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Gene: Atf1 (activating transcription factor 1) Rattus norvegicus

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Symbol:

Atf1

Name:

activating transcription factor 1

RGD ID:

1307360

Description:

Enables DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in several processes, including positive regulation of neuron projection development; positive regulation of nucleobase-containing compound metabolic process; and response to cobalt ion. Part of transcription regulator complex. Biomarker of polycystic kidney disease. Orthologous to human ATF1 (activating transcription factor 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

Atf-1; cyclic AMP-dependent transcription factor ATF-1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ATF1 (activating transcription factor 1)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI
Mus musculus (house mouse):	Atf1 (activating transcription factor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Atf1 (activating transcription factor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ATF1 (activating transcription factor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	ATF1 (activating transcription factor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Atf1 (activating transcription factor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ATF1 (activating transcription factor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	ATF1 (activating transcription factor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Atf1 (activating transcription factor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Atf1 (activating transcription factor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	ATF1 (activating transcription factor 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Atf1 (activating transcription factor 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	atf1 (activating transcription factor 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	CrebB	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER)
Caenorhabditis elegans (roundworm):	crh-1	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	atf1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	atf1	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	133,240,774 - 133,283,488 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	7	133,241,197 - 133,283,485 (+)	Ensembl				GRCr8
mRatBN7.2	7	131,361,962 - 131,404,677 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	131,362,450 - 131,404,670 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	7	133,164,873 - 133,207,777 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	135,390,454 - 135,433,359 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	135,302,985 - 135,345,888 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	141,882,261 - 141,924,790 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	141,882,251 - 141,924,788 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	7	139,692,651 - 139,735,616 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	7	138,971,063 - 139,014,690 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	7	127,839,929 - 127,882,623 (+)	NCBI		Celera
RGSC_v3.1	7	139,039,700 - 139,089,879 (+)	NCBI
Cytogenetic Map	7	q36	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

polycystic kidney disease (IEP)

polycystic ovary syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-anisomycin (ISO)

(S)-amphetamine (ISO)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

2-hydroxypropanoic acid (ISO)

4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one (ISO)

6-propyl-2-thiouracil (EXP)

arachidonic acid (ISO)

Aroclor 1254 (ISO)

atenolol (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

bucladesine (ISO)

Butylbenzyl phthalate (ISO)

cadmium dichloride (EXP,ISO)

cobalt dichloride (EXP)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

CU-O LINKAGE (ISO)

curcumin (ISO)

cyclosporin A (ISO)

deoxynivalenol (ISO)

desferrioxamine B (EXP)

Dibutyl phosphate (ISO)

dicrotophos (ISO)

dioxygen (ISO)

disulfiram (ISO)

dorsomorphin (ISO)

flutamide (EXP)

formaldehyde (ISO)

genistein (ISO)

gentamycin (EXP)

gold atom (ISO)

gold(0) (ISO)

gossypin (ISO)

homocysteine (EXP)

hydrogen peroxide (ISO)

ketoconazole (ISO)

L-mimosine (EXP)

manganese atom (EXP,ISO)

manganese(0) (EXP,ISO)

manganese(II) chloride (EXP,ISO)

mycophenolic acid (ISO)

N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide (ISO)

N-methyl-N-nitrosourea (ISO)

nefazodone (EXP)

paracetamol (ISO)

phorone (EXP)

proanthocyanidin (ISO)

prostaglandin E2 (ISO)

quercetin (ISO)

rac-lactic acid (ISO)

resveratrol (ISO)

SB 203580 (EXP,ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

tebufenpyrad (ISO)

tetrachloromethane (ISO)

thiram (ISO)

titanium dioxide (ISO)

trichloroethene (EXP)

trichostatin A (ISO)

tyrphostin AG 1478 (ISO)

valproic acid (ISO)

vorinostat (ISO)

Xamoterol (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cAMP/PKA signal transduction (IBA,IEA,ISO)

positive regulation of DNA replication (IMP)

positive regulation of neuron projection development (IMP)

positive regulation of transcription by RNA polymerase II (IEA,IMP,ISO)

protein-containing complex assembly (IMP)

regulation of DNA-templated transcription (IEA)

regulation of transcription by RNA polymerase II (IBA,IEA,ISO)

response to cobalt ion (IEP)

response to purine-containing compound (IEA,ISO)

Cellular Component

ATF1-ATF4 transcription factor complex (IEA,ISO)

ATF4-CREB1 transcription factor complex (IBA)

nucleoplasm (IEA,ISO)

nucleus (IEA,ISO)

RNA polymerase II transcription regulator complex (IEA,ISO)

transcription regulator complex (IDA,IEA,ISO)

Molecular Function

DNA binding (IEA,ISO)

DNA-binding transcription activator activity, RNA polymerase II-specific (IEA,ISO)

DNA-binding transcription factor activity (IEA)

DNA-binding transcription factor activity, RNA polymerase II-specific (IBA,IDA)

identical protein binding (IEA,ISO)

protein binding (ISO)

protein-containing complex binding (IDA,IPI)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IBA)

RNA polymerase II transcription regulatory region sequence-specific DNA binding (IEA,ISO)

sequence-specific DNA binding (IDA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	ATF-1 mediates protease-activated receptor-1 but not receptor tyrosine kinase-induced DNA synthesis in vascular smooth muscle cells.PG -	Ghosh SK, etal., J Biol Chem 2002 Jun 14;277(24):21325-31.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	Red wine polyphenols inhibit proliferation of vascular smooth muscle cells and downregulate expression of cyclin A gene.	Iijima K, etal., Circulation. 2000 Feb 22;101(7):805-11.
5.	The cAMP-response element mediates induction of secretogranin II by CHX and FSK in GH4C1 cells.	Jones LC and Scammell JG, Am J Physiol. 1998 Apr;274(4 Pt 1):E656-64.
6.	Myocyte enhancer factor 2B is involved in the inducible expression of NOX1/NADPH oxidase, a vascular superoxide-producing enzyme.	Katsuyama M, etal., FEBS J. 2007 Oct;274(19):5128-36. Epub 2007 Sep 5.
7.	CREB-AP1 protein complexes regulate transcription of the collagen XXIV gene (Col24a1) in osteoblasts.	Matsuo N, etal., J Biol Chem. 2006 Mar 3;281(9):5445-52. Epub 2005 Dec 22.
8.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
9.	Transforming growth factor-beta1 down-regulation of major histocompatibility complex class I in thyrocytes: coordinate regulation of two separate elements by thyroid-specific as well as ubiquitous transcription factors.	Napolitano G, etal., Mol Endocrinol. 2000 Apr;14(4):486-505.
10.	GOA pipeline	RGD automated data pipeline
11.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
12.	Dominant negative ATF1 blocks cyclic AMP-induced neurite outgrowth in PC12D cells.	Shimomura A, etal., J Neurochem. 1998 Mar;70(3):1029-34.
13.	Transfection of K-rasAsp12 cDNA markedly elevates IL-1beta- and lipopolysaccharide-mediated inducible nitric oxide synthase expression in rat intestinal epithelial cells.	Takahashi M, etal., Oncogene. 2003 Oct 23;22(48):7667-76.
14.	Cyclic nucleotide signaling in polycystic kidney disease.	Wang X, etal., Kidney Int. 2010 Jan;77(2):129-40. Epub 2009 Nov 18.
15.	Protection from oxidative stress-induced apoptosis in cortical neuronal cultures by iron chelators is associated with enhanced DNA binding of hypoxia-inducible factor-1 and ATF-1/CREB and increased expression of glycolytic enzymes, p21(waf1/cip1), and erythropoietin.	Zaman K, etal., J Neurosci. 1999 Nov 15;19(22):9821-30.
16.	Ref-1/Ape is critical for formation of the hypoxia-inducible transcriptional complex on the hypoxic response element of the rat pulmonary artery endothelial cell VEGF gene.	Ziel KA, etal., FASEB J. 2004 Jun;18(9):986-8. Epub 2004 Apr 14.

Additional References at PubMed

PMID:1655749	PMID:8798441	PMID:8889548	PMID:11354513	PMID:12477932	PMID:12871976	PMID:15710429	PMID:20102225	PMID:21045134

Genomics

Comparative Map Data

Atf1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	133,240,774 - 133,283,488 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	7	133,241,197 - 133,283,485 (+)	Ensembl				GRCr8
mRatBN7.2	7	131,361,962 - 131,404,677 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	131,362,450 - 131,404,670 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	7	133,164,873 - 133,207,777 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	135,390,454 - 135,433,359 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	135,302,985 - 135,345,888 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	141,882,261 - 141,924,790 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	141,882,251 - 141,924,788 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	7	139,692,651 - 139,735,616 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	7	138,971,063 - 139,014,690 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	7	127,839,929 - 127,882,623 (+)	NCBI		Celera
RGSC_v3.1	7	139,039,700 - 139,089,879 (+)	NCBI
Cytogenetic Map	7	q36	NCBI

ATF1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	50,763,459 - 50,821,162 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	50,763,710 - 50,821,162 (+)	Ensembl			hg38	GRCh38
GRCh37	12	51,157,242 - 51,214,945 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	49,444,086 - 49,501,174 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	12	49,444,127 - 49,500,327	NCBI
Celera	12	49,959,051 - 50,016,446 (+)	NCBI		Celera
Cytogenetic Map	12	q13.12	NCBI
HuRef	12	48,190,680 - 48,247,722 (+)	NCBI		HuRef
CHM1_1	12	51,124,299 - 51,181,471 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	12	50,726,620 - 50,784,323 (+)	NCBI		T2T-CHM13v2.0

Atf1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	100,125,729 - 100,159,129 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	15	100,125,700 - 100,159,125 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	15	100,227,859 - 100,261,248 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	100,227,819 - 100,261,244 (+)	Ensembl			mm10	GRCm38
MGSCv37	15	100,058,290 - 100,091,679 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	15	100,055,893 - 100,089,282 (+)	NCBI		MGSCv36	mm8
Celera	15	102,384,029 - 102,412,594 (+)	NCBI		Celera
Cytogenetic Map	15	F1	NCBI
cM Map	15	56.22	NCBI

Atf1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955547	1,257,944 - 1,299,519 (+)	Ensembl
ChiLan1.0	NW_004955547	1,263,288 - 1,299,525 (+)	NCBI	ChiLan1.0	ChiLan1.0

ATF1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	43,363,059 - 43,421,056 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	43,359,823 - 43,420,975 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	37,930,383 - 37,988,476 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	38,832,318 - 38,888,157 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	38,832,318 - 38,888,204 (-)	Ensembl			panPan2	panpan1.1

ATF1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	27	3,904,635 - 3,993,387 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	27	3,877,355 - 3,992,904 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	27	42,264,552 - 42,352,571 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	27	3,965,558 - 4,040,154 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	27	3,965,553 - 4,040,102 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	27	3,918,858 - 4,006,920 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	27	3,906,679 - 3,994,477 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	27	42,659,869 - 42,734,156 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Atf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	64,738,987 - 64,785,934 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936512	8,379,797 - 8,426,186 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936512	8,379,802 - 8,426,574 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ATF1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	16,618,623 - 16,681,686 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	5	16,619,130 - 16,681,391 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	17,197,022 - 17,198,589 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ATF1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	46,992,068 - 47,049,142 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	47,003,621 - 47,049,381 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666037	199,054,422 - 199,112,143 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Atf1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624816	1,527,620 - 1,596,066 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624816	1,529,082 - 1,592,932 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Atf1
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	1	262,807,087 - 262,849,601 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Atf1
264 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	107
Count of miRNA genes:	94
Interacting mature miRNAs:	96
Transcripts:	ENSRNOT00000055390
Prediction methods:	Miranda
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1331748	Bp215	Blood pressure QTL 215	4.043		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	110725024	135371468	Rat
1354582	Stl11	Serum triglyceride level QTL 11	3.42		blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	7	121393075	137014596	Rat
634331	Pia17	Pristane induced arthritis QTL 17	4.7		joint integrity trait (VT:0010548)	arthritic paw count (CMO:0001460)	7	132099939	137014596	Rat
731176	Glom5	Glomerulus QTL 5	2.5	0.0035	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)	7	98549867	137014596	Rat
1300112	Bp183	Blood pressure QTL 183	3.51		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	7	119280025	135560836	Rat
61428	Scl3	Serum cholesterol level QTL 3	3.2		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	7	100548246	137014596	Rat
61397	Bw17	Body weight QTL 17	6.3		body mass (VT:0001259)	body weight (CMO:0000012)	7	95485047	137014596	Rat
1331746	Kidm9	Kidney mass QTL 9	3.934		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	7	82111245	134948181	Rat
1358914	Bp266	Blood pressure QTL 266			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	115313999	136544683	Rat
1331731	Bp216	Blood pressure QTL 216	2.851		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	104186212	135371468	Rat
1549899	Stresp8	Stress response QTL 8	4.37	0.0008	stress-related behavior trait (VT:0010451)	defensive burying duration (CMO:0001961)	7	92362341	137014596	Rat
1358891	Bp265	Blood pressure QTL 265	2.21		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	71827901	136544683	Rat

Markers in Region

D7Got138

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	7	133,287,887 - 133,288,048 (+)	Marker Load Pipeline
Rnor_5.0	7	139,739,694 - 139,739,840	NCBI	Rnor5.0
RGSC_v3.4	7	139,019,267 - 139,019,428	RGD	RGSC3.4
RGSC_v3.4	7	139,019,268 - 139,019,428	UniSTS	RGSC3.4
Celera	7	127,887,019 - 127,887,169	UniSTS
RGSC_v3.1	7	139,095,705 - 139,095,865	RGD
RH 3.4 Map	7	1081.3	UniSTS
RH 3.4 Map	7	1081.3	RGD
RH 2.0 Map	7	812.1	RGD
Cytogenetic Map	7	q36	UniSTS

RH140584

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	131,404,122 - 131,404,325 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	141,924,236 - 141,924,438	NCBI	Rnor6.0
Rnor_5.0	7	139,735,062 - 139,735,264	UniSTS	Rnor5.0
RGSC_v3.4	7	139,014,136 - 139,014,338	UniSTS	RGSC3.4
Celera	7	127,882,069 - 127,882,271	UniSTS
RH 3.4 Map	7	1076.0	UniSTS
Cytogenetic Map	7	q36	UniSTS

AI409936

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	131,352,218 - 131,352,391 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	141,881,590 - 141,881,763	NCBI	Rnor6.0
Rnor_6.0	7	139,547,902 - 139,548,074	NCBI	Rnor6.0
Rnor_5.0	7	139,682,909 - 139,683,081	UniSTS	Rnor5.0
RGSC_v3.4	7	138,961,321 - 138,961,493	UniSTS	RGSC3.4
Celera	7	127,830,217 - 127,830,389	UniSTS
RH 3.4 Map	7	1076.0	UniSTS
Cytogenetic Map	7	q36	UniSTS

BM389484

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	131,418,457 - 131,418,668 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	141,938,574 - 141,938,784	NCBI	Rnor6.0
Rnor_5.0	7	139,748,986 - 139,749,196	UniSTS	Rnor5.0
RGSC_v3.4	7	139,027,595 - 139,027,805	UniSTS	RGSC3.4
Celera	7	127,896,395 - 127,896,605	UniSTS
RH 3.4 Map	7	1077.4	UniSTS
Cytogenetic Map	7	q36	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	164	91	90	59	92	59	6	356	192	11	143	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001100895	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039079335	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063263673	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010052984	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC091222	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC105853	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC168224	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474035	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CN541536	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CO565801	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000079011 ⟹ ENSRNOP00000073249

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	7	141,889,444 - 141,924,785 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000087298 ⟹ ENSRNOP00000073278

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	7	133,241,197 - 133,283,485 (+)	Ensembl
mRatBN7.2 Ensembl	7	131,362,450 - 131,404,670 (+)	Ensembl
Rnor_6.0 Ensembl	7	141,882,251 - 141,924,788 (+)	Ensembl

RefSeq Acc Id:

NM_001100895 ⟹ NP_001094365

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	133,240,774 - 133,283,488 (+)	NCBI
mRatBN7.2	7	131,361,962 - 131,404,677 (+)	NCBI
Rnor_6.0	7	141,882,261 - 141,924,790 (+)	NCBI
Rnor_5.0	7	139,692,651 - 139,735,616 (+)	NCBI
RGSC_v3.4	7	138,971,063 - 139,014,690 (+)	RGD
Celera	7	127,839,929 - 127,882,623 (+)	RGD

Sequence:

show sequence

TCCCGCGCACTCCTCGGCCCCCCTCCCCAGCCCCCGGCCTGTGCGGATCATGCCGCCAGCGACG
CCCCTCGCGGCCGGGAAACGGTAGCCGGGACGGTTGGCTCTTAAGTTACGACGTTCTTTTTCCG
CGCCCCGCCGACCGCAGGGACCGGCGCCACCCCGCCGCGGTGCGCGGCTGGCAAGTGAGGAGTG
AGGTCGGCGCCGCCTGGGACGGGGGAGTGGAGCTTCCCGCCCCGGGCAGCGGCCAGGAGGCTTC
GCGGTTGATTATGGAAGATTCCCACAAGAGTAACACTTCAGAGACTGCATCACAGCCTGGTTCA
ACAGTTCCGGGAATCATTTCTCAGATAGTCCATCAGGTGTCATCGTTGTCAGAAAGTGAGGAGT
CTCAGGACTCATCTGACAGCATAGGCTCCTCACAGAAAGCTCACGGGATCCTGGCGCGGCGCCC
ATCTTACAGGAAAATTTTGAAAGACCTCTCTTCTGAAGACACACGGGGCAGAAAAGGAGACGGA
GAAAATCCCAGCATTTCTGCCGTCACTTCTATGTCTGTTCCGACTCCCATCTATCAGACTAGCA
GCGGACAGTACATTGCCATTGCCCCAAACGGAGCCTTACAGTTGGCCAGTCCAGGCCCAGATGG
AGTACAGGCCCTGCAGACATTGACCATGACAAATTCAAGCAGTGCTCAGCAAGGGGCGATCCTC
CAGTACGCGCAGACCTCTGACGGACAGCAGATACTCGTCCCGAGCAACCAGGTGGTGGTGCAGA
CTGCATCAGGAGATATGCAGACCTACCAGATCCGTACCACACCATCTGCCACGTCACTTCCACA
GACCATGGTGATGACTTCTCCTGTTACCCTTACATCTCAGACAACAAAGACAGATGACCCCCAA
CTCAAAAGAGAAATACGGCTGATGAAAAACAGAGAAGCTGCCCGGGAGTGCCGGCGGAAGAAGA
AGGAGTATGTGAAGTGCCTGGAGAACCGAGTTGCTGTTCTGGAAAACCAAAATAAAACCCTAAT
AGAGGAGCTAAAGACTCTGAAGGACCTTTATTCTCATAAAAGTGTTTGATTCTTTAAAGAGAAA
GTATTTTCGTGGACTTTTAAGCTTAAAAATTAGGTGTATTTCTTTTTAGTGGAATTGTATTAAT
TCAAAGGTCAAAGAAGCCACTCTGTTGGGTTGTCACAGCCAATGAGATGGAGGGTGAATGGAGA
CGGCCTTCAGGAAGCTGCTGGCTCAGCTGGAAGCTCCCAAAGGAGAGATGCTCAAGGAAACGGA
CTTTCAGCAGTTTAAATGGAAATAAAATAATAGTCAGCAACGAAAATGGCAGGTGACATTAGTG
AAGCAGTCAATGCCTGCTAAGTCTTTATCTCTGTTCCCTAAAACTTGCCTTTCTGTGTGTGTTG
TGTGCGTGCGTGTGTGTGCGTATTTCTGCCAATAAATTTAAATTACAAATGTAAAAGAATGCAT
AAACCGTTGCTAAGTGTGTAAATTATGTGTCTGACTGTGTCGTACTGTCAGGCTGTGTTGAGTG
AGTTTTTCAGTTAGTTTTGTTGGACTAGATGGTTCGTGAAGATCTGAACGATGTGGACATACAT
CCTTCTATGGTGATGGTGGCTTGTGACTTTTTATCAGAATAGAAAGAGAACTGTCTGCAAGTTT
GACAGTTTAATAGTTTGGTTTTTTGCTTCCTCTGATAAGGGCGATTTTTCTTAAGAACATAATA
AATTGGTCTTTTTTTATTTTATTTTTTTGATTCTCTAATCCTGTATGCAGGTGAAGATCATTAT
TCTTTTGTGCTTTAACAGAATGAAGTGTTTACAAACGCCCTTAAAATGTTTAAATAACCTGAAG
ATGTACACCAAAGCTCTCCTGAGGGATTTTATAATCATCTTACCGTAGTCTGTCAGGTTCTGAG
AGAGTTACTGAGGCCATCTCACATCGAGACTGCTGTGTGTAGCCTACGGTACCTTTATAAAAGA
AGTGACTGCCGATATATTTTTATAGTGAATCTTTATAAATTCTAATGTTGAGTTTTAAATGATT
ATTTTAAATGTTTATATAGTTTGTTTAGTAAAAGAAAATTTGTATCTCAAAGTATCATTTTTAT
ATTATGAGAAGAGTAAAGTTTTCAATTGGCTGATAATTGAATTGTATGTTTTATATAAAGTTTT
ATCTGAAGTTCCAGCTGTGGTCAGTACAGCAGCATTTAACCTCTGTATTCTAATCTGTGTTCAC
TTGGAAACTGCAAAACTATTGTGTGCCTACACAGTATGTTTCATATTGTCTATGAAATTAAAGA
ACATTTGATAAGACTAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039079335 ⟹ XP_038935263

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	133,248,237 - 133,283,484 (+)	NCBI
mRatBN7.2	7	131,369,416 - 131,404,677 (+)	NCBI

RefSeq Acc Id:

XM_063263673 ⟹ XP_063119743

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	133,274,499 - 133,283,484 (+)	NCBI

RefSeq Acc Id:

XR_010052984

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	133,240,899 - 133,282,197 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001094365	(Get FASTA)	NCBI Sequence Viewer
	XP_038935263	(Get FASTA)	NCBI Sequence Viewer
	XP_063119743	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH91222	(Get FASTA)	NCBI Sequence Viewer
	AAI05854	(Get FASTA)	NCBI Sequence Viewer
	EDL86959	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000073278
	ENSRNOP00000073278.1

RefSeq Acc Id:

NP_001094365 ⟸ NM_001100895

- UniProtKB:

F7FD47 (UniProtKB/TrEMBL), A6KCI3 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MEDSHKSNTSETASQPGSTVPGIISQIVHQVSSLSESEESQDSSDSIGSSQKAHGILARRPSYR
KILKDLSSEDTRGRKGDGENPSISAVTSMSVPTPIYQTSSGQYIAIAPNGALQLASPGPDGVQA
LQTLTMTNSSSAQQGAILQYAQTSDGQQILVPSNQVVVQTASGDMQTYQIRTTPSATSLPQTMV
MTSPVTLTSQTTKTDDPQLKREIRLMKNREAARECRRKKKEYVKCLENRVAVLENQNKTLIEEL
KTLKDLYSHKSV

hide sequence

Ensembl Acc Id:

ENSRNOP00000073249 ⟸ ENSRNOT00000079011

Ensembl Acc Id:

ENSRNOP00000073278 ⟸ ENSRNOT00000087298

RefSeq Acc Id:	XP_038935263 ⟸ XM_039079335
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_063119743 ⟸ XM_063263673
- Peptide Label:	isoform X2

Protein Domains

bZIP KID

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-F7FD47-F1-model_v2	AlphaFold	F7FD47	1-268	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1307360	AgrOrtholog
BioCyc Gene	G2FUF-32033	BioCyc
Ensembl Genes	ENSRNOG00000061088	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000087298	ENTREZGENE
	ENSRNOT00000087298.3	UniProtKB/TrEMBL
Gene3D-CATH	1.20.5.170	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7125615	IMAGE-MGC_LOAD
	IMAGE:7453603	IMAGE-MGC_LOAD
InterPro	bZIP_sf	UniProtKB/TrEMBL
	Coactivator_CBP_pKID	UniProtKB/TrEMBL
	Leuzip_CREB	UniProtKB/TrEMBL
	TF_bZIP	UniProtKB/TrEMBL
KEGG Report	rno:315305	UniProtKB/TrEMBL
MGC_CLONE	MGC:108957	IMAGE-MGC_LOAD
	MGC:125091	IMAGE-MGC_LOAD
NCBI Gene	315305	ENTREZGENE
PANTHER	PTHR45879	UniProtKB/TrEMBL
	PTHR45879:SF2	UniProtKB/TrEMBL
Pfam	bZIP_1	UniProtKB/TrEMBL
	pKID	UniProtKB/TrEMBL
PharmGKB	ATF1	RGD
PhenoGen	Atf1	PhenoGen
PRINTS	LEUZIPPRCREB	UniProtKB/TrEMBL
PROSITE	BZIP	UniProtKB/TrEMBL
	BZIP_BASIC	UniProtKB/TrEMBL
	KID	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000061088	RatGTEx
SMART	BRLZ	UniProtKB/TrEMBL
Superfamily-SCOP	SSF57959	UniProtKB/TrEMBL
UniProt	A6KCI3	ENTREZGENE, UniProtKB/TrEMBL
	F7FD47	ENTREZGENE, UniProtKB/TrEMBL
	Q3KR79_RAT	UniProtKB/TrEMBL
	Q5BK34_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2005-12-06	Atf1	activating transcription factor 1	Atf1_predicted	activating transcription factor 1 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Atf1_predicted	activating transcription factor 1 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD