Ripk2 (receptor-interacting serine-threonine kinase 2) - Rat Genome Database

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Gene: Ripk2 (receptor-interacting serine-threonine kinase 2) Rattus norvegicus
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Symbol: Ripk2
Name: receptor-interacting serine-threonine kinase 2
RGD ID: 1309167
Description: Predicted to enable several functions, including JUN kinase kinase kinase activity; caspase binding activity; and protein domain specific binding activity. Predicted to be involved in several processes, including MAPK cascade; cellular response to muramyl dipeptide; and positive regulation of macromolecule metabolic process. Predicted to act upstream of or within several processes, including positive regulation of cytokine production; positive regulation of immune response; and response to bacterium. Predicted to be located in cytoskeleton and vesicle. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human RIPK2 (receptor interacting serine/threonine kinase 2); PARTICIPATES IN interleukin-12 signaling pathway; nuclear factor kappa B signaling pathway; neurotrophic factor signaling pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 2,3,7,8-tetrachlorodibenzodioxine; aconitine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC362491; receptor (TNFRSF)-interacting serine-threonine kinase 2; receptor-interacting serine/threonine-protein kinase 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8534,428,573 - 34,459,808 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl534,428,573 - 34,459,663 (-)EnsemblGRCr8
mRatBN7.2529,630,806 - 29,662,804 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl529,631,570 - 29,662,657 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx531,792,628 - 31,823,715 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0533,385,294 - 33,416,381 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0533,345,474 - 33,376,561 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0529,838,713 - 29,870,390 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl529,838,747 - 29,870,735 (-)Ensemblrn6Rnor6.0
Rnor_5.0534,512,111 - 34,543,807 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4530,714,817 - 30,745,941 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera528,836,598 - 28,867,674 (-)NCBICelera
RGSC_v3.1530,715,463 - 30,738,284 (-)NCBI
Cytogenetic Map5q13NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-methylcholine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6alpha-methylprednisolone  (ISO)
aconitine  (EXP,ISO)
all-trans-retinoic acid  (ISO)
aristolochic acid A  (ISO)
azathioprine  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
cadmium dichloride  (EXP)
caffeine  (ISO)
calcitriol  (ISO)
capsaicin  (ISO)
chlorpyrifos  (ISO)
cholesterol  (EXP)
chromium(6+)  (ISO)
cisplatin  (ISO)
cobalt atom  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
corn oil  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
DDE  (EXP)
deoxynivalenol  (ISO)
Dibutyl phosphate  (ISO)
dicrotophos  (ISO)
dieldrin  (EXP)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
etoposide  (ISO)
fipronil  (EXP)
fluoranthene  (ISO)
flutamide  (EXP)
folic acid  (ISO)
FR900359  (ISO)
furan  (EXP)
gentamycin  (EXP)
GSK-J4  (ISO)
lamivudine  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
metam  (ISO)
metformin  (ISO)
methotrexate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
Mitotane  (EXP)
N-acetyl-L-cysteine  (EXP)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP)
paraquat  (ISO)
perfluorononanoic acid  (ISO)
PF-3758309  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (ISO)
phenylarsine oxide  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
prednisolone  (ISO)
propylparaben  (ISO)
pyrethrins  (ISO)
quercetin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium aurothiomalate  (ISO)
Soman  (EXP)
sulfasalazine  (ISO)
tert-butyl hydroperoxide  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (EXP)
triptonide  (ISO)
troglitazone  (ISO)
Tungsten carbide  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
usnic acid  (ISO)
valproic acid  (ISO)
vincristine  (ISO)
VX nerve agent  (ISO)
zidovudine  (ISO)
zinc oxide  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adaptive immune response  (IEA,ISO)
apoptotic process  (IEA,ISO)
canonical NF-kappaB signal transduction  (IEA,ISO)
cell surface toll-like receptor signaling pathway  (IEA)
cellular response to lipopolysaccharide  (ISO)
cellular response to lipoteichoic acid  (ISO)
cellular response to muramyl dipeptide  (IEA,ISO)
cellular response to peptidoglycan  (ISO)
defense response to bacterium  (IEA,ISO)
defense response to Gram-positive bacterium  (ISO)
immune system process  (IEA)
innate immune response  (IBA,IEA,ISO)
lipopolysaccharide-mediated signaling pathway  (ISO)
MAPK cascade  (IEA)
nucleotide-binding oligomerization domain containing 1 signaling pathway  (IEA,ISO)
nucleotide-binding oligomerization domain containing 2 signaling pathway  (IEA,ISO)
obsolete positive regulation of NF-kappaB transcription factor activity  (ISO)
positive regulation of alpha-beta T cell proliferation  (ISO)
positive regulation of apoptotic process  (IEA,ISO)
positive regulation of canonical NF-kappaB signal transduction  (IBA,IEA,ISO)
positive regulation of chemokine production  (ISO)
positive regulation of cytokine production  (IEA)
positive regulation of cytokine-mediated signaling pathway  (ISO)
positive regulation of defense response  (IEA)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of immature T cell proliferation  (ISO)
positive regulation of interleukin-1 beta production  (IEA,ISO)
positive regulation of interleukin-2 production  (ISO)
positive regulation of interleukin-6 production  (IEA,ISO)
positive regulation of intracellular signal transduction  (IEA)
positive regulation of JNK cascade  (ISO)
positive regulation of metabolic process  (IEA)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of protein K63-linked ubiquitination  (IEA,ISO)
positive regulation of protein ubiquitination  (IEA,ISO)
positive regulation of stress-activated MAPK cascade  (ISO)
positive regulation of T-helper 1 cell differentiation  (ISO)
positive regulation of T-helper 1 type immune response  (ISO)
positive regulation of tumor necrosis factor production  (IEA,ISO)
positive regulation of type II interferon production  (ISO)
positive regulation of xenophagy  (ISO)
protein homooligomerization  (IEA,ISO)
regulation of apoptotic process  (IEA)
regulation of primary metabolic process  (IEA)
response to exogenous dsRNA  (ISO)
response to interleukin-1  (ISO)
response to interleukin-12  (ISO)
response to interleukin-18  (ISO)
signal transduction  (IBA)
T cell proliferation  (ISO)
T cell receptor signaling pathway  (ISO)
toll-like receptor 2 signaling pathway  (ISO)
toll-like receptor 4 signaling pathway  (ISO)

Cellular Component
cytoplasm  (IBA,IEA,ISO)
cytoskeleton  (IEA,ISO)
cytosol  (IEA,ISO)
endoplasmic reticulum  (IEA)
plasma membrane  (IEA,ISO)
protein-containing complex  (IEA,ISO)
vesicle  (IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10329646   PMID:11087742   PMID:11432859   PMID:11536016   PMID:11821383   PMID:11894097   PMID:11894098   PMID:12477932   PMID:14638696   PMID:14663141   PMID:14743216   PMID:15190255  
PMID:15383541   PMID:15620648   PMID:15657077   PMID:16920334   PMID:18261938   PMID:19337385   PMID:21469090   PMID:21887730   PMID:21931591   PMID:22033934   PMID:23806334   PMID:24790089  
PMID:25416956   PMID:26138652   PMID:27169686   PMID:30352081   PMID:37128885   PMID:38064597  


Genomics

Comparative Map Data
Ripk2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8534,428,573 - 34,459,808 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl534,428,573 - 34,459,663 (-)EnsemblGRCr8
mRatBN7.2529,630,806 - 29,662,804 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl529,631,570 - 29,662,657 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx531,792,628 - 31,823,715 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0533,385,294 - 33,416,381 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0533,345,474 - 33,376,561 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0529,838,713 - 29,870,390 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl529,838,747 - 29,870,735 (-)Ensemblrn6Rnor6.0
Rnor_5.0534,512,111 - 34,543,807 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4530,714,817 - 30,745,941 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera528,836,598 - 28,867,674 (-)NCBICelera
RGSC_v3.1530,715,463 - 30,738,284 (-)NCBI
Cytogenetic Map5q13NCBI
RIPK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38889,757,816 - 89,791,064 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl889,757,783 - 89,791,064 (+)Ensemblhg38GRCh38
GRCh37890,770,044 - 90,803,292 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36890,839,110 - 90,872,433 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34890,839,172 - 90,872,432NCBI
Celera886,964,831 - 86,998,139 (+)NCBICelera
Cytogenetic Map8q21.3NCBI
HuRef885,980,380 - 86,013,697 (+)NCBIHuRef
CHM1_1890,811,006 - 90,844,310 (+)NCBICHM1_1
T2T-CHM13v2.0890,880,976 - 90,914,226 (+)NCBIT2T-CHM13v2.0
Ripk2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39416,122,740 - 16,163,674 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl416,122,733 - 16,163,647 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38416,122,732 - 16,163,678 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl416,122,733 - 16,163,647 (-)Ensemblmm10GRCm38
MGSCv37416,050,522 - 16,090,645 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36416,050,522 - 16,090,647 (-)NCBIMGSCv36mm8
Celera415,919,468 - 15,959,561 (-)NCBICelera
Cytogenetic Map4A2NCBI
cM Map46.7NCBI
Ripk2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554176,669,675 - 6,702,228 (+)Ensembl
ChiLan1.0NW_0049554176,669,675 - 6,698,142 (+)NCBIChiLan1.0ChiLan1.0
RIPK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27107,156,375 - 107,189,911 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1882,693,378 - 82,735,495 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0886,447,216 - 86,480,511 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1888,397,768 - 88,431,690 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl888,398,468 - 88,456,268 (+)EnsemblpanPan2panpan1.1
RIPK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12935,283,209 - 35,311,608 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2935,282,072 - 35,311,333 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2935,435,813 - 35,464,812 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02935,480,726 - 35,509,728 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2935,479,776 - 35,509,034 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12935,472,061 - 35,501,046 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02935,492,803 - 35,521,758 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02935,926,135 - 35,955,236 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ripk2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530344,137,166 - 44,185,801 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365443,606,879 - 3,655,532 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365443,606,925 - 3,653,248 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RIPK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl447,027,098 - 47,074,704 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1447,026,558 - 47,075,133 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2451,491,234 - 51,539,306 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RIPK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1884,843,391 - 84,881,087 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl884,843,471 - 84,881,303 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603955,998,663 - 56,036,344 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ripk2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247442,201,319 - 2,226,890 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247442,194,339 - 2,227,498 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Ripk2
163 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:127
Count of miRNA genes:97
Interacting mature miRNAs:117
Transcripts:ENSRNOT00000012963
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2293666Bmd38Bone mineral density QTL 384.4femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)51373115343590997Rat
1578776Stresp18Stress response QTL 182.9thymus mass (VT:0004954)thymus wet weight (CMO:0000855)53275164977751649Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)5692228281330203Rat
6903306Scl35Serum cholesterol QTL 352.60.0073blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53331167378311673Rat
1358353Srcrtb2Stress Responsive Cort Basal QTL 23.480.003blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)52367149379046465Rat
1300117Hrtrt8Heart rate QTL 83.49heart pumping trait (VT:2000009)heart rate (CMO:0000002)5862723052665523Rat
7394712Emca13Estrogen-induced mammary cancer QTL 13mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)51460607859606078Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)51757663362576633Rat
1578774Tcas8Tongue tumor susceptibility QTL 83.47tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)51570745160707451Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)51001906491770353Rat
2312562Pur18Proteinuria QTL 182.60.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)5692228237468560Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5706553574335773Rat
6903292Stl28Serum triglyceride level QTL 282.60.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)53331167378311673Rat
1641903Alcrsp3Alcohol response QTL 3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)51748608062486080Rat
1578767Stresp17Stress response QTL 174.30.01blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)53275164977751649Rat
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)51001906487027358Rat
8552954Pigfal14Plasma insulin-like growth factor 1 level QTL 149blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)52602321171023211Rat
2303577Gluco47Glucose level QTL 473blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51652001961520019Rat
1549901Neudeg2Neurodegradation QTL 240nervous system integrity trait (VT:0010566)mononuclear cell count (CMO:0002119)53113042148841739Rat
1641922Alcrsp8Alcohol response QTL 8alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)51748608062486080Rat
2313085Bss59Bone structure and strength QTL 592.90.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)5862723053627230Rat
1600358Mamtr5Mammary tumor resistance QTL 5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)52367149368671493Rat

Markers in Region
RH144493  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2529,631,649 - 29,631,831 (+)MAPPERmRatBN7.2
Rnor_6.0529,839,557 - 29,839,738NCBIRnor6.0
Rnor_5.0534,512,955 - 34,513,136UniSTSRnor5.0
RGSC_v3.4530,714,897 - 30,715,078UniSTSRGSC3.4
Celera528,836,678 - 28,836,859UniSTS
RH 3.4 Map5161.12UniSTS
Cytogenetic Map5q13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000012963   ⟹   ENSRNOP00000012963
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl534,428,573 - 34,459,663 (-)Ensembl
mRatBN7.2 Ensembl529,631,570 - 29,662,657 (-)Ensembl
Rnor_6.0 Ensembl529,838,747 - 29,870,735 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000132116   ⟹   ENSRNOP00000101162
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl534,428,573 - 34,459,663 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000137247   ⟹   ENSRNOP00000102452
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl534,428,573 - 34,459,663 (-)Ensembl
RefSeq Acc Id: NM_001191865   ⟹   NP_001178794
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8534,428,573 - 34,459,663 (-)NCBI
mRatBN7.2529,631,570 - 29,662,657 (-)NCBI
Rnor_6.0529,839,477 - 29,870,390 (-)NCBI
Rnor_5.0534,512,111 - 34,543,807 (-)NCBI
Celera528,836,598 - 28,867,674 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017593470   ⟹   XP_017448959
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8534,428,573 - 34,459,345 (-)NCBI
mRatBN7.2529,630,806 - 29,662,339 (-)NCBI
Rnor_6.0529,838,713 - 29,870,077 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039110221   ⟹   XP_038966149
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8534,428,573 - 34,454,592 (-)NCBI
mRatBN7.2529,630,806 - 29,657,581 (-)NCBI
RefSeq Acc Id: XR_005504472
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8534,432,659 - 34,459,808 (-)NCBI
mRatBN7.2529,635,658 - 29,662,804 (-)NCBI
RefSeq Acc Id: XR_005504473
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8534,432,585 - 34,459,808 (-)NCBI
mRatBN7.2529,635,582 - 29,662,803 (-)NCBI
RefSeq Acc Id: NP_001178794   ⟸   NM_001191865
- UniProtKB: G3V783 (UniProtKB/TrEMBL),   A6IIB5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017448959   ⟸   XM_017593470
- Peptide Label: isoform X1
- UniProtKB: Q3B7U0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000012963   ⟸   ENSRNOT00000012963
RefSeq Acc Id: XP_038966149   ⟸   XM_039110221
- Peptide Label: isoform X2
- UniProtKB: Q3B7U0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000101162   ⟸   ENSRNOT00000132116
Ensembl Acc Id: ENSRNOP00000102452   ⟸   ENSRNOT00000137247
Protein Domains
CARD   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V783-F1-model_v2 AlphaFold G3V783 1-539 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693582
Promoter ID:EPDNEW_R4107
Type:initiation region
Name:Ripk2_1
Description:receptor-interacting serine-threonine kinase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0529,870,383 - 29,870,443EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309167 AgrOrtholog
BioCyc Gene G2FUF-41857 BioCyc
Ensembl Genes ENSRNOG00000009389 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000012963 ENTREZGENE
  ENSRNOT00000012963.7 UniProtKB/TrEMBL
  ENSRNOT00000132116.1 UniProtKB/TrEMBL
  ENSRNOT00000137247.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.533.10 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7458993 IMAGE-MGC_LOAD
InterPro CARD UniProtKB/TrEMBL
  CARD_RIP2 UniProtKB/TrEMBL
  DEATH-like UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Rcpt-int_Ser/Thr_kinase-2 UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
  Ser/Thr_Kinases-Pseudokinases UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/TrEMBL
KEGG Report rno:362491 UniProtKB/TrEMBL
MGC_CLONE MGC:125253 IMAGE-MGC_LOAD
NCBI Gene 362491 ENTREZGENE
PANTHER RECEPTOR-INTERACTING SERINE_THREONINE-PROTEIN KINASE 2 UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED UniProtKB/TrEMBL
Pfam CARD UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/TrEMBL
PhenoGen Ripk2 PhenoGen
PIRSF STPK_RIP2 UniProtKB/TrEMBL
PROSITE CARD UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
RatGTEx ENSRNOG00000009389 RatGTEx
SMART S_TKc UniProtKB/TrEMBL
  TyrKc UniProtKB/TrEMBL
Superfamily-SCOP DEATH_like UniProtKB/TrEMBL
  Kinase_like UniProtKB/TrEMBL
UniProt A0ABK0L1Q4_RAT UniProtKB/TrEMBL
  A0ABK0L8S4_RAT UniProtKB/TrEMBL
  A6IIB5 ENTREZGENE, UniProtKB/TrEMBL
  G3V783 ENTREZGENE, UniProtKB/TrEMBL
  Q3B7U0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-09 Ripk2  receptor-interacting serine-threonine kinase 2  Ripk2  receptor (TNFRSF)-interacting serine-threonine kinase 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Ripk2  receptor (TNFRSF)-interacting serine-threonine kinase 2  Ripk2_predicted  receptor (TNFRSF)-interacting serine-threonine kinase 2 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Ripk2_predicted  receptor (TNFRSF)-interacting serine-threonine kinase 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED