Ptpn22 (protein tyrosine phosphatase, non-receptor type 22) - Rat Genome Database

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Gene: Ptpn22 (protein tyrosine phosphatase, non-receptor type 22) Rattus norvegicus
Analyze
Symbol: Ptpn22
Name: protein tyrosine phosphatase, non-receptor type 22
RGD ID: 1307992
Description: Enables protein tyrosine kinase binding activity. Involved in regulation of calcium ion transmembrane transport. Predicted to be located in cytoplasmic side of plasma membrane and perinuclear region of cytoplasm. Predicted to be active in cytoplasm and nucleus. Used to study type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including arthritis (multiple); autoimmune disease of endocrine system (multiple); autoimmune disease of musculoskeletal system (multiple); autoimmune disease of the nervous system (multiple); and vasculitis (multiple). Orthologous to human PTPN22 (protein tyrosine phosphatase non-receptor type 22); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC295338; protein tyrosine phosphatase, non-receptor type 22 (lymphoid); protein tyrosine phosphatase, non-receptor type 8; Ptpn8; tyrosine-protein phosphatase non-receptor type 22
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Iddm26 Iddm33 Iddm55
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82194,055,165 - 194,103,209 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2194,045,746 - 194,103,209 (+)EnsemblGRCr8
mRatBN7.22191,366,761 - 191,414,782 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2191,366,808 - 191,414,779 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2198,963,704 - 199,011,553 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02196,836,441 - 196,884,289 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02191,653,405 - 191,701,246 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02206,342,066 - 206,390,348 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2206,342,066 - 206,390,348 (+)Ensemblrn6Rnor6.0
Rnor_5.02225,765,744 - 225,814,130 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42199,083,186 - 199,144,309 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2183,836,919 - 183,884,957 (+)NCBICelera
RGSC_v3.12199,045,987 - 199,095,515 (+)NCBI
Cytogenetic Map2q34NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to muramyl dipeptide  (ISO)
lipopolysaccharide-mediated signaling pathway  (ISO)
negative regulation of autophagy  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of interleukin-6 production  (ISO)
negative regulation of interleukin-8 production  (ISO)
negative regulation of JUN kinase activity  (ISO)
negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway  (ISO)
negative regulation of p38MAPK cascade  (ISO)
negative regulation of T cell activation  (IBA,ISO,ISS)
negative regulation of T cell receptor signaling pathway  (ISO)
negative regulation of tumor necrosis factor production  (ISO)
phosphoanandamide dephosphorylation  (ISO,ISS)
positive regulation of CD8-positive, alpha-beta T cell proliferation  (ISO)
positive regulation of defense response to virus by host  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of granzyme B production  (ISO)
positive regulation of interferon-alpha production  (ISO)
positive regulation of interferon-beta production  (ISO)
positive regulation of NLRP3 inflammasome complex assembly  (ISO)
positive regulation of protein import into nucleus  (ISO)
positive regulation of protein K63-linked ubiquitination  (ISO)
positive regulation of toll-like receptor 3 signaling pathway  (ISO)
positive regulation of toll-like receptor 4 signaling pathway  (ISO)
positive regulation of toll-like receptor 7 signaling pathway  (ISO)
positive regulation of toll-like receptor 9 signaling pathway  (ISO)
positive regulation of type I interferon production  (ISO)
positive regulation of type II interferon production  (ISO)
protein dephosphorylation  (ISO)
regulation of antigen processing and presentation  (ISO)
regulation of calcium ion transmembrane transport  (IMP)
regulation of innate immune response  (IBA)
regulation of leukocyte migration  (ISO)
regulation of natural killer cell proliferation  (ISO,ISS)
regulation of non-canonical NF-kappaB signal transduction  (IBA,ISO)
regulation of peptidyl-tyrosine phosphorylation  (IMP)
response to lipopolysaccharide  (ISO)
T cell differentiation  (ISO)
T cell receptor signaling pathway  (IBA,ISO)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. The role of PTPN22 gene polymorphism in childhood immune thrombocytopenic purpura. Anis SK, etal., Blood Coagul Fibrinolysis. 2011 Sep;22(6):521-5.
2. Multiplex family-based study in systemic lupus erythematosus: association between the R620W polymorphism of PTPN22 and the FcgammaRIIa (CD32A) R131 allele. Balada E, etal., Tissue Antigens. 2006 Nov;68(5):432-8.
3. The association of the PTPN22 620W polymorphism with Behcet's disease. Baranathan V, etal., Ann Rheum Dis. 2007 Nov;66(11):1531-3. Epub 2007 Jul 27.
4. Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Barrett JC, etal., Nat Genet. 2008 Aug;40(8):955-62. Epub 2008 Jun 29.
5. A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis. Begovich AB, etal., Am J Hum Genet. 2004 Aug;75(2):330-7. Epub 2004 Jun 18.
6. A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes. Bottini N, etal., Nat Genet. 2004 Apr;36(4):337-8. Epub 2004 Mar 7.
7. PTPN22 polymorphism presumably plays a role in the genetic background of chronic spontaneous autoreactive urticaria. Brzoza Z, etal., Dermatology. 2012;224(4):340-5. doi: 10.1159/000339332. Epub 2012 Jun 19.
8. A single-nucleotide polymorphism in the gene encoding lymphoid protein tyrosine phosphatase (PTPN22) confers susceptibility to generalised vitiligo. Canton I, etal., Genes Immun. 2005 Oct;6(7):584-7.
9. High basal activity of the PTPN22 gain-of-function variant blunts leukocyte responsiveness negatively affecting IL-10 production in ANCA vasculitis. Cao Y, etal., PLoS One. 2012;7(8):e42783. doi: 10.1371/journal.pone.0042783. Epub 2012 Aug 3.
10. The protein tyrosine phosphatase N22 gene is associated with juvenile and adult idiopathic inflammatory myopathy independent of the HLA 8.1 haplotype in British Caucasian patients. Chinoy H, etal., Arthritis Rheum. 2008 Oct;58(10):3247-54. doi: 10.1002/art.23900.
11. The PTPN22gain-of-function+1858T(+) genotypes correlate with low IL-2 expression in thymomas and predispose to myasthenia gravis. Chuang WY, etal., Genes Immun. 2009 Dec;10(8):667-72. Epub 2009 Aug 20.
12. Analysis of families in the multiple autoimmune disease genetics consortium (MADGC) collection: the PTPN22 620W allele associates with multiple autoimmune phenotypes. Criswell LA, etal., Am J Hum Genet. 2005 Apr;76(4):561-71. Epub 2005 Feb 17.
13. A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models. Dai X, etal., J Clin Invest. 2013 May 1;123(5):2024-36. doi: 10.1172/JCI66963. Epub 2013 Apr 24.
14. Analysis of the influence of PTPN22 gene polymorphisms in systemic sclerosis. Diaz-Gallo LM, etal., Ann Rheum Dis. 2011 Mar;70(3):454-62. Epub 2010 Dec 3.
15. Protein tyrosine phosphatase non-receptor type 22 gene variants at position 1858 are associated with type 1 and type 2 diabetes in Estonian population. Douroudis K, etal., Tissue Antigens. 2008 Nov;72(5):425-30. Epub 2008 Aug 26.
16. Novel associations for hypothyroidism include known autoimmune risk loci. Eriksson N, etal., PLoS One. 2012;7(4):e34442. Epub 2012 Apr 6.
17. Recipient PTPN22 -1123 C/C genotype predicts acute graft-versus-host disease after HLA fully matched unrelated bone marrow transplantation for hematologic malignancies. Espinoza JL, etal., Biol Blood Marrow Transplant. 2013 Feb;19(2):240-6. doi: 10.1016/j.bbmt.2012.09.014. Epub 2012 Sep 28.
18. PTPN22 controls virally-induced autoimmune diabetes by modulating cytotoxic T lymphocyte responses in an epitope-specific manner. Fousteri G, etal., Clin Immunol. 2015 Feb;156(2):98-108. doi: 10.1016/j.clim.2014.12.002. Epub 2014 Dec 13.
19. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
20. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
21. PTPN22 C1858T polymorphism in women with endometriosis. Gomes FM, etal., Am J Reprod Immunol. 2010 Mar 1;63(3):227-32. Epub 2010 Jan 12.
22. PTPN22 C1858T polymorphism in Colombian patients with autoimmune diseases. Gomez LM, etal., Genes Immun. 2005 Oct;6(7):628-31.
23. Lack of association of a functional single nucleotide polymorphism of PTPN22, encoding lymphoid protein phosphatase, with susceptibility to biopsy-proven giant cell arteritis. Gonzalez-Gay MA, etal., J Rheumatol. 2005 Aug;32(8):1510-2.
24. Genetic evidence of PTPN22 effects on chronic lymphocytic leukemia. Hebbring SJ, etal., Blood. 2013 Jan 3;121(1):237-8. doi: 10.1182/blood-2012-08-450221.
25. Association between the PTPN22 gene and rheumatoid arthritis and juvenile idiopathic arthritis in a UK population: further support that PTPN22 is an autoimmunity gene. Hinks A, etal., Arthritis Rheum. 2005 Jun;52(6):1694-9.
26. Genetic analysis of adult-onset autoimmune diabetes. Howson JM, etal., Diabetes. 2011 Oct;60(10):2645-53. Epub 2011 Aug 26.
27. No evidence for association between 1858 C/T single-nucleotide polymorphism of PTPN22 gene and primary Sjogren's syndrome. Ittah M, etal., Genes Immun. 2005 Aug;6(5):457-8.
28. Association between the PTPN22 +1858 C/T polymorphism and psoriatic arthritis. Juneblad K, etal., Arthritis Res Ther. 2011 Mar 16;13(2):R45.
29. The non-synonymous C1858T substitution in the PTPN22 gene is associated with susceptibility to the severe forms of alopecia areata. Kemp EH, etal., Hum Immunol. 2006 Jul;67(7):535-9. Epub 2006 May 4.
30. The PTPN22-1858C>T (R620W) functional polymorphism is associated with generalized vitiligo in the Romanian population. Laberge GS, etal., Pigment Cell Melanoma Res. 2008 Apr;21(2):206-8. doi: 10.1111/j.1755-148X.2008.00443.x.
31. Association of PTPN22 gene functional variants with development of pulmonary tuberculosis in Moroccan population. Lamsyah H, etal., Tissue Antigens. 2009 Sep;74(3):228-32. Epub 2009 Jun 25.
32. Further genetic evidence for three psoriasis-risk genes: ADAM33, CDKAL1, and PTPN22. Li Y, etal., J Invest Dermatol. 2009 Mar;129(3):629-34. doi: 10.1038/jid.2008.297. Epub 2008 Oct 16.
33. No impact of PTPN22, PTPRJ and ACP1 genes polymorphisms on the risk of immune thrombocytopenia in French adult patients. Lioger B, etal., Thromb Res. 2016 Aug;144:76-8. doi: 10.1016/j.thromres.2016.04.013. Epub 2016 Apr 25.
34. Association of a functional polymorphism of PTPN22 encoding a lymphoid protein phosphatase in bilateral Meniere's disease. Lopez-Escamez JA, etal., Laryngoscope. 2010 Jan;120(1):103-7. doi: 10.1002/lary.20650.
35. Association of Protein Tyrosine Phosphatase Nonreceptor 22 (PTPN22) C1858T gene polymorphism with susceptibility to autoimmune thyroid diseases: a meta-analysis. Luo L, etal., Endocr J. 2012 Feb 25.
36. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
37. PTPN22 association in systemic lupus erythematosus (SLE) with respect to individual ancestry and clinical sub-phenotypes. Namjou B, etal., PLoS One. 2013 Aug 7;8(8):e69404. doi: 10.1371/journal.pone.0069404. eCollection 2013.
38. Overexpression of the autoimmunity-associated phosphatase PTPN22 promotes survival of antigen-stimulated CLL cells by selectively activating AKT. Negro R, etal., Blood. 2012 Jun 28;119(26):6278-87. doi: 10.1182/blood-2012-01-403162. Epub 2012 May 8.
39. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
40. A loss-of-function variant of PTPN22 is associated with reduced risk of systemic lupus erythematosus. Orru V, etal., Hum Mol Genet. 2009 Feb 1;18(3):569-79. doi: 10.1093/hmg/ddn363. Epub 2008 Nov 3.
41. GOA pipeline RGD automated data pipeline
42. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
43. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
44. Comprehensive gene review and curation RGD comprehensive gene curation
45. The PTPN22 R263Q polymorphism is a risk factor for rheumatoid arthritis in Caucasian case-control samples. Rodriguez-Rodriguez L, etal., Arthritis Rheum. 2011 Feb;63(2):365-72. doi: 10.1002/art.30145.
46. Atherosclerosis and PTPN22: a study in coronary artery disease. Saccucci P, etal., Cardiology. 2011;119(1):54-6. Epub 2011 Aug 12.
47. A functional polymorphism of Ptpn22 is associated with type 1 diabetes in the BioBreeding rat. Sarmiento J, etal., J Immunol. 2015 Jan 15;194(2):615-29. doi: 10.4049/jimmunol.1302689. Epub 2014 Dec 12.
48. Identification of the PTPN22 functional variant R620W as susceptibility genetic factor for giant cell arteritis. Serrano A, etal., Ann Rheum Dis. 2013 Nov 1;72(11):1882-6. doi: 10.1136/annrheumdis-2013-203641. Epub 2013 Aug 14.
49. Mutation screening of PTPN22: association of the 1858T-allele with Addison's disease. Skinningsrud B, etal., Eur J Hum Genet. 2008 Aug;16(8):977-82. Epub 2008 Feb 27.
50. Polymorphisms in the PTPN22 region are associated with psoriasis of early onset. Smith RL, etal., Br J Dermatol. 2008 May;158(5):962-8. doi: 10.1111/j.1365-2133.2008.08482.x. Epub 2008 Mar 13.
51. Replication of an association between the lymphoid tyrosine phosphatase locus (LYP/PTPN22) with type 1 diabetes, and evidence for its role as a general autoimmunity locus. Smyth D, etal., Diabetes. 2004 Nov;53(11):3020-3.
52. Preliminary evidence for interaction of PTPN12 polymorphism with TSHR genotype and association with Graves' ophthalmopathy. Syed AA, etal., Clin Endocrinol (Oxf). 2007 Nov;67(5):663-7. Epub 2007 Jul 3.
53. Comparative genetic analysis of inflammatory bowel disease and type 1 diabetes implicates multiple loci with opposite effects. Wang K, etal., Hum Mol Genet. 2010 May 15;19(10):2059-67. doi: 10.1093/hmg/ddq078. Epub 2010 Feb 22.
54. Lack of association between the protein tyrosine phosphatase non-receptor 22 (PTPN22)*620W allele and systemic sclerosis in the French Caucasian population. Wipff J, etal., Ann Rheum Dis. 2006 Sep;65(9):1230-2. Epub 2006 Feb 7.
55. Expression of peptidylarginine deiminase 4 and protein tyrosine phosphatase nonreceptor type 22 in the synovium of collagen-induced arthritis rats. Xu YB, etal., Chin Med Sci J. 2014 Jun;29(2):85-90.
56. [Association of polymorphism of protein tyrosine phosphatase nonreceptor-22 gene with AITD]. Yu ZY, etal., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2008 Aug;24(8):804-7.
57. The protein tyrosine phosphatase, non-receptor type 22 R620W polymorphism does not confer susceptibility to psoriasis in the genetic homogeneous population of Crete. Zervou MI, etal., Genet Test Mol Biomarkers. 2010 Feb;14(1):107-11. doi: 10.1089/gtmb.2009.0130.
58. No association of PTPN22 polymorphisms with susceptibility to ocular Behcet's disease in two Chinese Han populations. Zhang Q, etal., PLoS One. 2012;7(3):e31230. doi: 10.1371/journal.pone.0031230. Epub 2012 Mar 2.
59. Association of PTPN22 1858T/T genotype with type 1 diabetes, Graves' disease but not with rheumatoid arthritis in Russian population. Zhebrun D, etal., Aging (Albany NY). 2011 Apr;3(4):368-73.
60. Meta-analysis reveals an association of PTPN22 C1858T with autoimmune diseases, which depends on the localization of the affected tissue. Zheng J, etal., Genes Immun. 2012 Dec;13(8):641-52. doi: 10.1038/gene.2012.46. Epub 2012 Oct 18.
Additional References at PubMed
PMID:8890164   PMID:10068674   PMID:10940933   PMID:14752163   PMID:16461343   PMID:16938887   PMID:18056643   PMID:18299186   PMID:20522204   PMID:21044313   PMID:23871208   PMID:23991106  


Genomics

Comparative Map Data
Ptpn22
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82194,055,165 - 194,103,209 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2194,045,746 - 194,103,209 (+)EnsemblGRCr8
mRatBN7.22191,366,761 - 191,414,782 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2191,366,808 - 191,414,779 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2198,963,704 - 199,011,553 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02196,836,441 - 196,884,289 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02191,653,405 - 191,701,246 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02206,342,066 - 206,390,348 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2206,342,066 - 206,390,348 (+)Ensemblrn6Rnor6.0
Rnor_5.02225,765,744 - 225,814,130 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42199,083,186 - 199,144,309 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2183,836,919 - 183,884,957 (+)NCBICelera
RGSC_v3.12199,045,987 - 199,095,515 (+)NCBI
Cytogenetic Map2q34NCBI
PTPN22
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381113,813,811 - 113,871,759 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1113,813,811 - 113,871,753 (-)Ensemblhg38GRCh38
GRCh371114,356,433 - 114,414,334 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361114,157,960 - 114,215,857 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341114,068,480 - 114,126,376NCBI
Celera1112,585,654 - 112,643,598 (-)NCBICelera
Cytogenetic Map1p13.2NCBI
HuRef1112,214,556 - 112,272,493 (-)NCBIHuRef
CHM1_11114,471,278 - 114,529,225 (-)NCBICHM1_1
T2T-CHM13v2.01113,825,481 - 113,883,420 (-)NCBIT2T-CHM13v2.0
Ptpn22
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393103,763,891 - 103,819,568 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3103,767,111 - 103,819,563 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm383103,856,575 - 103,912,252 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3103,859,795 - 103,912,247 (+)Ensemblmm10GRCm38
MGSCv373103,664,215 - 103,716,170 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv363103,989,353 - 104,041,308 (+)NCBIMGSCv36mm8
Celera3106,063,559 - 106,114,657 (+)NCBICelera
Cytogenetic Map3F2.2NCBI
cM Map345.52NCBI
Ptpn22
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495543517,082,762 - 17,139,067 (-)NCBIChiLan1.0ChiLan1.0
PTPN22
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21106,474,157 - 106,530,586 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11106,066,567 - 106,123,889 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0188,685,736 - 88,743,164 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11123,734,511 - 123,790,830 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1123,734,511 - 123,790,830 (+)EnsemblpanPan2panpan1.1
PTPN22
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11751,623,628 - 51,683,039 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1751,623,623 - 51,682,858 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1751,274,140 - 51,334,343 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01752,501,113 - 52,561,235 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1752,501,116 - 52,561,182 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11751,508,535 - 51,568,572 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01751,576,143 - 51,636,627 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01752,148,984 - 52,209,317 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ptpn22
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505815,244,798 - 15,296,846 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366902,181,047 - 2,232,958 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366902,180,804 - 2,232,869 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTPN22
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4106,686,604 - 106,758,099 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.14106,692,102 - 106,758,101 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24116,897,216 - 116,927,483 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PTPN22
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12019,792,807 - 19,855,784 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2019,793,083 - 19,855,827 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603822,562,918 - 22,626,522 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ptpn22
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247729,472,913 - 9,550,990 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247729,472,869 - 9,552,751 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Ptpn22
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1354,165,175 - 54,214,052 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ptpn22
514 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:26
Count of miRNA genes:22
Interacting mature miRNAs:26
Transcripts:ENSRNOT00000026556
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2163997722225110681Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2169358774214358774Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170656145239614549Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2149957381221199885Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2138595962205135428Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
61458Bp10Blood pressure QTL 103.42arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2191709311217961898Rat
1581578Cm49Cardiac mass QTL 494.90.01heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2145807215220931416Rat
152025245Scl81Serum cholesterol level QTL 813.49blood cholesterol amount (VT:0000180)2124537199209621565Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)278269809208420281Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2122597372215234002Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2154723085199723085Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2154723085199723085Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2159440891205135267Rat
10043139Iddm55Insulin dependent diabetes mellitus QTL 553.10.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2150313808195313808Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2154723085199723085Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2154723085199723085Rat
1549833Bp257Blood pressure QTL 2570.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170652929215652929Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2159440891220931218Rat
4889834Pur24Proteinuria QTL 245.80.014urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)2171994826205135428Rat
1581499Esta2Estrogen-induced thymic atrophy QTL 2thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2192287802229609668Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2188565047233565047Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2154723085199723085Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2184856304229856304Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2184856304229856304Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2159440760195313808Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2144882354205135428Rat
1298083Bp158Blood pressure QTL 1582.62arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2191709311217961898Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845182205135428Rat
1357991Ael2Aortic elastin QTL 24.20.000071aorta elastin amount (VT:0003905)aortic elastin2169227906214227906Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
1331745Bp203Blood pressure QTL 2034.377arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2192287802221089121Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
61366Iddm3Insulin dependent diabetes mellitus QTL 34.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2192287802237287802Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2184856304229856304Rat
1578671Bmd10Bone mineral density QTL 105.4femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)2175931416220931416Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660251712708Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2182024327227024327Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)278269809205135428Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2159440760228950743Rat
2301408Kidm36Kidney mass QTL 360.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2184482291229482291Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2143344967251712708Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2143746578205135428Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2143344967251712708Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150096616195096616Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2114384617215381366Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2145306936212705578Rat
7488929Bp366Blood pressure QTL 3660.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2187663373195783351Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2186850607231850607Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2113746222205135428Rat
61398Bp50Blood pressure QTL 504.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2192287802237287802Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2114384617215381366Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660223841096Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2117415288205135428Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150096616195096616Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2182635347227635347Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
631522Bp74Blood pressure QTL 740.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2175008837220008837Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2184856304229856304Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2165453811210453811Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2163253030208253030Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166372086229820014Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)276328396209350714Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 159 91 90 59 92 59 6 356 192 11 137 81 91 31 16 16

Sequence


Ensembl Acc Id: ENSRNOT00000026556   ⟹   ENSRNOP00000026556
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2194,055,232 - 194,103,201 (+)Ensembl
mRatBN7.2 Ensembl2191,366,808 - 191,414,779 (+)Ensembl
Rnor_6.0 Ensembl2206,342,066 - 206,390,348 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000120162   ⟹   ENSRNOP00000087016
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2194,055,232 - 194,100,501 (+)Ensembl
mRatBN7.2 Ensembl2191,366,808 - 191,414,779 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000146905   ⟹   ENSRNOP00000107210
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2194,045,746 - 194,103,209 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000158318   ⟹   ENSRNOP00000111980
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2194,055,232 - 194,097,102 (+)Ensembl
RefSeq Acc Id: NM_001106460   ⟹   NP_001099930
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82194,055,244 - 194,103,209 (+)NCBI
mRatBN7.22191,366,808 - 191,414,779 (+)NCBI
Rnor_6.02206,342,066 - 206,390,348 (+)NCBI
Rnor_5.02225,765,744 - 225,814,130 (+)NCBI
RGSC_v3.42199,083,186 - 199,144,309 (+)RGD
Celera2183,836,919 - 183,884,957 (+)RGD
Sequence:
RefSeq Acc Id: XM_039102072   ⟹   XP_038958000
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82194,055,168 - 194,103,203 (+)NCBI
mRatBN7.22191,366,763 - 191,414,782 (+)NCBI
RefSeq Acc Id: XM_063281637   ⟹   XP_063137707
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82194,055,165 - 194,097,097 (+)NCBI
RefSeq Acc Id: NP_001099930   ⟸   NM_001106460
- UniProtKB: D4A2D5 (UniProtKB/TrEMBL),   A6K3N2 (UniProtKB/TrEMBL),   A0A8I6A706 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000026556   ⟸   ENSRNOT00000026556
RefSeq Acc Id: XP_038958000   ⟸   XM_039102072
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A706 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000087016   ⟸   ENSRNOT00000120162
RefSeq Acc Id: XP_063137707   ⟸   XM_063281637
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A706 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000107210   ⟸   ENSRNOT00000146905
Ensembl Acc Id: ENSRNOP00000111980   ⟸   ENSRNOT00000158318
Protein Domains
Tyrosine specific protein phosphatases   Tyrosine-protein phosphatase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A2D5-F1-model_v2 AlphaFold D4A2D5 1-804 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691633
Promoter ID:EPDNEW_R2158
Type:single initiation site
Name:Ptpn22_1
Description:protein tyrosine phosphatase, non-receptor type 22
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02206,342,054 - 206,342,114EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307992 AgrOrtholog
BioCyc Gene G2FUF-51791 BioCyc
Ensembl Genes ENSRNOG00000019614 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000026556 ENTREZGENE
  ENSRNOT00000026556.7 UniProtKB/TrEMBL
  ENSRNOT00000120162.2 UniProtKB/TrEMBL
  ENSRNOT00000146905 ENTREZGENE
  ENSRNOT00000146905.1 UniProtKB/TrEMBL
  ENSRNOT00000158318 ENTREZGENE
  ENSRNOT00000158318.1 UniProtKB/TrEMBL
Gene3D-CATH 3.90.190.10 UniProtKB/TrEMBL
InterPro Dual-sp/Tyr_phosphatase UniProtKB/TrEMBL
  Prot-tyrosine_phosphatase-like UniProtKB/TrEMBL
  PTN12/18/22 UniProtKB/TrEMBL
  PTN22_cat UniProtKB/TrEMBL
  Tyr_Pase_AS UniProtKB/TrEMBL
  Tyr_Pase_cat UniProtKB/TrEMBL
  Tyr_Pase_rcpt/non-rcpt UniProtKB/TrEMBL
KEGG Report rno:295338 UniProtKB/TrEMBL
NCBI Gene 295338 ENTREZGENE
PANTHER TYROSINE PHOSPHATSE N18, PUTATIVE-RELATED UniProtKB/TrEMBL
  TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 22 UniProtKB/TrEMBL
Pfam Y_phosphatase UniProtKB/TrEMBL
PhenoGen Ptpn22 PhenoGen
PRINTS PRTYPHPHTASE UniProtKB/TrEMBL
PROSITE TYR_PHOSPHATASE_1 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_2 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_PTP UniProtKB/TrEMBL
RatGTEx ENSRNOG00000019614 RatGTEx
SMART PTPc UniProtKB/TrEMBL
  PTPc_motif UniProtKB/TrEMBL
Superfamily-SCOP SSF52799 UniProtKB/TrEMBL
UniProt A0A8I6A706 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LXN3_RAT UniProtKB/TrEMBL
  A0ABK0M7P1_RAT UniProtKB/TrEMBL
  A6K3N2 ENTREZGENE, UniProtKB/TrEMBL
  D4A2D5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-21 Ptpn22  protein tyrosine phosphatase, non-receptor type 22  Ptpn22  protein tyrosine phosphatase, non-receptor type 22 (lymphoid)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Ptpn22  protein tyrosine phosphatase, non-receptor type 22 (lymphoid)   Ptpn22_predicted  protein tyrosine phosphatase, non-receptor type 22 (lymphoid) (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Ptpn22_predicted  protein tyrosine phosphatase, non-receptor type 22 (lymphoid) (predicted)  Ptpn8_predicted  protein tyrosine phosphatase, non-receptor type 8 (predicted)  Symbol and Name updated 1299863 APPROVED
2005-01-12 Ptpn8_predicted  protein tyrosine phosphatase, non-receptor type 8 (predicted)      Symbol and Name status set to approved 70820 APPROVED