SNRNP70 (small nuclear ribonucleoprotein U1 subunit 70) - Rat Genome Database

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Gene: SNRNP70 (small nuclear ribonucleoprotein U1 subunit 70) Homo sapiens
Analyze
Symbol: SNRNP70
Name: small nuclear ribonucleoprotein U1 subunit 70
RGD ID: 1316126
HGNC Page HGNC:11150
Description: Enables U1 snRNA binding activity. Involved in mRNA splicing, via spliceosome and regulation of RNA splicing. Located in nucleoplasm. Part of U1 snRNP and spliceosomal complex. Implicated in disease of mental health and systemic lupus erythematosus. Biomarker of Alzheimer's disease.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: RNPU1Z; RPU1; small nuclear ribonucleoprotein 70kDa (U1); small nuclear ribonucleoprotein, U1 70kDa subunit; Snp1; SNRP70; U1 small nuclear ribonucleoprotein 70 kDa; U1 snRNP 70 kDa; U1-70K; U170K; U1AP; U1RNP
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381949,085,451 - 49,108,604 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1949,085,419 - 49,108,605 (+)EnsemblGRCh38hg38GRCh38
GRCh371949,588,708 - 49,611,861 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361954,280,277 - 54,303,682 (+)NCBINCBI36Build 36hg18NCBI36
Build 341954,280,276 - 54,303,681NCBI
Celera1946,455,683 - 46,479,094 (+)NCBICelera
Cytogenetic Map19q13.33NCBI
HuRef1945,964,935 - 45,988,033 (+)NCBIHuRef
CHM1_11949,590,572 - 49,613,985 (+)NCBICHM1_1
T2T-CHM13v2.01952,080,187 - 52,103,340 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nuclear speck  (IEA,ISS)
nucleoplasm  (IDA,IEA,TAS)
nucleus  (IDA,IEA,NAS)
precatalytic spliceosome  (IEA)
ribonucleoprotein complex  (IEA)
spliceosomal complex  (IDA,IPI)
U1 snRNP  (IBA,IDA,IEA,IPI,ISO)
U2-type prespliceosome  (IBA,IEA)

Molecular Function
mRNA binding  (IBA,IEA)
nucleic acid binding  (IEA)
protein binding  (IPI)
RNA binding  (HDA,IEA,IMP)
U1 snRNA binding  (IBA,IDA,IEA)
U1 snRNP binding  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. U1 small nuclear ribonucleoprotein complex and RNA splicing alterations in Alzheimer's disease. Bai B, etal., Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):16562-7. doi: 10.1073/pnas.1310249110. Epub 2013 Sep 10.
2. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
3. Serum antibodies against the 70k polypeptides of the U1 ribonucleoprotein complex are associated with psychiatric syndromes in systemic lupus erythematosus: a retrospective study. Katsumata Y, etal., Mod Rheumatol. 2013 Jan;23(1):71-80. doi: 10.1007/s10165-012-0624-y. Epub 2012 Mar 28.
4. B and T cell immune response to small nuclear ribonucleoprotein particles in lupus mice: autoreactive CD4(+) T cells recognize a T cell epitope located within the RNP80 motif of the 70K protein. Monneaux F, etal., Eur J Immunol. 2000 Aug;30(8):2191-200.
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Structural analyses of the pre-mRNA splicing machinery. Zhang L, etal., Protein Sci. 2013 Jun;22(6):677-92. doi: 10.1002/pro.2266. Epub 2013 May 8.
Additional References at PubMed
PMID:1833625   PMID:2147422   PMID:2447561   PMID:2467746   PMID:2477447   PMID:3028775   PMID:7516470   PMID:8261509   PMID:8332490   PMID:8642305   PMID:8746626   PMID:8816452  
PMID:8889548   PMID:9016565   PMID:9281376   PMID:9447963   PMID:9472028   PMID:9531537   PMID:9685421   PMID:9731529   PMID:9799243   PMID:9826776   PMID:10339552   PMID:10725331  
PMID:11448987   PMID:11500380   PMID:11514619   PMID:11741604   PMID:11748230   PMID:11780068   PMID:11850407   PMID:12115232   PMID:12193588   PMID:12218166   PMID:12226669   PMID:12417631  
PMID:12456665   PMID:12477932   PMID:12486009   PMID:12548559   PMID:12549820   PMID:12560496   PMID:14561889   PMID:14688384   PMID:14702039   PMID:14765198   PMID:15144186   PMID:15146197  
PMID:15231748   PMID:15489334   PMID:15862967   PMID:16055720   PMID:16344560   PMID:16964243   PMID:17043677   PMID:17081983   PMID:17332742   PMID:17353931   PMID:17622584   PMID:18202700  
PMID:18523312   PMID:18559666   PMID:18559850   PMID:18951082   PMID:19232124   PMID:19419839   PMID:19738201   PMID:19784376   PMID:19928837   PMID:20195357   PMID:20205790   PMID:20467437  
PMID:20500824   PMID:20519584   PMID:20811636   PMID:21081503   PMID:21113136   PMID:21145461   PMID:21244100   PMID:21348812   PMID:21536904   PMID:21642987   PMID:21832049   PMID:21873635  
PMID:21942715   PMID:21988832   PMID:22113938   PMID:22174317   PMID:22365833   PMID:22379092   PMID:22490866   PMID:22586326   PMID:22623428   PMID:22658674   PMID:22681889   PMID:22939629  
PMID:22990118   PMID:23084401   PMID:23151878   PMID:23246001   PMID:23398456   PMID:23602568   PMID:23752268   PMID:23793891   PMID:23874216   PMID:24457600   PMID:24461387   PMID:24711643  
PMID:24773620   PMID:24778252   PMID:24981860   PMID:25052091   PMID:25178676   PMID:25355317   PMID:25437307   PMID:25555158   PMID:25665578   PMID:25719862   PMID:25795785   PMID:25921289  
PMID:26124092   PMID:26167880   PMID:26186194   PMID:26333287   PMID:26344197   PMID:26354767   PMID:26496610   PMID:26527279   PMID:26641092   PMID:26673895   PMID:26760575   PMID:26828962  
PMID:27025967   PMID:27105840   PMID:27432908   PMID:27609421   PMID:27684187   PMID:28077445   PMID:28225217   PMID:28514442   PMID:28515276   PMID:28533407   PMID:28561026   PMID:28977666  
PMID:29229926   PMID:29298432   PMID:29331416   PMID:29395067   PMID:29507755   PMID:29509190   PMID:29764937   PMID:29802200   PMID:29884807   PMID:30021884   PMID:30033366   PMID:30110629  
PMID:30209976   PMID:30404004   PMID:30463901   PMID:30532072   PMID:30804502   PMID:30833792   PMID:30890647   PMID:30948266   PMID:31048545   PMID:31059266   PMID:31091453   PMID:31107149  
PMID:31239290   PMID:31253590   PMID:31478661   PMID:31553912   PMID:31586073   PMID:31723601   PMID:31805275   PMID:31995728   PMID:32203420   PMID:32296183   PMID:32707033   PMID:32780723  
PMID:32807901   PMID:32828285   PMID:32915994   PMID:32989298   PMID:32994395   PMID:33106477   PMID:33301849   PMID:33306668   PMID:33545068   PMID:33677607   PMID:33729478   PMID:33766124  
PMID:33811140   PMID:33863777   PMID:33961781   PMID:34004371   PMID:34133714   PMID:34185411   PMID:34189442   PMID:34244565   PMID:34349018   PMID:34373451   PMID:34551306   PMID:34650049  
PMID:34662580   PMID:34709727   PMID:34921745   PMID:35013218   PMID:35101583   PMID:35140242   PMID:35182466   PMID:35235311   PMID:35253629   PMID:35256949   PMID:35271311   PMID:35320554  
PMID:35439318   PMID:35509820   PMID:35563538   PMID:35652658   PMID:35709258   PMID:35777956   PMID:35819319   PMID:35831314   PMID:35850772   PMID:35914814   PMID:35944360   PMID:35987950  
PMID:36114006   PMID:36168627   PMID:36180527   PMID:36215168   PMID:36243803   PMID:36244648   PMID:36273042   PMID:36373674   PMID:36424410   PMID:36517590   PMID:36641841   PMID:37616343  
PMID:38113892   PMID:38172120   PMID:38500533  


Genomics

Comparative Map Data
SNRNP70
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381949,085,451 - 49,108,604 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1949,085,419 - 49,108,605 (+)EnsemblGRCh38hg38GRCh38
GRCh371949,588,708 - 49,611,861 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361954,280,277 - 54,303,682 (+)NCBINCBI36Build 36hg18NCBI36
Build 341954,280,276 - 54,303,681NCBI
Celera1946,455,683 - 46,479,094 (+)NCBICelera
Cytogenetic Map19q13.33NCBI
HuRef1945,964,935 - 45,988,033 (+)NCBIHuRef
CHM1_11949,590,572 - 49,613,985 (+)NCBICHM1_1
T2T-CHM13v2.01952,080,187 - 52,103,340 (+)NCBIT2T-CHM13v2.0
Snrnp70
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39745,025,878 - 45,045,177 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl745,025,877 - 45,045,166 (-)EnsemblGRCm39 Ensembl
GRCm38745,376,454 - 45,395,742 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl745,376,453 - 45,395,742 (-)EnsemblGRCm38mm10GRCm38
MGSCv37752,631,824 - 52,651,017 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36745,244,496 - 45,263,689 (-)NCBIMGSCv36mm8
Celera740,832,480 - 40,851,675 (-)NCBICelera
Cytogenetic Map7B3NCBI
cM Map729.28NCBI
Snrnp70
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81104,992,518 - 105,012,851 (-)NCBIGRCr8
mRatBN7.2195,856,038 - 95,876,434 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl195,856,036 - 95,876,392 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1101,241,472 - 101,261,800 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01109,714,149 - 109,734,477 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01103,004,549 - 103,024,877 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01101,367,470 - 101,388,153 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1101,367,471 - 101,388,129 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01102,431,122 - 102,468,602 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4195,853,923 - 95,868,393 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1195,925,963 - 95,946,503 (-)NCBI
Celera190,118,420 - 90,132,674 (-)NCBICelera
Cytogenetic Map1q22NCBI
Snrnp70
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555591,614,039 - 1,634,142 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555591,618,246 - 1,634,144 (-)NCBIChiLan1.0ChiLan1.0
SNRNP70
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22055,199,729 - 55,221,922 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11957,118,085 - 57,141,420 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01946,094,679 - 46,118,022 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11955,021,402 - 55,044,351 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1955,021,402 - 55,046,281 (+)Ensemblpanpan1.1panPan2
SNRNP70
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11107,340,484 - 107,356,280 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1107,113,974 - 107,356,241 (-)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.01107,865,353 - 107,881,109 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1107,865,361 - 107,881,086 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11107,533,257 - 107,549,010 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01107,179,479 - 107,195,244 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01108,015,085 - 108,030,850 (-)NCBIUU_Cfam_GSD_1.0
Snrnp70
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934921,417,537 - 21,436,387 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049366643,035,679 - 3,054,577 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SNRNP70
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl654,288,397 - 54,304,103 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1654,288,354 - 54,304,272 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2650,024,183 - 50,040,138 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SNRNP70
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1642,305,961 - 42,329,289 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl642,305,687 - 42,330,332 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607322,196,694 - 22,220,757 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Snrnp70
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248324,973,251 - 4,988,679 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in SNRNP70
20 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 19q13.33-13.43(chr19:47908540-58539965)x3 copy number gain See cases [RCV000052914] Chr19:47908540..58539965 [GRCh38]
Chr19:48411797..59051332 [GRCh37]
Chr19:53103609..63743144 [NCBI36]
Chr19:19q13.33-13.43		 pathogenic
GRCh38/hg38 19q13.33-13.43(chr19:47929575-58572206)x3 copy number gain See cases [RCV000052915] Chr19:47929575..58572206 [GRCh38]
Chr19:48432832..59083573 [GRCh37]
Chr19:53124644..63775385 [NCBI36]
Chr19:19q13.33-13.43		 pathogenic
NM_003089.5(SNRNP70):c.265+111G>A single nucleotide variant Lung cancer [RCV000101291] Chr19:49090631 [GRCh38]
Chr19:49593888 [GRCh37]
Chr19:19q13.33		 uncertain significance
NM_003089.6(SNRNP70):c.1243A>G (p.Met415Val) single nucleotide variant not specified [RCV004281658] Chr19:49108372 [GRCh38]
Chr19:49611629 [GRCh37]
Chr19:19q13.33		 uncertain significance
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888) copy number gain See cases [RCV000512296] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888)x3 copy number gain See cases [RCV000511289] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic|uncertain significance
NM_003089.6(SNRNP70):c.985G>C (p.Asp329His) single nucleotide variant not specified [RCV004327345] Chr19:49108114 [GRCh38]
Chr19:49611371 [GRCh37]
Chr19:19q13.33		 uncertain significance
GRCh37/hg19 19q13.33(chr19:49556215-49651042)x1 copy number loss not provided [RCV000752727] Chr19:49556215..49651042 [GRCh37]
Chr19:19q13.33		 benign
GRCh37/hg19 19p13.3-q13.43(chr19:260912-59097160)x3 copy number gain not provided [RCV000752444] Chr19:260912..59097160 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:68029-59110290)x3 copy number gain not provided [RCV000752439] Chr19:68029..59110290 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic
GRCh37/hg19 19q13.33(chr19:48119589-49595956)x3 copy number gain not provided [RCV000848800] Chr19:48119589..49595956 [GRCh37]
Chr19:19q13.33		 uncertain significance
GRCh37/hg19 19q13.33(chr19:49600909-51366070)x3 copy number gain not provided [RCV000847250] Chr19:49600909..51366070 [GRCh37]
Chr19:19q13.33		 uncertain significance
GRCh37/hg19 19q13.32-13.42(chr19:47939842-54626871) copy number gain not provided [RCV001249294] Chr19:47939842..54626871 [GRCh37]
Chr19:19q13.32-13.42		 not provided
GRCh37/hg19 19q13.31-13.42(chr19:44738088-53621561)x3 copy number gain not provided [RCV001007050] Chr19:44738088..53621561 [GRCh37]
Chr19:19q13.31-13.42		 pathogenic
GRCh37/hg19 19q13.33-13.43(chr19:48463931-57095254)x3 copy number gain not provided [RCV001259944] Chr19:48463931..57095254 [GRCh37]
Chr19:19q13.33-13.43		 pathogenic
NM_003089.6(SNRNP70):c.772C>T (p.Arg258Cys) single nucleotide variant Global developmental delay [RCV001527630] Chr19:49107901 [GRCh38]
Chr19:49611158 [GRCh37]
Chr19:19q13.33		 uncertain significance
NC_000019.9:g.(?_49519325)_(50366015_?)dup duplication Developmental and epileptic encephalopathy, 12 [RCV002030046] Chr19:49519325..50366015 [GRCh37]
Chr19:19q13.33		 uncertain significance
NC_000019.9:g.(?_48618906)_(50921204_?)dup duplication Developmental and epileptic encephalopathy, 12 [RCV001939968]|not provided [RCV001916178] Chr19:48618906..50921204 [GRCh37]
Chr19:19q13.33		 uncertain significance
NC_000019.9:g.(?_49472545)_(49714755_?)del deletion Progressive familial heart block type IB [RCV003119771] Chr19:49472545..49714755 [GRCh37]
Chr19:19q13.33		 uncertain significance
NM_003089.6(SNRNP70):c.980C>G (p.Pro327Arg) single nucleotide variant not specified [RCV004310839] Chr19:49108109 [GRCh38]
Chr19:49611366 [GRCh37]
Chr19:19q13.33		 uncertain significance
NM_003089.6(SNRNP70):c.287A>G (p.Asn96Ser) single nucleotide variant not specified [RCV004247026] Chr19:49098448 [GRCh38]
Chr19:49601705 [GRCh37]
Chr19:19q13.33		 uncertain significance
NM_003089.6(SNRNP70):c.934G>A (p.Gly312Ser) single nucleotide variant not specified [RCV004135721] Chr19:49108063 [GRCh38]
Chr19:49611320 [GRCh37]
Chr19:19q13.33		 uncertain significance
NM_003089.6(SNRNP70):c.1196A>C (p.Gln399Pro) single nucleotide variant not specified [RCV004149680] Chr19:49108325 [GRCh38]
Chr19:49611582 [GRCh37]
Chr19:19q13.33		 uncertain significance
NM_003089.6(SNRNP70):c.1163G>T (p.Gly388Val) single nucleotide variant not specified [RCV004219947] Chr19:49108292 [GRCh38]
Chr19:49611549 [GRCh37]
Chr19:19q13.33		 uncertain significance
NM_003089.6(SNRNP70):c.686C>T (p.Pro229Leu) single nucleotide variant not specified [RCV004209567] Chr19:49107815 [GRCh38]
Chr19:49611072 [GRCh37]
Chr19:19q13.33		 uncertain significance
NM_003089.6(SNRNP70):c.985G>T (p.Asp329Tyr) single nucleotide variant not specified [RCV004082729] Chr19:49108114 [GRCh38]
Chr19:49611371 [GRCh37]
Chr19:19q13.33		 uncertain significance
NM_003089.6(SNRNP70):c.1090C>T (p.Arg364Trp) single nucleotide variant not specified [RCV004151143] Chr19:49108219 [GRCh38]
Chr19:49611476 [GRCh37]
Chr19:19q13.33		 uncertain significance
NM_003089.6(SNRNP70):c.1231C>G (p.Arg411Gly) single nucleotide variant not specified [RCV004232936] Chr19:49108360 [GRCh38]
Chr19:49611617 [GRCh37]
Chr19:19q13.33		 uncertain significance
NM_003089.6(SNRNP70):c.995C>T (p.Pro332Leu) single nucleotide variant not specified [RCV004098593] Chr19:49108124 [GRCh38]
Chr19:49611381 [GRCh37]
Chr19:19q13.33		 uncertain significance
NM_003089.6(SNRNP70):c.1253A>C (p.Glu418Ala) single nucleotide variant not specified [RCV004262604] Chr19:49108382 [GRCh38]
Chr19:49611639 [GRCh37]
Chr19:19q13.33		 uncertain significance
NM_003089.6(SNRNP70):c.778C>G (p.Arg260Gly) single nucleotide variant not specified [RCV004283325] Chr19:49107907 [GRCh38]
Chr19:49611164 [GRCh37]
Chr19:19q13.33		 uncertain significance
NM_003089.6(SNRNP70):c.1264G>A (p.Gly422Ser) single nucleotide variant not specified [RCV004366011] Chr19:49108393 [GRCh38]
Chr19:49611650 [GRCh37]
Chr19:19q13.33		 uncertain significance
NM_003089.6(SNRNP70):c.114T>C (p.Tyr38=) single nucleotide variant not provided [RCV003425321] Chr19:49086528 [GRCh38]
Chr19:49589785 [GRCh37]
Chr19:19q13.33		 likely benign
GRCh37/hg19 19q13.33-13.41(chr19:48905537-51614930)x3 copy number gain not specified [RCV003986127] Chr19:48905537..51614930 [GRCh37]
Chr19:19q13.33-13.41		 likely pathogenic
NM_003089.6(SNRNP70):c.869G>T (p.Arg290Leu) single nucleotide variant not specified [RCV004464404] Chr19:49107998 [GRCh38]
Chr19:49611255 [GRCh37]
Chr19:19q13.33		 uncertain significance
NM_003089.6(SNRNP70):c.1180G>C (p.Gly394Arg) single nucleotide variant not specified [RCV004464402] Chr19:49108309 [GRCh38]
Chr19:49611566 [GRCh37]
Chr19:19q13.33		 uncertain significance
NM_003089.6(SNRNP70):c.935G>T (p.Gly312Val) single nucleotide variant not specified [RCV004464405] Chr19:49108064 [GRCh38]
Chr19:49611321 [GRCh37]
Chr19:19q13.33		 uncertain significance
NM_003089.6(SNRNP70):c.1127G>A (p.Arg376His) single nucleotide variant not specified [RCV004464401] Chr19:49108256 [GRCh38]
Chr19:49611513 [GRCh37]
Chr19:19q13.33		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:4281
Count of miRNA genes:1018
Interacting mature miRNAs:1277
Transcripts:ENST00000221448, ENST00000401730, ENST00000544278, ENST00000595231, ENST00000597936, ENST00000598441, ENST00000598984, ENST00000599687, ENST00000601065, ENST00000601411
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
SHGC-58615  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371949,606,411 - 49,606,586UniSTSGRCh37
Build 361954,298,223 - 54,298,398RGDNCBI36
Celera1946,473,635 - 46,473,810RGD
Cytogenetic Map19q13.3UniSTS
HuRef1945,982,574 - 45,982,749UniSTS
TNG Radiation Hybrid Map1918156.0UniSTS
SHGC-149512  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371949,600,534 - 49,600,866UniSTSGRCh37
Build 361954,292,346 - 54,292,678RGDNCBI36
Celera1946,467,755 - 46,468,087RGD
Cytogenetic Map19q13.3UniSTS
HuRef1945,976,694 - 45,977,026UniSTS
TNG Radiation Hybrid Map1918156.0UniSTS
SNRP70  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371949,611,593 - 49,611,692UniSTSGRCh37
Build 361954,303,405 - 54,303,504RGDNCBI36
Celera1946,478,817 - 46,478,916RGD
HuRef1945,987,756 - 45,987,855UniSTS
RH11471  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371949,611,702 - 49,611,809UniSTSGRCh37
Build 361954,303,514 - 54,303,621RGDNCBI36
Celera1946,478,926 - 46,479,033RGD
Cytogenetic Map19q13.3UniSTS
HuRef1945,987,865 - 45,987,972UniSTS
GeneMap99-GB4 RH Map19269.13UniSTS
NCBI RH Map19533.4UniSTS
SHGC-57460  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371949,607,070 - 49,607,222UniSTSGRCh37
Build 361954,298,882 - 54,299,034RGDNCBI36
Celera1946,474,294 - 46,474,446RGD
Cytogenetic Map19q13.3UniSTS
HuRef1945,983,233 - 45,983,385UniSTS
TNG Radiation Hybrid Map1918146.0UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 27 19 1 38 33 27 1
Medium 2439 2989 1697 622 1925 463 4356 2197 3695 419 1427 1586 175 1 1204 2787 6 2
Low 2 2 2 7 2 1
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001301069 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_003089 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011527240 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011527241 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047439252 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054321840 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054321841 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054321842 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC008687 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC245081 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH001532 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK027127 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK056808 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK096783 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK293120 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL117399 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL117507 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL560281 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL832819 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC000342 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC001315 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BE397125 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM969999 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471177 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CN292681 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA403443 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB031937 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB189176 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M22636 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X06811 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X06812 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X06813 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X06814 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X06815 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X06816 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X06817 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X06818 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X06819 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X07401 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X07402 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X07403 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X84841 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000221448   ⟹   ENSP00000221448
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1949,085,451 - 49,108,563 (+)Ensembl
RefSeq Acc Id: ENST00000401730   ⟹   ENSP00000385077
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1949,085,451 - 49,108,603 (+)Ensembl
RefSeq Acc Id: ENST00000544278
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1949,102,411 - 49,108,602 (+)Ensembl
RefSeq Acc Id: ENST00000595231   ⟹   ENSP00000471006
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1949,085,495 - 49,108,605 (+)Ensembl
RefSeq Acc Id: ENST00000597936
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1949,085,451 - 49,090,639 (+)Ensembl
RefSeq Acc Id: ENST00000598441   ⟹   ENSP00000472998
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1949,085,451 - 49,108,604 (+)Ensembl
RefSeq Acc Id: ENST00000598984   ⟹   ENSP00000470023
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1949,085,423 - 49,102,118 (+)Ensembl
RefSeq Acc Id: ENST00000599687
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1949,086,524 - 49,101,668 (+)Ensembl
RefSeq Acc Id: ENST00000601065   ⟹   ENSP00000468952
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1949,085,419 - 49,108,598 (+)Ensembl
RefSeq Acc Id: ENST00000601411   ⟹   ENSP00000468828
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1949,086,480 - 49,098,459 (+)Ensembl
RefSeq Acc Id: NM_001301069   ⟹   NP_001287998
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381949,085,451 - 49,108,604 (+)NCBI
CHM1_11949,590,504 - 49,613,985 (+)NCBI
T2T-CHM13v2.01952,080,187 - 52,103,340 (+)NCBI
Sequence:
RefSeq Acc Id: NM_003089   ⟹   NP_003080
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381949,085,451 - 49,108,604 (+)NCBI
GRCh371949,588,465 - 49,611,870 (+)ENTREZGENE
GRCh371949,588,465 - 49,611,870 (+)NCBI
Build 361954,280,277 - 54,303,682 (+)NCBI Archive
HuRef1945,964,935 - 45,988,033 (+)ENTREZGENE
CHM1_11949,590,504 - 49,613,985 (+)NCBI
T2T-CHM13v2.01952,080,187 - 52,103,340 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011527240   ⟹   XP_011525542
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381949,098,834 - 49,108,604 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011527241   ⟹   XP_011525543
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381949,103,427 - 49,108,604 (+)NCBI
Sequence:
RefSeq Acc Id: XM_047439252   ⟹   XP_047295208
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381949,102,159 - 49,108,604 (+)NCBI
RefSeq Acc Id: XM_054321840   ⟹   XP_054177815
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01952,093,576 - 52,103,340 (+)NCBI
RefSeq Acc Id: XM_054321841   ⟹   XP_054177816
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01952,098,164 - 52,103,340 (+)NCBI
RefSeq Acc Id: XM_054321842   ⟹   XP_054177817
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01952,096,896 - 52,103,340 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001287998 (Get FASTA)   NCBI Sequence Viewer  
  NP_003080 (Get FASTA)   NCBI Sequence Viewer  
  XP_011525542 (Get FASTA)   NCBI Sequence Viewer  
  XP_011525543 (Get FASTA)   NCBI Sequence Viewer  
  XP_047295208 (Get FASTA)   NCBI Sequence Viewer  
  XP_054177815 (Get FASTA)   NCBI Sequence Viewer  
  XP_054177816 (Get FASTA)   NCBI Sequence Viewer  
  XP_054177817 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA03001 (Get FASTA)   NCBI Sequence Viewer  
  AAA36571 (Get FASTA)   NCBI Sequence Viewer  
  AAA36572 (Get FASTA)   NCBI Sequence Viewer  
  AAA36573 (Get FASTA)   NCBI Sequence Viewer  
  AAH00342 (Get FASTA)   NCBI Sequence Viewer  
  AAH01315 (Get FASTA)   NCBI Sequence Viewer  
  BAF85809 (Get FASTA)   NCBI Sequence Viewer  
  BAG51812 (Get FASTA)   NCBI Sequence Viewer  
  BAG53365 (Get FASTA)   NCBI Sequence Viewer  
  CAA29960 (Get FASTA)   NCBI Sequence Viewer  
  CAA29961 (Get FASTA)   NCBI Sequence Viewer  
  CAA29962 (Get FASTA)   NCBI Sequence Viewer  
  CAA29963 (Get FASTA)   NCBI Sequence Viewer  
  CAA29964 (Get FASTA)   NCBI Sequence Viewer  
  CAA29965 (Get FASTA)   NCBI Sequence Viewer  
  CAA29966 (Get FASTA)   NCBI Sequence Viewer  
  CAA29967 (Get FASTA)   NCBI Sequence Viewer  
  CAA30303 (Get FASTA)   NCBI Sequence Viewer  
  CAA30304 (Get FASTA)   NCBI Sequence Viewer  
  CAA30305 (Get FASTA)   NCBI Sequence Viewer  
  CAA59278 (Get FASTA)   NCBI Sequence Viewer  
  CAB55900 (Get FASTA)   NCBI Sequence Viewer  
  CAB55969 (Get FASTA)   NCBI Sequence Viewer  
  EAW52445 (Get FASTA)   NCBI Sequence Viewer  
  EAW52446 (Get FASTA)   NCBI Sequence Viewer  
  EAW52447 (Get FASTA)   NCBI Sequence Viewer  
  EAW52448 (Get FASTA)   NCBI Sequence Viewer  
  EAW52449 (Get FASTA)   NCBI Sequence Viewer  
  EAW52450 (Get FASTA)   NCBI Sequence Viewer  
  EAW52451 (Get FASTA)   NCBI Sequence Viewer  
  EAW52452 (Get FASTA)   NCBI Sequence Viewer  
  EAW52453 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000221448
  ENSP00000221448.5
  ENSP00000385077.1
  ENSP00000468828.1
  ENSP00000468952.1
  ENSP00000470023.1
  ENSP00000471006.1
  ENSP00000472998
  ENSP00000472998.1
GenBank Protein P08621 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_003080   ⟸   NM_003089
- Peptide Label: isoform 1
- UniProtKB: Q9UE48 (UniProtKB/Swiss-Prot),   Q9UE47 (UniProtKB/Swiss-Prot),   Q9UE46 (UniProtKB/Swiss-Prot),   Q9UE45 (UniProtKB/Swiss-Prot),   Q99377 (UniProtKB/Swiss-Prot),   Q15689 (UniProtKB/Swiss-Prot),   Q15687 (UniProtKB/Swiss-Prot),   Q15686 (UniProtKB/Swiss-Prot),   Q15364 (UniProtKB/Swiss-Prot),   P78494 (UniProtKB/Swiss-Prot),   P78493 (UniProtKB/Swiss-Prot),   B3KUA3 (UniProtKB/Swiss-Prot),   Q9UFQ6 (UniProtKB/Swiss-Prot),   P08621 (UniProtKB/Swiss-Prot),   A8KAQ5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001287998   ⟸   NM_001301069
- Peptide Label: isoform 2
- UniProtKB: A8KAQ5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011525542   ⟸   XM_011527240
- Peptide Label: isoform X1
- UniProtKB: B3KPV0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011525543   ⟸   XM_011527241
- Peptide Label: isoform X2
- UniProtKB: Q9UFS1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000471006   ⟸   ENST00000595231
RefSeq Acc Id: ENSP00000470023   ⟸   ENST00000598984
RefSeq Acc Id: ENSP00000472998   ⟸   ENST00000598441
RefSeq Acc Id: ENSP00000385077   ⟸   ENST00000401730
RefSeq Acc Id: ENSP00000468828   ⟸   ENST00000601411
RefSeq Acc Id: ENSP00000468952   ⟸   ENST00000601065
RefSeq Acc Id: ENSP00000221448   ⟸   ENST00000221448
RefSeq Acc Id: XP_047295208   ⟸   XM_047439252
- Peptide Label: isoform X2
- UniProtKB: Q9UFS1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054177815   ⟸   XM_054321840
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054177817   ⟸   XM_054321842
- Peptide Label: isoform X2
- UniProtKB: Q9UFS1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054177816   ⟸   XM_054321841
- Peptide Label: isoform X2
- UniProtKB: Q9UFS1 (UniProtKB/TrEMBL)
Protein Domains
RRM   U1 small nuclear ribonucleoprotein of 70kDa N-

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P08621-F1-model_v2 AlphaFold P08621 1-437 view protein structure

Promoters
RGD ID:13205075
Promoter ID:EPDNEW_H26118
Type:initiation region
Name:SNRNP70_1
Description:small nuclear ribonucleoprotein U1 subunit 70
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381949,085,451 - 49,085,511EPDNEW
RGD ID:6796066
Promoter ID:HG_KWN:30513
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_003089,   UC002PMH.1,   UC002PMI.1,   UC002PML.1,   UC002PMM.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361954,280,149 - 54,280,649 (+)MPROMDB
RGD ID:6851732
Promoter ID:EP73671
Type:multiple initiation site
Name:HS_SNRP70
Description:Small nuclear ribonucleoprotein 70kDa polypeptide (RNP antigen).
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:NEDO full length human cDNA sequencing project.; Oligo-capping
Position:
Human AssemblyChrPosition (strand)Source
Build 361954,280,520 - 54,280,580EPD
RGD ID:6796057
Promoter ID:HG_KWN:30514
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562,   Lymphoblastoid
Transcripts:UC002PMN.1,   UC002PMO.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361954,298,786 - 54,299,772 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:11150 AgrOrtholog
COSMIC SNRNP70 COSMIC
Ensembl Genes ENSG00000104852 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000221448 ENTREZGENE
  ENST00000221448.9 UniProtKB/Swiss-Prot
  ENST00000401730.5 UniProtKB/Swiss-Prot
  ENST00000595231.5 UniProtKB/Swiss-Prot
  ENST00000598441 ENTREZGENE
  ENST00000598441.6 UniProtKB/Swiss-Prot
  ENST00000598984.5 UniProtKB/TrEMBL
  ENST00000601065.5 UniProtKB/Swiss-Prot
  ENST00000601411.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.330 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000104852 GTEx
HGNC ID HGNC:11150 ENTREZGENE
Human Proteome Map SNRNP70 Human Proteome Map
InterPro Nucleotide-bd_a/b_plait_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RBD_domain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RRM_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  snRNP70_RRM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  U1snRNP70_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:6625 UniProtKB/Swiss-Prot
NCBI Gene 6625 ENTREZGENE
OMIM 180740 OMIM
PANTHER U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KDA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam RRM_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  U1snRNP70_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA35992 PharmGKB
PROSITE RRM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART RRM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54928 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A8KAQ5 ENTREZGENE, UniProtKB/TrEMBL
  B3KPV0 ENTREZGENE, UniProtKB/TrEMBL
  B3KUA3 ENTREZGENE
  M0QX04_HUMAN UniProtKB/TrEMBL
  M0QYR1_HUMAN UniProtKB/TrEMBL
  P08621 ENTREZGENE
  P78493 ENTREZGENE
  P78494 ENTREZGENE
  Q15364 ENTREZGENE
  Q15686 ENTREZGENE
  Q15687 ENTREZGENE
  Q15689 ENTREZGENE
  Q99377 ENTREZGENE
  Q9UE45 ENTREZGENE
  Q9UE46 ENTREZGENE
  Q9UE47 ENTREZGENE
  Q9UE48 ENTREZGENE
  Q9UFQ6 ENTREZGENE
  Q9UFS1 ENTREZGENE, UniProtKB/TrEMBL
  RU17_HUMAN UniProtKB/Swiss-Prot
UniProt Secondary B3KUA3 UniProtKB/Swiss-Prot
  P78493 UniProtKB/Swiss-Prot
  P78494 UniProtKB/Swiss-Prot
  Q15364 UniProtKB/Swiss-Prot
  Q15686 UniProtKB/Swiss-Prot
  Q15687 UniProtKB/Swiss-Prot
  Q15689 UniProtKB/Swiss-Prot
  Q99377 UniProtKB/Swiss-Prot
  Q9UE45 UniProtKB/Swiss-Prot
  Q9UE46 UniProtKB/Swiss-Prot
  Q9UE47 UniProtKB/Swiss-Prot
  Q9UE48 UniProtKB/Swiss-Prot
  Q9UFQ6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-14 SNRNP70  small nuclear ribonucleoprotein U1 subunit 70    small nuclear ribonucleoprotein, U1 70kDa subunit  Symbol and/or name change 5135510 APPROVED
2015-11-10 SNRNP70  small nuclear ribonucleoprotein, U1 70kDa subunit    small nuclear ribonucleoprotein 70kDa (U1)  Symbol and/or name change 5135510 APPROVED