CUL3 (cullin 3) - Rat Genome Database

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Pathways
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Gene: CUL3 (cullin 3) Sus scrofa
Analyze
Symbol: CUL3
Name: cullin 3
RGD ID: 14140793
Description: ENCODES a protein that exhibits ubiquitin-protein transferase activity (ortholog); INVOLVED IN anaphase-promoting complex-dependent catabolic process (ortholog); cell morphogenesis (ortholog); fibroblast apoptotic process (ortholog); PARTICIPATES IN nuclear factor, erythroid 2 like 2 signaling pathway; proteasome degradation pathway involving cullin-dependent ubiquitin ligases; Wnt signaling, canonical pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); autosomal dominant pseudohypoaldosteronism type 1 (ortholog); Episodic Ataxia Type 9 (ortholog); FOUND IN cytoplasm (ortholog); glutamatergic synapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: cullin-3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15126,189,851 - 126,287,005 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115126,191,605 - 126,287,148 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215139,621,601 - 139,781,465 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anaphase-promoting complex-dependent catabolic process  (IEA,ISO)
cell migration  (IEA)
cell morphogenesis  (IEA,ISO)
cellular response to amino acid stimulus  (IEA)
COPII vesicle coating  (IEA)
embryonic cleavage  (IEA)
endoplasmic reticulum to Golgi vesicle-mediated transport  (IEA)
fibroblast apoptotic process  (IEA,ISO)
gastrulation  (IEA,ISO)
gene expression  (IEA)
in utero embryonic development  (IEA,ISO)
inflammatory response  (IEA)
integrin-mediated signaling pathway  (IEA)
liver morphogenesis  (IEA,ISO)
mitotic cell cycle  (IEA,ISO)
mitotic metaphase chromosome alignment  (IEA)
negative regulation of Rho protein signal transduction  (IEA)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
negative regulation of type I interferon production  (IEA)
nuclear protein quality control by the ubiquitin-proteasome system  (IEA)
positive regulation of cytokinesis  (IEA)
positive regulation of mitotic cell cycle phase transition  (IEA)
positive regulation of mitotic metaphase/anaphase transition  (IEA)
positive regulation of protein ubiquitination  (IEA)
positive regulation of TORC1 signaling  (IEA)
proteasome-mediated ubiquitin-dependent protein catabolic process  (IEA,ISO)
protein autoubiquitination  (IEA)
protein catabolic process  (IEA)
protein destabilization  (IEA)
protein K48-linked ubiquitination  (IEA)
protein monoubiquitination  (IEA)
protein polyubiquitination  (IEA,ISO)
protein ubiquitination  (IBA,IEA)
regulation of cellular response to insulin stimulus  (ISO)
regulation of transcription by RNA polymerase II  (IEA,ISO)
regulation protein catabolic process at postsynapse  (IEA)
stem cell division  (IEA)
stress fiber assembly  (IEA)
trophectodermal cellular morphogenesis  (IEA,ISO)
ubiquitin-dependent protein catabolic process  (IEA,ISO)
Wnt signaling pathway  (IEA,ISO)

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
CUL3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15126,189,851 - 126,287,005 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115126,191,605 - 126,287,148 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215139,621,601 - 139,781,465 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CUL3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382224,470,150 - 224,585,363 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2224,470,150 - 224,585,397 (-)EnsemblGRCh38hg38GRCh38
GRCh372225,334,867 - 225,450,080 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362225,043,113 - 225,158,358 (-)NCBINCBI36Build 36hg18NCBI36
Build 342225,160,373 - 225,275,619NCBI
Celera2219,099,731 - 219,215,637 (-)NCBICelera
Cytogenetic Map2q36.2NCBI
HuRef2217,186,560 - 217,301,844 (-)NCBIHuRef
CHM1_12225,341,500 - 225,456,770 (-)NCBICHM1_1
T2T-CHM13v2.02224,952,401 - 225,067,578 (-)NCBIT2T-CHM13v2.0
Cul3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39180,242,640 - 80,318,426 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl180,242,640 - 80,318,197 (-)EnsemblGRCm39 Ensembl
GRCm38180,264,923 - 80,340,690 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl180,264,923 - 80,340,480 (-)EnsemblGRCm38mm10GRCm38
MGSCv37180,263,393 - 80,337,005 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36180,145,842 - 80,219,467 (-)NCBIMGSCv36mm8
Celera180,291,823 - 80,365,420 (-)NCBICelera
Cytogenetic Map1C5NCBI
cM Map141.24NCBI
Cul3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8989,040,987 - 89,118,775 (-)NCBIGRCr8
mRatBN7.2981,592,641 - 81,670,428 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl981,592,641 - 81,670,462 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx990,022,642 - 90,100,355 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0995,151,541 - 95,229,253 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0993,534,067 - 93,611,783 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0986,044,485 - 86,129,066 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl986,044,485 - 86,129,329 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0985,794,367 - 85,853,471 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4979,574,062 - 79,634,396 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1979,757,935 - 79,837,198 (-)NCBI
Celera979,070,793 - 79,129,030 (-)NCBICelera
Cytogenetic Map9q34NCBI
Cul3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554539,564,522 - 9,629,976 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554539,546,554 - 9,629,976 (+)NCBIChiLan1.0ChiLan1.0
CUL3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213127,089,437 - 127,200,964 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B127,104,406 - 127,215,480 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B111,714,533 - 111,827,080 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B230,289,195 - 230,373,537 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B230,289,195 - 230,378,991 (-)Ensemblpanpan1.1panPan2
CUL3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12537,730,903 - 37,819,851 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2537,733,229 - 37,800,886 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2538,338,004 - 38,427,804 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02537,967,156 - 38,056,983 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2537,968,235 - 38,057,261 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12537,907,667 - 37,997,226 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02537,748,392 - 37,838,350 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02537,923,140 - 38,012,960 (-)NCBIUU_Cfam_GSD_1.0
Cul3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303179,724,396 - 179,788,614 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365696,065,367 - 6,132,316 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365696,067,230 - 6,131,467 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CUL3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110110,425,895 - 110,541,431 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10110,425,076 - 110,541,538 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604088,866,367 - 88,980,363 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cul3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624823766,780 - 852,727 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624823767,347 - 854,065 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CUL3
1753 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 9 2 3 5 2 23 2 3 3
Low 1 2
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000017677   ⟹   ENSSSCP00000017198
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl15126,189,851 - 126,286,932 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000048139   ⟹   ENSSSCP00000038142
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl15126,189,851 - 126,264,591 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000102734   ⟹   ENSSSCP00000079200
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl15126,191,609 - 126,287,005 (-)Ensembl
RefSeq Acc Id: XM_021075736   ⟹   XP_020931395
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.115126,191,605 - 126,287,148 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021075737   ⟹   XP_020931396
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.115126,191,605 - 126,287,131 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021075738   ⟹   XP_020931397
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.115126,191,605 - 126,264,446 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_020931395   ⟸   XM_021075736
- Peptide Label: isoform X1
- UniProtKB: A0A4X1U9E1 (UniProtKB/TrEMBL),   A0A8W4FJX5 (UniProtKB/TrEMBL),   A0A8D0J219 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020931396   ⟸   XM_021075737
- Peptide Label: isoform X2
- UniProtKB: A0A4X1U7F0 (UniProtKB/TrEMBL),   F1SR61 (UniProtKB/TrEMBL),   A0A8D0J1F2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020931397   ⟸   XM_021075738
- Peptide Label: isoform X3
- UniProtKB: A0A8D0J1F2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000017198   ⟸   ENSSSCT00000017677
RefSeq Acc Id: ENSSSCP00000038142   ⟸   ENSSSCT00000048139
RefSeq Acc Id: ENSSSCP00000079200   ⟸   ENSSSCT00000102734
Protein Domains
Cullin family profile


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000016234 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005018697 UniProtKB/TrEMBL
  ENSSSCG00015028604 UniProtKB/TrEMBL
  ENSSSCG00025032248 UniProtKB/TrEMBL
  ENSSSCG00030049978 UniProtKB/TrEMBL
  ENSSSCG00035073819 UniProtKB/TrEMBL
  ENSSSCG00040068476 UniProtKB/TrEMBL
  ENSSSCG00045029541 UniProtKB/TrEMBL
  ENSSSCG00050070897 UniProtKB/TrEMBL
  ENSSSCG00055029088 UniProtKB/TrEMBL
  ENSSSCG00060021461 UniProtKB/TrEMBL
  ENSSSCG00065054281 UniProtKB/TrEMBL
  ENSSSCG00070015110 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000017677 ENTREZGENE
  ENSSSCT00000017677.5 UniProtKB/TrEMBL
  ENSSSCT00000048139.2 UniProtKB/TrEMBL
  ENSSSCT00000102734 ENTREZGENE
  ENSSSCT00000102734.1 UniProtKB/TrEMBL
  ENSSSCT00005029657.1 UniProtKB/TrEMBL
  ENSSSCT00005029906.1 UniProtKB/TrEMBL
  ENSSSCT00015037921.1 UniProtKB/TrEMBL
  ENSSSCT00015038178.1 UniProtKB/TrEMBL
  ENSSSCT00025043828.1 UniProtKB/TrEMBL
  ENSSSCT00030069723.1 UniProtKB/TrEMBL
  ENSSSCT00035100150.1 UniProtKB/TrEMBL
  ENSSSCT00040094047.1 UniProtKB/TrEMBL
  ENSSSCT00045050391.1 UniProtKB/TrEMBL
  ENSSSCT00050096703.1 UniProtKB/TrEMBL
  ENSSSCT00055057838.1 UniProtKB/TrEMBL
  ENSSSCT00055057914.1 UniProtKB/TrEMBL
  ENSSSCT00060029107.1 UniProtKB/TrEMBL
  ENSSSCT00065074374.1 UniProtKB/TrEMBL
  ENSSSCT00070029718.1 UniProtKB/TrEMBL
  ENSSSCT00070029725.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/TrEMBL
  Cullin Repeats UniProtKB/TrEMBL
InterPro Cullin UniProtKB/TrEMBL
  Cullin_CS UniProtKB/TrEMBL
  Cullin_homology UniProtKB/TrEMBL
  Cullin_homology_sf UniProtKB/TrEMBL
  Cullin_N UniProtKB/TrEMBL
  Cullin_neddylation_domain UniProtKB/TrEMBL
  Cullin_repeat-like_dom_sf UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/TrEMBL
NCBI Gene CUL3 ENTREZGENE
PANTHER CULLIN-3 UniProtKB/TrEMBL
  PTHR11932 UniProtKB/TrEMBL
Pfam Cullin UniProtKB/TrEMBL
  Cullin_Nedd8 UniProtKB/TrEMBL
PROSITE CULLIN_1 UniProtKB/TrEMBL
  CULLIN_2 UniProtKB/TrEMBL
SMART CULLIN UniProtKB/TrEMBL
  Cullin_Nedd8 UniProtKB/TrEMBL
Superfamily-SCOP SSF46785 UniProtKB/TrEMBL
  SSF74788 UniProtKB/TrEMBL
  SSF75632 UniProtKB/TrEMBL
UniProt A0A287A2J9_PIG UniProtKB/TrEMBL
  A0A4X1U7F0 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1U9E1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0J1F2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0J219 ENTREZGENE, UniProtKB/TrEMBL
  A0A8W4FJX5 ENTREZGENE, UniProtKB/TrEMBL
  F1SR61 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:96091 ENTREZGENE