PAPPA (pappalysin 1) - Rat Genome Database

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Gene: PAPPA (pappalysin 1) Chlorocebus sabaeus
Analyze
Symbol: PAPPA
Name: pappalysin 1
RGD ID: 18575788
Description: ENCODES a protein that exhibits endopeptidase activity (ortholog); INVOLVED IN female pregnancy (ortholog); protein catabolic process (ortholog); response to dexamethasone (ortholog); ASSOCIATED WITH Acute Coronary Syndrome (ortholog); arteriosclerosis (ortholog); autosomal dominant nonsyndromic deafness 56 (ortholog); FOUND IN extracellular region (ortholog); extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: pappalysin-1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11223,182,856 - 23,427,092 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1223,184,704 - 23,427,165 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603519,450,870 - 19,695,969 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
PAPPA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11223,182,856 - 23,427,092 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1223,184,704 - 23,427,165 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603519,450,870 - 19,695,969 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
PAPPA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389116,153,791 - 116,402,321 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9116,153,791 - 116,402,321 (+)EnsemblGRCh38hg38GRCh38
GRCh379118,916,070 - 119,164,600 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369117,955,892 - 118,204,421 (+)NCBINCBI36Build 36hg18NCBI36
Build 349115,995,624 - 116,244,153NCBI
Celera989,563,743 - 89,812,291 (+)NCBICelera
Cytogenetic Map9q33.1NCBI
HuRef988,522,043 - 88,770,156 (+)NCBIHuRef
CHM1_19119,062,528 - 119,311,011 (+)NCBICHM1_1
T2T-CHM13v2.09128,346,843 - 128,595,327 (+)NCBIT2T-CHM13v2.0
Pappa
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39465,041,993 - 65,276,776 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl465,042,411 - 65,275,746 (+)EnsemblGRCm39 Ensembl
GRCm38465,124,174 - 65,357,509 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl465,124,174 - 65,357,509 (+)EnsemblGRCm38mm10GRCm38
MGSCv37464,785,208 - 65,018,543 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36464,610,535 - 64,843,870 (+)NCBIMGSCv36mm8
Celera463,757,793 - 63,990,719 (+)NCBICelera
Cytogenetic Map4C1NCBI
cM Map434.14NCBI
Pappa
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8583,513,358 - 83,751,364 (+)NCBIGRCr8
mRatBN7.2578,497,660 - 78,735,873 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl578,498,300 - 78,730,666 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx580,896,842 - 81,127,185 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0582,714,097 - 82,944,461 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0582,689,523 - 82,919,890 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0580,919,932 - 81,153,904 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl580,920,568 - 81,150,940 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0585,016,666 - 85,250,825 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4581,826,649 - 82,096,446 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1581,831,223 - 82,101,515 (+)NCBI
Celera577,424,809 - 77,652,094 (+)NCBICelera
Cytogenetic Map5q24NCBI
Pappa
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541911,420,638 - 11,646,145 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541911,415,666 - 11,645,994 (-)NCBIChiLan1.0ChiLan1.0
PAPPA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21122,942,556 - 23,192,781 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1922,944,917 - 23,192,972 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0987,287,289 - 87,535,414 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19115,671,212 - 115,889,135 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9115,671,212 - 115,883,435 (+)Ensemblpanpan1.1panPan2
PAPPA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11169,979,295 - 70,220,256 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1169,982,268 - 70,219,550 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1168,392,497 - 68,629,030 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01171,108,595 - 71,345,430 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1171,107,725 - 71,343,011 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11169,628,797 - 69,865,662 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01169,664,343 - 69,901,964 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01170,393,453 - 70,630,160 (+)NCBIUU_Cfam_GSD_1.0
Pappa
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947185,275,435 - 185,613,104 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364875,144,044 - 5,376,367 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364875,000,279 - 5,379,786 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PAPPA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1256,544,928 - 256,780,760 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11256,544,496 - 256,784,813 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21287,904,036 - 288,142,436 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pappa
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476018,848,021 - 19,078,657 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476018,842,353 - 19,078,657 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium
Low 27 12 37
Below cutoff 9 5 23

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000011089   ⟹   ENSCSAP00000009173
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl1223,184,704 - 23,427,165 (-)Ensembl
RefSeq Acc Id: XM_037982479   ⟹   XP_037838407
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366603519,450,870 - 19,695,969 (+)NCBI
Protein Sequences
Protein RefSeqs XP_037838407 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000009173.1
Reference Protein Sequences
RefSeq Acc Id: ENSCSAP00000009173   ⟸   ENSCSAT00000011089
RefSeq Acc Id: XP_037838407   ⟸   XM_037982479
- UniProtKB: A0A0D9RKN4 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000013073 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000011089.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.200 UniProtKB/TrEMBL
  3.40.390.10 UniProtKB/TrEMBL
  Complement Module, domain 1 UniProtKB/TrEMBL
InterPro ConA-like_dom_sf UniProtKB/TrEMBL
  LamG-like UniProtKB/TrEMBL
  MetalloPept_cat_dom_sf UniProtKB/TrEMBL
  Myxo_disulph_rpt UniProtKB/TrEMBL
  Notch_dom UniProtKB/TrEMBL
  PAPPA/PAPPA2 UniProtKB/TrEMBL
  Peptidase_M43 UniProtKB/TrEMBL
  Sushi/SCR/CCP_sf UniProtKB/TrEMBL
  Sushi_SCR_CCP_dom UniProtKB/TrEMBL
NCBI Gene PAPPA ENTREZGENE
PANTHER PTHR46130 UniProtKB/TrEMBL
  PTHR46130:SF2 UniProtKB/TrEMBL
Pfam Laminin_G_3 UniProtKB/TrEMBL
  Peptidase_M43 UniProtKB/TrEMBL
  Sushi UniProtKB/TrEMBL
PROSITE SUSHI UniProtKB/TrEMBL
SMART CCP UniProtKB/TrEMBL
  LamGL UniProtKB/TrEMBL
  SM00004 UniProtKB/TrEMBL
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/TrEMBL
  SSF49899 UniProtKB/TrEMBL
  SSF57535 UniProtKB/TrEMBL
UniProt A0A0D9RKN4 ENTREZGENE, UniProtKB/TrEMBL