Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Gpc5 | Rat | 1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene | multiple interactions | ISO | Gpc5 (Mus musculus) | 6480464 | [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... | CTD | PMID:25510870 | Gpc5 | Rat | 1,2-dichloroethane | increases expression | ISO | Gpc5 (Mus musculus) | 6480464 | ethylene dichloride results in increased expression of GPC5 mRNA | CTD | PMID:28960355 | Gpc5 | Rat | 17beta-estradiol | multiple interactions | EXP | | 6480464 | [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in decreased expression of GPC5 mRNA | CTD | PMID:32741896 | Gpc5 | Rat | 17beta-estradiol 3-benzoate | multiple interactions | EXP | | 6480464 | [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in decreased expression of GPC5 mRNA | CTD | PMID:32741896 | Gpc5 | Rat | 17beta-estradiol 3-benzoate | decreases expression | EXP | | 6480464 | estradiol 3-benzoate results in decreased expression of GPC5 mRNA | CTD | PMID:32741896 | Gpc5 | Rat | 2,2',4,4',5,5'-hexachlorobiphenyl | multiple interactions | ISO | Gpc5 (Mus musculus) | 6480464 | [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... | CTD | PMID:25510870 | Gpc5 | Rat | 2,2',5,5'-tetrachlorobiphenyl | multiple interactions | ISO | Gpc5 (Mus musculus) | 6480464 | [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... | CTD | PMID:25510870 | Gpc5 | Rat | 2,3',4,4',5-Pentachlorobiphenyl | affects expression | ISO | Gpc5 (Mus musculus) | 6480464 | 2,3',4,4',5-pentachlorobiphenyl affects the expression of GPC5 mRNA | CTD | PMID:31388691 | Gpc5 | Rat | 2,4,4'-trichlorobiphenyl | multiple interactions | ISO | Gpc5 (Mus musculus) | 6480464 | [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... | CTD | PMID:25510870 | Gpc5 | Rat | 4,4'-diaminodiphenylmethane | increases expression | ISO | Gpc5 (Mus musculus) | 6480464 | 4,4'-diaminodiphenylmethane results in increased expression of GPC5 mRNA | CTD | PMID:18648102 | Gpc5 | Rat | aflatoxin B1 | decreases methylation | ISO | GPC5 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of GPC5 gene | CTD | PMID:27153756 | Gpc5 | Rat | aflatoxin B1 | decreases expression | ISO | GPC5 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased expression of GPC5 mRNA | CTD | PMID:32234424 | Gpc5 | Rat | aflatoxin B1 | affects methylation | ISO | GPC5 (Homo sapiens) | 6480464 | Aflatoxin B1 affects the methylation of GPC5 intron | CTD | PMID:30157460 | Gpc5 | Rat | Aflatoxin B2 alpha | decreases methylation | ISO | GPC5 (Homo sapiens) | 6480464 | aflatoxin B2 results in decreased methylation of GPC5 intron | CTD | PMID:30157460 | Gpc5 | Rat | aldehydo-D-glucose | multiple interactions | ISO | Gpc5 (Mus musculus) | 6480464 | [lard co-treated with Cholesterol, Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose more ... | CTD | PMID:37567420 | Gpc5 | Rat | antirheumatic drug | decreases expression | ISO | GPC5 (Homo sapiens) | 6480464 | Antirheumatic Agents results in decreased expression of GPC5 mRNA | CTD | PMID:24449571 | Gpc5 | Rat | atrazine | increases expression | ISO | GPC5 (Homo sapiens) | 6480464 | Atrazine results in increased expression of GPC5 mRNA | CTD | PMID:22378314 | Gpc5 | Rat | atrazine | affects methylation | EXP | | 6480464 | Atrazine affects the methylation of GPC5 gene | CTD | PMID:35440735 | Gpc5 | Rat | Azaspiracid | decreases expression | ISO | GPC5 (Homo sapiens) | 6480464 | azaspiracid results in decreased expression of GPC5 mRNA | CTD | PMID:28939011 | Gpc5 | Rat | benzo[a]pyrene | decreases expression | ISO | GPC5 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of GPC5 mRNA | CTD | PMID:20106945 | Gpc5 | Rat | benzo[a]pyrene | affects methylation | ISO | GPC5 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of GPC5 3' UTR; Benzo(a)pyrene affects the methylation of GPC5 intron | CTD | PMID:27901495|PMID:30157460 | Gpc5 | Rat | benzo[a]pyrene | increases methylation | ISO | GPC5 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of GPC5 5' UTR; Benzo(a)pyrene results in increased methylation of more ... | CTD | PMID:27901495 | Gpc5 | Rat | benzo[e]pyrene | decreases methylation | ISO | GPC5 (Homo sapiens) | 6480464 | benzo(e)pyrene results in decreased methylation of GPC5 intron | CTD | PMID:30157460 | Gpc5 | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of GPC5 mRNA | CTD | PMID:25181051 | Gpc5 | Rat | bisphenol A | multiple interactions | ISO | GPC5 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] affects the methylation of GPC5 gene | CTD | PMID:31601247 | Gpc5 | Rat | bisphenol A | increases methylation | ISO | GPC5 (Homo sapiens) | 6480464 | bisphenol A results in increased methylation of GPC5 gene | CTD | PMID:31601247 | Gpc5 | Rat | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of GPC5 mRNA | CTD | PMID:34947998 | Gpc5 | Rat | bisphenol A | decreases expression | ISO | GPC5 (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of GPC5 mRNA | CTD | PMID:31715268 | Gpc5 | Rat | bisphenol A | increases methylation | EXP | | 6480464 | bisphenol A results in increased methylation of GPC5 gene | CTD | PMID:28505145 | Gpc5 | Rat | bisphenol F | increases methylation | ISO | GPC5 (Homo sapiens) | 6480464 | bisphenol F results in increased methylation of GPC5 gene | CTD | PMID:31601247 | Gpc5 | Rat | Butylbenzyl phthalate | decreases methylation | ISO | Gpc5 (Mus musculus) | 6480464 | butylbenzyl phthalate results in decreased methylation of GPC5 intron | CTD | PMID:28392331 | Gpc5 | Rat | CGP 52608 | multiple interactions | ISO | GPC5 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to GPC5 gene] | CTD | PMID:28238834 | Gpc5 | Rat | chenodeoxycholic acid | multiple interactions | ISO | GPC5 (Homo sapiens) | 6480464 | [Acetaminophen co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with more ... | CTD | PMID:34589561 | Gpc5 | Rat | cocaine | increases expression | ISO | Gpc5 (Mus musculus) | 6480464 | Cocaine results in increased expression of GPC5 mRNA | CTD | PMID:18355967 | Gpc5 | Rat | cocaine | multiple interactions | ISO | Gpc5 (Mus musculus) | 6480464 | FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of GPC5 mRNA] | CTD | PMID:18355967 | Gpc5 | Rat | D-glucose | multiple interactions | ISO | Gpc5 (Mus musculus) | 6480464 | [lard co-treated with Cholesterol, Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose more ... | CTD | PMID:37567420 | Gpc5 | Rat | daunorubicin | affects response to substance | ISO | GPC5 (Homo sapiens) | 6480464 | GPC5 affects the susceptibility to Daunorubicin | CTD | PMID:17545624 | Gpc5 | Rat | deoxycholic acid | multiple interactions | ISO | GPC5 (Homo sapiens) | 6480464 | [Acetaminophen co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with more ... | CTD | PMID:34589561 | Gpc5 | Rat | dinophysistoxin 1 | decreases expression | ISO | GPC5 (Homo sapiens) | 6480464 | dinophysistoxin 1 results in decreased expression of GPC5 mRNA | CTD | PMID:28939011 | Gpc5 | Rat | dorsomorphin | multiple interactions | ISO | GPC5 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ... | CTD | PMID:27188386 | Gpc5 | Rat | epoxiconazole | increases expression | ISO | Gpc5 (Mus musculus) | 6480464 | epoxiconazole results in increased expression of GPC5 mRNA | CTD | PMID:35436446 | Gpc5 | Rat | ethanol | increases expression | ISO | Gpc5 (Mus musculus) | 6480464 | Ethanol results in increased expression of GPC5 mRNA | CTD | PMID:30319688 | Gpc5 | Rat | ethylparaben | increases expression | ISO | GPC5 (Homo sapiens) | 6480464 | ethyl-p-hydroxybenzoate results in increased expression of GPC5 mRNA | CTD | PMID:37690743 | Gpc5 | Rat | Evodiamine | increases expression | ISO | GPC5 (Homo sapiens) | 6480464 | evodiamine results in increased expression of GPC5 mRNA | CTD | PMID:32057900 | Gpc5 | Rat | folic acid | decreases expression | ISO | GPC5 (Homo sapiens) | 6480464 | Folic Acid results in decreased expression of GPC5 mRNA | CTD | PMID:21867686 | Gpc5 | Rat | fructose | multiple interactions | ISO | Gpc5 (Mus musculus) | 6480464 | [lard co-treated with Cholesterol, Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose more ... | CTD | PMID:37567420 | Gpc5 | Rat | fulvestrant | multiple interactions | ISO | GPC5 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] affects the methylation of GPC5 gene | CTD | PMID:31601247 | Gpc5 | Rat | glucose | multiple interactions | ISO | Gpc5 (Mus musculus) | 6480464 | [lard co-treated with Cholesterol, Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose more ... | CTD | PMID:37567420 | Gpc5 | Rat | glycochenodeoxycholic acid | multiple interactions | ISO | GPC5 (Homo sapiens) | 6480464 | [Acetaminophen co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with more ... | CTD | PMID:34589561 | Gpc5 | Rat | glycocholic acid | multiple interactions | ISO | GPC5 (Homo sapiens) | 6480464 | [Acetaminophen co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with more ... | CTD | PMID:34589561 | Gpc5 | Rat | glycodeoxycholic acid | multiple interactions | ISO | GPC5 (Homo sapiens) | 6480464 | [Acetaminophen co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with more ... | CTD | PMID:34589561 | Gpc5 | Rat | glyphosate | decreases expression | EXP | | 6480464 | Glyphosate results in decreased expression of GPC5 mRNA | CTD | PMID:38314887 | Gpc5 | Rat | herbicide | multiple interactions | ISO | Gpc5 (Mus musculus) | 6480464 | [lard co-treated with Cholesterol, Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose more ... | CTD | PMID:37567420 | Gpc5 | Rat | indole-3-methanol | multiple interactions | EXP | | 6480464 | [indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of GPC5 mRNA; [indole-3-carbinol more ... | CTD | PMID:22129741 | Gpc5 | Rat | methapyrilene | decreases methylation | ISO | GPC5 (Homo sapiens) | 6480464 | Methapyrilene results in decreased methylation of GPC5 intron | CTD | PMID:30157460 | Gpc5 | Rat | methoxychlor | affects methylation | EXP | | 6480464 | Methoxychlor affects the methylation of GPC5 gene | CTD | PMID:35440735 | Gpc5 | Rat | N-acetyl-L-cysteine | multiple interactions | EXP | | 6480464 | [indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of GPC5 mRNA; Acetylcysteine more ... | CTD | PMID:22129741 | Gpc5 | Rat | N-nitrosodiethylamine | multiple interactions | EXP | | 6480464 | [indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of GPC5 mRNA; [indole-3-carbinol more ... | CTD | PMID:22129741 | Gpc5 | Rat | O-methyleugenol | decreases expression | ISO | GPC5 (Homo sapiens) | 6480464 | methyleugenol results in decreased expression of GPC5 mRNA | CTD | PMID:32234424 | Gpc5 | Rat | paracetamol | increases expression | ISO | GPC5 (Homo sapiens) | 6480464 | Acetaminophen results in increased expression of GPC5 mRNA | CTD | PMID:29067470 | Gpc5 | Rat | paracetamol | multiple interactions | ISO | GPC5 (Homo sapiens) | 6480464 | [Acetaminophen co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with more ... | CTD | PMID:34589561 | Gpc5 | Rat | PCB138 | decreases expression | EXP | | 6480464 | 2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of GPC5 mRNA | CTD | PMID:23829299 | Gpc5 | Rat | PCB138 | multiple interactions | ISO | Gpc5 (Mus musculus) | 6480464 | [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... | CTD | PMID:25510870 | Gpc5 | Rat | SB 431542 | multiple interactions | ISO | GPC5 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ... | CTD | PMID:27188386 | Gpc5 | Rat | serpentine asbestos | increases methylation | ISO | GPC5 (Homo sapiens) | 6480464 | Asbestos, Serpentine results in increased methylation of GPC5 3' UTR | CTD | PMID:29523930 | Gpc5 | Rat | sodium arsenite | decreases expression | ISO | Gpc5 (Mus musculus) | 6480464 | sodium arsenite results in decreased expression of GPC5 mRNA | CTD | PMID:36209798 | Gpc5 | Rat | sulforaphane | decreases expression | ISO | GPC5 (Homo sapiens) | 6480464 | sulforaphane results in decreased expression of GPC5 mRNA | CTD | PMID:31838189 | Gpc5 | Rat | testosterone | multiple interactions | EXP | | 6480464 | [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in decreased expression of GPC5 mRNA | CTD | PMID:32741896 | Gpc5 | Rat | tricetin | decreases expression | ISO | GPC5 (Homo sapiens) | 6480464 | tricetin results in decreased expression of GPC5 mRNA | CTD | PMID:38654487 | Gpc5 | Rat | triclosan | increases expression | ISO | GPC5 (Homo sapiens) | 6480464 | Triclosan results in increased expression of GPC5 mRNA | CTD | PMID:30510588 | Gpc5 | Rat | urethane | increases expression | ISO | GPC5 (Homo sapiens) | 6480464 | Urethane results in increased expression of GPC5 mRNA | CTD | PMID:28818685 | Gpc5 | Rat | valproic acid | decreases methylation | ISO | GPC5 (Homo sapiens) | 6480464 | Valproic Acid results in decreased methylation of GPC5 gene | CTD | PMID:29154799 | Gpc5 | Rat | valproic acid | increases expression | ISO | GPC5 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of GPC5 mRNA | CTD | PMID:23179753|PMID:24383497|PMID:26272509|PMID:28001369 | Gpc5 | Rat | valproic acid | multiple interactions | ISO | GPC5 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ... | CTD | PMID:27188386 | | 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