Sdhb (succinate dehydrogenase complex iron sulfur subunit B) - Rat Genome Database

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Gene: Sdhb (succinate dehydrogenase complex iron sulfur subunit B) Rattus norvegicus
Analyze
Symbol: Sdhb
Name: succinate dehydrogenase complex iron sulfur subunit B
RGD ID: 1308598
Description: Enables succinate dehydrogenase (quinone) activity. Involved in respiratory electron transport chain and succinate metabolic process. Located in mitochondrial inner membrane. Biomarker of acute myocardial infarction. Human ortholog(s) of this gene implicated in Carney-Stratakis syndrome; gastrointestinal stromal tumor; mitochondrial complex II deficiency; paraganglioma; and pheochromocytoma. Orthologous to human SDHB (succinate dehydrogenase complex iron sulfur subunit B); PARTICIPATES IN altered citric acid cycle pathway; citric acid cycle pathway; electron transport chain pathway; INTERACTS WITH 2,2,2-tetramine; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ip; iron-sulfur subunit of complex II; LOC298596; malate dehydrogenase [quinone] iron-sulfur subunit; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85158,547,775 - 158,568,589 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5158,547,689 - 158,569,667 (+)EnsemblGRCr8
mRatBN7.25153,264,906 - 153,285,570 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5153,264,899 - 153,314,293 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5155,953,279 - 155,973,810 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05157,726,549 - 157,747,081 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05157,715,729 - 157,736,265 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05159,484,378 - 159,505,063 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5159,484,370 - 159,505,064 (+)Ensemblrn6Rnor6.0
Rnor_5.05163,197,045 - 163,217,315 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45159,818,669 - 159,839,772 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5151,629,862 - 151,650,475 (+)NCBICelera
RGSC_v3.15159,828,844 - 159,849,873 (+)NCBI
Cytogenetic Map5q36NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2,2-tetramine  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dimethoxyphenol  (ISO)
2-bromohexadecanoic acid  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrolein  (EXP,ISO)
acrylamide  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amitrole  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
aspartame  (ISO)
atrazine  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
Brodifacoum  (EXP)
Butylbenzyl phthalate  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (ISO)
calycosin  (EXP,ISO)
capsaicin  (ISO)
carbon nanotube  (ISO)
celastrol  (ISO)
chloropicrin  (ISO)
choline  (ISO)
colistin  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
desferrioxamine B  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloromethane  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
fenofibrate  (ISO)
folic acid  (ISO)
fulvestrant  (ISO)
furfural  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glyphosate  (EXP,ISO)
hydrogen peroxide  (ISO)
isobutanol  (ISO)
isoniazide  (ISO)
isopimaric acid  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lamivudine  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
lenvatinib  (EXP)
lipopolysaccharide  (ISO)
maneb  (ISO)
melatonin  (ISO)
Mesaconitine  (EXP)
metformin  (ISO)
methimazole  (EXP)
monosodium L-glutamate  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-Acetyl-S-(1,2-dichlorovinyl)-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosomorpholine  (EXP)
nickel dichloride  (ISO)
ochratoxin A  (ISO)
olaparib  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
p-menthan-3-ol  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (EXP)
phlorizin  (ISO)
picoxystrobin  (ISO)
pramipexole  (EXP)
Pyridostigmine bromide  (EXP)
pyrimidifen  (ISO)
rac-1,2-dichloropropane  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
Salvianolic acid A  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
staurosporine  (ISO)
streptozocin  (EXP,ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
T-2 toxin  (EXP)
talazoparib  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (EXP)
thioacetamide  (EXP)
tolcapone  (EXP)
toluene  (EXP)
tributylstannane  (EXP)
triphenyl phosphate  (ISO)
Triptolide  (EXP,ISO)
valproic acid  (ISO)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Gene mutations in the succinate dehydrogenase subunit SDHB cause susceptibility to familial pheochromocytoma and to familial paraganglioma. Astuti D, etal., Am J Hum Genet. 2001 Jul;69(1):49-54. Epub 2001 Jun 12.
2. SDH mutations in cancer. Bardella C, etal., Biochim Biophys Acta. 2011 Nov;1807(11):1432-43. doi: 10.1016/j.bbabio.2011.07.003. Epub 2011 Jul 13.
3. Succinate dehydrogenase deficiency in human. Briere JJ, etal., Cell Mol Life Sci. 2005 Oct;62(19-20):2317-24.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Surgically Metabolic Resection of Pericardial Fat to Ameliorate Myocardial Mitochondrial Dysfunction in Acute Myocardial Infarction Obese Rats. Kang KW, etal., J Korean Med Sci. 2022 Mar 7;37(9):e55. doi: 10.3346/jkms.2022.37.e55.
7. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
8. Decreased complex II respiration and HNE-modified SDH subunit in diabetic heart. Lashin OM, etal., Free Radic Biol Med. 2006 Mar 1;40(5):886-96. Epub 2005 Nov 2.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Comprehensive gene review and curation RGD comprehensive gene curation
17. Assembly of mammalian oxidative phosphorylation complexes I-V and supercomplexes. Signes A and Fernandez-Vizarra E, Essays Biochem. 2018 Jul 20;62(3):255-270. doi: 10.1042/EBC20170098. Print 2018 Jul 20.
Additional References at PubMed
PMID:2494655   PMID:11829486   PMID:12477932   PMID:12865426   PMID:14651853   PMID:15989954   PMID:16103131   PMID:16120479   PMID:16751257   PMID:16751776   PMID:17480203   PMID:18614015  
PMID:19808025   PMID:19837698   PMID:19849834   PMID:21700703   PMID:23376485   PMID:24154540   PMID:29476059   PMID:36005845  


Genomics

Comparative Map Data
Sdhb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85158,547,775 - 158,568,589 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5158,547,689 - 158,569,667 (+)EnsemblGRCr8
mRatBN7.25153,264,906 - 153,285,570 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5153,264,899 - 153,314,293 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5155,953,279 - 155,973,810 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05157,726,549 - 157,747,081 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05157,715,729 - 157,736,265 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05159,484,378 - 159,505,063 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5159,484,370 - 159,505,064 (+)Ensemblrn6Rnor6.0
Rnor_5.05163,197,045 - 163,217,315 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45159,818,669 - 159,839,772 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5151,629,862 - 151,650,475 (+)NCBICelera
RGSC_v3.15159,828,844 - 159,849,873 (+)NCBI
Cytogenetic Map5q36NCBI
SDHB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38117,018,722 - 17,054,032 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl117,018,664 - 17,054,151 (-)Ensemblhg38GRCh38
GRCh37117,345,217 - 17,380,527 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36117,217,804 - 17,253,252 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34117,090,558 - 17,125,952NCBI
Celera115,667,559 - 15,703,013 (-)NCBICelera
Cytogenetic Map1p36.13NCBI
HuRef115,589,311 - 15,624,677 (-)NCBIHuRef
CHM1_1117,453,561 - 17,489,010 (-)NCBICHM1_1
T2T-CHM13v2.0116,829,151 - 16,864,469 (-)NCBIT2T-CHM13v2.0
Sdhb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394140,688,582 - 140,706,509 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4140,688,514 - 140,706,504 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm384140,961,271 - 140,979,198 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4140,961,203 - 140,979,193 (+)Ensemblmm10GRCm38
MGSCv374140,517,186 - 140,535,108 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv364140,233,347 - 140,251,269 (+)NCBIMGSCv36mm8
Celera4142,761,706 - 142,779,666 (+)NCBICelera
Cytogenetic Map4D3NCBI
cM Map473.24NCBI
Sdhb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555271,768,940 - 1,792,361 (+)Ensembl
ChiLan1.0NW_0049555271,769,280 - 1,792,496 (+)NCBIChiLan1.0ChiLan1.0
SDHB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21210,076,010 - 210,111,744 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11209,194,917 - 209,230,579 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0115,962,383 - 15,998,056 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1117,018,531 - 17,054,509 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl117,018,542 - 17,054,509 (-)EnsemblpanPan2panpan1.1
SDHB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1281,158,291 - 81,190,110 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl281,158,291 - 81,190,109 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha277,695,312 - 77,727,188 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0281,804,258 - 81,836,607 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl281,804,258 - 81,836,606 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1278,557,290 - 78,589,612 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0279,574,320 - 79,606,173 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0280,642,748 - 80,674,635 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Sdhb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505838,168,442 - 38,196,545 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364743,990,778 - 4,021,423 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364743,993,224 - 4,021,359 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SDHB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl675,648,215 - 75,678,378 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1675,648,362 - 75,678,111 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2669,991,035 - 70,021,085 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SDHB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120115,537,880 - 115,571,150 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20115,538,026 - 115,571,142 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666033549,592 - 583,182 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sdhb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247642,650,604 - 2,679,005 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247642,655,138 - 2,679,138 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Sdhb
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1117,166,088 - 17,185,705 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Sdhb
123 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:41
Count of miRNA genes:38
Interacting mature miRNAs:41
Transcripts:ENSRNOT00000010593
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5130249266172190305Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5116702075161702075Rat
1354583Despr3Despair related QTL34.980.0002locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)5132930505172190305Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5141212838172190305Rat
1300119Bp180Blood pressure QTL 1803.82arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5149642129171146538Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)599905133172190305Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5133789363172190305Rat
1331803Rf32Renal function QTL 322.798kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)5134369199172190305Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)565089051166764498Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5136631198172190305Rat
1354631Swd2Spike wave discharge measurement QTL 23.640.0002brain electrophysiology trait (VT:0010557)brain total spike-and-wave discharge duration (CMO:0001740)5156396728172190305Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5133081618172190305Rat
631263Cm24Cardiac mass QTL 243.5heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)5149805999162987697Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5138002522170842766Rat
1581505Rf54Renal function QTL 54kidney physiology trait (VT:0002136)kidney 20-HETE level (CMO:0001854)5133270647172190305Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)5141764300172190305Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5148093485172129029Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5133789363172190305Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5125969677172190305Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
631272Lanf1Left ventricular atrial natriuretic factor QTL 112heart left ventricle natriuretic peptide A amount (VT:0010596)heart left ventricle natriuretic peptide A level (CMO:0002165)5156396728167181764Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5131708216172190305Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5114131300159131300Rat
2313096Bmd78Bone mineral density QTL 783.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)5149661912166600247Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5116702075161702075Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5116702075161702075Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5116702075161702075Rat
1298090Bp155Blood pressure QTL 1553.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)5156289283171137955Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5114131300159131300Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5133081618172190305Rat

Markers in Region
RH129180  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25153,283,964 - 153,285,543 (+)MAPPERmRatBN7.2
Rnor_6.05159,503,458 - 159,505,036NCBIRnor6.0
Rnor_5.05163,215,710 - 163,217,288UniSTSRnor5.0
RGSC_v3.45159,838,167 - 159,839,745UniSTSRGSC3.4
Celera5151,648,870 - 151,650,448UniSTS
RH 3.4 Map51051.6UniSTS
Cytogenetic Map5q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000010593   ⟹   ENSRNOP00000010593
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5153,264,904 - 153,285,559 (+)Ensembl
Rnor_6.0 Ensembl5159,484,370 - 159,505,064 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000098351   ⟹   ENSRNOP00000080180
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5158,547,929 - 158,568,555 (+)Ensembl
mRatBN7.2 Ensembl5153,264,899 - 153,285,567 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000105563   ⟹   ENSRNOP00000088032
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5158,547,689 - 158,569,667 (+)Ensembl
mRatBN7.2 Ensembl5153,264,903 - 153,314,293 (+)Ensembl
RefSeq Acc Id: NM_001100539   ⟹   NP_001094009
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85158,547,934 - 158,568,589 (+)NCBI
mRatBN7.25153,264,906 - 153,285,570 (+)NCBI
Rnor_6.05159,484,378 - 159,505,063 (+)NCBI
Rnor_5.05163,197,045 - 163,217,315 (+)NCBI
RGSC_v3.45159,818,669 - 159,839,772 (+)RGD
Celera5151,629,862 - 151,650,475 (+)RGD
Sequence:
RefSeq Acc Id: XM_063287472   ⟹   XP_063143542
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85158,547,775 - 158,568,589 (+)NCBI
RefSeq Acc Id: NP_001094009   ⟸   NM_001100539
- Peptide Label: precursor
- UniProtKB: B0BMZ2 (UniProtKB/Swiss-Prot),   Q0QEZ3 (UniProtKB/Swiss-Prot),   P21913 (UniProtKB/Swiss-Prot),   A0A8L2Q4P2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000010593   ⟸   ENSRNOT00000010593
Ensembl Acc Id: ENSRNOP00000080180   ⟸   ENSRNOT00000098351
Ensembl Acc Id: ENSRNOP00000088032   ⟸   ENSRNOT00000105563
RefSeq Acc Id: XP_063143542   ⟸   XM_063287472
- Peptide Label: isoform X1
- UniProtKB: A6ITQ1 (UniProtKB/TrEMBL),   A0A8L2Q4P2 (UniProtKB/TrEMBL)
Protein Domains
2Fe-2S ferredoxin-type   4Fe-4S ferredoxin-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P21913-F1-model_v2 AlphaFold P21913 1-282 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694216
Promoter ID:EPDNEW_R4739
Type:multiple initiation site
Name:Sdhb_1
Description:succinate dehydrogenase complex iron sulfur subunit B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05159,484,382 - 159,484,442EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308598 AgrOrtholog
BioCyc Gene G2FUF-39375 BioCyc
BioCyc Pathway PWY-3781 [aerobic respiration I (cytochrome c)] BioCyc
  PWY-7279 [aerobic respiration II (cytochrome c) (yeast)] BioCyc
BioCyc Pathway Image PWY-3781 BioCyc
  PWY-7279 BioCyc
Ensembl Genes ENSRNOG00000007967 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000105563 ENTREZGENE
  ENSRNOT00000105563.1 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.1060.10 UniProtKB/Swiss-Prot
  3.10.20.30 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7446362 IMAGE-MGC_LOAD
InterPro 2Fe-2S_ferredoxin-like_sf UniProtKB/Swiss-Prot
  2Fe-2S_ferredoxin-type UniProtKB/Swiss-Prot
  2Fe2S_fd_BS UniProtKB/Swiss-Prot
  4Fe4S_Fe-S-bd UniProtKB/Swiss-Prot
  4Fe4S_Fe_S_CS UniProtKB/Swiss-Prot
  Beta-grasp_dom_sf UniProtKB/Swiss-Prot
  Helical_ferredxn UniProtKB/Swiss-Prot
  SDH/FRD_Iron-Sulfur UniProtKB/Swiss-Prot
  Succ_DH/fum_Rdtase_Fe-S UniProtKB/Swiss-Prot
  Succ_DH/fum_Rdtase_N UniProtKB/Swiss-Prot
KEGG Report rno:298596 UniProtKB/Swiss-Prot
MGC_CLONE MGC:187514 IMAGE-MGC_LOAD
NCBI Gene 298596 ENTREZGENE
PANTHER SUCCINATE DEHYDROGENASE [UBIQUINONE] IRON-SULFUR SUBUNIT, MITOCHONDRIAL UniProtKB/Swiss-Prot
  SUCCINATE DEHYDROGENASE IRON-SULFUR PROTEIN UniProtKB/Swiss-Prot
Pfam Fer2_3 UniProtKB/Swiss-Prot
  Fer4_17 UniProtKB/Swiss-Prot
PhenoGen Sdhb PhenoGen
PROSITE 2FE2S_FER_1 UniProtKB/Swiss-Prot
  2FE2S_FER_2 UniProtKB/Swiss-Prot
  4FE4S_FER_1 UniProtKB/Swiss-Prot
  4FE4S_FER_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000007967 RatGTEx
Superfamily-SCOP alpha-helical ferredoxin UniProtKB/Swiss-Prot
  SSF54292 UniProtKB/Swiss-Prot
UniProt A0A8I5ZPQ5_RAT UniProtKB/TrEMBL
  A0A8L2Q4P2 ENTREZGENE
  A6ITQ1 ENTREZGENE, UniProtKB/TrEMBL
  B0BMZ2 ENTREZGENE
  P21913 ENTREZGENE
  Q0QEZ3 ENTREZGENE
  SDHB_RAT UniProtKB/Swiss-Prot
UniProt Secondary B0BMZ2 UniProtKB/Swiss-Prot
  Q0QEZ3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-03 Sdhb  succinate dehydrogenase complex iron sulfur subunit B  Sdhb  succinate dehydrogenase complex, subunit B, iron sulfur (Ip)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Sdhb  succinate dehydrogenase complex, subunit B, iron sulfur (Ip)   Sdhb_predicted  succinate dehydrogenase complex, subunit B, iron sulfur (Ip) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Sdhb_predicted  succinate dehydrogenase complex, subunit B, iron sulfur (Ip) (predicted)      Symbol and Name status set to approved 70820 APPROVED