Cdh19 (cadherin 19) - Rat Genome Database

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Gene: Cdh19 (cadherin 19) Rattus norvegicus
Analyze
Symbol: Cdh19
Name: cadherin 19
RGD ID: 1307169
Description: Predicted to enable beta-catenin binding activity and cadherin binding activity. Predicted to be involved in several processes, including calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; cell-cell adhesion mediated by cadherin; and cell-cell junction organization. Predicted to be located in plasma membrane. Predicted to be part of catenin complex. Predicted to be active in adherens junction. Orthologous to human CDH19 (cadherin 19); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cadherin 19, type 2; cadherin-19; LOC360835
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81328,450,361 - 28,561,932 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1328,451,283 - 28,533,753 (-)EnsemblGRCr8
mRatBN7.21327,935,915 - 28,047,490 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1327,936,668 - 28,019,310 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1328,329,664 - 28,411,052 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01329,614,185 - 29,695,576 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01328,262,267 - 28,343,715 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01332,344,954 - 32,469,887 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1332,344,966 - 32,427,177 (-)Ensemblrn6Rnor6.0
Rnor_5.01337,482,078 - 37,607,514 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41318,148,715 - 18,230,353 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1327,679,457 - 27,760,138 (-)NCBICelera
RGSC_v3.11318,151,455 - 18,233,094 (-)NCBI
Cytogenetic Map13q11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15580626  


Genomics

Comparative Map Data
Cdh19
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81328,450,361 - 28,561,932 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1328,451,283 - 28,533,753 (-)EnsemblGRCr8
mRatBN7.21327,935,915 - 28,047,490 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1327,936,668 - 28,019,310 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1328,329,664 - 28,411,052 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01329,614,185 - 29,695,576 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01328,262,267 - 28,343,715 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01332,344,954 - 32,469,887 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1332,344,966 - 32,427,177 (-)Ensemblrn6Rnor6.0
Rnor_5.01337,482,078 - 37,607,514 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41318,148,715 - 18,230,353 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1327,679,457 - 27,760,138 (-)NCBICelera
RGSC_v3.11318,151,455 - 18,233,094 (-)NCBI
Cytogenetic Map13q11NCBI
CDH19
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381866,501,083 - 66,604,090 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1866,501,083 - 66,604,438 (-)Ensemblhg38GRCh38
GRCh371864,168,320 - 64,271,327 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361862,322,301 - 62,422,196 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341862,322,300 - 62,422,196NCBI
Celera1860,889,278 - 60,989,190 (-)NCBICelera
Cytogenetic Map18q22.1NCBI
HuRef1860,868,984 - 60,971,955 (-)NCBIHuRef
CHM1_11864,163,645 - 64,266,628 (-)NCBICHM1_1
T2T-CHM13v2.01866,699,077 - 66,802,147 (-)NCBIT2T-CHM13v2.0
Cdh19
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391110,811,802 - 110,905,331 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1110,816,056 - 110,905,314 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381110,888,002 - 110,977,601 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1110,888,326 - 110,977,584 (-)Ensemblmm10GRCm38
MGSCv371112,785,772 - 112,873,949 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361112,716,742 - 112,804,919 (-)NCBIMGSCv36mm8
Celera1113,646,024 - 113,729,311 (-)NCBICelera
Cytogenetic Map1E2.1NCBI
cM Map150.78NCBI
Cdh19
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540250,112,516 - 50,213,896 (-)Ensembl
ChiLan1.0NW_00495540250,110,907 - 50,213,882 (-)NCBIChiLan1.0ChiLan1.0
CDH19
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21784,005,355 - 84,107,699 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11869,697,969 - 69,800,300 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01859,852,350 - 59,954,744 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11863,156,263 - 63,258,546 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1863,156,263 - 63,258,767 (-)EnsemblpanPan2panpan1.1
CDH19
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1111,074,216 - 11,168,816 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl111,074,305 - 11,165,626 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha112,099,395 - 12,193,906 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0110,925,758 - 11,020,339 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl110,925,808 - 11,020,334 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1110,957,834 - 11,052,271 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0110,899,197 - 10,994,210 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0111,144,592 - 11,239,098 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Cdh19
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494424,452,037 - 24,483,848 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049381822,674 - 13,253 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDH19
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1155,669,420 - 155,758,548 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11155,669,361 - 155,758,550 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21172,916,611 - 173,006,358 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CDH19
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11813,155,504 - 13,256,781 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1813,187,487 - 13,256,691 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366606012,513,300 - 12,621,161 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cdh19
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479212,635,240 - 12,752,439 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462479212,633,803 - 12,752,267 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Cdh19
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11085,656,401 - 85,730,890 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cdh19
1176 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:20
Count of miRNA genes:19
Interacting mature miRNAs:20
Transcripts:ENSRNOT00000044628
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2317027Aia22Adjuvant induced arthritis QTL 222.29joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)13134785618Rat
9589141Insul28Insulin level QTL 2810.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)131186625456866254Rat
2317034Aia9Adjuvant induced arthritis QTL 94.62joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)131228551734884386Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132485392569853925Rat
1300163Cardf1Cardiac cell morphology QTL 14.18aorta morphology trait (VT:0000272)artery lesion measurement (CMO:0000975)131244842147969993Rat
2317040Aia21Adjuvant induced arthritis QTL 212.75joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)131238432057384320Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131746828262468282Rat
2303030Bp327Blood pressure QTL 327arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)13143736554Rat
2317046Aia8Adjuvant induced arthritis QTL 83.9700000286102295joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)131238432057384320Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13742179187286911Rat
2317044Aia23Adjuvant induced arthritis QTL 232.3joint integrity trait (VT:0010548)ankle joint diameter (CMO:0002148)131228551734884386Rat
61339Bp24Blood pressure QTL 240.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13600200847359539Rat
1331784Bp222Blood pressure QTL 2222.944arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)132433543255601132Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
2302275Gluco37Glucose level QTL 373.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)131244842148744906Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1321120177109350286Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132624480871244808Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1311081740103588154Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
12879471Bp398Blood pressure QTL 398arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)13308875548088755Rat
631672Iddm12Insulin dependent diabetes mellitus QTL 122.20.0032blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)13600200837088115Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132624480871244808Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131103588154Rat
9589164Gluco66Glucose level QTL 666.670.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)131771133662711336Rat
738036Lnnr4Liver neoplastic nodule remodeling QTL 43.64liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)13134785618Rat
7411662Foco29Food consumption QTL 2920.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)131186625456866254Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
9 12 59 137 64 63 32 25 32 6 216 117 11 116 50 84 31 8 8

Sequence


Ensembl Acc Id: ENSRNOT00000044628   ⟹   ENSRNOP00000047360
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1328,451,283 - 28,533,753 (-)Ensembl
mRatBN7.2 Ensembl1327,936,668 - 28,019,310 (-)Ensembl
Rnor_6.0 Ensembl1332,344,966 - 32,427,177 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000122113   ⟹   ENSRNOP00000101100
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1328,452,281 - 28,533,753 (-)Ensembl
RefSeq Acc Id: NM_001009448   ⟹   NP_001009448
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81328,452,281 - 28,533,753 (-)NCBI
mRatBN7.21327,937,835 - 28,019,310 (-)NCBI
Rnor_6.01332,346,867 - 32,427,016 (-)NCBI
Rnor_5.01337,482,078 - 37,607,514 (-)NCBI
RGSC_v3.41318,148,715 - 18,230,353 (-)RGD
Celera1327,679,457 - 27,760,138 (-)RGD
Sequence:
RefSeq Acc Id: XM_017598843   ⟹   XP_017454332
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81328,450,361 - 28,561,931 (-)NCBI
mRatBN7.21327,935,915 - 28,047,489 (-)NCBI
Rnor_6.01332,344,954 - 32,453,990 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039090877   ⟹   XP_038946805
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81328,450,361 - 28,561,930 (-)NCBI
mRatBN7.21327,935,915 - 28,047,489 (-)NCBI
RefSeq Acc Id: XM_039090879   ⟹   XP_038946807
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81328,450,361 - 28,561,932 (-)NCBI
mRatBN7.21327,935,915 - 28,047,490 (-)NCBI
RefSeq Acc Id: XM_039090880   ⟹   XP_038946808
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81328,450,361 - 28,515,126 (-)NCBI
mRatBN7.21327,935,915 - 28,000,682 (-)NCBI
RefSeq Acc Id: NP_001009448   ⟸   NM_001009448
- Peptide Label: precursor
- UniProtKB: Q5NUI3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017454332   ⟸   XM_017598843
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000047360   ⟸   ENSRNOT00000044628
RefSeq Acc Id: XP_038946807   ⟸   XM_039090879
- Peptide Label: isoform X2
- UniProtKB: F7FIC1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946805   ⟸   XM_039090877
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038946808   ⟸   XM_039090880
- Peptide Label: isoform X3
- UniProtKB: A6JSW5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000101100   ⟸   ENSRNOT00000122113
Protein Domains
Cadherin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5NUI3-F1-model_v2 AlphaFold Q5NUI3 1-770 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307169 AgrOrtholog
BioCyc Gene G2FUF-18553 BioCyc
Ensembl Genes ENSRNOG00000029841 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000044628 ENTREZGENE
  ENSRNOT00000044628.4 UniProtKB/TrEMBL
  ENSRNOT00000122113 ENTREZGENE
  ENSRNOT00000122113.1 UniProtKB/TrEMBL
Gene3D-CATH 4.10.900.10 UniProtKB/TrEMBL
  Cadherins UniProtKB/TrEMBL
InterPro Cadherin UniProtKB/TrEMBL
  Cadherin UniProtKB/TrEMBL
  Cadherin-like UniProtKB/TrEMBL
  Cadherin_CS UniProtKB/TrEMBL
  Cadherin_cytoplasmic-dom UniProtKB/TrEMBL
  Catenin_binding_dom UniProtKB/TrEMBL
KEGG Report rno:360835 UniProtKB/TrEMBL
NCBI Gene 360835 ENTREZGENE
PANTHER CADHERIN-19 UniProtKB/TrEMBL
  PTHR24027 UniProtKB/TrEMBL
Pfam Cadherin UniProtKB/TrEMBL
  Cadherin_C UniProtKB/TrEMBL
PhenoGen Cdh19 PhenoGen
PRINTS CADHERIN UniProtKB/TrEMBL
PROSITE CADHERIN_1 UniProtKB/TrEMBL
  CADHERIN_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000029841 RatGTEx
SMART SM00112 UniProtKB/TrEMBL
Superfamily-SCOP Cadherin UniProtKB/TrEMBL
UniProt A0ABK0KZW0_RAT UniProtKB/TrEMBL
  A6JSW5 ENTREZGENE, UniProtKB/TrEMBL
  F7FIC1 ENTREZGENE, UniProtKB/TrEMBL
  Q5NUI3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-20 Cdh19  cadherin 19  Cdh19  cadherin 19, type 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Cdh19  cadherin 19, type 2  Cdh19_predicted  cadherin 19, type 2 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Cdh19_predicted  cadherin 19, type 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED