384 - 26,186,520UniSTS
RGSC_v3.1626,692,348 - 26,692,485RGD
RH 3.4 Map6118.0RGD
RH 3.4 Map6118.0UniSTS
Cytogenetic Map6q14UniSTS
D6Uia2  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8632,461,208 - 32,461,372 (+)Marker Load Pipeline
mRatBN7.2626,741,665 - 26,741,829 (+)MAPPERmRatBN7.2
Rnor_6.0628,155,426 - 28,155,589NCBIRnor6.0
Rnor_5.0637,964,588 - 37,964,751UniSTSRnor5.0
RGSC_v3.4626,719,868 - 26,720,032RGDRGSC3.4
RGSC_v3.4626,719,869 - 26,720,032UniSTSRGSC3.4
Celera626,216,665 - 26,216,828UniSTS
RGSC_v3.1626,722,821 - 26,722,985RGD
Cytogenetic Map6q14UniSTS
BF405608  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2626,696,812 - 26,696,912 (+)MAPPERmRatBN7.2
Rnor_6.0628,111,208 - 28,111,307NCBIRnor6.0
Rnor_5.0637,920,370 - 37,920,469UniSTSRnor5.0
RGSC_v3.4626,675,117 - 26,675,216UniSTSRGSC3.4
Celera626,171,900 - 26,171,999UniSTS
RH 3.4 Map6118.48UniSTS
Cytogenetic Map6q14UniSTS
MARC_10279-10280:998924900:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2626,755,118 - 26,756,122 (+)MAPPERmRatBN7.2
Rnor_6.0628,168,890 - 28,169,893NCBIRnor6.0
Rnor_5.0637,977,819 - 37,978,822UniSTSRnor5.0
RGSC_v3.4626,733,854 - 26,734,857UniSTSRGSC3.4
Celera626,230,116 - 26,231,119UniSTS
Cytogenetic Map6q14UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 91 59 6 355 191 11 143 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001393801 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_172013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006239818 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594216 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594217 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594218 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112487 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262062 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262063 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262064 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262067 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262068 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001838174 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001838175 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001838176 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001838177 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001838178 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001838179 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001838180 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001838181 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001838182 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010052106 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010052107 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010052108 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010052109 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010052110 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010052111 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010052112 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010052113 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010052114 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010052115 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC081889 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226040 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000060810   ⟹   ENSRNOP00000057536
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl632,286,482 - 32,482,985 (+)Ensembl
mRatBN7.2 Ensembl626,566,925 - 26,766,335 (+)Ensembl
Rnor_6.0 Ensembl627,975,849 - 28,177,214 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000077830   ⟹   ENSRNOP00000069544
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl632,285,978 - 32,483,006 (+)Ensembl
mRatBN7.2 Ensembl626,566,925 - 26,766,335 (+)Ensembl
Rnor_6.0 Ensembl627,975,417 - 28,175,458 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000094568   ⟹   ENSRNOP00000091273
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl626,566,925 - 26,766,335 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000101006   ⟹   ENSRNOP00000095615
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl632,285,941 - 32,485,872 (+)Ensembl
mRatBN7.2 Ensembl626,566,925 - 26,766,335 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000114344   ⟹   ENSRNOP00000092832
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl632,286,482 - 32,482,985 (+)Ensembl
mRatBN7.2 Ensembl626,566,925 - 26,766,335 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000117452   ⟹   ENSRNOP00000087517
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl632,285,948 - 32,483,005 (+)Ensembl
mRatBN7.2 Ensembl626,566,925 - 26,766,335 (+)Ensembl
RefSeq Acc Id: NM_001393801   ⟹   NP_001380730
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8632,286,482 - 32,483,007 (+)NCBI
mRatBN7.2626,566,925 - 26,763,467 (+)NCBI
RefSeq Acc Id: NR_172013
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8632,286,482 - 32,483,007 (+)NCBI
mRatBN7.2626,566,925 - 26,763,467 (+)NCBI
RefSeq Acc Id: XM_039112487   ⟹   XP_038968415
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8632,286,022 - 32,476,579 (+)NCBI
mRatBN7.2626,566,418 - 26,756,302 (+)NCBI
RefSeq Acc Id: XM_063262062   ⟹   XP_063118132
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8632,286,031 - 32,483,007 (+)NCBI
RefSeq Acc Id: XM_063262063   ⟹   XP_063118133
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8632,286,031 - 32,483,007 (+)NCBI
RefSeq Acc Id: XM_063262064   ⟹   XP_063118134
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8632,286,031 - 32,483,007 (+)NCBI
RefSeq Acc Id: XM_063262065   ⟹   XP_063118135
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8632,286,031 - 32,483,007 (+)NCBI
RefSeq Acc Id: XM_063262066   ⟹   XP_063118136
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8632,286,022 - 32,483,007 (+)NCBI
RefSeq Acc Id: XM_063262067   ⟹   XP_063118137
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8632,286,022 - 32,483,007 (+)NCBI
RefSeq Acc Id: XM_063262068   ⟹   XP_063118138
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8632,286,022 - 32,483,007 (+)NCBI
RefSeq Acc Id: XR_010052106
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8632,286,031 - 32,483,007 (+)NCBI
RefSeq Acc Id: XR_010052107
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8632,286,031 - 32,483,007 (+)NCBI
RefSeq Acc Id: XR_010052108
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8632,286,031 - 32,483,007 (+)NCBI
RefSeq Acc Id: XR_010052109
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8632,286,031 - 32,483,007 (+)NCBI
RefSeq Acc Id: XR_010052110
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8632,286,022 - 32,483,007 (+)NCBI
RefSeq Acc Id: XR_010052111
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8632,286,022 - 32,483,007 (+)NCBI
RefSeq Acc Id: XR_010052112
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8632,286,022 - 32,483,007 (+)NCBI
RefSeq Acc Id: XR_010052113
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8632,316,739 - 32,483,007 (+)NCBI
RefSeq Acc Id: XR_010052114
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8632,321,248 - 32,483,007 (+)NCBI
RefSeq Acc Id: XR_010052115
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8632,397,699 - 32,483,007 (+)NCBI
Ensembl Acc Id: ENSRNOP00000057536   ⟸   ENSRNOT00000060810
Ensembl Acc Id: ENSRNOP00000069544   ⟸   ENSRNOT00000077830
RefSeq Acc Id: XP_038968415   ⟸   XM_039112487
- Peptide Label: isoform X5
- UniProtKB: P84060 (UniProtKB/Swiss-Prot),   Q66HF4 (UniProtKB/Swiss-Prot),   A0A8I6AK26 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000092832   ⟸   ENSRNOT00000114344
Ensembl Acc Id: ENSRNOP00000087517   ⟸   ENSRNOT00000117452
Ensembl Acc Id: ENSRNOP00000095615   ⟸   ENSRNOT00000101006
Ensembl Acc Id: ENSRNOP00000091273   ⟸   ENSRNOT00000094568
RefSeq Acc Id: NP_001380730   ⟸   NM_001393801
- UniProtKB: A0A8I6AK26 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063118136   ⟸   XM_063262066
- Peptide Label: isoform X6
- UniProtKB: A0A8I6AK26 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063118137   ⟸   XM_063262067
- Peptide Label: isoform X7
- UniProtKB: A0A8I6AE63 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063118138   ⟸   XM_063262068
- Peptide Label: isoform X8
- UniProtKB: A0A8I6AE63 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063118132   ⟸   XM_063262062
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AHC0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063118134   ⟸   XM_063262064
- Peptide Label: isoform X3
- UniProtKB: A0A8L2UMY1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063118133   ⟸   XM_063262063
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AK26 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063118135   ⟸   XM_063262065
- Peptide Label: isoform X4
- UniProtKB: A0A8I6AE63 (UniProtKB/TrEMBL)
Protein Domains
ZZ-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P84060-F1-model_v2 AlphaFold P84060 1-654 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694472
Promoter ID:EPDNEW_R4994
Type:initiation region
Name:Dtnb_1
Description:dystrobrevin, beta
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0627,975,344 - 27,975,404EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309579 AgrOrtholog
BioCyc Gene G2FUF-38291 BioCyc
Ensembl Genes ENSRNOG00000011914 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000060810 ENTREZGENE
  ENSRNOT00000077830 ENTREZGENE
  ENSRNOT00000101006 ENTREZGENE
  ENSRNOT00000114344 ENTREZGENE
  ENSRNOT00000117452 ENTREZGENE
Gene3D-CATH 3.30.60.90 UniProtKB/Swiss-Prot
  EF-hand UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7109493 IMAGE-MGC_LOAD
InterPro Distrobrevin UniProtKB/Swiss-Prot
  EF-hand-dom_pair UniProtKB/Swiss-Prot
  EF-hand_dom_typ1 UniProtKB/Swiss-Prot
  EF-hand_dom_typ2 UniProtKB/Swiss-Prot
  KCMF1/Dystrophin UniProtKB/Swiss-Prot
  Znf_ZZ UniProtKB/Swiss-Prot
  Znf_ZZ_sf UniProtKB/Swiss-Prot
MGC_CLONE MGC:93784 IMAGE-MGC_LOAD
NCBI Gene 362715 ENTREZGENE
PANTHER DYSTROBREVIN BETA UniProtKB/Swiss-Prot
  E3 UBIQUITIN-PROTEIN LIGASE KCMF1 UniProtKB/Swiss-Prot
Pfam EF-hand_2 UniProtKB/Swiss-Prot
  EF-hand_3 UniProtKB/Swiss-Prot
  PF00569 UniProtKB/Swiss-Prot
PhenoGen Dtnb PhenoGen
PIRSF Distrobrevin UniProtKB/Swiss-Prot
PROSITE ZF_ZZ_1 UniProtKB/Swiss-Prot
  ZF_ZZ_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000011914 RatGTEx
SMART ZnF_ZZ UniProtKB/Swiss-Prot
Superfamily-SCOP RING/U-box UniProtKB/Swiss-Prot
  SSF47473 UniProtKB/Swiss-Prot
UniProt A0A0G2JVM6_RAT UniProtKB/TrEMBL
  A0A8I6A4I7_RAT UniProtKB/TrEMBL
  A0A8I6AE63 ENTREZGENE
  A0A8I6AHC0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AK26 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2UMY1 ENTREZGENE, UniProtKB/TrEMBL
  DTNB_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q66HF4 ENTREZGENE
UniProt Secondary Q66HF4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Dtnb  dystrobrevin, beta  Dtnb_predicted  dystrobrevin, beta (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Dtnb_predicted  dystrobrevin, beta (predicted)      Symbol and Name status set to approved 70820 APPROVED