Nfkb2 (nuclear factor kappa B subunit 2) - Rat Genome Database

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Gene: Nfkb2 (nuclear factor kappa B subunit 2) Rattus norvegicus
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Symbol: Nfkb2
Name: nuclear factor kappa B subunit 2
RGD ID: 1307189
Description: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in response to cytokine and response to lipopolysaccharide. Predicted to be located in cytoplasm and nucleus. Predicted to be part of Bcl3/NF-kappaB2 complex. Used to study Parkinsonism. Human ortholog(s) of this gene implicated in common variable immunodeficiency 10. Orthologous to human NFKB2 (nuclear factor kappa B subunit 2); PARTICIPATES IN adenosine signaling pathway; interleukin-12 signaling pathway; nuclear factor kappa B signaling pathway; INTERACTS WITH (+)-schisandrin B; 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC309452; MGC93816; nuclear factor NF-kappa-B p100 subunit; nuclear factor of kappa light polypeptide gene enhancer in B-cells 2; nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100; RGD1307189; similar to nuclear factor kappa B subunit p100
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81255,106,010 - 255,114,649 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1255,107,374 - 255,114,637 (+)EnsemblGRCr8
mRatBN7.21245,164,586 - 245,173,225 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1245,165,950 - 245,173,213 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1253,288,361 - 253,294,615 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01259,983,048 - 259,989,300 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01252,634,805 - 252,641,057 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01266,050,634 - 266,059,277 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1266,053,002 - 266,059,256 (+)Ensemblrn6Rnor6.0
Rnor_5.01273,481,574 - 273,490,218 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41251,521,559 - 251,527,815 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1240,949,824 - 240,956,078 (+)NCBICelera
RGSC_v3.11251,784,632 - 251,790,888 (+)NCBI
Cytogenetic Map1q54NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (EXP)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
9-cis,11-trans-octadecadienoic acid  (ISO)
acetaldehyde  (ISO)
acetamide  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
amphetamine  (EXP)
anthracene  (ISO)
antimonite  (ISO)
antirheumatic drug  (ISO)
apigenin  (EXP)
aripiprazole  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
asbestos  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium selenide  (ISO)
caffeine  (ISO)
calciol  (EXP)
cannabidiol  (ISO)
carbon nanotube  (ISO)
casticin  (ISO)
cerium trichloride  (ISO)
cisplatin  (ISO)
citalopram  (EXP)
cocaine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
crocidolite asbestos  (ISO)
CU-O LINKAGE  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
DDE  (ISO)
Deoxycorticosterone acetate  (EXP)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dimethyl sulfoxide  (ISO)
dioxygen  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
ellagic acid  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
famotidine  (ISO)
fenamidone  (ISO)
flumequine  (ISO)
fluoranthene  (ISO)
flutamide  (EXP)
folic acid  (ISO)
FR900359  (ISO)
gemcitabine  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glyphosate  (ISO)
hexadecanoic acid  (ISO)
hydroquinone  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
lead diacetate  (EXP,ISO)
lipopolysaccharide  (EXP,ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
MeIQx  (ISO)
metformin  (ISO)
methapyrilene  (EXP)
methimazole  (EXP)
methotrexate  (ISO)
methoxychlor  (ISO)
Methylazoxymethanol acetate  (EXP)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
Muraglitazar  (EXP)
N-acetyl-L-cysteine  (ISO)
N-nitrosodiethylamine  (EXP)
naphthalene  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel subsulfide  (EXP)
niclosamide  (ISO)
nicotine  (ISO)
nitrates  (ISO)
NMS-873  (ISO)
o-anisidine  (ISO)
obeticholic acid  (ISO)
okadaic acid  (ISO)
omacetaxine mepesuccinate  (ISO)
ozone  (EXP,ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
pentanal  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenanthrene  (ISO)
phenethyl caffeate  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (EXP)
pirinixic acid  (ISO)
procyanidin B3  (ISO)
progesterone  (ISO)
pyrene  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
ruxolitinib  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
selenium atom  (ISO)
serpentine asbestos  (ISO)
sertraline  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
SM-164  (ISO)
sodium arsenite  (ISO)
sodium hydrogencarbonate  (ISO)
Soman  (EXP)
succimer  (ISO)
sulfadimethoxine  (EXP)
tacrolimus hydrate  (ISO)
tetrachloromethane  (EXP)
thapsigargin  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
tofacitinib  (ISO)
trichloroethene  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
troglitazone  (EXP)
valproic acid  (ISO)
zinc atom  (ISO)
zinc oxide  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
Bcl3/NF-kappaB2 complex  (IEA,ISO)
cytoplasm  (IEA,ISO)
cytosol  (IEA,ISO)
NF-kappaB complex  (ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Differential requirement for NF-kappa B family members in control of helminth infection and intestinal inflammation. Artis D, etal., J Immunol. 2002 Oct 15;169(8):4481-7. doi: 10.4049/jimmunol.169.8.4481.
2. Alteration of NF-kappaB activity leads to mitochondrial apoptosis after infection with pathological prion protein. Bourteele S, etal., Cell Microbiol. 2007 Sep;9(9):2202-17. doi: 10.1111/j.1462-5822.2007.00950.x. Epub 2007 Jun 15.
3. Signaling mediated by the NF-κB sub-units NF-κB1, NF-κB2 and c-Rel differentially regulate Helicobacter felis-induced gastric carcinogenesis in C57BL/6 mice. Burkitt MD, etal., Oncogene. 2013 Dec 12;32(50):5563-73. doi: 10.1038/onc.2013.334. Epub 2013 Aug 26.
4. The involvement of NF-kappaB p65/p52 in the effects of GDNF on DA neurons in early PD rats. Cao JP, etal., Brain Res Bull. 2008 Jul 30;76(5):505-11. Epub 2008 Apr 9.
5. The alternative NF-kappaB signalling pathway is a prerequisite for an appropriate immune response against lymphocytic choriomeningitis virus infection. Droebner K, etal., Viral Immunol. 2010 Jun;23(3):295-308. doi: 10.1089/vim.2009.0101.
6. Diabetes-induced atrophy is associated with a muscle-specific alteration in NF-kappaB activation and expression. Frier BC, etal., Cell Stress Chaperones. 2008 Jul 17.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Shared principles in NF-kappaB signaling. Hayden MS and Ghosh S, Cell. 2008 Feb 8;132(3):344-62.
10. The regulation of inducible nitric oxide synthase gene expression induced by lipopolysaccharide and tumor necrosis factor-alpha in C6 cells: involvement of AP-1 and NFkappaB. Lee JK, etal., Life Sci. 2003 Jun 20;73(5):595-609.
11. Age-dependent modulation of NF-kappaB expression in rat adrenal gland. Medicherla R, etal., Mech Ageing Dev. 2002 May;123(9):1211-27.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
16. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
17. GOA pipeline RGD automated data pipeline
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Distinct patterns of intracerebral hemorrhage-induced alterations in NF-kappaB subunit, iNOS, and COX-2 expression. Zhao X, etal., J Neurochem. 2007 May;101(3):652-63. Epub 2007 Jan 23.
Additional References at PubMed
PMID:8360178   PMID:9407099   PMID:10402669   PMID:10586052   PMID:12477932   PMID:12835724   PMID:15677444   PMID:18703048   PMID:23564451   PMID:23583643   PMID:26824492  


Genomics

Comparative Map Data
Nfkb2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81255,106,010 - 255,114,649 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1255,107,374 - 255,114,637 (+)EnsemblGRCr8
mRatBN7.21245,164,586 - 245,173,225 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1245,165,950 - 245,173,213 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1253,288,361 - 253,294,615 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01259,983,048 - 259,989,300 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01252,634,805 - 252,641,057 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01266,050,634 - 266,059,277 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1266,053,002 - 266,059,256 (+)Ensemblrn6Rnor6.0
Rnor_5.01273,481,574 - 273,490,218 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41251,521,559 - 251,527,815 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1240,949,824 - 240,956,078 (+)NCBICelera
RGSC_v3.11251,784,632 - 251,790,888 (+)NCBI
Cytogenetic Map1q54NCBI
NFKB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810102,394,110 - 102,402,529 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10102,394,110 - 102,402,529 (+)Ensemblhg38GRCh38
GRCh3710104,153,867 - 104,162,286 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610104,144,219 - 104,152,271 (+)NCBIBuild 36Build 36hg18NCBI36
Build 3410104,145,452 - 104,152,257NCBI
Celera1097,895,118 - 97,903,169 (+)NCBICelera
Cytogenetic Map10q24.32NCBI
HuRef1097,787,077 - 97,795,460 (+)NCBIHuRef
CHM1_110104,437,286 - 104,445,707 (+)NCBICHM1_1
T2T-CHM13v2.010103,279,058 - 103,287,478 (+)NCBIT2T-CHM13v2.0
Nfkb2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391946,285,478 - 46,300,839 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1946,292,759 - 46,300,824 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381946,300,994 - 46,312,400 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1946,304,320 - 46,312,385 (+)Ensemblmm10GRCm38
MGSCv371946,379,227 - 46,386,580 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361946,358,929 - 46,365,401 (+)NCBIMGSCv36mm8
Celera1947,067,972 - 47,075,305 (+)NCBICelera
Cytogenetic Map19C3NCBI
cM Map1938.8NCBI
Nfkb2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554857,994,874 - 8,000,444 (-)Ensembl
ChiLan1.0NW_0049554857,994,730 - 8,001,776 (-)NCBIChiLan1.0ChiLan1.0
NFKB2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28114,278,824 - 114,290,026 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110114,284,119 - 114,295,805 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01098,997,604 - 99,006,407 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110102,463,503 - 102,471,907 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10102,463,503 - 102,471,907 (+)EnsemblpanPan2panpan1.1
NFKB2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12814,902,212 - 14,910,437 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2814,902,706 - 14,910,395 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2815,075,041 - 15,082,885 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02815,376,710 - 15,384,554 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2815,376,790 - 15,384,554 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12814,921,754 - 14,929,597 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02814,960,852 - 14,968,695 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02815,093,467 - 15,101,311 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Nfkb2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721331,861,791 - 31,868,033 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366003,465,162 - 3,471,205 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366003,465,016 - 3,471,258 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NFKB2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14113,406,004 - 113,414,169 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.114113,406,412 - 113,414,177 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214123,260,742 - 123,270,847 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NFKB2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1995,426,193 - 95,434,560 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl995,427,785 - 95,434,570 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604856,531,952 - 56,540,324 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nfkb2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248311,803,917 - 1,810,187 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248311,804,050 - 1,810,309 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Nfkb2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1245,766,326 - 45,773,637 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Nfkb2
56 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:77
Count of miRNA genes:68
Interacting mature miRNAs:72
Transcripts:ENSRNOT00000026235
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1186658830266453731Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1210980612255980612Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1226175591270518180Rat
1578775Iddm21Insulin dependent diabetes mellitus QTL 214.13blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1245782829270518180Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1205233991267096252Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1218829748263829748Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1186658830266453731Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
631837Niddm35Non-insulin dependent diabetes mellitus QTL 350.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1248619887269633915Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
631836Stl31Serum triglyceride level QTL 314.645e-06blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1247133834270518180Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
2293694Bss38Bone structure and strength QTL 387.050.0001femur strength trait (VT:0010010)femur stiffness (CMO:0001674)1210980612255980612Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
1300108Rf8Renal function QTL 83.75renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1237995023269633915Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1233480549270108840Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1200449456256003563Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1234540191270518180Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1233480549270108840Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1207163993269633915Rat
2300175Bmd40Bone mineral density QTL 4015.40.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)1210980612255980612Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
724538Kidm1Kidney mass QTL 13.2kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1223134011262090599Rat
2293655Bss36Bone structure and strength QTL 3610.660.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1210980612255980612Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1225108840270108840Rat
724533Rf51Renal function QTL 515.30.0002kidney plasma flow trait (VT:0005524)renal plasma flow (CMO:0001914)1228180370266453608Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1208479811269633915Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1224633915269633915Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1232312773270518180Rat
2316896Gluco57Glucose level QTL 577.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1238398865255849249Rat
1358916Kidm22Kidney mass QTL 223.32kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1212738576257738576Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1194786607262083703Rat
61400Niddm1Non-insulin dependent diabetes mellitus QTL 111blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1228180243255849249Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
2293700Bmd27Bone mineral density QTL 276.60.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1210980612255980612Rat
2293701Bmd34Bone mineral density QTL 348.30.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)1210980612255980612Rat
7387289Uae45Urinary albumin excretion QTL 452.860.0021urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1233204160270518180Rat
1581544Rf52Renal function QTL 520.05urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)1241569529269633915Rat
1600363Hc6Hypercalciuria QTL 62.7urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1210980612255980612Rat
631536Lnnr2Liver neoplastic nodule remodeling QTL 22.90.0005liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)1243953669270518180Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1185857683270518180Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1226175591270518180Rat
631669Iddm9Insulin dependent diabetes mellitus QTL 92.80.039blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1233349180270518180Rat
7394701Uae46Urinary albumin excretion QTL 463.60.0056urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1210980612255980612Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1228174566270518180Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 92 59 6 356 192 11 142 81 92 31 15 15

Sequence


Ensembl Acc Id: ENSRNOT00000026235   ⟹   ENSRNOP00000026235
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1255,107,374 - 255,114,637 (+)Ensembl
mRatBN7.2 Ensembl1245,165,950 - 245,173,213 (+)Ensembl
Rnor_6.0 Ensembl1266,053,002 - 266,059,256 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000103016   ⟹   ENSRNOP00000080319
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1255,107,374 - 255,114,637 (+)Ensembl
mRatBN7.2 Ensembl1245,165,950 - 245,173,213 (+)Ensembl
RefSeq Acc Id: NM_001008349   ⟹   NP_001008350
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81255,108,374 - 255,114,628 (+)NCBI
mRatBN7.21245,166,950 - 245,173,204 (+)NCBI
Rnor_6.01266,053,002 - 266,059,256 (+)NCBI
Rnor_5.01273,481,574 - 273,490,218 (+)NCBI
RGSC_v3.41251,521,559 - 251,527,815 (+)RGD
Celera1240,949,824 - 240,956,078 (+)RGD
Sequence:
RefSeq Acc Id: XM_006231503   ⟹   XP_006231565
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81255,106,010 - 255,114,649 (+)NCBI
mRatBN7.21245,164,586 - 245,173,225 (+)NCBI
Rnor_6.01266,050,634 - 266,059,277 (+)NCBI
Rnor_5.01273,481,574 - 273,490,218 (+)NCBI
Sequence:
RefSeq Acc Id: NP_001008350   ⟸   NM_001008349
- UniProtKB: Q5U2Z4 (UniProtKB/TrEMBL),   A6JHL8 (UniProtKB/TrEMBL),   A0A8I6G6F3 (UniProtKB/TrEMBL),   A6JHL7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006231565   ⟸   XM_006231503
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000026235   ⟸   ENSRNOT00000026235
Ensembl Acc Id: ENSRNOP00000080319   ⟸   ENSRNOT00000103016
Protein Domains
RHD

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5U2Z4-F1-model_v2 AlphaFold Q5U2Z4 1-898 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690960
Promoter ID:EPDNEW_R1485
Type:initiation region
Name:Nfkb2_1
Description:nuclear factor kappa B subunit 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01266,053,002 - 266,053,062EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307189 AgrOrtholog
BioCyc Gene G2FUF-55518 BioCyc
Ensembl Genes ENSRNOG00000019311 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000026235 ENTREZGENE
  ENSRNOT00000026235.5 UniProtKB/TrEMBL
  ENSRNOT00000103016 ENTREZGENE
  ENSRNOT00000103016.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.533.10 UniProtKB/TrEMBL
  1.25.40.20 UniProtKB/TrEMBL
  2.60.40.10 UniProtKB/TrEMBL
  2.60.40.340 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7110486 IMAGE-MGC_LOAD
InterPro Ankyrin_rpt UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/TrEMBL
  Death UniProtKB/TrEMBL
  DEATH-like UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_E-set UniProtKB/TrEMBL
  IPT_NFkappaB UniProtKB/TrEMBL
  IPT_TIG_rcpt UniProtKB/TrEMBL
  NF_Rel_dor UniProtKB/TrEMBL
  NFkB_p100 UniProtKB/TrEMBL
  p53-like_TF_DNA-bd UniProtKB/TrEMBL
  RHD UniProtKB/TrEMBL
  RHD_CS UniProtKB/TrEMBL
  RHD_dimer UniProtKB/TrEMBL
  RHD_DNA_bind_dom_sf UniProtKB/TrEMBL
KEGG Report rno:309452 UniProtKB/TrEMBL
MGC_CLONE MGC:93816 IMAGE-MGC_LOAD
NCBI Gene 309452 ENTREZGENE
PANTHER PTHR24169 UniProtKB/TrEMBL
  PTHR24169:SF21 UniProtKB/TrEMBL
Pfam Ank_2 UniProtKB/TrEMBL
  Death UniProtKB/TrEMBL
  RHD UniProtKB/TrEMBL
  RHD_dimer UniProtKB/TrEMBL
PhenoGen Nfkb2 PhenoGen
PRINTS ANKYRIN UniProtKB/TrEMBL
  NFKBTNSCPFCT UniProtKB/TrEMBL
PROSITE ANK_REP_REGION UniProtKB/TrEMBL
  ANK_REPEAT UniProtKB/TrEMBL
  REL_1 UniProtKB/TrEMBL
  REL_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000019311 RatGTEx
SMART ANK UniProtKB/TrEMBL
  DEATH UniProtKB/TrEMBL
  IPT UniProtKB/TrEMBL
Superfamily-SCOP ANK UniProtKB/TrEMBL
  DEATH_like UniProtKB/TrEMBL
  Ig_E-set UniProtKB/TrEMBL
  P53_like_DNA_bnd UniProtKB/TrEMBL
UniProt A0A8I6G6F3 ENTREZGENE, UniProtKB/TrEMBL
  A6JHL7 ENTREZGENE, UniProtKB/TrEMBL
  A6JHL8 ENTREZGENE, UniProtKB/TrEMBL
  Q5U2Z4 ENTREZGENE
UniProt Secondary Q5U2Z4 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-04 Nfkb2  nuclear factor kappa B subunit 2  Nfkb2  nuclear factor of kappa light polypeptide gene enhancer in B-cells 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-03-01 Nfkb2  nuclear factor of kappa light polypeptide gene enhancer in B-cells 2  Nfkb2  nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Nfkb2  nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100  RGD1307189  similar to nuclear factor kappa B subunit p100  Symbol and Name updated 1299863 APPROVED
2005-12-06 RGD1307189  similar to nuclear factor kappa B subunit p100  RGD1307189_predicted  similar to nuclear factor kappa B subunit p100 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1307189_predicted  similar to nuclear factor kappa B subunit p100 (predicted)  LOC309452_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC309452_predicted  similar to nuclear factor kappa B subunit p100 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL