Arhgef15 (Rho guanine nucleotide exchange factor 15) - Rat Genome Database

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Gene: Arhgef15 (Rho guanine nucleotide exchange factor 15) Rattus norvegicus
Analyze
Symbol: Arhgef15
Name: Rho guanine nucleotide exchange factor 15
RGD ID: 1306961
Description: Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in negative regulation of synapse maturation; regulation of actin cytoskeleton organization; and regulation of postsynapse assembly. Predicted to act upstream of or within retina vasculature morphogenesis in camera-type eye. Predicted to be located in dendrite. Predicted to be active in glutamatergic synapse and postsynapse. Orthologous to human ARHGEF15 (Rho guanine nucleotide exchange factor 15); PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: E5; ephexin-5; LOC287418; Rho guanine nucleotide exchange factor (GEF) 15
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81054,149,372 - 54,162,128 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1054,149,372 - 54,162,128 (-)EnsemblGRCr8
mRatBN7.21053,650,521 - 53,663,269 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1053,650,553 - 53,663,913 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1058,311,746 - 58,324,031 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01057,800,344 - 57,812,630 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01053,309,305 - 53,321,725 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01055,532,097 - 55,545,675 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1055,532,077 - 55,544,429 (-)Ensemblrn6Rnor6.0
Rnor_5.01055,274,558 - 55,288,124 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41055,703,919 - 55,716,219 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1052,816,914 - 52,829,189 (-)NCBICelera
RGSC_v3.11055,719,072 - 55,729,109 (-)NCBI
Cytogenetic Map10q24NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IDA)
dendrite  (IEA,ISO)
glutamatergic synapse  (IEA,ISO)
plasma membrane  (IEA,ISO)
postsynapse  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. EphA4-mediated Rho activation via Vsm-RhoGEF expressed specifically in vascular smooth muscle cells. Ogita H, etal., Circ Res. 2003 Jul 11;93(1):23-31. Epub 2003 May 29.
3. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:21029865   PMID:22535667  


Genomics

Comparative Map Data
Arhgef15
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81054,149,372 - 54,162,128 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1054,149,372 - 54,162,128 (-)EnsemblGRCr8
mRatBN7.21053,650,521 - 53,663,269 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1053,650,553 - 53,663,913 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1058,311,746 - 58,324,031 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01057,800,344 - 57,812,630 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01053,309,305 - 53,321,725 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01055,532,097 - 55,545,675 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1055,532,077 - 55,544,429 (-)Ensemblrn6Rnor6.0
Rnor_5.01055,274,558 - 55,288,124 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41055,703,919 - 55,716,219 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1052,816,914 - 52,829,189 (-)NCBICelera
RGSC_v3.11055,719,072 - 55,729,109 (-)NCBI
Cytogenetic Map10q24NCBI
ARHGEF15
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38178,310,241 - 8,322,511 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl178,310,241 - 8,323,127 (+)Ensemblhg38GRCh38
GRCh37178,213,559 - 8,225,829 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36178,154,315 - 8,166,554 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34178,154,314 - 8,166,553NCBI
Celera178,244,326 - 8,256,604 (+)NCBICelera
Cytogenetic Map17p13.1NCBI
HuRef178,108,796 - 8,121,074 (+)NCBIHuRef
CHM1_1178,222,461 - 8,234,738 (+)NCBICHM1_1
T2T-CHM13v2.0178,216,478 - 8,228,747 (+)NCBIT2T-CHM13v2.0
Arhgef15
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391168,819,726 - 68,847,760 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1168,833,981 - 68,848,306 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381168,928,900 - 68,956,934 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1168,943,155 - 68,957,480 (-)Ensemblmm10GRCm38
MGSCv371168,756,656 - 68,770,360 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361168,759,349 - 68,773,053 (-)NCBIMGSCv36mm8
Celera1175,885,590 - 75,899,659 (-)NCBICelera
Cytogenetic Map11B3NCBI
cM Map1142.21NCBI
Arhgef15
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554678,587,873 - 8,602,747 (-)Ensembl
ChiLan1.0NW_0049554678,590,217 - 8,603,778 (-)NCBIChiLan1.0ChiLan1.0
ARHGEF15
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21965,430,225 - 65,448,985 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11770,239,706 - 70,258,476 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01743,336,764 - 43,349,787 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11748,070,223 - 48,082,499 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1748,070,223 - 48,082,499 (-)EnsemblpanPan2panpan1.1
ARHGEF15
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1533,096,108 - 33,110,551 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl533,098,159 - 33,121,083 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha533,232,023 - 33,246,695 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0533,199,015 - 33,213,954 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl533,199,053 - 33,213,946 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1533,165,967 - 33,180,883 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0533,121,691 - 33,136,319 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0533,301,486 - 33,316,166 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Arhgef15
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560248,057,476 - 48,071,035 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365951,534,717 - 1,543,448 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365951,531,694 - 1,545,206 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARHGEF15
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1253,495,453 - 53,506,352 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11253,495,409 - 53,506,373 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21255,970,955 - 55,981,937 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ARHGEF15
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1167,674,190 - 7,687,129 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl167,674,577 - 7,687,834 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605913,712,012 - 13,724,581 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Arhgef15
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478610,892,422 - 10,901,430 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462478610,872,793 - 10,902,948 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Arhgef15
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1948,541,099 - 48,554,210 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Arhgef15
40 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:249
Count of miRNA genes:161
Interacting mature miRNAs:193
Transcripts:ENSRNOT00000067528
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103589345164140567Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105107189796071897Rat
152025229Scl83Serum cholesterol level QTL 834.33blood cholesterol amount (VT:0000180)103621155669161158Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103179628176796281Rat
152025227Bw195Body weight QTL 1955.73body mass (VT:0001259)104748901769161158Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101577675460776754Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)102744378772443787Rat
152025224Bw193Body weight QTL 1936.47body mass (VT:0001259)105216243375582749Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
1578762Toxo1Toxoplasma gondii resistance QTL 1brain integrity trait (VT:0010579)percentage of study population displaying Toxoplasma gondii brain cysts at a point in time (CMO:0002028)105269900459876693Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)101993920764939207Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)101803578263035782Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104183127886831278Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105046480295464802Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104552916496099749Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104493935989939359Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101866841963668419Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102183375861843633Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105086028895860288Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102895035373950353Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103589326364653589Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102980091064653589Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102744378772443787Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14282327487823274Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104493935989939359Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104282327487823274Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)104949549294495492Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)101465354159653541Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101553301273695498Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)102466212373695339Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102702353561843633Rat
2298480Eau7Experimental allergic uveoretinitis QTL 70.0049uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103550938380509383Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
2298495Eae23Experimental allergic encephalomyelitis QTL 2316.93nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)101617552561175525Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)102011061465110614Rat
2289985Bp305Blood pressure QTL 305arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102907697874076978Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101803578263035782Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104360879388608793Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)102744378772443787Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104994371094943710Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103112911376129113Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104493935989939359Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104786912992869129Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105060467795604677Rat
12880050Am10Aortic mass QTL 100.016aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)103950348784503487Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103550938388177745Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)102011061465110614Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat

Markers in Region
RH131949  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21053,650,712 - 53,650,900 (+)MAPPERmRatBN7.2
Rnor_6.01055,532,289 - 55,532,476NCBIRnor6.0
Rnor_5.01055,274,776 - 55,274,963UniSTSRnor5.0
RGSC_v3.41055,704,079 - 55,704,266UniSTSRGSC3.4
Celera1052,817,074 - 52,817,261UniSTS
Cytogenetic Map10q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 160 91 90 59 72 59 6 336 172 11 139 81 92 31 16 16

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001414295 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008767788 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008767789 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008767790 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008767791 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008767793 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597083 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597084 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039085436 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001840036 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005489733 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005489734 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_594717 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC126877 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000067528   ⟹   ENSRNOP00000060721
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1054,149,372 - 54,162,128 (-)Ensembl
mRatBN7.2 Ensembl1053,650,553 - 53,662,846 (-)Ensembl
Rnor_6.0 Ensembl1055,532,129 - 55,544,429 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000084385   ⟹   ENSRNOP00000068844
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1054,149,372 - 54,162,128 (-)Ensembl
mRatBN7.2 Ensembl1053,650,578 - 53,663,913 (-)Ensembl
Rnor_6.0 Ensembl1055,532,077 - 55,543,527 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000162011   ⟹   ENSRNOP00000111313
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1054,150,925 - 54,161,818 (-)Ensembl
RefSeq Acc Id: NM_001414295   ⟹   NP_001401224
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81054,149,372 - 54,162,128 (-)NCBI
mRatBN7.21053,650,521 - 53,663,269 (-)NCBI
RefSeq Acc Id: XM_039085436   ⟹   XP_038941364
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81054,149,372 - 54,160,758 (-)NCBI
mRatBN7.21053,650,521 - 53,661,930 (-)NCBI
RefSeq Acc Id: XR_005489733
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81054,149,372 - 54,160,758 (-)NCBI
mRatBN7.21053,650,521 - 53,662,914 (-)NCBI
RefSeq Acc Id: XR_005489734
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81054,152,372 - 54,160,758 (-)NCBI
mRatBN7.21053,653,519 - 53,662,914 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001401224 (Get FASTA)   NCBI Sequence Viewer  
  XP_038941364 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM04823 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000060721.2
  ENSRNOP00000068844
  ENSRNOP00000068844.1
  ENSRNOP00000111313.1
Ensembl Acc Id: ENSRNOP00000060721   ⟸   ENSRNOT00000067528
Ensembl Acc Id: ENSRNOP00000068844   ⟸   ENSRNOT00000084385
RefSeq Acc Id: XP_038941364   ⟸   XM_039085436
- Peptide Label: isoform X1
RefSeq Acc Id: NP_001401224   ⟸   NM_001414295
- UniProtKB: A0A0G2JTU0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000111313   ⟸   ENSRNOT00000162011
Protein Domains
DH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JTU0-F1-model_v2 AlphaFold A0A0G2JTU0 1-850 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306961 AgrOrtholog
BioCyc Gene G2FUF-24616 BioCyc
Ensembl Genes ENSRNOG00000004566 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000067528.3 UniProtKB/TrEMBL
  ENSRNOT00000084385 ENTREZGENE
  ENSRNOT00000084385.3 UniProtKB/TrEMBL
  ENSRNOT00000162011 ENTREZGENE
  ENSRNOT00000162011.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.900.10 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
InterPro DBL_dom_sf UniProtKB/TrEMBL
  DH-domain UniProtKB/TrEMBL
  Ephexin-like UniProtKB/TrEMBL
  PH_dom-like UniProtKB/TrEMBL
  PH_ephexin UniProtKB/TrEMBL
NCBI Gene 287418 ENTREZGENE
PANTHER GUANINE NUCLEOTIDE EXCHANGE FACTOR UniProtKB/TrEMBL
  RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 15 UniProtKB/TrEMBL
Pfam RhoGEF UniProtKB/TrEMBL
PhenoGen Arhgef15 PhenoGen
PROSITE DH_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004566 RatGTEx
SMART RhoGEF UniProtKB/TrEMBL
Superfamily-SCOP DH-domain UniProtKB/TrEMBL
  PH domain-like UniProtKB/TrEMBL
UniProt A0A0G2JTU0 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LZZ4_RAT UniProtKB/TrEMBL
  D3ZPJ8_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-19 Arhgef15  Rho guanine nucleotide exchange factor 15  Arhgef15  Rho guanine nucleotide exchange factor (GEF) 15  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Arhgef15  Rho guanine nucleotide exchange factor (GEF) 15   Arhgef15_predicted  Rho guanine nucleotide exchange factor (GEF) 15 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Arhgef15_predicted  Rho guanine nucleotide exchange factor (GEF) 15 (predicted)      Symbol and Name status set to approved 70820 APPROVED