Fyco1 (FYVE and coiled-coil domain autophagy adaptor 1) - Rat Genome Database

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Pathways
Gene: Fyco1 (FYVE and coiled-coil domain autophagy adaptor 1) Rattus norvegicus
Analyze
Symbol: Fyco1
Name: FYVE and coiled-coil domain autophagy adaptor 1
RGD ID: 1309069
Description: Predicted to enable zinc ion binding activity. Predicted to be involved in plus-end-directed vesicle transport along microtubule and positive regulation of autophagosome maturation. Predicted to be located in Golgi apparatus and endosome. Predicted to be active in autophagosome; late endosome; and lysosome. Human ortholog(s) of this gene implicated in cataract 18. Orthologous to human FYCO1 (FYVE and coiled-coil domain autophagy adaptor 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acrylamide; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: FYVE and coiled-coil domain containing 1; FYVE and coiled-coil domain-containing protein 1; LOC301085
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88132,289,538 - 132,356,810 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8132,289,539 - 132,356,451 (-)EnsemblGRCr8
mRatBN7.28123,412,105 - 123,479,315 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8123,412,112 - 123,479,021 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx8129,003,808 - 129,071,231 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08127,202,785 - 127,270,208 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08125,032,024 - 125,099,409 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.08132,844,042 - 132,910,905 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8132,844,043 - 132,911,193 (-)Ensemblrn6Rnor6.0
Rnor_5.08131,995,143 - 132,061,908 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.48128,543,895 - 128,612,184 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera8122,520,323 - 122,587,206 (-)NCBICelera
RGSC_v3.18128,566,529 - 128,632,267 (-)NCBI
Cytogenetic Map8q32NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
autophagosome  (IBA,IEA,ISO)
cytoplasmic vesicle  (IEA)
endosome  (IEA)
late endosome  (IBA,IEA,ISO)
lysosome  (IBA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:19946888   PMID:20100911   PMID:26468287  


Genomics

Comparative Map Data
Fyco1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88132,289,538 - 132,356,810 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8132,289,539 - 132,356,451 (-)EnsemblGRCr8
mRatBN7.28123,412,105 - 123,479,315 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8123,412,112 - 123,479,021 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx8129,003,808 - 129,071,231 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08127,202,785 - 127,270,208 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08125,032,024 - 125,099,409 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.08132,844,042 - 132,910,905 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8132,844,043 - 132,911,193 (-)Ensemblrn6Rnor6.0
Rnor_5.08131,995,143 - 132,061,908 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.48128,543,895 - 128,612,184 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera8122,520,323 - 122,587,206 (-)NCBICelera
RGSC_v3.18128,566,529 - 128,632,267 (-)NCBI
Cytogenetic Map8q32NCBI
FYCO1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38345,917,903 - 45,995,824 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl345,917,903 - 45,995,838 (-)Ensemblhg38GRCh38
GRCh37345,959,395 - 46,037,316 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36345,934,399 - 46,012,311 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34345,934,399 - 46,012,304NCBI
Celera345,897,023 - 45,974,921 (-)NCBICelera
Cytogenetic Map3p21.31NCBI
HuRef346,003,424 - 46,081,373 (-)NCBIHuRef
CHM1_1345,909,364 - 45,987,237 (-)NCBICHM1_1
T2T-CHM13v2.0345,933,786 - 46,011,702 (-)NCBIT2T-CHM13v2.0
Fyco1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399123,618,565 - 123,681,110 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9123,618,565 - 123,680,964 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm389123,789,500 - 123,851,899 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9123,789,500 - 123,851,899 (-)Ensemblmm10GRCm38
MGSCv379123,698,628 - 123,761,020 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv369123,638,208 - 123,700,267 (-)NCBIMGSCv36mm8
Celera9124,237,925 - 124,300,275 (-)NCBICelera
Cytogenetic Map9F4NCBI
cM Map974.52NCBI
Fyco1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542026,019,514 - 26,074,492 (+)Ensembl
ChiLan1.0NW_00495542026,019,621 - 26,076,846 (+)NCBIChiLan1.0ChiLan1.0
FYCO1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2245,882,811 - 45,960,720 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1345,887,576 - 45,965,488 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0345,825,670 - 45,903,595 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1346,932,148 - 47,009,676 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl346,932,148 - 47,009,676 (-)EnsemblpanPan2panpan1.1
FYCO1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12042,520,241 - 42,593,886 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2042,525,435 - 42,590,243 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2042,436,100 - 42,509,739 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02043,002,992 - 43,076,845 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2043,003,044 - 43,074,828 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12042,244,102 - 42,317,757 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02042,651,320 - 42,724,955 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02042,926,619 - 43,000,264 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Fyco1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118200,454,799 - 200,532,091 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365963,720 - 81,257 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365963,938 - 81,226 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FYCO1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1329,066,986 - 29,146,755 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11329,068,107 - 29,146,792 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21332,200,269 - 32,239,205 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FYCO1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1227,388,796 - 7,466,463 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl227,388,704 - 7,466,430 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666041159,699,253 - 159,777,243 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fyco1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473074,923,027 - 74,982,990 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473074,923,072 - 74,982,882 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Fyco1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v18114,892,119 - 114,959,137 (-)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:830
Count of miRNA genes:293
Interacting mature miRNAs:399
Transcripts:ENSRNOT00000008630
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)8102413464132782436Rat
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)8105462581132782436Rat
634332Pia18Pristane induced arthritis QTL 184joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)884192326132782436Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)879394435132782436Rat

Markers in Region
BQ205885  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28123,439,115 - 123,439,281 (+)MAPPERmRatBN7.2
Rnor_6.08132,871,049 - 132,871,214NCBIRnor6.0
Rnor_5.08132,022,149 - 132,022,314UniSTSRnor5.0
RGSC_v3.48128,570,901 - 128,571,066UniSTSRGSC3.4
Celera8122,547,331 - 122,547,496UniSTS
RH 3.4 Map81333.2UniSTS
Cytogenetic Map8q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000008630   ⟹   ENSRNOP00000008630
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8132,289,539 - 132,356,451 (-)Ensembl
mRatBN7.2 Ensembl8123,412,112 - 123,479,021 (-)Ensembl
Rnor_6.0 Ensembl8132,844,043 - 132,910,905 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000087799   ⟹   ENSRNOP00000073803
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8132,289,539 - 132,345,173 (-)Ensembl
mRatBN7.2 Ensembl8123,412,112 - 123,467,743 (-)Ensembl
Rnor_6.0 Ensembl8132,846,626 - 132,911,193 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000123167   ⟹   ENSRNOP00000104750
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8132,289,539 - 132,356,451 (-)Ensembl
RefSeq Acc Id: NM_001106870   ⟹   NP_001100340
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88132,289,539 - 132,356,451 (-)NCBI
mRatBN7.28123,412,112 - 123,479,021 (-)NCBI
Rnor_6.08132,844,043 - 132,910,905 (-)NCBI
Rnor_5.08131,995,143 - 132,061,908 (-)NCBI
RGSC_v3.48128,543,895 - 128,612,184 (-)RGD
Celera8122,520,323 - 122,587,206 (-)RGD
Sequence:
RefSeq Acc Id: XM_017595602   ⟹   XP_017451091
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88132,289,538 - 132,347,904 (-)NCBI
mRatBN7.28123,412,105 - 123,470,540 (-)NCBI
Rnor_6.08132,844,042 - 132,903,293 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039081318   ⟹   XP_038937246
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88132,289,538 - 132,356,810 (-)NCBI
mRatBN7.28123,412,105 - 123,479,315 (-)NCBI
RefSeq Acc Id: NP_001100340   ⟸   NM_001106870
- UniProtKB: D3Z9D2 (UniProtKB/TrEMBL),   A6I4C6 (UniProtKB/TrEMBL),   A0A0G2K6G5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017451091   ⟸   XM_017595602
- Peptide Label: isoform X1
- UniProtKB: D3Z9D2 (UniProtKB/TrEMBL),   A6I4C6 (UniProtKB/TrEMBL),   A0A0G2K6G5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000008630   ⟸   ENSRNOT00000008630
Ensembl Acc Id: ENSRNOP00000073803   ⟸   ENSRNOT00000087799
RefSeq Acc Id: XP_038937246   ⟸   XM_039081318
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000104750   ⟸   ENSRNOT00000123167
Protein Domains
FYVE-type   GOLD   RUN

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3Z9D2-F1-model_v2 AlphaFold D3Z9D2 1-1451 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696420
Promoter ID:EPDNEW_R6938
Type:multiple initiation site
Name:Fyco1_1
Description:FYVE and coiled-coil domain containing 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08132,911,147 - 132,911,207EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309069 AgrOrtholog
BioCyc Gene G2FUF-28606 BioCyc
Ensembl Genes ENSRNOG00000006336 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000008630 ENTREZGENE
  ENSRNOT00000008630.8 UniProtKB/TrEMBL
  ENSRNOT00000087799 ENTREZGENE
  ENSRNOT00000087799.3 UniProtKB/TrEMBL
  ENSRNOT00000123167.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.58.900 UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/TrEMBL
  GOLD domain UniProtKB/TrEMBL
InterPro FYVE_FYCO1 UniProtKB/TrEMBL
  GOLD UniProtKB/TrEMBL
  GOLD_dom_sf UniProtKB/TrEMBL
  Run UniProtKB/TrEMBL
  Run_dom_sf UniProtKB/TrEMBL
  RUN_FYCO1 UniProtKB/TrEMBL
  Znf_FYVE UniProtKB/TrEMBL
  Znf_FYVE-rel UniProtKB/TrEMBL
  Znf_FYVE_PHD UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
KEGG Report rno:301085 UniProtKB/TrEMBL
NCBI Gene 301085 ENTREZGENE
PANTHER FYVE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 1 UniProtKB/TrEMBL
  FYVE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 1 UniProtKB/TrEMBL
Pfam FYVE UniProtKB/TrEMBL
  RUN UniProtKB/TrEMBL
PhenoGen Fyco1 PhenoGen
PROSITE GOLD UniProtKB/TrEMBL
  RUN UniProtKB/TrEMBL
  ZF_FYVE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000006336 RatGTEx
SMART FYVE UniProtKB/TrEMBL
Superfamily-SCOP FYVE_PHD_ZnF UniProtKB/TrEMBL
  GOLD UniProtKB/TrEMBL
  SSF140741 UniProtKB/TrEMBL
UniProt A0A0G2K6G5 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LIQ5_RAT UniProtKB/TrEMBL
  A6I4C6 ENTREZGENE, UniProtKB/TrEMBL
  D3Z9D2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-10-04 Fyco1  FYVE and coiled-coil domain autophagy adaptor 1  Fyco1  FYVE and coiled-coil domain containing 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Fyco1  FYVE and coiled-coil domain containing 1   Fyco1_predicted  FYVE and coiled-coil domain containing 1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Fyco1_predicted  FYVE and coiled-coil domain containing 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED