Cul3 (cullin 3) - Rat Genome Database

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Gene: Cul3 (cullin 3) Rattus norvegicus
Analyze
Symbol: Cul3
Name: cullin 3
RGD ID: 1308190
Description: Predicted to enable several functions, including Notch binding activity; POZ domain binding activity; and cyclin binding activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in several processes, including COPII vesicle coating; positive regulation of cell cycle process; and protein ubiquitination. Predicted to act upstream of or within several processes, including regulation of TORC1 signaling; regulation of type I interferon production; and transcription by RNA polymerase II. Predicted to be located in several cellular components, including Golgi apparatus; microtubule cytoskeleton; and sperm flagellum. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in glutamatergic synapse. Human ortholog(s) of this gene implicated in pseudohypoaldosteronism. Orthologous to human CUL3 (cullin 3); PARTICIPATES IN neddylation pathway; nuclear factor, erythroid 2 like 2 signaling pathway; proteasome degradation pathway involving cullin-dependent ubiquitin ligases; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cullin-3; LOC301555; MGC189292
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8989,040,987 - 89,118,775 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl989,040,987 - 89,118,427 (-)EnsemblGRCr8
mRatBN7.2981,592,641 - 81,670,428 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl981,592,641 - 81,670,462 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx990,022,642 - 90,100,355 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0995,151,541 - 95,229,253 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0993,534,067 - 93,611,783 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0986,044,485 - 86,129,066 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl986,044,485 - 86,129,329 (-)Ensemblrn6Rnor6.0
Rnor_5.0985,794,367 - 85,853,471 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4979,574,062 - 79,634,396 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera979,070,793 - 79,129,030 (-)NCBICelera
RGSC_v3.1979,757,935 - 79,837,198 (-)NCBI
Cytogenetic Map9q34NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-tert-butylhydroquinone  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
alpha-pinene  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
auramine O  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bortezomib  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
clozapine  (ISO)
curcumin  (ISO)
decabromodiphenyl ether  (ISO)
diallyl trisulfide  (EXP)
diazinon  (EXP)
diclofenac  (ISO)
diethylstilbestrol  (ISO)
dorsomorphin  (ISO)
elemental selenium  (ISO)
entinostat  (ISO)
ethanol  (ISO)
folic acid  (ISO)
FR900359  (ISO)
furan  (EXP)
gentamycin  (EXP)
inulin  (ISO)
ivermectin  (ISO)
leflunomide  (ISO)
melphalan  (ISO)
mercury dibromide  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
motexafin gadolinium  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenylmercury acetate  (ISO)
pyrogallol  (ISO)
resveratrol  (ISO)
rimonabant  (ISO)
salvianolic acid B  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sodium fluoride  (ISO)
solanesol  (ISO)
succimer  (ISO)
sulforaphane  (ISO)
tert-butyl hydroperoxide  (ISO)
topotecan  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vitamin E  (ISO)
zinc acetate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anaphase-promoting complex-dependent catabolic process  (ISO)
apoptotic process  (IEA)
biological_process  (ND)
cell division  (IEA)
cell migration  (IEA,ISO)
cell morphogenesis  (ISO)
cell projection organization  (IEA)
cellular response to amino acid stimulus  (IEA,ISO)
cellular response to oxidative stress  (IEA,ISO)
COPII vesicle coating  (IEA,ISO,ISS)
embryonic cleavage  (IEA,ISO,ISS)
endoplasmic reticulum to Golgi vesicle-mediated transport  (IEA,ISO,ISS)
fibroblast apoptotic process  (ISO)
gastrulation  (ISO)
gene expression  (IEA,ISO)
in utero embryonic development  (ISO)
inflammatory response  (IEA,ISO)
integrin-mediated signaling pathway  (IEA,ISO,ISS)
kidney development  (IEA,ISO)
liver morphogenesis  (ISO)
mitotic cell cycle  (IEA,ISO)
mitotic metaphase chromosome alignment  (IEA,ISO)
negative regulation of Rho protein signal transduction  (IEA,ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of type I interferon production  (IEA,ISO)
nuclear protein quality control by the ubiquitin-proteasome system  (IEA,ISO,ISS)
positive regulation of cytokinesis  (IEA,ISO,ISS)
positive regulation of mitotic cell cycle phase transition  (IEA,ISO,ISS)
positive regulation of mitotic metaphase/anaphase transition  (IEA,ISO)
positive regulation of protein ubiquitination  (IEA,ISO)
positive regulation of TORC1 signaling  (IEA,ISO)
proteasome-mediated ubiquitin-dependent protein catabolic process  (IBA,IEA,ISO,ISS)
protein autoubiquitination  (IEA,ISO)
protein catabolic process  (IEA,ISO)
protein destabilization  (IEA,ISO)
protein K48-linked ubiquitination  (IEA,ISO,ISS)
protein monoubiquitination  (IEA,ISO,ISS)
protein polyubiquitination  (IEA,ISO,ISS)
protein ubiquitination  (IBA,IEA,ISO,ISS)
regulation of cellular response to insulin stimulus  (IEA,ISO)
regulation of gene expression  (IEA)
regulation of primary metabolic process  (IEA)
regulation of transcription by RNA polymerase II  (ISO)
regulation protein catabolic process at postsynapse  (IEA,ISO)
response to stress  (IEA)
signal transduction  (IEA)
stem cell division  (IEA,ISO,ISS)
stress fiber assembly  (IEA,ISO)
trophectodermal cellular morphogenesis  (ISO)
ubiquitin-dependent protein catabolic process  (IEA,ISO,ISS)
vesicle-mediated transport  (IEA)
Wnt signaling pathway  (ISO)

Cellular Component
centrosome  (IEA,ISO,ISS)
Cul3-RING ubiquitin ligase complex  (IBA,IEA,ISO,ISS)
cullin-RING ubiquitin ligase complex  (IEA)
cytoplasm  (IEA,ISO,ISS)
glutamatergic synapse  (IEA,ISO)
Golgi apparatus  (IEA,ISO)
mitotic spindle  (IEA,ISO,ISS)
motile cilium  (IEA)
nucleus  (IBA,IEA,ISO,ISS)
plasma membrane  (IEA,ISO,ISS)
polar microtubule  (IEA,ISO)
postsynapse  (IEA)
sperm flagellum  (IEA,ISO,ISS)
spindle  (IEA)
spindle pole  (IEA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase. Furukawa M and Xiong Y, Mol Cell Biol. 2005 Jan;25(1):162-71.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. The Nrf2 regulatory network provides an interface between redox and intermediary metabolism. Hayes JD and Dinkova-Kostova AT, Trends Biochem Sci. 2014 Apr;39(4):199-218. doi: 10.1016/j.tibs.2014.02.002. Epub 2014 Mar 16.
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. Neddylation and deneddylation of CUL-3 is required to target MEI-1/Katanin for degradation at the meiosis-to-mitosis transition in C. elegans. Pintard L, etal., Curr Biol. 2003 May 27;13(11):911-21.
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Comprehensive gene review and curation RGD comprehensive gene curation
13. Actinfilin is a Cul3 substrate adaptor, linking GluR6 kainate receptor subunits to the ubiquitin-proteasome pathway. Salinas GD, etal., J Biol Chem. 2006 Dec 29;281(52):40164-73. Epub 2006 Oct 24.
Additional References at PubMed
PMID:10500095   PMID:12477932   PMID:14528312   PMID:15983046   PMID:17339333   PMID:17543862   PMID:19056867   PMID:19056892   PMID:19158078   PMID:19261606   PMID:19782033   PMID:19946888  
PMID:19995937   PMID:20389280   PMID:20811152   PMID:22358839   PMID:22578813   PMID:22709582   PMID:22871113   PMID:23213400   PMID:23453970   PMID:23455478   PMID:23576762   PMID:24768539  
PMID:24844779   PMID:24863065   PMID:25002582   PMID:25401743   PMID:26399832   PMID:27561354   PMID:27708159   PMID:28395323   PMID:34036379   PMID:36720302  


Genomics

Comparative Map Data
Cul3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8989,040,987 - 89,118,775 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl989,040,987 - 89,118,427 (-)EnsemblGRCr8
mRatBN7.2981,592,641 - 81,670,428 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl981,592,641 - 81,670,462 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx990,022,642 - 90,100,355 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0995,151,541 - 95,229,253 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0993,534,067 - 93,611,783 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0986,044,485 - 86,129,066 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl986,044,485 - 86,129,329 (-)Ensemblrn6Rnor6.0
Rnor_5.0985,794,367 - 85,853,471 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4979,574,062 - 79,634,396 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera979,070,793 - 79,129,030 (-)NCBICelera
RGSC_v3.1979,757,935 - 79,837,198 (-)NCBI
Cytogenetic Map9q34NCBI
CUL3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382224,470,150 - 224,585,363 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2224,470,150 - 224,585,397 (-)Ensemblhg38GRCh38
GRCh372225,334,867 - 225,450,080 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362225,043,113 - 225,158,358 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342225,160,373 - 225,275,619NCBI
Celera2219,099,731 - 219,215,637 (-)NCBICelera
Cytogenetic Map2q36.2NCBI
HuRef2217,186,560 - 217,301,844 (-)NCBIHuRef
CHM1_12225,341,500 - 225,456,770 (-)NCBICHM1_1
T2T-CHM13v2.02224,952,401 - 225,067,578 (-)NCBIT2T-CHM13v2.0
Cul3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39180,242,640 - 80,318,426 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl180,242,640 - 80,318,197 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38180,264,923 - 80,340,690 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl180,264,923 - 80,340,480 (-)Ensemblmm10GRCm38
MGSCv37180,263,393 - 80,337,005 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36180,145,842 - 80,219,467 (-)NCBIMGSCv36mm8
Celera180,291,823 - 80,365,420 (-)NCBICelera
Cytogenetic Map1C5NCBI
cM Map141.24NCBI
Cul3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554539,564,522 - 9,629,976 (+)Ensembl
ChiLan1.0NW_0049554539,546,554 - 9,629,976 (+)NCBIChiLan1.0ChiLan1.0
CUL3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213127,089,437 - 127,200,964 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B127,104,406 - 127,215,480 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B111,714,533 - 111,827,080 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B230,289,195 - 230,373,537 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B230,289,195 - 230,378,991 (-)EnsemblpanPan2panpan1.1
CUL3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12537,730,903 - 37,819,851 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2537,733,229 - 37,800,886 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2538,338,004 - 38,427,804 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02537,967,156 - 38,056,983 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2537,968,235 - 38,057,261 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12537,907,667 - 37,997,226 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02537,748,392 - 37,838,350 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02537,923,140 - 38,012,960 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Cul3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303179,724,396 - 179,788,614 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365696,065,367 - 6,132,316 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365696,067,230 - 6,131,467 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CUL3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15126,189,851 - 126,287,005 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.115126,191,605 - 126,287,148 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215139,621,601 - 139,781,465 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CUL3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110110,425,895 - 110,541,431 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10110,425,076 - 110,541,538 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604088,866,367 - 88,980,363 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cul3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624823766,780 - 852,727 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624823767,347 - 854,065 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Cul3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v14153,303,041 - 153,377,377 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cul3
632 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:222
Count of miRNA genes:160
Interacting mature miRNAs:183
Transcripts:ENSRNOT00000021528
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)956047863101047863Rat
1582203Gluco19Glucose level QTL 193.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)963376862108376862Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)965657365108376720Rat
724547Cm21Cardiac mass QTL 212.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)986720043110356905Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)94445825699506504Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)986720043121768150Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)964220169109220169Rat
6903941Pur31Proteinuria QTL 310.036urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)98672213292642305Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)964220169109220169Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)964220169109220169Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)968875497121768150Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)983161999118999486Rat
4889852Pur26Proteinuria QTL 26150.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)985262459109044727Rat
7794784Mcs31Mammary carcinoma susceptibility QTL 312.98mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)985262459118999486Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)948718864108376862Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)964220169109220169Rat
4889943Bss90Bone structure and strength QTL 904.1tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)95450650499506504Rat

Markers in Region
AI072520  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2981,593,418 - 81,593,612 (+)MAPPERmRatBN7.2
Rnor_6.0986,045,263 - 86,045,456NCBIRnor6.0
Rnor_5.0985,795,145 - 85,795,338UniSTSRnor5.0
RGSC_v3.4979,574,840 - 79,575,033UniSTSRGSC3.4
Celera979,071,571 - 79,071,764UniSTS
RH 3.4 Map9716.8UniSTS
Cytogenetic Map9q34UniSTS
CUL3-1  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8989,057,250 - 89,057,807 (+)Marker Load Pipeline
mRatBN7.2981,608,905 - 81,609,462 (+)MAPPERmRatBN7.2
Rnor_6.0986,060,749 - 86,061,305NCBIRnor6.0
Rnor_5.0985,810,631 - 85,811,187UniSTSRnor5.0
RGSC_v3.4979,590,326 - 79,590,882UniSTSRGSC3.4
Celera979,087,057 - 79,087,613UniSTS
Cytogenetic Map9q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000021528   ⟹   ENSRNOP00000021528
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl989,040,987 - 89,118,338 (-)Ensembl
mRatBN7.2 Ensembl981,592,641 - 81,669,996 (-)Ensembl
Rnor_6.0 Ensembl986,044,485 - 86,103,158 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000093554
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl986,069,805 - 86,129,329 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000093730   ⟹   ENSRNOP00000076209
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl989,040,987 - 89,099,849 (-)Ensembl
mRatBN7.2 Ensembl981,592,641 - 81,670,462 (-)Ensembl
Rnor_6.0 Ensembl986,046,187 - 86,129,073 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097044   ⟹   ENSRNOP00000086948
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl989,040,987 - 89,118,427 (-)Ensembl
mRatBN7.2 Ensembl981,592,641 - 81,670,462 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000118892   ⟹   ENSRNOP00000097410
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl989,040,987 - 89,099,849 (-)Ensembl
mRatBN7.2 Ensembl981,592,641 - 81,670,462 (-)Ensembl
RefSeq Acc Id: NM_001106923   ⟹   NP_001100393
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8989,040,987 - 89,118,427 (-)NCBI
mRatBN7.2981,592,641 - 81,670,085 (-)NCBI
Rnor_6.0986,044,485 - 86,103,158 (-)NCBI
Rnor_5.0985,794,367 - 85,853,471 (-)NCBI
RGSC_v3.4979,574,062 - 79,634,396 (-)RGD
Celera979,070,793 - 79,129,030 (-)RGD
Sequence:
RefSeq Acc Id: XM_008767227   ⟹   XP_008765449
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8989,042,672 - 89,098,692 (-)NCBI
mRatBN7.2981,593,141 - 81,650,350 (-)NCBI
Rnor_6.0986,044,980 - 86,101,995 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017596376   ⟹   XP_017451865
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8989,042,672 - 89,118,775 (-)NCBI
mRatBN7.2981,593,141 - 81,670,428 (-)NCBI
Rnor_6.0986,044,980 - 86,129,064 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001100393   ⟸   NM_001106923
- UniProtKB: B5DF89 (UniProtKB/Swiss-Prot),   A6JW85 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008765449   ⟸   XM_008767227
- Peptide Label: isoform X1
- UniProtKB: A0A8I6ASL8 (UniProtKB/TrEMBL),   A0A1W2Q6C6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017451865   ⟸   XM_017596376
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A4V1 (UniProtKB/TrEMBL),   A0A1W2Q6C6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000021528   ⟸   ENSRNOT00000021528
Ensembl Acc Id: ENSRNOP00000076209   ⟸   ENSRNOT00000093730
Ensembl Acc Id: ENSRNOP00000086948   ⟸   ENSRNOT00000097044
Ensembl Acc Id: ENSRNOP00000097410   ⟸   ENSRNOT00000118892
Protein Domains
Cullin family profile   Cullin neddylation

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B5DF89-F1-model_v2 AlphaFold B5DF89 1-768 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696799
Promoter ID:EPDNEW_R7319
Type:multiple initiation site
Name:Cul3_1
Description:cullin 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0986,129,293 - 86,129,353EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308190 AgrOrtholog
BioCyc Gene G2FUF-27004 BioCyc
Ensembl Genes ENSRNOG00000015633 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000097044 ENTREZGENE
  ENSRNOT00000118892 ENTREZGENE
Gene3D-CATH 1.10.10.10 UniProtKB/Swiss-Prot
  Cullin Repeats UniProtKB/Swiss-Prot
  Cullin, Chain C, Domain 2 UniProtKB/Swiss-Prot
InterPro Cullin UniProtKB/Swiss-Prot
  Cullin_CS UniProtKB/Swiss-Prot
  Cullin_homology UniProtKB/Swiss-Prot
  Cullin_homology_sf UniProtKB/Swiss-Prot
  Cullin_N UniProtKB/Swiss-Prot
  Cullin_neddylation_domain UniProtKB/Swiss-Prot
  Cullin_repeat-like_dom_sf UniProtKB/Swiss-Prot
  WH-like_DNA-bd_sf UniProtKB/Swiss-Prot
  WH_DNA-bd_sf UniProtKB/Swiss-Prot
NCBI Gene 301555 ENTREZGENE
PANTHER PTHR11932 UniProtKB/Swiss-Prot
Pfam Cullin UniProtKB/Swiss-Prot
  Cullin_Nedd8 UniProtKB/Swiss-Prot
PhenoGen Cul3 PhenoGen
PROSITE CULLIN_1 UniProtKB/Swiss-Prot
  CULLIN_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000015633 RatGTEx
SMART CULLIN UniProtKB/Swiss-Prot
  Cullin_Nedd8 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF46785 UniProtKB/Swiss-Prot
  SSF74788 UniProtKB/Swiss-Prot
  SSF75632 UniProtKB/Swiss-Prot
UniProt A0A0G2JSP3_RAT UniProtKB/TrEMBL
  A0A1W2Q6C6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A4V1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ASL8 ENTREZGENE, UniProtKB/TrEMBL
  A6JW85 ENTREZGENE, UniProtKB/TrEMBL
  B5DF89 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Cul3  cullin 3   Cul3_predicted  cullin 3 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Cul3_predicted  cullin 3 (predicted)      Symbol and Name status set to approved 70820 APPROVED