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Gene: Pappa (pappalysin 1) Rattus norvegicus

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Symbol:

Pappa

Name:

pappalysin 1 (Ensembl:pappalysin)

RGD ID:

1307742

Description:

Predicted to enable metalloendopeptidase activity. Involved in several processes, including female pregnancy; response to dexamethasone; and response to follicle-stimulating hormone. Located in extracellular space. Human ortholog(s) of this gene implicated in myocardial infarction. Orthologous to human PAPPA (pappalysin 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 3-chloropropane-1,2-diol.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC313262; Pappa1; pappalysin; pappalysin-1; pregnancy-associated plasma protein A

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PAPPA (pappalysin 1)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther
Mus musculus (house mouse):	Pappa (pregnancy-associated plasma protein A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Pappa (pappalysin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PAPPA (pappalysin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PAPPA (pappalysin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Pappa (pappalysin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PAPPA (pappalysin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PAPPA (pappalysin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Pappa (pappalysin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Pappa (pappalysin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	PAPPA (pappalysin 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Pappa (pregnancy-associated plasma protein A)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	pappab (pregnancy-associated plasma protein A, pappalysin 1b)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	pappab (pregnancy-associated plasma protein A, pappalysin 1b)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	pappaa (pregnancy-associated plasma protein A, pappalysin 1a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	pappa	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	83,513,358 - 83,751,364 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	5	83,513,358 - 83,751,361 (+)	Ensembl				GRCr8
mRatBN7.2	5	78,497,660 - 78,735,873 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	78,498,300 - 78,730,666 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	5	80,896,842 - 81,127,185 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	82,714,097 - 82,944,461 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	82,689,523 - 82,919,890 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	80,919,932 - 81,153,904 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	80,920,568 - 81,150,940 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	5	85,016,666 - 85,250,825 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	5	81,826,649 - 82,096,446 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	5	77,424,809 - 77,652,094 (+)	NCBI		Celera
RGSC_v3.1	5	81,831,223 - 82,101,515 (+)	NCBI
Cytogenetic Map	5	q24	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Acute Coronary Syndrome (ISO)

arteriosclerosis (ISO)

carotid artery disease (ISO)

coronary artery disease (ISO)

degenerative disc disease (ISO)

endometriosis (ISO)

Female Infertility (ISO)

genetic disease (ISO)

Hypercholesterolemia (ISO)

hypertension (ISO)

intermediate coronary syndrome (ISO)

myocardial infarction (ISO)

Pregnancy in Diabetics (ISO)

type 2 diabetes mellitus (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

3,4-dichloroaniline (ISO)

3-chloropropane-1,2-diol (EXP)

6-propyl-2-thiouracil (EXP)

8-Br-cAMP (ISO)

actinomycin D (ISO)

aflatoxin B1 (ISO)

Aflatoxin B2 alpha (ISO)

all-trans-retinoic acid (ISO)

amitrole (EXP)

anthra[1,9-cd]pyrazol-6(2H)-one (ISO)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

arsenite(3-) (ISO)

arsenous acid (ISO)

Azoxymethane (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

benzo[e]pyrene (ISO)

Benzo[k]fluoranthene (ISO)

beta-naphthoflavone (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

butanal (ISO)

C60 fullerene (EXP)

cadmium dichloride (ISO)

calcitriol (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chlorpyrifos (ISO)

cisplatin (ISO)

crocidolite asbestos (ISO)

cycloheximide (ISO)

DDE (ISO)

dexamethasone (ISO)

dextran sulfate (ISO)

diarsenic trioxide (ISO)

dibutyl phthalate (ISO)

dimethylarsinic acid (ISO)

dioxygen (ISO)

disodium selenite (ISO)

diuron (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

entinostat (ISO)

ferric oxide (EXP)

formaldehyde (ISO)

geldanamycin (ISO)

gemcitabine (ISO)

gentamycin (EXP)

levonorgestrel (ISO)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

mercury dibromide (ISO)

methapyrilene (ISO)

methimazole (EXP)

methoxychlor (EXP)

methylmercury chloride (ISO)

microcystin-LR (ISO)

N(6)-methyladenosine (ISO)

naphthalene (ISO)

Nutlin-3 (ISO)

Octicizer (ISO)

ozone (ISO)

paracetamol (EXP)

phenethyl isothiocyanate (ISO)

phenylmercury acetate (ISO)

potassium dichromate (ISO)

progesterone (ISO)

raloxifene (ISO)

resveratrol (ISO)

SB 431542 (ISO)

serpentine asbestos (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

succimer (ISO)

sulfadimethoxine (EXP)

sunitinib (ISO)

temozolomide (ISO)

testosterone undecanoate (ISO)

titanium dioxide (ISO)

triadimefon (ISO)

trichloroethene (EXP)

trichostatin A (ISO)

triphenyl phosphate (ISO)

troglitazone (ISO)

valproic acid (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell surface receptor signaling pathway (IBA)

female pregnancy (IEP)

protein catabolic process (IMP)

proteolysis (IBA,IEA)

response to dexamethasone (IMP)

response to follicle-stimulating hormone (IEP)

Cellular Component

extracellular region (IEA,ISO)

extracellular space (IBA,IDA)

Molecular Function

endopeptidase activity (IEA,ISO)

hydrolase activity (IEA)

metal ion binding (IEA)

metalloendopeptidase activity (IBA,ISO)

metallopeptidase activity (IEA,ISO)

peptidase activity (IEA)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Elevated pregnancy-associated plasma protein-a in sera from type 2 diabetic patients with hypercholesterolemia: associations with carotid atherosclerosis and toe-brachial index.	Aso Y, etal., J Clin Endocrinol Metab. 2004 Nov;89(11):5713-7.
2.	Serum plasma pregnancy-associated protein A: a potential marker of echogenic carotid atherosclerotic plaques in asymptomatic hyperlipidemic subjects at high cardiovascular risk.	Beaudeux JL, etal., Arterioscler Thromb Vasc Biol. 2003 Jan 1;23(1):e7-10.
3.	Relationship among pregnancy associated plasma protein-A levels, clinical characteristics, and coronary artery disease extent in patients with chronic stable angina pectoris.	Cosin-Sales J, etal., Eur Heart J. 2005 Oct;26(20):2093-8. Epub 2005 Jul 29.
4.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
6.	Immunolocalization and biochemical evidence of pregnancy-associated plasma protein A in the intervertebral disc.	Gruber HE, etal., Spine (Phila Pa 1976). 2008 Jun 15;33(14):E447-54. doi: 10.1097/BRS.0b013e318178e642.
7.	Genetic deletion of pregnancy-associated plasma protein-A is associated with resistance to atherosclerotic lesion development in apolipoprotein E-deficient mice challenged with a high-fat diet.	Harrington SC, etal., Circ Res. 2007 Jun 22;100(12):1696-702. Epub 2007 May 17.
8.	Pregnancy-associated plasma protein-A proteolytic activity in rat vertebral cell cultures: stimulation by dexamethasone--a potential mechanism for glucocorticoid regulation of osteoprogenitor proliferation and differentiation.	Jia D and Heersche JN, J Cell Physiol. 2005 Sep;204(3):848-58.
9.	Pregnancy-associated plasma protein-a production in rat granulosa cells: stimulation by follicle-stimulating hormone and inhibition by the oocyte-derived bone morphogenetic protein-15.	Matsui M, etal., Endocrinology. 2004 Aug;145(8):3686-95. Epub 2004 Apr 15.
10.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
11.	Increased pregnancy-associated plasma protein-A as a marker for peripheral atherosclerosis: results from the Linz Peripheral Arterial Disease Study.	Mueller T, etal., Clin Chem. 2006 Jun;52(6):1096-103. Epub 2006 Apr 13.
12.	Genetic polymorphism in the pregnancy-associated plasma protein-A associated with acute myocardial infarction.	Park S, etal., Coron Artery Dis. 2007 Sep;18(6):417-22.
13.	Serum levels of human placental lactogen, pregnancy-associated plasma protein A and endometrial secretory protein PP14 in first trimester of diabetic pregnancy.	Pedersen JF, etal., Acta Obstet Gynecol Scand. 1998 Feb;77(2):155-8.
14.	Pregnancy-associated plasma protein-a levels are related to glycemic control but not to lipid profile or hemostatic parameters in type 2 diabetes.	Pellitero S, etal., Diabetes Care. 2007 Dec;30(12):3083-5. Epub 2007 Aug 29.
15.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
17.	Increased levels of pregnancy-associated plasma protein-A in patients with hypercholesterolemia: the effect of atorvastatin treatment.	Stulc T, etal., Am Heart J. 2003 Dec;146(6):E21.
18.	Detection and immunohistochemical localization of alpha 1-pregnancy-associated protein (alpha 1-PAP) in rats.	Waites GT, etal., Immunology. 1986 Jun;58(2):303-9.
19.	Decreased first trimester PAPP-A is a predictor of adverse pregnancy outcome.	Yaron Y, etal., Prenat Diagn. 2002 Sep;22(9):778-82.

Additional References at PubMed

PMID:10077652	PMID:11513734	PMID:11985604	PMID:22204188	PMID:23169786	PMID:24006456	PMID:27537370	PMID:34906040	PMID:39244846

Genomics

Comparative Map Data

Pappa
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	83,513,358 - 83,751,364 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	5	83,513,358 - 83,751,361 (+)	Ensembl				GRCr8
mRatBN7.2	5	78,497,660 - 78,735,873 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	78,498,300 - 78,730,666 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	5	80,896,842 - 81,127,185 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	82,714,097 - 82,944,461 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	82,689,523 - 82,919,890 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	80,919,932 - 81,153,904 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	80,920,568 - 81,150,940 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	5	85,016,666 - 85,250,825 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	5	81,826,649 - 82,096,446 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	5	77,424,809 - 77,652,094 (+)	NCBI		Celera
RGSC_v3.1	5	81,831,223 - 82,101,515 (+)	NCBI
Cytogenetic Map	5	q24	NCBI

PAPPA
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	9	116,153,791 - 116,402,321 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	9	116,153,791 - 116,402,321 (+)	Ensembl			hg38	GRCh38
GRCh37	9	118,916,070 - 119,164,600 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	117,955,892 - 118,204,421 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	9	115,995,624 - 116,244,153	NCBI
Celera	9	89,563,743 - 89,812,291 (+)	NCBI		Celera
Cytogenetic Map	9	q33.1	NCBI
HuRef	9	88,522,043 - 88,770,156 (+)	NCBI		HuRef
CHM1_1	9	119,062,528 - 119,311,011 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	9	128,346,843 - 128,595,327 (+)	NCBI		T2T-CHM13v2.0

Pappa
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	65,041,993 - 65,276,776 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	65,042,411 - 65,275,746 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	4	65,124,174 - 65,357,509 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	65,124,174 - 65,357,509 (+)	Ensembl			mm10	GRCm38
MGSCv37	4	64,785,208 - 65,018,543 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	4	64,610,535 - 64,843,870 (+)	NCBI		MGSCv36	mm8
Celera	4	63,757,793 - 63,990,719 (+)	NCBI		Celera
Cytogenetic Map	4	C1	NCBI
cM Map	4	34.14	NCBI

Pappa
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955419	11,420,638 - 11,646,145 (-)	Ensembl
ChiLan1.0	NW_004955419	11,415,666 - 11,645,994 (-)	NCBI	ChiLan1.0	ChiLan1.0

PAPPA
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	11	22,942,556 - 23,192,781 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	9	22,944,917 - 23,192,972 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	9	87,287,289 - 87,535,414 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	9	115,671,212 - 115,889,135 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	9	115,671,212 - 115,883,435 (+)	Ensembl			panPan2	panpan1.1

PAPPA
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	11	69,979,295 - 70,220,256 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	11	69,982,268 - 70,219,550 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	11	68,392,497 - 68,629,030 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	11	71,108,595 - 71,345,430 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	11	71,107,725 - 71,343,011 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	11	69,628,797 - 69,865,662 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	11	69,664,343 - 69,901,964 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	11	70,393,453 - 70,630,160 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Pappa
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	185,275,435 - 185,613,104 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936487	5,144,044 - 5,376,367 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936487	5,000,279 - 5,379,786 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PAPPA
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	256,544,928 - 256,780,760 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	1	256,544,496 - 256,784,813 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	287,904,036 - 288,142,436 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PAPPA
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	12	23,182,856 - 23,427,092 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	12	23,184,704 - 23,427,165 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666035	19,450,870 - 19,695,969 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Pappa
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624760	18,848,021 - 19,078,657 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624760	18,842,353 - 19,078,657 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Pappa
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	1	88,345,955 - 88,534,416 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Pappa
1587 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	165
Count of miRNA genes:	120
Interacting mature miRNAs:	144
Transcripts:	ENSRNOT00000040898
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1300115	Hrtrt7	Heart rate QTL 7	2.76		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	5	52665372	94894052	Rat
1357396	Bw44	Body weight QTL 44	4.19		body mass (VT:0001259)	body weight (CMO:0000012)	5	73779642	118779642	Rat
1549845	Scl44	Serum cholesterol level QTL 44	6		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	44924861	153890773	Rat
61380	Edpm5	Estrogen-dependent pituitary mass QTL 5	4.5	0.92	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	5	73779642	103472210	Rat
70212	Niddm25	Non-insulin dependent diabetes mellitus QTL 25	3.54		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	5	38207390	136631402	Rat
61386	Bp49	Blood pressure QTL 49	16.6		cerebrum integrity trait (VT:0010549)	brain infarction volume (CMO:0001013)	5	65089051	103648916	Rat
1331801	Rf33	Renal function QTL 33	4.149		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	5	48523123	134369373	Rat
2302381	Bw84	Body weight QTL 84	4.47		body mass (VT:0001259)	body mass index (BMI) (CMO:0000105)	5	73779642	118779642	Rat
1357402	Bw46	Body weight QTL 46	4.47		body mass (VT:0001259)	body mass index (BMI) (CMO:0000105)	5	73779642	118779642	Rat
61393	Bp7	Blood pressure QTL 7	4.5	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	65089051	166764498	Rat
1331782	Rf36	Renal function QTL 36	3.296		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	5	39019942	102105896	Rat
1578766	Tcas11	Tongue tumor susceptibility QTL 11	4.12		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	5	51657967	166600247	Rat
1576312	Emca8	Estrogen-induced mammary cancer QTL 8	4.1		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	55124766	172190305	Rat
1641912	Alcrsp18	Alcohol response QTL 18			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	5	39985948	84985948	Rat
7394708	Emca11	Estrogen-induced mammary cancer QTL 11			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	73176602	118176602	Rat
1576317	Eutr2	Estrogen induced uterine response QTL 2		0.01	uterus integrity trait (VT:0010575)	pyometritis severity score (CMO:0002009)	5	39526924	84526924	Rat
1331773	Scl26	Serum cholesterol level QTL 26	3.065		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	48523123	91770353	Rat
1578673	Bmd13	Bone mineral density QTL 13	4.9		femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	5	69474415	114474415	Rat
70189	Mcs5	Mammary carcinoma susceptibility QTL 5	10.51		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	60601597	137492949	Rat
1331771	Rf35	Renal function QTL 35	4.36965		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	5	10019064	91770353	Rat
61359	Eaex	Experimental allergic encephalomyelitis QTL x	3		nervous system integrity trait (VT:0010566)	post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)	5	60511627	105511627	Rat
2290448	Scl54	Serum cholesterol level QTL 54	2.93		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	36460764	136631402	Rat
61426	Scl2	Serum cholesterol level QTL 2	7.3	0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	64589016	109589016	Rat
1354598	Srn6	Serum renin concentration QTL 6	3.8		blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	5	74335621	156302135	Rat
1600362	Mcs19	Mammary carcinoma susceptibility QTL 19	2.5		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	82032155	127032155	Rat
2290005	Mcs24	Mammary carcinoma susceptibility QTL 24			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	69835120	114835120	Rat
1331756	Rf34	Renal function QTL 34	4.16275		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	5	10019064	87027358	Rat
2306971	Anxrr21	Anxiety related response QTL 21	9.47		fear/anxiety-related behavior trait (VT:1000241)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	5	70969494	136328156	Rat
2316954	Rf57	Renal function QTL 57	0		kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	5	64589016	93503770	Rat
2316959	Gluco59	Glucose level QTL 59	4.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	5	56546393	101546393	Rat
2312671	Scl64	Serum cholesterol level QTL 64		0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	73779642	118779642	Rat
2316957	Pur21	Proteinuria QTL 21	6.2		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	5	64589016	91762830	Rat

Markers in Region

RH139343

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	78,723,105 - 78,723,237 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	81,144,580 - 81,144,711	NCBI	Rnor6.0
Rnor_5.0	5	85,241,510 - 85,241,641	UniSTS	Rnor5.0
RGSC_v3.4	5	82,090,073 - 82,090,204	UniSTS	RGSC3.4
Celera	5	77,645,706 - 77,645,837	UniSTS
RH 3.4 Map	3	946.9	UniSTS
Cytogenetic Map	5	q24	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	11	67	144	72	71	40	25	40	6	268	123	11	123	81	92	31	16	16

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001401319	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039109884	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473978	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000040898 ⟹ ENSRNOP00000046248

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	5	80,920,621 - 81,150,940 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000076111 ⟹ ENSRNOP00000068120

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	5	83,513,358 - 83,739,178 (+)	Ensembl
mRatBN7.2 Ensembl	5	78,498,949 - 78,729,466 (+)	Ensembl
Rnor_6.0 Ensembl	5	80,920,568 - 81,150,929 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000076467 ⟹ ENSRNOP00000068419

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	5	83,513,358 - 83,733,719 (+)	Ensembl
mRatBN7.2 Ensembl	5	78,498,300 - 78,730,666 (+)	Ensembl
Rnor_6.0 Ensembl	5	80,920,568 - 81,150,929 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000126167 ⟹ ENSRNOP00000099637

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	5	83,513,358 - 83,751,361 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000164842 ⟹ ENSRNOP00000102729

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	5	83,513,358 - 83,751,361 (+)	Ensembl

RefSeq Acc Id:

NM_001401319 ⟹ NP_001388248

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	83,513,358 - 83,751,361 (+)	NCBI
mRatBN7.2	5	78,497,863 - 78,735,870 (+)	NCBI

RefSeq Acc Id:

XM_039109884 ⟹ XP_038965812

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	83,579,333 - 83,751,364 (+)	NCBI
mRatBN7.2	5	78,563,829 - 78,735,873 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001388248	(Get FASTA)	NCBI Sequence Viewer
	XP_038965812	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM10508	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000068120.2
	ENSRNOP00000068419.2
	ENSRNOP00000099637.1
	ENSRNOP00000102729
	ENSRNOP00000102729.1

Ensembl Acc Id:

ENSRNOP00000046248 ⟸ ENSRNOT00000040898

Ensembl Acc Id:

ENSRNOP00000068120 ⟸ ENSRNOT00000076111

Ensembl Acc Id:

ENSRNOP00000068419 ⟸ ENSRNOT00000076467

RefSeq Acc Id:	XP_038965812 ⟸ XM_039109884
- Peptide Label:	isoform X1

RefSeq Acc Id:	NP_001388248 ⟸ NM_001401319
- Peptide Label:	precursor
- UniProtKB:	A0A096MK86 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000102729 ⟸ ENSRNOT00000164842

Ensembl Acc Id:

ENSRNOP00000099637 ⟸ ENSRNOT00000126167

Protein Domains

Sushi

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-A0A096MJG5-F1-model_v2	AlphaFold	A0A096MJG5	1-1502	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13693811

Promoter ID:

EPDNEW_R4330

Type:

single initiation site

Name:

Pappa1_1

Description:

pappalysin 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	5	80,920,555 - 80,920,615	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1307742	AgrOrtholog
BioCyc Gene	G2FUF-41040	BioCyc
Ensembl Genes	ENSRNOG00000033527	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000076111.4	UniProtKB/TrEMBL
	ENSRNOT00000076467.4	UniProtKB/TrEMBL
	ENSRNOT00000126167.1	UniProtKB/TrEMBL
	ENSRNOT00000164842	ENTREZGENE
	ENSRNOT00000164842.1	UniProtKB/TrEMBL
Gene3D-CATH	2.60.120.200	UniProtKB/TrEMBL
	3.30.300.320	UniProtKB/TrEMBL
	3.40.390.10	UniProtKB/TrEMBL
	Complement Module, domain 1	UniProtKB/TrEMBL
InterPro	ConA-like_subgrp	UniProtKB/TrEMBL
	LamG-like	UniProtKB/TrEMBL
	MetalloPept_cat_dom	UniProtKB/TrEMBL
	Myxo_disulph_rpt	UniProtKB/TrEMBL
	Notch_dom	UniProtKB/TrEMBL
	PAPPA/PAPPA2	UniProtKB/TrEMBL
	Peptidase_M43	UniProtKB/TrEMBL
	Sushi/SCR/CCP_sf	UniProtKB/TrEMBL
	Sushi_SCR_CCP	UniProtKB/TrEMBL
NCBI Gene	313262	ENTREZGENE
PANTHER	PTHR46130	UniProtKB/TrEMBL
	PTHR46130:SF2	UniProtKB/TrEMBL
Pfam	Laminin_G_3	UniProtKB/TrEMBL
	Peptidase_M43	UniProtKB/TrEMBL
	Sushi	UniProtKB/TrEMBL
PhenoGen	Pappa	PhenoGen
PROSITE	SUSHI	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000033527	RatGTEx
SMART	CCP	UniProtKB/TrEMBL
	LamGL	UniProtKB/TrEMBL
	SM00004	UniProtKB/TrEMBL
Superfamily-SCOP	Complement_control_module	UniProtKB/TrEMBL
	ConA_like_lec_gl	UniProtKB/TrEMBL
	Metalloproteases ('zincins'), catalytic domain	UniProtKB/TrEMBL
UniProt	A0A096MJG5_RAT	UniProtKB/TrEMBL
	A0A096MK86	ENTREZGENE, UniProtKB/TrEMBL
	A0ABK0L6N9_RAT	UniProtKB/TrEMBL
	A0ABK0LMY4_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2025-10-31	Pappa	pappalysin 1	Pappa	pappalysin	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2022-09-30	Pappa	pappalysin	Pappa1	pappalysin 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2017-03-27	Pappa1	pappalysin 1	Pappa	pregnancy-associated plasma protein A	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Pappa	pregnancy-associated plasma protein A	Pappa_predicted	pregnancy-associated plasma protein A (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Pappa_predicted	pregnancy-associated plasma protein A (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

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Imported Disease Annotations - ClinVar

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