Snrnp70 (small nuclear ribonucleoprotein U1 subunit 70) - Rat Genome Database

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Gene: Snrnp70 (small nuclear ribonucleoprotein U1 subunit 70) Rattus norvegicus
Analyze
Symbol: Snrnp70
Name: small nuclear ribonucleoprotein U1 subunit 70
RGD ID: 1307120
Description: Enables U1 snRNP binding activity. Involved in cellular response to retinoic acid; cellular response to transforming growth factor beta stimulus; and cellular response to tumor necrosis factor. Part of U1 snRNP. Human ortholog(s) of this gene implicated in disease of mental health and systemic lupus erythematosus. Orthologous to human SNRNP70 (small nuclear ribonucleoprotein U1 subunit 70); PARTICIPATES IN spliceosome pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC361574; small nuclear ribonucleoprotein 70 (U1); Snrp70; U1 small nuclear ribonucleoprotein 70 kDa; U1 small nuclear ribonucleoprotein polypeptide A
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81104,992,518 - 105,012,851 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1104,992,442 - 105,012,851 (-)EnsemblGRCr8
mRatBN7.2195,856,038 - 95,876,434 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl195,856,036 - 95,876,392 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1101,241,472 - 101,261,800 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01109,714,149 - 109,734,477 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01103,004,549 - 103,024,877 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01101,367,470 - 101,388,153 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1101,367,471 - 101,388,129 (-)Ensemblrn6Rnor6.0
Rnor_5.01102,431,122 - 102,468,602 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4195,853,923 - 95,868,393 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera190,118,420 - 90,132,674 (-)NCBICelera
RGSC_v3.1195,925,963 - 95,946,503 (-)NCBI
Cytogenetic Map1q22NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-bromohexadecanoic acid  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
5-aza-2'-deoxycytidine  (ISO)
7,12-dimethyltetraphene  (ISO)
acrylamide  (ISO)
all-trans-retinoic acid  (EXP,ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
bathocuproine disulfonic acid  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) chloride  (ISO)
decabromodiphenyl ether  (ISO)
diuron  (EXP)
enzyme inhibitor  (ISO)
fenthion  (ISO)
folic acid  (ISO)
FR900359  (ISO)
gamma-hexachlorocyclohexane  (EXP)
glafenine  (EXP)
glyphosate  (ISO)
hydralazine  (ISO)
inulin  (ISO)
ivermectin  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
lead(II) chloride  (ISO)
menadione  (ISO)
methidathion  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nefazodone  (EXP)
nickel atom  (ISO)
nitrates  (ISO)
ozone  (ISO)
paracetamol  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
pyrrolidine dithiocarbamate  (ISO)
resveratrol  (ISO)
sodium arsenite  (ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zinc sulfate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. U1 small nuclear ribonucleoprotein complex and RNA splicing alterations in Alzheimer's disease. Bai B, etal., Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):16562-7. doi: 10.1073/pnas.1310249110. Epub 2013 Sep 10.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Serum antibodies against the 70k polypeptides of the U1 ribonucleoprotein complex are associated with psychiatric syndromes in systemic lupus erythematosus: a retrospective study. Katsumata Y, etal., Mod Rheumatol. 2013 Jan;23(1):71-80. doi: 10.1007/s10165-012-0624-y. Epub 2012 Mar 28.
5. Dual posttranscriptional targets of retinoic acid-induced gene expression. Manji SS, etal., J Cell Biochem. 1999 Mar 1;72(3):411-22.
6. B and T cell immune response to small nuclear ribonucleoprotein particles in lupus mice: autoreactive CD4(+) T cells recognize a T cell epitope located within the RNP80 motif of the 70K protein. Monneaux F, etal., Eur J Immunol. 2000 Aug;30(8):2191-200.
7. Separation of nuclear protein complexes by blue native polyacrylamide gel electrophoresis. Novakova Z, etal., Electrophoresis. 2006 Apr;27(7):1277-87.
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Structural analyses of the pre-mRNA splicing machinery. Zhang L, etal., Protein Sci. 2013 Jun;22(6):677-92. doi: 10.1002/pro.2266. Epub 2013 May 8.
Additional References at PubMed
PMID:2467746   PMID:9531537   PMID:9731529   PMID:12477932   PMID:17656373   PMID:18559850   PMID:21113136   PMID:22658674   PMID:22681889   PMID:23636947   PMID:23793891   PMID:25555158  
PMID:30361391   PMID:31505169  


Genomics

Comparative Map Data
Snrnp70
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81104,992,518 - 105,012,851 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1104,992,442 - 105,012,851 (-)EnsemblGRCr8
mRatBN7.2195,856,038 - 95,876,434 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl195,856,036 - 95,876,392 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1101,241,472 - 101,261,800 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01109,714,149 - 109,734,477 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01103,004,549 - 103,024,877 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01101,367,470 - 101,388,153 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1101,367,471 - 101,388,129 (-)Ensemblrn6Rnor6.0
Rnor_5.01102,431,122 - 102,468,602 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4195,853,923 - 95,868,393 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera190,118,420 - 90,132,674 (-)NCBICelera
RGSC_v3.1195,925,963 - 95,946,503 (-)NCBI
Cytogenetic Map1q22NCBI
SNRNP70
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381949,085,451 - 49,108,604 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1949,085,164 - 49,108,613 (+)Ensemblhg38GRCh38
GRCh371949,588,708 - 49,611,861 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361954,280,277 - 54,303,682 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341954,280,276 - 54,303,681NCBI
Celera1946,455,683 - 46,479,094 (+)NCBICelera
Cytogenetic Map19q13.33NCBI
HuRef1945,964,935 - 45,988,033 (+)NCBIHuRef
CHM1_11949,590,572 - 49,613,985 (+)NCBICHM1_1
T2T-CHM13v2.01952,080,187 - 52,103,340 (+)NCBIT2T-CHM13v2.0
Snrnp70
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39745,025,878 - 45,045,177 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl745,025,877 - 45,045,166 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38745,376,454 - 45,395,742 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl745,376,453 - 45,395,742 (-)Ensemblmm10GRCm38
MGSCv37752,631,824 - 52,651,017 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36745,244,496 - 45,263,689 (-)NCBIMGSCv36mm8
Celera740,832,480 - 40,851,675 (-)NCBICelera
Cytogenetic Map7B3NCBI
cM Map729.28NCBI
Snrnp70
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555591,614,039 - 1,634,142 (-)Ensembl
ChiLan1.0NW_0049555591,618,246 - 1,634,144 (-)NCBIChiLan1.0ChiLan1.0
SNRNP70
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22055,199,729 - 55,221,922 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11957,118,085 - 57,141,420 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01946,094,679 - 46,118,022 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11955,021,402 - 55,044,351 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1955,021,402 - 55,046,281 (+)EnsemblpanPan2panpan1.1
SNRNP70
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11107,340,484 - 107,356,280 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1107,113,974 - 107,356,241 (-)EnsemblcanFam3CanFam3.1
ROS_Cfam_1.01107,865,353 - 107,881,109 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1107,865,361 - 107,881,086 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11107,533,257 - 107,549,010 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01107,179,479 - 107,195,244 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01108,015,085 - 108,030,850 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Snrnp70
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934921,417,537 - 21,436,387 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049366643,035,679 - 3,054,577 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SNRNP70
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl654,288,397 - 54,304,103 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1654,288,354 - 54,304,272 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2650,024,183 - 50,040,138 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SNRNP70
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1642,305,961 - 42,329,289 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl642,305,687 - 42,330,332 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607322,196,694 - 22,220,757 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Snrnp70
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248324,973,251 - 4,988,679 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Snrnp70
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12154,113,349 - 154,133,071 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Snrnp70
234 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:157
Count of miRNA genes:107
Interacting mature miRNAs:120
Transcripts:ENSRNOT00000028176, ENSRNOT00000049957
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1102780511182384005Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)192963855109494029Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1101228864146228864Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)191302413136302413Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)1102359314153680016Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)199645382182701046Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of, or within a discrete space in an open field apparatus (CMO:0001514)192683681137683681Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)192683681137683681Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)197582336142582336Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1101594089146594089Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1100345976145345976Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)196717367160111531Rat

Markers in Region
BE114951  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2195,856,123 - 95,856,280 (+)MAPPERmRatBN7.2
Rnor_6.01101,367,549 - 101,367,705NCBIRnor6.0
Rnor_5.01102,431,201 - 102,431,357UniSTSRnor5.0
RGSC_v3.4195,847,934 - 95,848,090UniSTSRGSC3.4
Celera190,112,425 - 90,112,581UniSTS
RH 3.4 Map1909.3UniSTS
Cytogenetic Map1q22UniSTS
AI325098  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2195,875,364 - 95,875,458 (+)MAPPERmRatBN7.2
Rnor_6.01101,387,119 - 101,387,212NCBIRnor6.0
Rnor_5.01102,467,572 - 102,467,665UniSTSRnor5.0
RGSC_v3.4195,867,383 - 95,867,476UniSTSRGSC3.4
Celera190,131,664 - 90,131,757UniSTS
Cytogenetic Map1q22UniSTS
RH141656  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2195,870,668 - 95,870,879 (+)MAPPERmRatBN7.2
Rnor_6.01101,382,425 - 101,382,635NCBIRnor6.0
Rnor_5.01102,462,878 - 102,463,088UniSTSRnor5.0
RGSC_v3.4195,862,689 - 95,862,899UniSTSRGSC3.4
Celera190,126,970 - 90,127,180UniSTS
RH 3.4 Map1909.6UniSTS
Cytogenetic Map1q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000028176   ⟹   ENSRNOP00000028176
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl195,856,038 - 95,876,392 (-)Ensembl
Rnor_6.0 Ensembl1101,367,471 - 101,388,125 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000049957   ⟹   ENSRNOP00000043074
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl195,862,117 - 95,876,375 (-)Ensembl
Rnor_6.0 Ensembl1101,373,539 - 101,388,129 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000098428   ⟹   ENSRNOP00000083303
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl195,872,318 - 95,876,375 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000118005   ⟹   ENSRNOP00000079909
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1104,992,442 - 105,012,851 (-)Ensembl
mRatBN7.2 Ensembl195,856,036 - 95,876,392 (-)Ensembl
RefSeq Acc Id: NM_001399641   ⟹   NP_001386570
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81104,992,518 - 105,012,851 (-)NCBI
mRatBN7.2195,856,038 - 95,876,375 (-)NCBI
RefSeq Acc Id: XM_006229102   ⟹   XP_006229164
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81104,992,527 - 105,012,578 (-)NCBI
mRatBN7.2195,856,039 - 95,875,904 (-)NCBI
Rnor_6.01101,367,470 - 101,387,658 (-)NCBI
Rnor_5.01102,431,122 - 102,468,602 (-)NCBI
Sequence:
RefSeq Acc Id: XP_006229164   ⟸   XM_006229102
- Peptide Label: isoform X1
- UniProtKB: B2RZ74 (UniProtKB/TrEMBL),   F7FIU1 (UniProtKB/TrEMBL),   A0A8I6G5W4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000028176   ⟸   ENSRNOT00000028176
Ensembl Acc Id: ENSRNOP00000043074   ⟸   ENSRNOT00000049957
Ensembl Acc Id: ENSRNOP00000083303   ⟸   ENSRNOT00000098428
Ensembl Acc Id: ENSRNOP00000079909   ⟸   ENSRNOT00000118005
RefSeq Acc Id: NP_001386570   ⟸   NM_001399641
- UniProtKB: B2RZ74 (UniProtKB/TrEMBL),   F7FIU1 (UniProtKB/TrEMBL),   A0A8I6G5W4 (UniProtKB/TrEMBL)
Protein Domains
RRM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B2RZ74-F1-model_v2 AlphaFold B2RZ74 1-451 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690035
Promoter ID:EPDNEW_R560
Type:initiation region
Name:Snrnp70_1
Description:small nuclear ribonucleoprotein U1 subunit 70
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01101,388,135 - 101,388,195EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307120 AgrOrtholog
BioCyc Gene G2FUF-59689 BioCyc
Ensembl Genes ENSRNOG00000020763 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000118005 ENTREZGENE
  ENSRNOT00000118005.2 UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.330 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:9089731 IMAGE-MGC_LOAD
InterPro Nucleotide-bd_a/b_plait_sf UniProtKB/TrEMBL
  RBD_domain_sf UniProtKB/TrEMBL
  RRM_RNP1 UniProtKB/TrEMBL
  snRNP70_RRM UniProtKB/TrEMBL
  U1_U11-U12_snRNP_70-35kDa UniProtKB/TrEMBL
  U1snRNP70_N UniProtKB/TrEMBL
MGC_CLONE MGC:189347 IMAGE-MGC_LOAD
NCBI Gene 361574 ENTREZGENE
PANTHER U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KD UniProtKB/TrEMBL
  U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KDA UniProtKB/TrEMBL
Pfam RRM_1 UniProtKB/TrEMBL
  U1snRNP70_N UniProtKB/TrEMBL
PhenoGen Snrnp70 PhenoGen
PROSITE RRM UniProtKB/TrEMBL
RatGTEx ENSRNOG00000020763 RatGTEx
SMART RRM UniProtKB/TrEMBL
Superfamily-SCOP SSF54928 UniProtKB/TrEMBL
UniProt A0A8I6G5W4 ENTREZGENE, UniProtKB/TrEMBL
  B2RZ74 ENTREZGENE
  F7FIU1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-07-15 Snrnp70  small nuclear ribonucleoprotein U1 subunit 70  Snrnp70  small nuclear ribonucleoprotein 70 (U1)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-10-22 Snrnp70  small nuclear ribonucleoprotein 70 (U1)  Snrp70  U1 small nuclear ribonucleoprotein polypeptide A   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Snrp70  U1 small nuclear ribonucleoprotein polypeptide A   Snrp70_predicted  U1 small nuclear ribonucleoprotein polypeptide A (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Snrp70_predicted  U1 small nuclear ribonucleoprotein polypeptide A (predicted)      Symbol and Name status set to approved 70820 APPROVED