Fbxo48 (F-box protein 48) - Rat Genome Database

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Gene: Fbxo48 (F-box protein 48) Rattus norvegicus
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Symbol: Fbxo48
Name: F-box protein 48
RGD ID: 1309073
Description: Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human FBXO48 (F-box protein 48); INTERACTS WITH acetamide; bisphenol A; flutamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: F-box only protein 48; LOC364205; RGD1309073; similar to RIKEN cDNA A630050E13 gene
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81495,582,493 - 95,583,950 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1495,581,279 - 95,587,616 (+)EnsemblGRCr8
mRatBN7.21491,380,857 - 91,382,314 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1491,380,857 - 91,382,314 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1495,694,828 - 95,696,285 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01496,939,153 - 96,940,610 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01493,404,222 - 93,405,679 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.014100,129,835 - 100,140,400 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl14100,135,271 - 100,136,728 (+)Ensemblrn6Rnor6.0
Rnor_5.014100,397,383 - 100,412,297 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41497,825,562 - 97,827,019 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1490,429,587 - 90,431,044 (+)NCBICelera
RGSC_v3.11497,844,792 - 97,854,902 (+)NCBI
Cytogenetic Map14q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Fbxo48
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81495,582,493 - 95,583,950 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1495,581,279 - 95,587,616 (+)EnsemblGRCr8
mRatBN7.21491,380,857 - 91,382,314 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1491,380,857 - 91,382,314 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1495,694,828 - 95,696,285 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01496,939,153 - 96,940,610 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01493,404,222 - 93,405,679 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.014100,129,835 - 100,140,400 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl14100,135,271 - 100,136,728 (+)Ensemblrn6Rnor6.0
Rnor_5.014100,397,383 - 100,412,297 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41497,825,562 - 97,827,019 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1490,429,587 - 90,431,044 (+)NCBICelera
RGSC_v3.11497,844,792 - 97,854,902 (+)NCBI
Cytogenetic Map14q22NCBI
FBXO48
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38268,459,422 - 68,467,294 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl268,459,422 - 68,467,317 (-)Ensemblhg38GRCh38
GRCh37268,686,554 - 68,694,426 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36268,543,002 - 68,547,894 (-)NCBIBuild 36Build 36hg18NCBI36
Celera268,539,478 - 68,544,370 (-)NCBICelera
Cytogenetic Map2p13.3NCBI
HuRef268,426,348 - 68,431,240 (-)NCBIHuRef
CHM1_1268,618,820 - 68,623,712 (-)NCBICHM1_1
T2T-CHM13v2.0268,471,784 - 68,479,683 (-)NCBIT2T-CHM13v2.0
Fbxo48
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391116,901,225 - 16,908,516 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1116,901,375 - 16,904,772 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381116,951,224 - 16,954,777 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1116,951,375 - 16,954,772 (+)Ensemblmm10GRCm38
MGSCv371116,851,413 - 16,854,775 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361116,851,413 - 16,854,775 (+)NCBIMGSCv36mm8
Celera1117,325,170 - 17,328,533 (+)NCBICelera
Cytogenetic Map11A2NCBI
cM Map119.41NCBI
Fbxo48
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542416,451,521 - 16,455,415 (+)Ensembl
ChiLan1.0NW_00495542416,449,166 - 16,455,034 (+)NCBIChiLan1.0ChiLan1.0
FBXO48
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21257,947,630 - 57,955,220 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A57,951,578 - 57,959,168 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A68,504,304 - 68,509,113 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A69,627,257 - 69,632,218 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A69,627,187 - 69,632,218 (-)EnsemblpanPan2panpan1.1
FBXO48
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11067,449,168 - 67,453,540 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1067,450,934 - 67,451,855 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1067,339,076 - 67,344,119 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01068,468,500 - 68,473,590 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1068,470,273 - 68,471,194 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11068,151,424 - 68,156,440 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01068,449,759 - 68,454,838 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01068,745,092 - 68,750,201 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Fbxo48
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629215,713,590 - 15,720,120 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649112,851,539 - 12,857,692 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493649112,854,829 - 12,857,682 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FBXO48
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl373,831,336 - 73,838,553 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1373,831,299 - 73,838,552 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2377,362,273 - 77,363,255 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FBXO48
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11438,636,899 - 38,640,875 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1438,638,522 - 38,640,190 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604573,335,611 - 73,339,879 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fbxo48
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247624,848,676 - 4,850,962 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247624,847,757 - 4,850,962 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Fbxo48
11 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:343
Count of miRNA genes:204
Interacting mature miRNAs:232
Transcripts:ENSRNOT00000032965
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631213Bw60Body weight QTL604.51retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)1484164970100078267Rat
1582236Gluco22Glucose level QTL 223.30.0164blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147764007196755654Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1459848686104848686Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1477914838104348525Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1433424686102238540Rat
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1474255551109089856Rat
1582197Gluco27Glucose level QTL 273.40.0006blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)147764007196755654Rat
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1462398852107398852Rat
1582250Gluco26Glucose level QTL 263.30.0009blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1477640071100078267Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1460854936105854936Rat
1641900Alcrsp11Alcohol response QTL 11alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)1474255551109089856Rat
4889951Bss92Bone structure and strength QTL 923.9tibia area (VT:1000281)tibia-fibula cortical bone total cross-sectional area (CMO:0001721)1486271332100078267Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1411334716100078267Rat
1582255Gluco29Glucose level QTL 293.10.0025blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)147764007196755654Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1459848686104848686Rat
1582209Gluco20Glucose level QTL 203.80.0005blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147764007196755654Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)144261625899224555Rat
1549834Scl45Serum cholesterol level QTL 455.8blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)146592028399224555Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 9 59 163 89 88 57 67 57 6 305 157 11 142 68 85 31 15 15

Sequence


Ensembl Acc Id: ENSRNOT00000032965   ⟹   ENSRNOP00000034586
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1491,380,857 - 91,382,314 (+)Ensembl
Rnor_6.0 Ensembl14100,135,271 - 100,136,728 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000163475   ⟹   ENSRNOP00000111898
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1495,581,279 - 95,587,616 (+)Ensembl
RefSeq Acc Id: NM_001108863   ⟹   NP_001102333
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81495,582,493 - 95,583,950 (+)NCBI
mRatBN7.21491,380,857 - 91,382,314 (+)NCBI
Rnor_6.014100,135,271 - 100,136,728 (+)NCBI
Rnor_5.014100,397,383 - 100,412,297 (-)NCBI
RGSC_v3.41497,825,562 - 97,827,019 (+)RGD
Celera1490,429,587 - 90,431,044 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001102333 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL97899 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000111898
  ENSRNOP00000111898.1
RefSeq Acc Id: NP_001102333   ⟸   NM_001108863
- UniProtKB: D3ZKN5 (UniProtKB/TrEMBL),   A6JPY2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000034586   ⟸   ENSRNOT00000032965
Ensembl Acc Id: ENSRNOP00000111898   ⟸   ENSRNOT00000163475
Protein Domains
F-box

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZKN5-F1-model_v2 AlphaFold D3ZKN5 1-160 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309073 AgrOrtholog
BioCyc Gene G2FUF-14940 BioCyc
Ensembl Genes ENSRNOG00000023026 Ensembl
  ENSRNOG00000075916 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000163475 ENTREZGENE
  ENSRNOT00000163475.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1280.50 UniProtKB/TrEMBL
InterPro F-box_dom_cyclin-like UniProtKB/TrEMBL
  F-box_dom_like UniProtKB/TrEMBL
KEGG Report rno:364205 UniProtKB/TrEMBL
NCBI Gene 364205 ENTREZGENE
PANTHER F-BOX ONLY PROTEIN 48 UniProtKB/TrEMBL
  PTHR12874 UniProtKB/TrEMBL
Pfam F-box-like UniProtKB/TrEMBL
PhenoGen Fbxo48 PhenoGen
PROSITE FBOX UniProtKB/TrEMBL
RatGTEx ENSRNOG00000023026 RatGTEx
  ENSRNOG00000075916 RatGTEx
SMART FBOX UniProtKB/TrEMBL
Superfamily-SCOP F-box_dom_Skp2-like UniProtKB/TrEMBL
UniProt A0ABK0M155_RAT UniProtKB/TrEMBL
  A6JPY2 ENTREZGENE, UniProtKB/TrEMBL
  D3ZKN5 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-05-27 Fbxo48  F-box protein 48  RGD1309073  similar to RIKEN cDNA A630050E13 gene   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1309073  similar to RIKEN cDNA A630050E13 gene   RGD1309073_predicted  similar to RIKEN cDNA A630050E13 gene (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-20 RGD1309073_predicted  similar to RIKEN cDNA A630050E13 gene (predicted)  LOC364205_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC364205_predicted  similar to RIKEN cDNA A630050E13 gene (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL