Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Hmgn1 | Rat | (-)-citrinin | multiple interactions | ISO | HMGN1 (Homo sapiens) | 6480464 | [Citrinin co-treated with ochratoxin A] results in decreased expression of HMGN1 protein | CTD | PMID:39638853 | Hmgn1 | Rat | (1->4)-beta-D-glucan | multiple interactions | ISO | Hmgn1 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of HMGN1 mRNA | CTD | PMID:36331819 | Hmgn1 | Rat | 1,2-dimethylhydrazine | multiple interactions | ISO | Hmgn1 (Mus musculus) | 6480464 | [1,2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of HMGN1 mRNA | CTD | PMID:22206623 | Hmgn1 | Rat | 17alpha-ethynylestradiol | affects expression | ISO | Hmgn1 (Mus musculus) | 6480464 | Ethinyl Estradiol affects the expression of HMGN1 mRNA | CTD | PMID:17555576 | Hmgn1 | Rat | 17alpha-ethynylestradiol | increases expression | EXP | | 6480464 | Ethinyl Estradiol results in increased expression of HMGN1 mRNA | CTD | PMID:17108234 | Hmgn1 | Rat | 17alpha-ethynylestradiol | increases expression | ISO | Hmgn1 (Mus musculus) | 6480464 | Ethinyl Estradiol results in increased expression of HMGN1 mRNA | CTD | PMID:17942748 | Hmgn1 | Rat | 17beta-estradiol | decreases expression | ISO | Hmgn1 (Mus musculus) | 6480464 | Estradiol results in decreased expression of HMGN1 protein | CTD | PMID:26903627 | Hmgn1 | Rat | 17beta-hydroxy-5alpha-androstan-3-one | increases expression | ISO | Hmgn1 (Mus musculus) | 6480464 | Dihydrotestosterone results in increased expression of HMGN1 mRNA | CTD | PMID:17023530 | Hmgn1 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Hmgn1 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of HMGN1 mRNA | CTD | PMID:18796159 | Hmgn1 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of HMGN1 mRNA | CTD | PMID:34747641 | Hmgn1 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Hmgn1 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of HMGN1 mRNA | CTD | PMID:21570461 | Hmgn1 | Rat | 2,4-dibromophenyl 2,4,5-tribromophenyl ether | affects expression | ISO | Hmgn1 (Mus musculus) | 6480464 | 2,2',4,4',5-brominated diphenyl ether affects the expression of HMGN1 mRNA | CTD | PMID:38648751 | Hmgn1 | Rat | 2,4-dinitrotoluene | affects expression | EXP | | 6480464 | 2,4-dinitrotoluene affects the expression of HMGN1 mRNA | CTD | PMID:21346803 | Hmgn1 | Rat | 2,6-dinitrotoluene | affects expression | EXP | | 6480464 | 2,6-dinitrotoluene affects the expression of HMGN1 mRNA | CTD | PMID:21346803 | Hmgn1 | Rat | 2-hydroxypropanoic acid | increases expression | ISO | HMGN1 (Homo sapiens) | 6480464 | Lactic Acid results in increased expression of HMGN1 mRNA | CTD | PMID:30851411 | Hmgn1 | Rat | 4,4'-sulfonyldiphenol | increases expression | ISO | Hmgn1 (Mus musculus) | 6480464 | bisphenol S results in increased expression of HMGN1 mRNA | CTD | PMID:39298647 | Hmgn1 | Rat | 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole | affects expression | EXP | | 6480464 | Omeprazole affects the expression of HMGN1 mRNA | CTD | PMID:19483382 | Hmgn1 | Rat | 6-propyl-2-thiouracil | affects expression | EXP | | 6480464 | Propylthiouracil affects the expression of HMGN1 mRNA | CTD | PMID:19483382 | Hmgn1 | Rat | 6-propyl-2-thiouracil | increases expression | EXP | | 6480464 | Propylthiouracil results in increased expression of HMGN1 mRNA | CTD | PMID:24780913 | Hmgn1 | Rat | acrolein | multiple interactions | ISO | HMGN1 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of more ... | CTD | PMID:32699268|PMID:32845096 | Hmgn1 | Rat | aflatoxin B1 | increases expression | ISO | Hmgn1 (Mus musculus) | 6480464 | Aflatoxin B1 results in increased expression of HMGN1 mRNA | CTD | PMID:19770486 | Hmgn1 | Rat | alpha-pinene | multiple interactions | ISO | HMGN1 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of more ... | CTD | PMID:32699268 | Hmgn1 | Rat | amiodarone | affects expression | EXP | | 6480464 | Amiodarone affects the expression of HMGN1 mRNA | CTD | PMID:19483382 | Hmgn1 | Rat | aristolochic acid A | decreases expression | ISO | HMGN1 (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of HMGN1 mRNA | CTD | PMID:33212167 | Hmgn1 | Rat | benzbromarone | affects expression | EXP | | 6480464 | Benzbromarone affects the expression of HMGN1 mRNA | CTD | PMID:19483382 | Hmgn1 | Rat | benzo[a]pyrene | increases expression | ISO | Hmgn1 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of HMGN1 mRNA | CTD | PMID:20504355|PMID:22610609 | Hmgn1 | Rat | benzo[a]pyrene | decreases methylation | ISO | HMGN1 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of HMGN1 promoter | CTD | PMID:27901495 | Hmgn1 | Rat | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of HMGN1 mRNA | CTD | PMID:25181051|PMID:26982218|PMID:34947998 | Hmgn1 | Rat | bisphenol A | increases expression | ISO | HMGN1 (Homo sapiens) | 6480464 | bisphenol A results in increased expression of HMGN1 protein | CTD | PMID:34186270 | Hmgn1 | Rat | bisphenol A | multiple interactions | ISO | HMGN1 (Homo sapiens) | 6480464 | [[ginger extract results in increased abundance of Oils, Volatile] which co-treated with bisphenol A] affects more ... | CTD | PMID:33376534 | Hmgn1 | Rat | bisphenol A | decreases expression | ISO | HMGN1 (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of HMGN1 protein | CTD | PMID:33376534 | Hmgn1 | Rat | bisphenol AF | increases expression | ISO | HMGN1 (Homo sapiens) | 6480464 | bisphenol AF results in increased expression of HMGN1 protein | CTD | PMID:34186270 | Hmgn1 | Rat | Bisphenol B | increases expression | ISO | HMGN1 (Homo sapiens) | 6480464 | bisphenol B results in increased expression of HMGN1 protein | CTD | PMID:34186270 | Hmgn1 | Rat | bisphenol F | increases expression | ISO | Hmgn1 (Mus musculus) | 6480464 | bisphenol F results in increased expression of HMGN1 mRNA | CTD | PMID:38685157 | Hmgn1 | Rat | C60 fullerene | decreases expression | EXP | | 6480464 | fullerene C60 results in decreased expression of HMGN1 mRNA | CTD | PMID:19167457 | Hmgn1 | Rat | cadmium dichloride | increases expression | EXP | | 6480464 | Cadmium Chloride results in increased expression of HMGN1 mRNA | CTD | PMID:33453195 | Hmgn1 | Rat | caffeine | decreases phosphorylation | ISO | HMGN1 (Homo sapiens) | 6480464 | Caffeine results in decreased phosphorylation of HMGN1 protein | CTD | PMID:35688186 | Hmgn1 | Rat | chloropicrin | affects expression | ISO | HMGN1 (Homo sapiens) | 6480464 | chloropicrin affects the expression of HMGN1 mRNA | CTD | PMID:26352163 | Hmgn1 | Rat | chlorpyrifos | decreases expression | EXP | | 6480464 | Chlorpyrifos results in decreased expression of HMGN1 mRNA | CTD | PMID:18668222 | Hmgn1 | Rat | chromium(6+) | affects expression | ISO | Hmgn1 (Mus musculus) | 6480464 | chromium hexavalent ion affects the expression of HMGN1 mRNA | CTD | PMID:28472532 | Hmgn1 | Rat | cisplatin | decreases expression | ISO | Hmgn1 (Mus musculus) | 6480464 | Cisplatin results in decreased expression of HMGN1 mRNA | CTD | PMID:21151649 | Hmgn1 | Rat | clofibrate | affects expression | EXP | | 6480464 | Clofibrate affects the expression of HMGN1 mRNA | CTD | PMID:19483382 | Hmgn1 | Rat | copper(II) sulfate | decreases expression | ISO | HMGN1 (Homo sapiens) | 6480464 | Copper Sulfate results in decreased expression of HMGN1 mRNA | CTD | PMID:19549813 | Hmgn1 | Rat | coumarin | decreases phosphorylation | ISO | HMGN1 (Homo sapiens) | 6480464 | coumarin results in decreased phosphorylation of HMGN1 protein | CTD | PMID:35688186 | Hmgn1 | Rat | cyproconazole | increases expression | ISO | Hmgn1 (Mus musculus) | 6480464 | cyproconazole results in increased expression of HMGN1 mRNA | CTD | PMID:22334560 | Hmgn1 | Rat | dibutyl phthalate | decreases expression | ISO | Hmgn1 (Mus musculus) | 6480464 | Dibutyl Phthalate results in decreased expression of HMGN1 mRNA | CTD | PMID:21266533 | Hmgn1 | Rat | dicrotophos | decreases expression | ISO | HMGN1 (Homo sapiens) | 6480464 | dicrotophos results in decreased expression of HMGN1 mRNA | CTD | PMID:28302478 | Hmgn1 | Rat | doxorubicin | increases expression | ISO | HMGN1 (Homo sapiens) | 6480464 | Doxorubicin results in increased expression of HMGN1 mRNA | CTD | PMID:29803840 | Hmgn1 | Rat | epoxiconazole | increases expression | ISO | Hmgn1 (Mus musculus) | 6480464 | epoxiconazole results in increased expression of HMGN1 mRNA | CTD | PMID:22334560 | Hmgn1 | Rat | ethanol | affects expression | ISO | Hmgn1 (Mus musculus) | 6480464 | Ethanol affects the expression of HMGN1 mRNA | CTD | PMID:30319688 | Hmgn1 | Rat | flutamide | increases expression | EXP | | 6480464 | Flutamide results in increased expression of HMGN1 mRNA | CTD | PMID:24136188 | Hmgn1 | Rat | folic acid | multiple interactions | ISO | Hmgn1 (Mus musculus) | 6480464 | [1,2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of HMGN1 mRNA | CTD | PMID:22206623 | Hmgn1 | Rat | FR900359 | affects phosphorylation | ISO | HMGN1 (Homo sapiens) | 6480464 | FR900359 affects the phosphorylation of HMGN1 protein | CTD | PMID:37730182 | Hmgn1 | Rat | fulvestrant | decreases methylation | ISO | HMGN1 (Homo sapiens) | 6480464 | Fulvestrant results in decreased methylation of HMGN1 gene | CTD | PMID:31601247 | Hmgn1 | Rat | genistein | multiple interactions | ISO | HMGN1 (Homo sapiens) | 6480464 | ESR1 promotes the reaction [Genistein results in decreased expression of HMGN1 protein] | CTD | PMID:20884965 | Hmgn1 | Rat | genistein | decreases expression | ISO | HMGN1 (Homo sapiens) | 6480464 | Genistein results in decreased expression of HMGN1 protein | CTD | PMID:20884965 | Hmgn1 | Rat | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of HMGN1 mRNA | CTD | PMID:22061828|PMID:33387578 | Hmgn1 | Rat | hydrogen peroxide | multiple interactions | ISO | Hmgn1 (Mus musculus) | 6480464 | N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of HMGN1 protein] | CTD | PMID:31494107 | Hmgn1 | Rat | inulin | multiple interactions | ISO | Hmgn1 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Inulin] results in increased expression of HMGN1 mRNA | CTD | PMID:36331819 | Hmgn1 | Rat | ketamine | decreases expression | EXP | | 6480464 | Ketamine results in decreased expression of HMGN1 mRNA | CTD | PMID:20080153 | Hmgn1 | Rat | L-ethionine | affects expression | EXP | | 6480464 | Ethionine affects the expression of HMGN1 mRNA | CTD | PMID:19483382 | Hmgn1 | Rat | leflunomide | increases expression | EXP | | 6480464 | leflunomide results in increased expression of HMGN1 mRNA | CTD | PMID:24136188 | Hmgn1 | Rat | lipopolysaccharide | increases expression | ISO | Hmgn1 (Mus musculus) | 6480464 | Lipopolysaccharides results in increased expression of HMGN1 mRNA | CTD | PMID:10975854 | Hmgn1 | Rat | methidathion | decreases expression | ISO | Hmgn1 (Mus musculus) | 6480464 | methidathion results in decreased expression of HMGN1 mRNA | CTD | PMID:34813904 | Hmgn1 | Rat | miconazole | increases expression | ISO | Hmgn1 (Mus musculus) | 6480464 | Miconazole results in increased expression of HMGN1 mRNA | CTD | PMID:27462272 | Hmgn1 | Rat | N-nitrosodiethylamine | increases expression | ISO | Hmgn1 (Mus musculus) | 6480464 | Diethylnitrosamine results in increased expression of HMGN1 mRNA | CTD | PMID:17854601 | Hmgn1 | Rat | N-nitrosodiethylamine | multiple interactions | ISO | Hmgn1 (Mus musculus) | 6480464 | RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of HMGN1 mRNA] | CTD | PMID:17854601 | Hmgn1 | Rat | nefazodone | increases expression | EXP | | 6480464 | nefazodone results in increased expression of HMGN1 mRNA | CTD | PMID:24136188 | Hmgn1 | Rat | nimesulide | increases expression | EXP | | 6480464 | nimesulide results in increased expression of HMGN1 mRNA | CTD | PMID:24136188 | Hmgn1 | Rat | nitrates | multiple interactions | ISO | Hmgn1 (Mus musculus) | 6480464 | [Particulate Matter results in increased abundance of Nitrates] which results in increased expression of HMGN1 more ... | CTD | PMID:35964746 | Hmgn1 | Rat | ochratoxin A | multiple interactions | ISO | HMGN1 (Homo sapiens) | 6480464 | [Citrinin co-treated with ochratoxin A] results in decreased expression of HMGN1 protein | CTD | PMID:39638853 | Hmgn1 | Rat | omeprazole | affects expression | EXP | | 6480464 | Omeprazole affects the expression of HMGN1 mRNA | CTD | PMID:19483382 | Hmgn1 | Rat | ozone | multiple interactions | ISO | HMGN1 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of more ... | CTD | PMID:32699268|PMID:32845096 | Hmgn1 | Rat | paracetamol | affects expression | ISO | Hmgn1 (Mus musculus) | 6480464 | Acetaminophen affects the expression of HMGN1 mRNA | CTD | PMID:17562736 | Hmgn1 | Rat | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Hmgn1 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of HMGN1 mRNA; [perfluorooctane sulfonic more ... | CTD | PMID:36331819 | Hmgn1 | Rat | phenobarbital | affects expression | ISO | Hmgn1 (Mus musculus) | 6480464 | Phenobarbital affects the expression of HMGN1 mRNA | CTD | PMID:23091169 | Hmgn1 | Rat | PhIP | increases expression | EXP | | 6480464 | 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of HMGN1 mRNA | CTD | PMID:15215175 | Hmgn1 | Rat | pirinixic acid | multiple interactions | ISO | Hmgn1 (Mus musculus) | 6480464 | PPARA protein promotes the reaction [pirinixic acid results in increased expression of HMGN1 mRNA] | CTD | PMID:17950772 | Hmgn1 | Rat | pirinixic acid | increases expression | ISO | Hmgn1 (Mus musculus) | 6480464 | pirinixic acid results in increased expression of HMGN1 mRNA | CTD | PMID:17950772|PMID:18301758|PMID:23811191 | Hmgn1 | Rat | pirinixic acid | affects expression | EXP | | 6480464 | pirinixic acid affects the expression of HMGN1 mRNA | CTD | PMID:19483382 | Hmgn1 | Rat | propiconazole | increases expression | ISO | Hmgn1 (Mus musculus) | 6480464 | propiconazole results in increased expression of HMGN1 mRNA | CTD | PMID:21278054|PMID:22334560 | Hmgn1 | Rat | rac-lactic acid | increases expression | ISO | HMGN1 (Homo sapiens) | 6480464 | Lactic Acid results in increased expression of HMGN1 mRNA | CTD | PMID:30851411 | Hmgn1 | Rat | resveratrol | multiple interactions | ISO | HMGN1 (Homo sapiens) | 6480464 | [Plant Extracts co-treated with Resveratrol] results in increased expression of HMGN1 mRNA | CTD | PMID:23557933 | Hmgn1 | Rat | sodium arsenate | increases expression | ISO | Hmgn1 (Mus musculus) | 6480464 | sodium arsenate results in increased expression of HMGN1 mRNA | CTD | PMID:39847705 | Hmgn1 | Rat | sodium arsenite | decreases expression | ISO | HMGN1 (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of HMGN1 mRNA | CTD | PMID:38568856 | Hmgn1 | Rat | sodium arsenite | increases expression | ISO | HMGN1 (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of HMGN1 protein | CTD | PMID:39571964 | Hmgn1 | Rat | sodium dichromate | increases expression | EXP | | 6480464 | sodium bichromate results in increased expression of HMGN1 mRNA | CTD | PMID:22561333 | Hmgn1 | Rat | sunitinib | decreases expression | ISO | HMGN1 (Homo sapiens) | 6480464 | Sunitinib results in decreased expression of HMGN1 mRNA | CTD | PMID:31533062 | Hmgn1 | Rat | tamoxifen | affects expression | ISO | Hmgn1 (Mus musculus) | 6480464 | Tamoxifen affects the expression of HMGN1 mRNA | CTD | PMID:17555576 | Hmgn1 | Rat | tetrachloromethane | increases expression | ISO | Hmgn1 (Mus musculus) | 6480464 | Carbon Tetrachloride results in increased expression of HMGN1 mRNA | CTD | PMID:27339419|PMID:31919559 | Hmgn1 | Rat | thioacetamide | affects expression | EXP | | 6480464 | Thioacetamide affects the expression of HMGN1 mRNA | CTD | PMID:19483382 | Hmgn1 | Rat | thiram | decreases expression | ISO | HMGN1 (Homo sapiens) | 6480464 | Thiram results in decreased expression of HMGN1 mRNA | CTD | PMID:38568856 | Hmgn1 | Rat | titanium dioxide | increases methylation | ISO | Hmgn1 (Mus musculus) | 6480464 | titanium dioxide results in increased methylation of HMGN1 gene | CTD | PMID:35295148 | Hmgn1 | Rat | titanium dioxide | decreases methylation | ISO | Hmgn1 (Mus musculus) | 6480464 | titanium dioxide results in decreased methylation of HMGN1 gene; titanium dioxide results in decreased methylation more ... | CTD | PMID:35295148 | Hmgn1 | Rat | trichloroethene | increases expression | ISO | Hmgn1 (Mus musculus) | 6480464 | Trichloroethylene results in increased expression of HMGN1 mRNA | CTD | PMID:19448997 | Hmgn1 | Rat | tungsten | increases expression | ISO | Hmgn1 (Mus musculus) | 6480464 | Tungsten results in increased expression of HMGN1 mRNA | CTD | PMID:30912803 | Hmgn1 | Rat | valdecoxib | increases expression | EXP | | 6480464 | valdecoxib results in increased expression of HMGN1 mRNA | CTD | PMID:24136188 | Hmgn1 | Rat | valproic acid | affects expression | ISO | Hmgn1 (Mus musculus) | 6480464 | Valproic Acid affects the expression of HMGN1 mRNA | CTD | PMID:17292431 | | |||||||||






















