Blm (BLM RecQ like helicase) - Rat Genome Database

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Gene: Blm (BLM RecQ like helicase) Rattus norvegicus
Analyze
Symbol: Blm
Name: BLM RecQ like helicase
RGD ID: 1308810
Description: Predicted to enable several functions, including ATP binding activity; DNA binding activity; and DNA helicase activity. Predicted to be involved in several processes, including DNA geometric change; DNA metabolic process; and regulation of nucleobase-containing compound metabolic process. Predicted to act upstream of or within several processes, including T cell differentiation; positive regulation of T cell proliferation; and regulation of DNA recombination. Predicted to be located in chromosome and nucleus. Predicted to be part of RecQ family helicase-topoisomerase III complex. Predicted to be active in chromosome; cytoplasm; and nucleus. Human ortholog(s) of this gene implicated in Bloom syndrome. Orthologous to human BLM (BLM RecQ like helicase); PARTICIPATES IN DNA replication pathway; homologous recombination pathway of double-strand break repair; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; all-trans-retinoic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Bloom syndrome; Bloom syndrome homolog; Bloom syndrome homolog (human); Bloom syndrome RecQ like helicase; Bloom syndrome, RecQ helicase-like; LOC308755; recQ-like DNA helicase BLM
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Mcs32
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81143,819,072 - 143,905,300 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1143,819,090 - 143,905,210 (-)EnsemblGRCr8
mRatBN7.21134,409,832 - 134,496,073 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1134,409,857 - 134,484,312 (-)EnsemblmRatBN7.2
Rnor_6.01142,246,773 - 142,332,616 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1142,246,790 - 142,332,588 (-)Ensemblrn6Rnor6.0
Rnor_5.01143,198,619 - 143,285,603 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41136,271,573 - 136,358,077 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1126,469,103 - 126,554,926 (-)NCBICelera
RGSC_v3.11136,350,811 - 136,606,090 (-)NCBI
Cytogenetic Map1q31NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(S)-colchicine  (ISO)
1,2-dichloroethane  (ISO)
17beta-estradiol  (EXP,ISO)
2,2'-Methylenebis(4-methyl-6-tert-butylphenol)  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-butoxyethanol  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
5-fluorouracil  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
adenine  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-pinene  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atrazine  (EXP,ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
biphenyl-4-amine  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
DDE  (ISO)
Dibutyl phosphate  (ISO)
dicrotophos  (ISO)
dioxygen  (EXP,ISO)
doxorubicin  (ISO)
Enterolactone  (ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
hydrogen peroxide  (ISO)
hydroxyurea  (ISO)
imiquimod  (ISO)
Lasiocarpine  (ISO)
lead(0)  (ISO)
lucanthone  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methyl methanesulfonate  (ISO)
mitomycin C  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
monocrotaline  (ISO)
monoethyl phthalate  (ISO)
nickel atom  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
oxybenzone  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorooctanoic acid  (ISO)
Pf-06840003  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (ISO)
progesterone  (ISO)
propanal  (ISO)
quercetin  (EXP,ISO)
quinoline yellow  (ISO)
resveratrol  (EXP,ISO)
riddelliine  (ISO)
sodium arsenite  (ISO)
succimer  (ISO)
sunitinib  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
Tributyltin oxide  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP,ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
valproic acid  (ISO)
vincristine  (ISO)
VX nerve agent  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Replication protein A physically interacts with the Bloom's syndrome protein and stimulates its helicase activity. Brosh RM Jr, etal., J Biol Chem. 2000 Aug 4;275(31):23500-8.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Regulation of homologous recombination in eukaryotes. Heyer WD, etal., Annu Rev Genet. 2010;44:113-39. doi: 10.1146/annurev-genet-051710-150955.
5. BLM (the causative gene of Bloom syndrome) protein translocation into the nucleus by a nuclear localization signal. Kaneko H, etal., Biochem Biophys Res Commun. 1997 Nov 17;240(2):348-53.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Comprehensive gene review and curation RGD comprehensive gene curation
12. Nuclear structure in normal and Bloom syndrome cells. Yankiwski V, etal., Proc Natl Acad Sci U S A. 2000 May 9;97(10):5214-9.
Additional References at PubMed
PMID:9388193   PMID:9671747   PMID:9808625   PMID:9840919   PMID:10359700   PMID:10728666   PMID:10871376   PMID:11046052   PMID:11101838   PMID:11309417   PMID:11433031   PMID:11500040  
PMID:11735402   PMID:11781842   PMID:12181313   PMID:12818200   PMID:15364958   PMID:15367665   PMID:15450411   PMID:15604258   PMID:16914751   PMID:17115688   PMID:17210642   PMID:17696610  
PMID:17878217   PMID:17982445   PMID:19734539   PMID:20639533   PMID:21325134   PMID:23509288   PMID:24816114   PMID:25520194   PMID:25597246   PMID:25901030   PMID:26195664   PMID:27010503  
PMID:28228481   PMID:33450132  


Genomics

Comparative Map Data
Blm
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81143,819,072 - 143,905,300 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1143,819,090 - 143,905,210 (-)EnsemblGRCr8
mRatBN7.21134,409,832 - 134,496,073 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1134,409,857 - 134,484,312 (-)EnsemblmRatBN7.2
Rnor_6.01142,246,773 - 142,332,616 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1142,246,790 - 142,332,588 (-)Ensemblrn6Rnor6.0
Rnor_5.01143,198,619 - 143,285,603 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41136,271,573 - 136,358,077 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1126,469,103 - 126,554,926 (-)NCBICelera
RGSC_v3.11136,350,811 - 136,606,090 (-)NCBI
Cytogenetic Map1q31NCBI
BLM
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381590,717,346 - 90,816,166 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1590,717,340 - 90,816,166 (+)Ensemblhg38GRCh38
GRCh371591,260,577 - 91,359,396 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361589,061,583 - 89,159,690 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341589,061,605 - 89,159,601NCBI
Celera1567,669,191 - 67,767,281 (+)NCBICelera
Cytogenetic Map15q26.1NCBI
HuRef1567,371,963 - 67,470,518 (+)NCBIHuRef
CHM1_11591,102,306 - 91,200,343 (+)NCBICHM1_1
T2T-CHM13v2.01588,475,676 - 88,575,539 (+)NCBIT2T-CHM13v2.0
Blm
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39780,104,839 - 80,184,896 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl780,104,481 - 80,184,867 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38780,454,993 - 80,535,148 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl780,454,733 - 80,535,119 (-)Ensemblmm10GRCm38
MGSCv37787,599,879 - 87,680,005 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36780,328,605 - 80,408,501 (-)NCBIMGSCv36mm8
Celera777,855,450 - 77,935,749 (-)NCBICelera
Cytogenetic Map7D2NCBI
cM Map745.65NCBI
Blm
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541614,842,033 - 14,899,687 (+)Ensembl
ChiLan1.0NW_00495541614,814,753 - 14,899,865 (+)NCBIChiLan1.0ChiLan1.0
BLM
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21680,267,894 - 80,368,918 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11583,965,915 - 84,066,920 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01569,407,248 - 69,508,070 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11588,607,157 - 88,707,864 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1588,607,157 - 88,707,864 (+)EnsemblpanPan2panpan1.1
BLM
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1353,408,120 - 53,506,728 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl353,408,217 - 53,473,146 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha356,045,661 - 56,144,322 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0353,824,072 - 53,922,767 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl353,824,080 - 53,922,707 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1353,343,266 - 53,441,845 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0353,555,047 - 53,653,568 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0353,894,900 - 53,993,588 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Blm
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640130,038,668 - 130,140,428 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648316,194,092 - 16,255,905 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648316,194,092 - 16,295,803 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BLM
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl753,317,540 - 53,412,645 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1753,317,515 - 53,412,649 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2758,374,719 - 58,443,673 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BLM
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1299,046,485 - 9,152,320 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl299,045,373 - 9,152,254 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605937,540,996 - 37,654,124 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Blm
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476817,421,291 - 17,522,799 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476817,422,267 - 17,522,894 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Blm
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12119,706,569 - 119,793,515 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Blm
641 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:133
Count of miRNA genes:113
Interacting mature miRNAs:122
Transcripts:ENSRNOT00000015065
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1131179947176179947Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)1137611478182611478Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1101228864146228864Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1130419227175419227Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1132760429191848948Rat
631684Bp117Blood pressure QTL 1178.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1120082258165082258Rat
9590300Scort16Serum corticosterone level QTL 164.390.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1112521556157521556Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1142582336182383862Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
1598850Bp297Blood pressure QTL 2972.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1130419227175419227Rat
631570Bp94Blood pressure QTL 940.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1132889797152403053Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1139442053223964440Rat
152025232Bw192Body weight QTL 1923.93body mass (VT:0001259)1127329268206393015Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)199645382182701046Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
61346Rf2Renal disease susceptibility QTL 23.7urine protein amount (VT:0005160)urine protein level (CMO:0000591)1142582180153680016Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1109493780193400781Rat
2317833Alcrsp19Alcohol response QTL 1912.40.001response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1110389869155389869Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1124975316152612788Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631202Gluco13Glucose level QTL 130.0001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1141173126169168317Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
631206Niddm40Non-insulin dependent diabetes mellitus QTL 40blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1140833106185833106Rat
1641897Alcrsp1Alcohol response QTL 1response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1110389869155389869Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1116099376191260518Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1101594089146594089Rat
2293140Bp313Blood pressure QTL 313arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1131243790176243790Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)196717367160111531Rat
737974Bp161Blood pressure QTL 1610.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1129182274174182274Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1132760429191848948Rat
631496Bp97Blood pressure QTL 973.08arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1115183611176289080Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1102780511182384005Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1111949780210707719Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1128019551173019551Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
61399Tcat1Tongue tumor resistance QTL 13.3tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 5 mm (CMO:0001879)1108680016153680016Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1139442053223964440Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)1102359314153680016Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1140048073185048073Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1111949780210707719Rat
634348Bp138Blood pressure QTL 138arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1135021436178317588Rat
8694370Bw154Body weight QTL 1548.910.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)1112521556157521556Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1140048073185048073Rat
1354623Rf46Renal function QTL 463.8blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)1111949780160574007Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1135021436180021436Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1132760429191190115Rat
152025212Bw190Body weight QTL 1905.7body mass (VT:0001259)1132966869206393015Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1132760429152404087Rat
631548Bp88Blood pressure QTL 8850.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1140915717185915717Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1100345976145345976Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1132760429191848948Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000015065   ⟹   ENSRNOP00000015065
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1143,819,090 - 143,893,546 (-)Ensembl
mRatBN7.2 Ensembl1134,409,857 - 134,484,312 (-)Ensembl
Rnor_6.0 Ensembl1142,246,790 - 142,332,588 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000131538   ⟹   ENSRNOP00000105655
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1143,819,090 - 143,905,210 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000132954   ⟹   ENSRNOP00000109578
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1143,819,090 - 143,905,210 (-)Ensembl
RefSeq Acc Id: NM_001426975   ⟹   NP_001413904
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81143,819,090 - 143,905,210 (-)NCBI
RefSeq Acc Id: XM_006229458   ⟹   XP_006229520
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81143,819,072 - 143,893,890 (-)NCBI
mRatBN7.21134,409,832 - 134,496,031 (-)NCBI
Rnor_6.01142,246,773 - 142,332,616 (-)NCBI
Rnor_5.01143,198,619 - 143,285,603 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039101056   ⟹   XP_038956984
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81143,819,072 - 143,893,909 (-)NCBI
mRatBN7.21134,409,832 - 134,496,034 (-)NCBI
RefSeq Acc Id: XM_039101057   ⟹   XP_038956985
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81143,819,072 - 143,905,300 (-)NCBI
mRatBN7.21134,409,832 - 134,496,073 (-)NCBI
RefSeq Acc Id: XM_063262635   ⟹   XP_063118705
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81143,819,072 - 143,893,955 (-)NCBI
RefSeq Acc Id: XM_063262640   ⟹   XP_063118710
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81143,819,072 - 143,893,888 (-)NCBI
RefSeq Acc Id: XP_006229520   ⟸   XM_006229458
- Peptide Label: isoform X4
- UniProtKB: D3ZQW1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000015065   ⟸   ENSRNOT00000015065
RefSeq Acc Id: XP_038956985   ⟸   XM_039101057
- Peptide Label: isoform X3
- UniProtKB: D3ZQW1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038956984   ⟸   XM_039101056
- Peptide Label: isoform X2
- UniProtKB: D3ZQW1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063118705   ⟸   XM_063262635
- Peptide Label: isoform X1
- UniProtKB: D3ZQW1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063118710   ⟸   XM_063262640
- Peptide Label: isoform X5
- UniProtKB: D3ZQW1 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001413904   ⟸   NM_001426975
- UniProtKB: D3ZQW1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000105655   ⟸   ENSRNOT00000131538
Ensembl Acc Id: ENSRNOP00000109578   ⟸   ENSRNOT00000132954

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZQW1-F1-model_v2 AlphaFold D3ZQW1 1-1401 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690159
Promoter ID:EPDNEW_R672
Type:multiple initiation site
Name:Blm_1
Description:Bloom syndrome RecQ like helicase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01142,332,600 - 142,332,660EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308810 AgrOrtholog
BioCyc Gene G2FUF-58727 BioCyc
Ensembl Genes ENSRNOG00000011213 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000015065 ENTREZGENE
  ENSRNOT00000015065.9 UniProtKB/TrEMBL
  ENSRNOT00000131538.1 UniProtKB/TrEMBL
  ENSRNOT00000132954 ENTREZGENE
  ENSRNOT00000132954.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/TrEMBL
  1.10.150.80 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
InterPro BDHCT UniProtKB/TrEMBL
  BDHCT_assoc UniProtKB/TrEMBL
  BLM_N UniProtKB/TrEMBL
  DEAD-like_N UniProtKB/TrEMBL
  DNA/RNA_helicase_C UniProtKB/TrEMBL
  DNA/RNA_helicase_DEAD/DEAH_N UniProtKB/TrEMBL
  DNA/RNA_helicase_DEAH_CS UniProtKB/TrEMBL
  DNA_helicase_ATP-dep_RecQ UniProtKB/TrEMBL
  HRDC-like UniProtKB/TrEMBL
  HRDC_dom UniProtKB/TrEMBL
  HRDC_dom_sf UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  RecQ_Zn-bd UniProtKB/TrEMBL
  RQC_domain UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/TrEMBL
NCBI Gene 308755 ENTREZGENE
PANTHER DNA HELICASE RECQ FAMILY MEMBER UniProtKB/TrEMBL
  RECQ-LIKE DNA HELICASE BLM UniProtKB/TrEMBL
Pfam BDHCT UniProtKB/TrEMBL
  BDHCT_assoc UniProtKB/TrEMBL
  BLM_N UniProtKB/TrEMBL
  DEAD UniProtKB/TrEMBL
  Helicase_C UniProtKB/TrEMBL
  HRDC UniProtKB/TrEMBL
  RecQ_Zn_bind UniProtKB/TrEMBL
  RQC UniProtKB/TrEMBL
PhenoGen Blm PhenoGen
PROSITE DEAH_ATP_HELICASE UniProtKB/TrEMBL
  HELICASE_ATP_BIND_1 UniProtKB/TrEMBL
  HELICASE_CTER UniProtKB/TrEMBL
  HRDC UniProtKB/TrEMBL
RatGTEx ENSRNOG00000011213 RatGTEx
SMART DEXDc UniProtKB/TrEMBL
  HELICc UniProtKB/TrEMBL
  HRDC UniProtKB/TrEMBL
  RQC UniProtKB/TrEMBL
Superfamily-SCOP HRDC_like UniProtKB/TrEMBL
  SSF46785 UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
UniProt A0ABK0LL17_RAT UniProtKB/TrEMBL
  A0ABK0M6B2_RAT UniProtKB/TrEMBL
  D3ZQW1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-08-21 Blm  BLM RecQ like helicase  Blm  Bloom syndrome RecQ like helicase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-11 Blm  Bloom syndrome RecQ like helicase  Blm  Bloom syndrome, RecQ helicase-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-01-06 Blm  Bloom syndrome, RecQ helicase-like  Blm  Bloom syndrome homolog (human)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Blm  Bloom syndrome homolog (human)   Blm_predicted  Bloom syndrome homolog (human) (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Blm_predicted  Bloom syndrome homolog (human) (predicted)    Bloom syndrome (predicted)  Name updated 1299863 APPROVED
2005-01-12 Blm_predicted  Bloom syndrome (predicted)      Symbol and Name status set to approved 70820 APPROVED