Slc35d3 (solute carrier family 35, member D3) - Rat Genome Database

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Gene: Slc35d3 (solute carrier family 35, member D3) Rattus norvegicus
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Symbol: Slc35d3
Name: solute carrier family 35, member D3
RGD ID: 1309428
Description: Predicted to enable UDP-glucose transmembrane transporter activity; antiporter activity; and protein-macromolecule adaptor activity. Predicted to be involved in UDP-glucose transmembrane transport; platelet dense granule organization; and positive regulation of autophagy. Predicted to act upstream of or within energy homeostasis and positive regulation of protein exit from endoplasmic reticulum. Predicted to be located in early endosome and endoplasmic reticulum. Predicted to be active in Golgi apparatus; early endosome membrane; and synaptic vesicle membrane. Orthologous to human SLC35D3 (solute carrier family 35 member D3); INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC308717; solute carrier family 35 member D3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8116,389,308 - 16,392,780 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl116,389,308 - 16,392,780 (-)EnsemblGRCr8
mRatBN7.2114,565,482 - 14,573,581 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl114,569,687 - 14,573,159 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx114,335,296 - 14,338,768 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0120,337,155 - 20,340,627 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0114,549,836 - 14,553,308 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0115,298,526 - 15,301,998 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl115,298,526 - 15,301,998 (-)Ensemblrn6Rnor6.0
Rnor_5.0116,846,809 - 16,850,281 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4115,086,254 - 15,089,726 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera113,011,985 - 13,015,457 (-)NCBICelera
RGSC_v3.1115,087,204 - 15,089,512 (-)NCBI
Cytogenetic Map1p12NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:24550737  


Genomics

Comparative Map Data
Slc35d3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8116,389,308 - 16,392,780 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl116,389,308 - 16,392,780 (-)EnsemblGRCr8
mRatBN7.2114,565,482 - 14,573,581 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl114,569,687 - 14,573,159 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx114,335,296 - 14,338,768 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0120,337,155 - 20,340,627 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0114,549,836 - 14,553,308 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0115,298,526 - 15,301,998 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl115,298,526 - 15,301,998 (-)Ensemblrn6Rnor6.0
Rnor_5.0116,846,809 - 16,850,281 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4115,086,254 - 15,089,726 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera113,011,985 - 13,015,457 (-)NCBICelera
RGSC_v3.1115,087,204 - 15,089,512 (-)NCBI
Cytogenetic Map1p12NCBI
SLC35D3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386136,922,301 - 136,925,660 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6136,922,301 - 136,925,660 (+)Ensemblhg38GRCh38
GRCh376137,243,439 - 137,246,798 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366137,285,095 - 137,288,470 (+)NCBIBuild 36Build 36hg18NCBI36
Celera6137,983,854 - 137,987,229 (+)NCBICelera
Cytogenetic Map6q23.3NCBI
HuRef6134,808,122 - 134,811,497 (+)NCBIHuRef
CHM1_16137,506,035 - 137,509,410 (+)NCBICHM1_1
T2T-CHM13v2.06138,110,480 - 138,113,839 (+)NCBIT2T-CHM13v2.0
Slc35d3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391019,723,662 - 19,728,195 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1019,723,662 - 19,727,205 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381019,847,917 - 19,856,634 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1019,847,916 - 19,851,459 (-)Ensemblmm10GRCm38
MGSCv371019,567,723 - 19,571,265 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361019,537,333 - 19,540,875 (-)NCBIMGSCv36mm8
Celera1019,734,650 - 19,738,192 (-)NCBICelera
Cytogenetic Map10A3NCBI
cM Map109.12NCBI
Slc35d3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543960,615 - 64,052 (-)Ensembl
ChiLan1.0NW_00495543960,689 - 63,968 (-)NCBIChiLan1.0ChiLan1.0
SLC35D3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25156,889,218 - 156,892,966 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16154,788,330 - 154,791,733 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06134,683,339 - 134,686,731 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16138,771,529 - 138,774,860 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6138,771,529 - 138,774,860 (+)EnsemblpanPan2panpan1.1
SLC35D3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1129,426,003 - 29,429,272 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl129,425,559 - 29,428,270 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha130,308,618 - 30,312,294 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0129,587,167 - 29,590,852 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl129,587,177 - 29,590,388 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1129,472,073 - 29,475,736 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0129,357,253 - 29,360,919 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0129,656,307 - 29,659,976 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Slc35d3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946124,529,177 - 124,534,182 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365604,308,928 - 4,313,347 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365604,309,136 - 4,313,259 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC35D3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl127,246,752 - 27,250,254 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1127,246,742 - 27,250,476 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2130,637,620 - 30,640,261 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SLC35D3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11336,475,017 - 36,478,506 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1336,475,981 - 36,478,292 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660408,662,442 - 8,669,609 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc35d3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624886867,631 - 870,247 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624886867,131 - 870,282 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Slc35d3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12216,751,593 - 216,755,115 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Slc35d3
27 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:147
Count of miRNA genes:99
Interacting mature miRNAs:122
Transcripts:ENSRNOT00000016400
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313090Bmd69Bone mineral density QTL 694.40.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)1529322934184556Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1774611852746118Rat
4889451Eae29Experimental allergic encephalomyelitis QTL 295.51nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1774612152746121Rat
70179Xhs2X-ray hypersensitivity QTL 23.2intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)1143965634Rat
1354647Despr8Despair related QTL 80.0000341locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1126564886Rat
1558642Prcr2Prostate cancer resistance QTL 24.3prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)11037949255379492Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1694102251941022Rat
2313070Bss52Bone structure and strength QTL 524.40.0001body length (VT:0001256)body length (CMO:0000013)1529322934184556Rat
1357401Bw43Body weight QTL 433.75body mass (VT:0001259)body weight (CMO:0000012)1690935351909353Rat
1600360Mcs16Mammary carcinoma susceptibility QTL 162.4mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1126564886Rat
5684998Bss101Bone structure and strength QTL 1013.6tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)1690935351909353Rat
5684999Bss102Bone structure and strength QTL 1025.57e-07tibia strength trait (VT:1000284)tibia stiffness (CMO:0001735)1690935351909353Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11282049457820494Rat
2317755Glom22Glomerulus QTL 223.8urine protein amount (VT:0005160)urine protein level (CMO:0000591)1134184556Rat
1300170Rf6Renal function QTL 63.14renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)1128483164Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)11168446456684464Rat
2313053Bss51Bone structure and strength QTL 513.80.0001tibia length (VT:0004357)tibia length (CMO:0000450)1529322934184556Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
14 1 19 132 54 43 31 30 31 6 137 74 11 106 18 47 12 9 9

Sequence


Ensembl Acc Id: ENSRNOT00000016400   ⟹   ENSRNOP00000016400
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl116,389,308 - 16,392,780 (-)Ensembl
mRatBN7.2 Ensembl114,569,687 - 14,573,159 (-)Ensembl
Rnor_6.0 Ensembl115,298,526 - 15,301,998 (-)Ensembl
RefSeq Acc Id: NM_001107522   ⟹   NP_001100992
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8116,389,308 - 16,392,780 (-)NCBI
mRatBN7.2114,569,687 - 14,573,159 (-)NCBI
Rnor_6.0115,298,526 - 15,301,998 (-)NCBI
Rnor_5.0116,846,809 - 16,850,281 (-)NCBI
RGSC_v3.4115,086,254 - 15,089,726 (-)RGD
Celera113,011,985 - 13,015,457 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001100992 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL93789 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000016400
  ENSRNOP00000016400.4
RefSeq Acc Id: NP_001100992   ⟸   NM_001107522
- UniProtKB: D4A5L7 (UniProtKB/TrEMBL),   A6JPB7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000016400   ⟸   ENSRNOT00000016400

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A5L7-F1-model_v2 AlphaFold D4A5L7 1-420 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309428 AgrOrtholog
BioCyc Gene G2FUF-62217 BioCyc
Ensembl Genes ENSRNOG00000012311 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000016400 ENTREZGENE
  ENSRNOT00000016400.6 UniProtKB/TrEMBL
InterPro TPT_transporter UniProtKB/TrEMBL
KEGG Report rno:308717 UniProtKB/TrEMBL
NCBI Gene 308717 ENTREZGENE
PANTHER SOLUTE CARRIER FAMILY 35 UniProtKB/TrEMBL
PhenoGen Slc35d3 PhenoGen
RatGTEx ENSRNOG00000012311 RatGTEx
UniProt A6JPB7 ENTREZGENE, UniProtKB/TrEMBL
  D4A5L7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Slc35d3  solute carrier family 35, member D3   Slc35d3_predicted  solute carrier family 35, member D3 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Slc35d3_predicted  solute carrier family 35, member D3 (predicted)      Symbol and Name status set to approved 70820 APPROVED