Eif4a2 (eukaryotic translation initiation factor 4A2) - Rat Genome Database

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Gene: Eif4a2 (eukaryotic translation initiation factor 4A2) Rattus norvegicus
Analyze
Symbol: Eif4a2
Name: eukaryotic translation initiation factor 4A2
RGD ID: 1309225
Description: Predicted to enable ATP hydrolysis activity and translation initiation factor activity. Predicted to be involved in cytoplasmic translational initiation. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with hypotonia and speech delay. Orthologous to human EIF4A2 (eukaryotic translation initiation factor 4A2); PARTICIPATES IN translation initiation pathway; RNA transport pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ATP-dependent RNA helicase eIF4A-2; eIF-4A-II; eIF4A-II; eukaryotic initiation factor 4A-II; eukaryotic translation initiation factor 4A; eukaryotic translation initiation factor 4A, isoform 2; LOC303831; MGC94588; protein synthesis initiation factor 4AII
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81191,268,730 - 91,276,738 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1191,268,731 - 91,275,323 (-)EnsemblGRCr8
mRatBN7.21177,764,126 - 77,770,810 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1177,764,124 - 77,770,781 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1186,514,572 - 86,521,165 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01179,152,230 - 79,158,832 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01178,228,872 - 78,235,465 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01181,373,047 - 81,379,680 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1181,373,048 - 81,379,871 (-)Ensemblrn6Rnor6.0
Rnor_5.01184,411,365 - 84,418,036 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41179,950,592 - 79,957,185 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1176,636,608 - 76,643,201 (-)NCBICelera
Cytogenetic Map11q23NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
acetaldehyde  (ISO)
acetamide  (EXP)
aconitine  (EXP)
acrolein  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (EXP)
alpha-pinene  (ISO)
amiodarone  (EXP)
amitrole  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzbromarone  (EXP)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP)
buspirone  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cadmium sulfate  (ISO)
calcitriol  (EXP)
calcium atom  (EXP)
calcium(0)  (EXP)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
chloropicrin  (ISO)
chromium(6+)  (ISO)
clofibrate  (EXP,ISO)
clofibric acid  (EXP)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
corosolic acid  (ISO)
cyclosporin A  (ISO)
DDT  (ISO)
Dibutyl phosphate  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (ISO)
diuron  (EXP)
doxorubicin  (ISO)
ethanol  (ISO)
fenthion  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
hydrogen peroxide  (ISO)
inulin  (ISO)
iron dichloride  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
L-ethionine  (EXP)
lipopolysaccharide  (ISO)
methidathion  (ISO)
methimazole  (EXP)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
niclosamide  (ISO)
Nutlin-3  (ISO)
okadaic acid  (ISO)
omeprazole  (EXP)
ozone  (ISO)
parathion  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
rac-lactic acid  (ISO)
resveratrol  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sulfadimethoxine  (EXP)
T-2 toxin  (EXP)
tamibarotene  (ISO)
temozolomide  (ISO)
tetrahydropalmatine  (ISO)
thapsigargin  (EXP)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
triadimefon  (ISO)
trichloroethene  (EXP)
triptonide  (ISO)
trovafloxacin  (EXP,ISO)
valproic acid  (ISO)
vincristine  (ISO)
vorinostat  (ISO)
zinc sulfate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. The diverse roles of the eIF4A family: you are the company you keep. Lu WT, etal., Biochem Soc Trans. 2014 Feb;42(1):166-72. doi: 10.1042/BST20130161.
4. mRNA helicases: the tacticians of translational control. Parsyan A, etal., Nat Rev Mol Cell Biol. 2011 Apr;12(4):235-45. doi: 10.1038/nrm3083.
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:9092667   PMID:11922617   PMID:12477932   PMID:15489334   PMID:20439489   PMID:22658674   PMID:22681889   PMID:22871113   PMID:26316108   PMID:29476059  


Genomics

Comparative Map Data
Eif4a2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81191,268,730 - 91,276,738 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1191,268,731 - 91,275,323 (-)EnsemblGRCr8
mRatBN7.21177,764,126 - 77,770,810 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1177,764,124 - 77,770,781 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1186,514,572 - 86,521,165 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01179,152,230 - 79,158,832 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01178,228,872 - 78,235,465 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01181,373,047 - 81,379,680 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1181,373,048 - 81,379,871 (-)Ensemblrn6Rnor6.0
Rnor_5.01184,411,365 - 84,418,036 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41179,950,592 - 79,957,185 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1176,636,608 - 76,643,201 (-)NCBICelera
Cytogenetic Map11q23NCBI
EIF4A2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383186,783,577 - 186,789,897 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3186,783,205 - 186,789,901 (+)Ensemblhg38GRCh38
GRCh373186,501,366 - 186,507,686 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363187,984,055 - 187,990,380 (+)NCBIBuild 36Build 36hg18NCBI36
Build 343187,984,086 - 187,990,385NCBI
Celera3184,937,523 - 184,943,848 (+)NCBICelera
Cytogenetic Map3q27.3NCBI
HuRef3183,911,038 - 183,917,363 (+)NCBIHuRef
CHM1_13186,464,938 - 186,471,263 (+)NCBICHM1_1
T2T-CHM13v2.03189,605,607 - 189,611,927 (+)NCBIT2T-CHM13v2.0
Eif4a2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391622,924,846 - 22,932,882 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1622,926,194 - 22,932,886 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381623,107,468 - 23,114,132 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1623,107,444 - 23,114,136 (+)Ensemblmm10GRCm38
MGSCv371623,107,552 - 23,114,205 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361623,023,090 - 23,029,280 (+)NCBIMGSCv36mm8
Celera1623,666,270 - 23,672,738 (+)NCBICelera
Cytogenetic Map16B1NCBI
cM Map1613.93NCBI
Eif4a2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542020,968,484 - 20,974,018 (-)Ensembl
ChiLan1.0NW_00495542020,967,848 - 20,974,093 (-)NCBIChiLan1.0ChiLan1.0
EIF4A2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22184,657,482 - 184,666,544 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13184,662,197 - 184,671,263 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03183,818,449 - 183,824,870 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13192,283,209 - 192,290,644 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3192,284,037 - 192,290,644 (+)EnsemblpanPan2panpan1.1
EIF4A2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13419,354,739 - 19,361,021 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3419,354,825 - 19,409,844 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3423,440,268 - 23,446,507 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03419,266,309 - 19,272,549 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3419,247,862 - 19,272,549 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13419,297,459 - 19,303,698 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03419,297,450 - 19,303,704 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03419,525,335 - 19,531,575 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Eif4a2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602117,127,988 - 117,133,415 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365783,217,765 - 3,225,528 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365783,219,842 - 3,225,261 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EIF4A2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13124,582,898 - 124,589,293 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.113124,582,822 - 124,589,296 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213133,973,198 - 133,979,671 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EIF4A2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11581,075,073 - 81,081,412 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1581,074,834 - 81,079,832 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604154,565,066 - 54,573,327 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Eif4a2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473069,996,219 - 70,005,910 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473069,999,879 - 70,006,008 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Eif4a2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v147,898,082 - 7,904,742 (+)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:388
Count of miRNA genes:229
Interacting mature miRNAs:275
Transcripts:ENSRNOT00000002484
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)114644316891443168Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)117330848796070872Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)115827236396350770Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)115892833699753367Rat
1549848Bvd6Brain ventricular dilatation QTL 63.10.0001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)117961851999753367Rat
10450831Scl80Serum cholesterol level QTL 804.70.01blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)119046178196556255Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)117385089499753367Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)115441539196071021Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)115893182292356038Rat
1354656Bvd3Brain ventricular dilatation QTL 33.640.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)118295102896351019Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)115775483796071021Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112019354996351019Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)116796218499753367Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)116859932196497754Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)116985594399753367Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)117330831599753367Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)115827236396350770Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)115107102196071021Rat

Markers in Region
RH134436  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21177,764,209 - 77,764,390 (+)MAPPERmRatBN7.2
Rnor_6.062,979,116 - 2,979,297NCBIRnor6.0
Rnor_6.01181,373,131 - 81,373,311NCBIRnor6.0
Rnor_5.01184,411,449 - 84,411,629UniSTSRnor5.0
RGSC_v3.41179,950,676 - 79,950,856UniSTSRGSC3.4
Celera1176,636,692 - 76,636,872UniSTS
Celera614,390,529 - 14,390,709UniSTS
Cytogenetic Map6q11UniSTS
Cytogenetic Map11q23UniSTS
PMC139890P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21177,766,651 - 77,766,783 (+)MAPPERmRatBN7.2
Rnor_6.01181,375,573 - 81,375,704NCBIRnor6.0
Rnor_5.01184,413,891 - 84,414,022UniSTSRnor5.0
RGSC_v3.41179,953,118 - 79,953,249UniSTSRGSC3.4
Celera1176,639,134 - 76,639,265UniSTS
Cytogenetic Map11q23UniSTS
Eif4a2  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81191,271,131 - 91,271,556 (+)Marker Load Pipeline
mRatBN7.21177,766,527 - 77,766,952 (+)MAPPERmRatBN7.2
Rnor_6.01181,375,449 - 81,375,873NCBIRnor6.0
Rnor_5.01184,413,767 - 84,414,191UniSTSRnor5.0
RGSC_v3.41179,952,994 - 79,953,418UniSTSRGSC3.4
Celera1176,639,010 - 76,639,434UniSTS
Cytogenetic Map11q23UniSTS
D20S1005  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21177,764,527 - 77,764,607 (+)MAPPERmRatBN7.2
Rnor_6.01181,373,449 - 81,373,528NCBIRnor6.0
Rnor_5.01184,411,767 - 84,411,846UniSTSRnor5.0
RGSC_v3.41179,950,994 - 79,951,073UniSTSRGSC3.4
Celera1176,637,010 - 76,637,089UniSTS
Cytogenetic Map11q23UniSTS
UniSTS:237474  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21177,768,984 - 77,769,210 (+)MAPPERmRatBN7.2
Rnor_6.01181,377,906 - 81,378,131NCBIRnor6.0
Rnor_5.01184,416,224 - 84,416,449UniSTSRnor5.0
RGSC_v3.41179,955,451 - 79,955,676UniSTSRGSC3.4
Celera1176,641,467 - 76,641,692UniSTS
Cytogenetic Map11q23UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001008335 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006248534 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006248535 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063270484 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063270485 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063270486 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063270488 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063270489 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005491022 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010055952 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_358387 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_358388 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC120949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC085859 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473999 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215479 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220942 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231114 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U64705 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000002484   ⟹   ENSRNOP00000002484
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1191,268,731 - 91,275,323 (-)Ensembl
mRatBN7.2 Ensembl1177,764,124 - 77,769,709 (-)Ensembl
Rnor_6.0 Ensembl1181,373,048 - 81,379,640 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000089294   ⟹   ENSRNOP00000074545
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1191,270,216 - 91,275,323 (-)Ensembl
mRatBN7.2 Ensembl1177,764,376 - 77,770,730 (-)Ensembl
Rnor_6.0 Ensembl1181,374,435 - 81,379,871 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000104777   ⟹   ENSRNOP00000096633
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1191,268,731 - 91,274,738 (-)Ensembl
mRatBN7.2 Ensembl1177,764,250 - 77,770,781 (-)Ensembl
RefSeq Acc Id: NM_001008335   ⟹   NP_001008336
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81191,268,730 - 91,275,323 (-)NCBI
mRatBN7.21177,764,126 - 77,770,719 (-)NCBI
Rnor_6.01181,373,047 - 81,379,640 (-)NCBI
Rnor_5.01184,411,365 - 84,418,036 (-)NCBI
RGSC_v3.41179,950,592 - 79,957,185 (-)RGD
Celera1176,636,608 - 76,643,201 (-)RGD
Sequence:
RefSeq Acc Id: XM_006248534   ⟹   XP_006248596
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81191,268,730 - 91,275,722 (-)NCBI
mRatBN7.21177,764,126 - 77,770,809 (-)NCBI
Rnor_6.01181,373,047 - 81,379,680 (-)NCBI
Rnor_5.01184,411,365 - 84,418,036 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006248535   ⟹   XP_006248597
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81191,268,730 - 91,275,419 (-)NCBI
mRatBN7.21177,765,608 - 77,770,809 (-)NCBI
Rnor_6.01181,374,529 - 81,379,680 (-)NCBI
Rnor_5.01184,411,365 - 84,418,036 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063270484   ⟹   XP_063126554
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81191,268,730 - 91,276,731 (-)NCBI
RefSeq Acc Id: XM_063270485   ⟹   XP_063126555
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81191,268,730 - 91,276,708 (-)NCBI
RefSeq Acc Id: XM_063270486   ⟹   XP_063126556
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81191,268,730 - 91,275,683 (-)NCBI
RefSeq Acc Id: XM_063270488   ⟹   XP_063126558
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81191,268,730 - 91,276,713 (-)NCBI
RefSeq Acc Id: XM_063270489   ⟹   XP_063126559
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81191,268,730 - 91,274,385 (-)NCBI
RefSeq Acc Id: XR_005491022
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81191,269,449 - 91,275,683 (-)NCBI
mRatBN7.21177,764,126 - 77,770,810 (-)NCBI
RefSeq Acc Id: XR_010055952
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81191,269,449 - 91,276,738 (-)NCBI
RefSeq Acc Id: XR_358387
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81191,269,402 - 91,275,419 (-)NCBI
mRatBN7.21177,764,126 - 77,770,809 (-)NCBI
Rnor_6.01181,373,047 - 81,379,680 (-)NCBI
Rnor_5.01184,411,365 - 84,418,036 (-)NCBI
Sequence:
RefSeq Acc Id: XR_358388
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81191,269,479 - 91,275,419 (-)NCBI
mRatBN7.21177,764,126 - 77,770,809 (-)NCBI
Rnor_6.01181,373,772 - 81,379,680 (-)NCBI
Rnor_5.01184,411,365 - 84,418,036 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001008336   ⟸   NM_001008335
- UniProtKB: Q5RKI1 (UniProtKB/Swiss-Prot),   A6JS30 (UniProtKB/TrEMBL),   A6HFS9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006248596   ⟸   XM_006248534
- Peptide Label: isoform X1
- UniProtKB: A6HFS9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006248597   ⟸   XM_006248535
- Peptide Label: isoform X3
- UniProtKB: A6HFS9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000074545   ⟸   ENSRNOT00000089294
Ensembl Acc Id: ENSRNOP00000002484   ⟸   ENSRNOT00000002484
Ensembl Acc Id: ENSRNOP00000096633   ⟸   ENSRNOT00000104777
RefSeq Acc Id: XP_063126554   ⟸   XM_063270484
- Peptide Label: isoform X1
- UniProtKB: A6HFS9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063126558   ⟸   XM_063270488
- Peptide Label: isoform X4
- UniProtKB: A6HFS9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063126555   ⟸   XM_063270485
- Peptide Label: isoform X2
- UniProtKB: Q5RKI1 (UniProtKB/Swiss-Prot),   A6HFS9 (UniProtKB/TrEMBL),   A6JS30 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063126556   ⟸   XM_063270486
- Peptide Label: isoform X4
- UniProtKB: A6HFS9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063126559   ⟸   XM_063270489
- Peptide Label: isoform X5
- UniProtKB: A0A8L2PZP8 (UniProtKB/TrEMBL)
Protein Domains
DEAD-box RNA helicase Q   Helicase ATP-binding   Helicase C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5RKI1-F1-model_v2 AlphaFold Q5RKI1 1-407 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698246
Promoter ID:EPDNEW_R8771
Type:single initiation site
Name:Eif4a2_1
Description:eukaryotic translation initiation factor 4A2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01181,379,653 - 81,379,713EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309225 AgrOrtholog
BioCyc Gene G2FUF-20856 BioCyc
Ensembl Genes ENSRNOG00000001815 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000002484 ENTREZGENE
  ENSRNOT00000089294 ENTREZGENE
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7190333 IMAGE-MGC_LOAD
InterPro DEAD/DEAH_box_helicase_dom UniProtKB/Swiss-Prot
  EIF4A_DEADc UniProtKB/Swiss-Prot
  Helicase_ATP-bd UniProtKB/Swiss-Prot
  Helicase_C UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
  RNA-helicase_DEAD-box_CS UniProtKB/Swiss-Prot
  RNA_helicase_DEAD_Q_motif UniProtKB/Swiss-Prot
KEGG Report rno:303831 UniProtKB/Swiss-Prot
MGC_CLONE MGC:94588 IMAGE-MGC_LOAD
NCBI Gene 303831 ENTREZGENE
PANTHER ATP-DEPENDENT RNA HELICASE DBP3 UniProtKB/Swiss-Prot
Pfam DEAD UniProtKB/Swiss-Prot
  Helicase_C UniProtKB/Swiss-Prot
PhenoGen Eif4a2 PhenoGen
PROSITE DEAD_ATP_HELICASE UniProtKB/Swiss-Prot
  HELICASE_ATP_BIND_1 UniProtKB/Swiss-Prot
  HELICASE_CTER UniProtKB/Swiss-Prot
  Q_MOTIF UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000001815 RatGTEx
SMART DEXDc UniProtKB/Swiss-Prot
  HELICc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
UniProt A0A0G2K8B7_RAT UniProtKB/TrEMBL
  A0A8I6AR25_RAT UniProtKB/TrEMBL
  A0A8L2PZP8 ENTREZGENE, UniProtKB/TrEMBL
  A6HFS9 ENTREZGENE, UniProtKB/TrEMBL
  A6JS30 ENTREZGENE, UniProtKB/TrEMBL
  A6JS31_RAT UniProtKB/TrEMBL
  A6JS33_RAT UniProtKB/TrEMBL
  IF4A2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-02 Eif4a2  eukaryotic translation initiation factor 4A2  Eif4a2  eukaryotic translation initiation factor 4A, isoform 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Eif4a2  eukaryotic translation initiation factor 4A2  Eif4a2_predicted  eukaryotic translation initiation factor 4A2 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Eif4a2_predicted  eukaryotic translation initiation factor 4A2 (predicted)      Symbol and Name status set to approved 70820 APPROVED