Sphk2 (sphingosine kinase 2) - Rat Genome Database

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Gene: Sphk2 (sphingosine kinase 2) Rattus norvegicus
Analyze
Symbol: Sphk2
Name: sphingosine kinase 2
RGD ID: 1307757
Description: Predicted to enable histone binding activity; sphingosine kinase activity; and sphingosine-1-phosphate receptor activity. Involved in female pregnancy. Predicted to be located in several cellular components, including cytosol; endoplasmic reticulum; and mitochondrial inner membrane. Predicted to be part of nucleosome. Predicted to be active in cytoplasm and membrane. Orthologous to human SPHK2 (sphingosine kinase 2); PARTICIPATES IN ceramide signaling pathway; Fabry disease pathway; Gaucher's disease pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC308589
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81105,317,332 - 105,324,985 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1105,317,333 - 105,321,637 (-)EnsemblGRCr8
mRatBN7.2196,180,872 - 96,188,592 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl196,180,887 - 96,188,391 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1101,566,308 - 101,570,613 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01110,039,006 - 110,043,311 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01103,329,383 - 103,333,688 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01101,692,972 - 101,700,604 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1101,692,973 - 101,697,277 (-)Ensemblrn6Rnor6.0
Rnor_5.01102,771,785 - 102,779,436 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4196,178,615 - 96,182,920 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera190,434,071 - 90,438,377 (-)NCBICelera
RGSC_v3.1196,256,726 - 96,261,031 (-)NCBI
Cytogenetic Map1q22NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
1H-pyrazole  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (EXP,ISO)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Brodifacoum  (EXP)
bupivacaine  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
choline  (ISO)
cobalt dichloride  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (EXP)
Dibutyl phosphate  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
doxorubicin  (ISO)
ethanol  (ISO)
finasteride  (EXP)
fingolimod hydrochloride  (ISO)
flutamide  (EXP)
folic acid  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
gallic acid  (ISO)
hydrogen peroxide  (ISO)
iron dichloride  (ISO)
isobutanol  (ISO)
isoprenaline  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
methotrexate  (ISO)
nefazodone  (EXP)
nickel dichloride  (EXP)
nitrates  (ISO)
okadaic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propiconazole  (ISO)
resveratrol  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
tacrolimus hydrate  (ISO)
temozolomide  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA,ISO)
cytosol  (IEA,ISO)
endomembrane system  (IEA)
endoplasmic reticulum  (IEA,ISO)
membrane  (IEA,ISO)
mitochondrial inner membrane  (IEA,ISO)
mitochondrion  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleosome  (IEA,ISO)
nucleus  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
6. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Signaling pathways involved in sphingosine kinase activation and sphingosine-1-phosphate release in rat myometrium in late pregnancy: role in the induction of cyclooxygenase 2. Serrano-Sanchez M, etal., Endocrinology. 2008 Sep;149(9):4669-79.
Additional References at PubMed
PMID:10751414   PMID:12477932   PMID:16093248   PMID:16103110   PMID:16118219   PMID:16314531   PMID:17346996   PMID:17635916   PMID:17897319   PMID:18805787   PMID:19729656   PMID:20371493  
PMID:20959514   PMID:21084291   PMID:23106337   PMID:25637806   PMID:26621495   PMID:29615132  


Genomics

Comparative Map Data
Sphk2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81105,317,332 - 105,324,985 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1105,317,333 - 105,321,637 (-)EnsemblGRCr8
mRatBN7.2196,180,872 - 96,188,592 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl196,180,887 - 96,188,391 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1101,566,308 - 101,570,613 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01110,039,006 - 110,043,311 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01103,329,383 - 103,333,688 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01101,692,972 - 101,700,604 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1101,692,973 - 101,697,277 (-)Ensemblrn6Rnor6.0
Rnor_5.01102,771,785 - 102,779,436 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4196,178,615 - 96,182,920 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera190,434,071 - 90,438,377 (-)NCBICelera
RGSC_v3.1196,256,726 - 96,261,031 (-)NCBI
Cytogenetic Map1q22NCBI
SPHK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381948,619,506 - 48,630,405 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1948,619,291 - 48,630,717 (+)Ensemblhg38GRCh38
GRCh371949,122,763 - 49,133,662 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361953,814,360 - 53,825,474 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341953,814,359 - 53,825,473NCBI
Celera1945,987,413 - 45,998,527 (+)NCBICelera
Cytogenetic Map19q13.33NCBI
HuRef1945,501,739 - 45,513,199 (+)NCBIHuRef
CHM1_11949,124,423 - 49,135,537 (+)NCBICHM1_1
T2T-CHM13v2.01951,613,990 - 51,624,887 (+)NCBIT2T-CHM13v2.0
Sphk2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39745,358,887 - 45,367,426 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl745,358,891 - 45,367,426 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38745,709,463 - 45,718,002 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl745,709,467 - 45,718,002 (-)Ensemblmm10GRCm38
MGSCv37752,964,833 - 52,973,372 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36745,578,303 - 45,585,957 (-)NCBIMGSCv36mm8
Celera741,172,020 - 41,180,543 (-)NCBICelera
Cytogenetic Map7B3NCBI
cM Map729.45NCBI
Sphk2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555591,917,301 - 1,928,493 (-)Ensembl
ChiLan1.0NW_0049555591,921,479 - 1,929,450 (-)NCBIChiLan1.0ChiLan1.0
SPHK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22054,725,763 - 54,735,466 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11956,652,115 - 56,661,802 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01945,620,980 - 45,631,786 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11954,213,166 - 54,224,033 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1954,213,166 - 54,224,767 (+)EnsemblpanPan2panpan1.1
SPHK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11107,681,425 - 107,689,790 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1107,680,599 - 107,689,707 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1107,202,917 - 107,211,393 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01108,205,468 - 108,213,966 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1108,205,468 - 108,212,765 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11107,872,017 - 107,880,502 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01107,519,318 - 107,527,797 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01108,355,012 - 108,363,506 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Sphk2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934921,050,633 - 21,058,418 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366642,669,920 - 2,676,587 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366642,668,708 - 2,676,608 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPHK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl653,979,012 - 53,986,768 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1653,982,911 - 53,986,779 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2649,726,086 - 49,734,104 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SPHK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1641,865,921 - 41,881,889 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl641,867,139 - 41,881,268 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607321,738,797 - 21,749,747 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sphk2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248325,246,895 - 5,253,207 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248325,246,328 - 5,254,247 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Sphk2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12153,803,260 - 153,810,895 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Sphk2
36 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:55
Count of miRNA genes:49
Interacting mature miRNAs:52
Transcripts:ENSRNOT00000028549
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1102780511182384005Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)192963855109494029Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1101228864146228864Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)191302413136302413Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)1102359314153680016Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)199645382182701046Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of, or within a discrete space in an open field apparatus (CMO:0001514)192683681137683681Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)192683681137683681Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)197582336142582336Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1101594089146594089Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1100345976145345976Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)196717367160111531Rat

Markers in Region
RH94402  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2196,180,566 - 96,180,725 (+)MAPPERmRatBN7.2
Rnor_6.01101,692,667 - 101,692,825NCBIRnor6.0
Rnor_5.01102,771,499 - 102,771,657UniSTSRnor5.0
RGSC_v3.4196,178,310 - 96,178,468UniSTSRGSC3.4
Celera190,433,766 - 90,433,924UniSTS
RH 3.4 Map1909.3UniSTS
Cytogenetic Map1q22UniSTS
RH141779  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2196,180,413 - 96,180,594 (+)MAPPERmRatBN7.2
Rnor_6.01101,692,514 - 101,692,694NCBIRnor6.0
Rnor_5.01102,771,346 - 102,771,526UniSTSRnor5.0
RGSC_v3.4196,178,157 - 96,178,337UniSTSRGSC3.4
Celera190,433,613 - 90,433,793UniSTS
RH 3.4 Map1909.49UniSTS
Cytogenetic Map1q22UniSTS
RH129117  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2196,180,923 - 96,181,112 (+)MAPPERmRatBN7.2
Rnor_6.01101,693,024 - 101,693,212NCBIRnor6.0
Rnor_5.01102,771,856 - 102,772,044UniSTSRnor5.0
RGSC_v3.4196,178,667 - 96,178,855UniSTSRGSC3.4
Celera190,434,123 - 90,434,311UniSTS
RH 3.4 Map1907.59UniSTS
Cytogenetic Map1q22UniSTS
BF415542  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2196,183,765 - 96,183,859 (+)MAPPERmRatBN7.2
Rnor_6.01101,695,866 - 101,695,959NCBIRnor6.0
Rnor_5.01102,774,698 - 102,774,791UniSTSRnor5.0
RGSC_v3.4196,181,509 - 96,181,602UniSTSRGSC3.4
Celera190,436,966 - 90,437,059UniSTS
RH 3.4 Map1908.9UniSTS
Cytogenetic Map1q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001012066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001437823 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001437824 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001437825 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001437826 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001437827 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001437829 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001437830 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001437831 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001437832 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006229085 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006229088 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008759383 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008759384 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112304 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262128 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC095693 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC079120 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211663 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000028549   ⟹   ENSRNOP00000028549
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1105,317,333 - 105,321,637 (-)Ensembl
mRatBN7.2 Ensembl196,180,887 - 96,188,391 (-)Ensembl
Rnor_6.0 Ensembl1101,692,973 - 101,697,277 (-)Ensembl
RefSeq Acc Id: NM_001012066   ⟹   NP_001012066
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81105,317,332 - 105,321,637 (-)NCBI
mRatBN7.2196,180,872 - 96,185,177 (-)NCBI
Rnor_6.01101,692,972 - 101,697,277 (-)NCBI
Rnor_5.01102,771,785 - 102,779,436 (-)NCBI
RGSC_v3.4196,178,615 - 96,182,920 (-)RGD
Celera190,434,071 - 90,438,377 (-)RGD
Sequence:
RefSeq Acc Id: XM_006229085   ⟹   XP_006229147
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81105,317,332 - 105,324,985 (-)NCBI
mRatBN7.2196,180,872 - 96,188,592 (-)NCBI
Rnor_6.01101,692,972 - 101,700,604 (-)NCBI
Rnor_5.01102,771,785 - 102,779,436 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008759383   ⟹   XP_008757605
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81105,317,332 - 105,324,976 (-)NCBI
mRatBN7.2196,180,872 - 96,188,517 (-)NCBI
Rnor_6.01101,692,972 - 101,700,572 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039112297   ⟹   XP_038968225
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81105,317,332 - 105,322,252 (-)NCBI
mRatBN7.2196,180,872 - 96,185,771 (-)NCBI
RefSeq Acc Id: XM_039112304   ⟹   XP_038968232
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81105,317,332 - 105,322,361 (-)NCBI
mRatBN7.2196,180,872 - 96,186,808 (-)NCBI
RefSeq Acc Id: XM_063262128   ⟹   XP_063118198
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81105,317,332 - 105,321,586 (-)NCBI
RefSeq Acc Id: NP_001012066   ⟸   NM_001012066
- UniProtKB: Q6AYB2 (UniProtKB/TrEMBL),   A6JB73 (UniProtKB/TrEMBL),   F7FEJ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229147   ⟸   XM_006229085
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_008757605   ⟸   XM_008759383
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000028549   ⟸   ENSRNOT00000028549
RefSeq Acc Id: XP_038968232   ⟸   XM_039112304
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038968225   ⟸   XM_039112297
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063118198   ⟸   XM_063262128
- Peptide Label: isoform X1
- UniProtKB: A6JB73 (UniProtKB/TrEMBL),   F7FEJ8 (UniProtKB/TrEMBL),   Q6AYB2 (UniProtKB/TrEMBL)
Protein Domains
DAGKc

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6AYB2-F1-model_v2 AlphaFold Q6AYB2 1-616 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690051
Promoter ID:EPDNEW_R575
Type:single initiation site
Name:Sphk2_1
Description:sphingosine kinase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01101,697,294 - 101,697,354EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307757 AgrOrtholog
BioCyc Gene G2FUF-59654 BioCyc
BioCyc Pathway PWY-6483 [ceramide degradation (generic)] BioCyc
  PWY3DJ-11470 [sphingosine and sphingosine-1-phosphate metabolism] BioCyc
BioCyc Pathway Image PWY-6483 BioCyc
  PWY3DJ-11470 BioCyc
Ensembl Genes ENSRNOG00000021032 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000028549 ENTREZGENE
  ENSRNOT00000028549.7 UniProtKB/TrEMBL
Gene3D-CATH 2.60.200.40 UniProtKB/TrEMBL
  Probable inorganic polyphosphate/atp-NAD kinase, domain 1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7126682 IMAGE-MGC_LOAD
InterPro ATP-NAD_kinase_dom_1 UniProtKB/TrEMBL
  ATP-NAD_kinase_PpnK-typ UniProtKB/TrEMBL
  Diacylglycerol_kinase_cat_dom UniProtKB/TrEMBL
  Lipid_Phosphate_FormReg UniProtKB/TrEMBL
  YegS/DAGK_C UniProtKB/TrEMBL
KEGG Report rno:308589 UniProtKB/TrEMBL
MGC_CLONE MGC:94123 IMAGE-MGC_LOAD
NCBI Gene 308589 ENTREZGENE
PANTHER SPHINGOSINE KINASE UniProtKB/TrEMBL
  SPHINGOSINE KINASE 2 UniProtKB/TrEMBL
Pfam DAGK_cat UniProtKB/TrEMBL
  YegS_C UniProtKB/TrEMBL
PhenoGen Sphk2 PhenoGen
PROSITE DAGK UniProtKB/TrEMBL
RatGTEx ENSRNOG00000021032 RatGTEx
SMART DAGKc UniProtKB/TrEMBL
Superfamily-SCOP SSF111331 UniProtKB/TrEMBL
UniProt A6JB73 ENTREZGENE, UniProtKB/TrEMBL
  F7FEJ8 ENTREZGENE, UniProtKB/TrEMBL
  Q6AYB2 ENTREZGENE
UniProt Secondary Q6AYB2 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Sphk2  sphingosine kinase 2  Sphk2_predicted  sphingosine kinase 2 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Sphk2_predicted  sphingosine kinase 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED