Med16 (mediator complex subunit 16) - Rat Genome Database

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Gene: Med16 (mediator complex subunit 16) Rattus norvegicus
Analyze
Symbol: Med16
Name: mediator complex subunit 16
RGD ID: 1308001
Description: Predicted to enable nuclear thyroid hormone receptor binding activity and transcription coactivator activity. Predicted to be involved in positive regulation of transcription initiation by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of core mediator complex and mediator complex. Orthologous to human MED16 (mediator complex subunit 16); PARTICIPATES IN RNA polymerase II transcription pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC299607; mediator of RNA polymerase II transcription subunit 16; Thrap5; thyroid hormone receptor associated protein 5
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8710,449,273 - 10,461,797 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl710,449,186 - 10,461,797 (+)EnsemblGRCr8
mRatBN7.279,798,641 - 9,811,172 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl79,798,668 - 9,811,172 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx712,680,662 - 12,693,158 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0714,555,979 - 14,568,475 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0712,417,166 - 12,429,673 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0712,619,739 - 12,632,241 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl712,542,713 - 12,632,298 (+)Ensemblrn6Rnor6.0
Rnor_5.0712,789,458 - 12,801,962 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4711,311,063 - 11,323,562 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera77,973,419 - 7,985,920 (+)NCBICelera
RGSC_v3.1711,312,038 - 11,323,250 (+)NCBI
Cytogenetic Map7q11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
core mediator complex  (IEA,ISO)
mediator complex  (IBA,IEA,ISO)
nucleus  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. The Mediator complex and transcription regulation. Poss ZC, etal., Crit Rev Biochem Mol Biol. 2013 Nov-Dec;48(6):575-608. doi: 10.3109/10409238.2013.840259. Epub 2013 Oct 3.
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:10198638   PMID:11867769   PMID:12093747   PMID:12218053   PMID:15340084   PMID:19946888   PMID:20508642  


Genomics

Comparative Map Data
Med16
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8710,449,273 - 10,461,797 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl710,449,186 - 10,461,797 (+)EnsemblGRCr8
mRatBN7.279,798,641 - 9,811,172 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl79,798,668 - 9,811,172 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx712,680,662 - 12,693,158 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0714,555,979 - 14,568,475 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0712,417,166 - 12,429,673 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0712,619,739 - 12,632,241 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl712,542,713 - 12,632,298 (+)Ensemblrn6Rnor6.0
Rnor_5.0712,789,458 - 12,801,962 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4711,311,063 - 11,323,562 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera77,973,419 - 7,985,920 (+)NCBICelera
RGSC_v3.1711,312,038 - 11,323,250 (+)NCBI
Cytogenetic Map7q11NCBI
MED16
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3819867,963 - 893,187 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl19867,630 - 893,218 (-)Ensemblhg38GRCh38
GRCh3719867,963 - 893,187 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3619818,962 - 844,218 (-)NCBIBuild 36Build 36hg18NCBI36
Build 3419818,961 - 844,218NCBI
Celera19793,449 - 825,585 (-)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef19636,814 - 665,338 (-)NCBIHuRef
CHM1_119867,504 - 891,842 (-)NCBICHM1_1
T2T-CHM13v2.019824,038 - 855,915 (-)NCBIT2T-CHM13v2.0
Med16
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391079,730,543 - 79,744,757 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1079,730,542 - 79,744,757 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381079,894,706 - 79,908,938 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1079,894,708 - 79,908,923 (-)Ensemblmm10GRCm38
MGSCv371079,357,452 - 79,371,683 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361079,297,839 - 79,312,021 (-)NCBIMGSCv36mm8
Celera1080,909,517 - 80,923,748 (-)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Med16
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554956,934,078 - 6,959,190 (+)Ensembl
ChiLan1.0NW_0049554956,939,084 - 6,955,885 (+)NCBIChiLan1.0ChiLan1.0
MED16
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2205,200,059 - 5,224,297 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1194,437,887 - 4,463,688 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v019238,822 - 260,277 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.119840,896 - 864,857 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl19841,367 - 863,080 (-)EnsemblpanPan2panpan1.1
MED16
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12057,771,543 - 57,782,839 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2057,777,827 - 57,782,819 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2057,573,573 - 57,584,839 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02058,513,804 - 58,525,092 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2058,514,422 - 58,525,087 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12057,568,647 - 57,579,908 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02058,048,361 - 58,059,617 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02058,251,302 - 58,262,567 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Med16
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118217,463,817 - 217,482,056 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936588355,353 - 370,859 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936588352,723 - 370,898 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MED16
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl277,492,501 - 77,509,796 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1277,490,953 - 77,526,872 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2277,470,547 - 77,506,670 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MED16
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.16617,998 - 638,340 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660818,275,509 - 8,298,538 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Med16
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248287,695,316 - 7,713,603 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248287,695,401 - 7,713,603 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Med16
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11154,966,826 - 154,978,539 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Med16
70 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:48
Count of miRNA genes:45
Interacting mature miRNAs:48
Transcripts:ENSRNOT00000015257
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7166965846669658Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)7123748937Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7721609752216097Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)71011291699900612Rat
2290372Gluco33Glucose level QTL 332.71blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)7131777942Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7170952746709527Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7132612984Rat
1582260Bw72Body weight QTL 723.20.0043body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582261Bw69Body weight QTL 693.20.0048body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582262Bw75Body weight QTL 7530.0038body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)71011291660150541Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7946087754460877Rat
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7129716167Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134650782Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7132612984Rat

Markers in Region
RH128461  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.279,810,924 - 9,811,130 (+)MAPPERmRatBN7.2
Rnor_6.0712,631,993 - 12,632,198NCBIRnor6.0
Rnor_5.0712,801,715 - 12,801,920UniSTSRnor5.0
RGSC_v3.4711,323,315 - 11,323,520UniSTSRGSC3.4
Celera77,985,673 - 7,985,878UniSTS
Cytogenetic Map7q11UniSTS
BE118278  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8710,450,291 - 10,450,815 (+)Marker Load Pipeline
mRatBN7.279,799,660 - 9,800,184 (+)MAPPERmRatBN7.2
Rnor_6.0712,620,735 - 12,621,258NCBIRnor6.0
Rnor_5.0712,790,457 - 12,790,980UniSTSRnor5.0
RGSC_v3.4711,312,056 - 11,312,579UniSTSRGSC3.4
Celera77,974,412 - 7,974,935UniSTS
RH 3.4 Map747.1UniSTS
Cytogenetic Map7q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 92 59 6 356 192 11 141 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001106768 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006240861 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006240862 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006240864 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006240865 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006240866 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594714 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078637 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078640 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078641 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263164 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263165 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263166 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263167 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263168 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263169 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH474029 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000015257   ⟹   ENSRNOP00000015257
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl710,449,186 - 10,461,797 (+)Ensembl
mRatBN7.2 Ensembl79,798,668 - 9,811,172 (+)Ensembl
Rnor_6.0 Ensembl712,619,774 - 12,631,969 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000080089   ⟹   ENSRNOP00000072279
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl710,449,506 - 10,461,794 (+)Ensembl
mRatBN7.2 Ensembl79,798,668 - 9,811,172 (+)Ensembl
Rnor_6.0 Ensembl712,542,713 - 12,632,298 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000093264   ⟹   ENSRNOP00000076087
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl710,449,304 - 10,461,793 (+)Ensembl
mRatBN7.2 Ensembl79,798,668 - 9,811,172 (+)Ensembl
Rnor_6.0 Ensembl712,624,040 - 12,628,441 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000093524
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl712,626,461 - 12,629,016 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000093620
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl712,629,560 - 12,631,910 (+)Ensembl
RefSeq Acc Id: NM_001106768   ⟹   NP_001100238
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,449,299 - 10,461,797 (+)NCBI
mRatBN7.279,798,668 - 9,811,172 (+)NCBI
Rnor_6.0712,619,742 - 12,632,240 (+)NCBI
Rnor_5.0712,789,458 - 12,801,962 (+)NCBI
RGSC_v3.4711,311,063 - 11,323,562 (+)RGD
Celera77,973,419 - 7,985,920 (+)RGD
Sequence:
RefSeq Acc Id: XM_006240861   ⟹   XP_006240923
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,449,273 - 10,461,795 (+)NCBI
mRatBN7.279,798,641 - 9,811,172 (+)NCBI
Rnor_6.0712,619,739 - 12,632,241 (+)NCBI
Rnor_5.0712,789,458 - 12,801,962 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006240862   ⟹   XP_006240924
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,449,278 - 10,461,795 (+)NCBI
mRatBN7.279,798,646 - 9,811,172 (+)NCBI
Rnor_6.0712,619,739 - 12,632,241 (+)NCBI
Rnor_5.0712,789,458 - 12,801,962 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006240864   ⟹   XP_006240926
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,449,278 - 10,461,795 (+)NCBI
mRatBN7.279,798,697 - 9,811,172 (+)NCBI
Rnor_6.0712,619,739 - 12,632,241 (+)NCBI
Rnor_5.0712,789,458 - 12,801,962 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006240865   ⟹   XP_006240927
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,449,588 - 10,461,795 (+)NCBI
mRatBN7.279,798,952 - 9,811,172 (+)NCBI
Rnor_6.0712,620,062 - 12,632,241 (+)NCBI
Rnor_5.0712,789,458 - 12,801,962 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006240866   ⟹   XP_006240928
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,449,659 - 10,461,795 (+)NCBI
mRatBN7.279,799,000 - 9,811,172 (+)NCBI
Rnor_6.0712,620,062 - 12,632,241 (+)NCBI
Rnor_5.0712,789,458 - 12,801,962 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039078637   ⟹   XP_038934565
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,449,303 - 10,461,795 (+)NCBI
mRatBN7.279,798,663 - 9,811,172 (+)NCBI
RefSeq Acc Id: XM_039078640   ⟹   XP_038934568
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,454,300 - 10,461,795 (+)NCBI
mRatBN7.279,805,230 - 9,811,172 (+)NCBI
RefSeq Acc Id: XM_039078641   ⟹   XP_038934569
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,450,224 - 10,461,378 (+)NCBI
mRatBN7.279,798,641 - 9,810,753 (+)NCBI
RefSeq Acc Id: XM_063263164   ⟹   XP_063119234
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,450,224 - 10,461,795 (+)NCBI
RefSeq Acc Id: XM_063263165   ⟹   XP_063119235
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,449,273 - 10,461,795 (+)NCBI
RefSeq Acc Id: XM_063263166   ⟹   XP_063119236
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,449,312 - 10,461,795 (+)NCBI
RefSeq Acc Id: XM_063263167   ⟹   XP_063119237
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,449,273 - 10,461,795 (+)NCBI
RefSeq Acc Id: XM_063263168   ⟹   XP_063119238
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,449,307 - 10,461,795 (+)NCBI
RefSeq Acc Id: XM_063263169   ⟹   XP_063119239
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,450,224 - 10,459,979 (+)NCBI
RefSeq Acc Id: NP_001100238   ⟸   NM_001106768
- UniProtKB: A6K8V2 (UniProtKB/TrEMBL),   D3ZHA9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006240923   ⟸   XM_006240861
- Peptide Label: isoform X3
- UniProtKB: D3ZHA9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006240924   ⟸   XM_006240862
- Peptide Label: isoform X4
- UniProtKB: D3ZHA9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006240926   ⟸   XM_006240864
- Peptide Label: isoform X6
- UniProtKB: D3ZHA9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006240927   ⟸   XM_006240865
- Peptide Label: isoform X7
- UniProtKB: A0A0G2K2K5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006240928   ⟸   XM_006240866
- Peptide Label: isoform X7
- UniProtKB: A0A0G2K2K5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000072279   ⟸   ENSRNOT00000080089
Ensembl Acc Id: ENSRNOP00000076087   ⟸   ENSRNOT00000093264
Ensembl Acc Id: ENSRNOP00000015257   ⟸   ENSRNOT00000015257
RefSeq Acc Id: XP_038934569   ⟸   XM_039078641
- Peptide Label: isoform X11
- UniProtKB: A6K8V4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934565   ⟸   XM_039078637
- Peptide Label: isoform X2
- UniProtKB: D3ZHA9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934568   ⟸   XM_039078640
- Peptide Label: isoform X10
RefSeq Acc Id: XP_063119235   ⟸   XM_063263165
- Peptide Label: isoform X5
- UniProtKB: D3ZHA9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119237   ⟸   XM_063263167
- Peptide Label: isoform X8
- UniProtKB: D3ZHA9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119238   ⟸   XM_063263168
- Peptide Label: isoform X2
- UniProtKB: D3ZHA9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119236   ⟸   XM_063263166
- Peptide Label: isoform X7
- UniProtKB: A0A0G2K2K5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119234   ⟸   XM_063263164
- Peptide Label: isoform X1
- UniProtKB: D3ZHA9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119239   ⟸   XM_063263169
- Peptide Label: isoform X9
Protein Domains
Mediator complex subunit 16 C-terminal   Mediator complex subunit Med16 N-terminal   Mediator of RNA polymerase II transcription subunit

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZHA9-F1-model_v2 AlphaFold D3ZHA9 1-829 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695042
Promoter ID:EPDNEW_R5566
Type:multiple initiation site
Name:Med16_1
Description:mediator complex subunit 16
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R5567  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0712,619,747 - 12,619,807EPDNEW
RGD ID:13695050
Promoter ID:EPDNEW_R5567
Type:single initiation site
Name:Med16_2
Description:mediator complex subunit 16
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R5566  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0712,629,558 - 12,629,618EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308001 AgrOrtholog
BioCyc Gene G2FUF-34897 BioCyc
Ensembl Genes ENSRNOG00000011315 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000015257 ENTREZGENE
  ENSRNOT00000015257.8 UniProtKB/TrEMBL
  ENSRNOT00000080089 ENTREZGENE
  ENSRNOT00000080089.3 UniProtKB/TrEMBL
  ENSRNOT00000093264 ENTREZGENE
  ENSRNOT00000093264.3 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.10 UniProtKB/TrEMBL
InterPro MED16_bridge UniProtKB/TrEMBL
  Mediator_Med16 UniProtKB/TrEMBL
  Mediator_Med16 UniProtKB/TrEMBL
  Mediator_Med16_C UniProtKB/TrEMBL
  Quinoprot_gluc/sorb_DH UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom UniProtKB/TrEMBL
  WD40_repeat UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/TrEMBL
KEGG Report rno:299607 UniProtKB/TrEMBL
NCBI Gene 299607 ENTREZGENE
PANTHER MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 16 UniProtKB/TrEMBL
  PTHR13224 UniProtKB/TrEMBL
Pfam Med16 UniProtKB/TrEMBL
  Med16_bridge UniProtKB/TrEMBL
  Med16_C UniProtKB/TrEMBL
  WD40 UniProtKB/TrEMBL
PhenoGen Med16 PhenoGen
PROSITE WD_REPEATS_2 UniProtKB/TrEMBL
  WD_REPEATS_REGION UniProtKB/TrEMBL
RatGTEx ENSRNOG00000011315 RatGTEx
SMART WD40 UniProtKB/TrEMBL
Superfamily-SCOP SSF50952 UniProtKB/TrEMBL
  WD40_like UniProtKB/TrEMBL
UniProt A0A0G2K2K5 ENTREZGENE, UniProtKB/TrEMBL
  A0A1W2Q603_RAT UniProtKB/TrEMBL
  A6K8V2 ENTREZGENE, UniProtKB/TrEMBL
  A6K8V4 ENTREZGENE, UniProtKB/TrEMBL
  D3ZHA9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-04 Med16  mediator complex subunit 16  Thrap5_predicted  thyroid hormone receptor associated protein 5 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-12 Thrap5_predicted  thyroid hormone receptor associated protein 5 (predicted)      Symbol and Name status set to approved 70820 APPROVED