Insm2 (INSM transcriptional repressor 2) - Rat Genome Database

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Gene: Insm2 (INSM transcriptional repressor 2) Rattus norvegicus
Analyze
Symbol: Insm2
Name: INSM transcriptional repressor 2
RGD ID: 1306949
Description: Orthologous to human INSM2 (INSM transcriptional repressor 2); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 6-propyl-2-thiouracil; amitrole.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: insulinoma-associated 2; insulinoma-associated protein 2; LOC314131
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8678,708,983 - 78,711,575 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl678,705,641 - 78,717,027 (+)EnsemblGRCr8
mRatBN7.2672,973,861 - 72,976,453 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx673,395,488 - 73,398,078 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0673,701,858 - 73,704,448 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0673,129,368 - 73,131,958 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0676,380,681 - 76,386,240 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl676,383,446 - 76,384,933 (+)Ensemblrn6Rnor6.0
Rnor_5.0685,914,501 - 85,919,811 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4675,846,090 - 75,847,587 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera671,812,955 - 71,818,504 (+)NCBICelera
RGSC_v3.1675,849,225 - 75,850,715 (+)NCBI
Cytogenetic Map6q23NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleus  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Insm2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8678,708,983 - 78,711,575 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl678,705,641 - 78,717,027 (+)EnsemblGRCr8
mRatBN7.2672,973,861 - 72,976,453 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx673,395,488 - 73,398,078 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0673,701,858 - 73,704,448 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0673,129,368 - 73,131,958 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0676,380,681 - 76,386,240 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl676,383,446 - 76,384,933 (+)Ensemblrn6Rnor6.0
Rnor_5.0685,914,501 - 85,919,811 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4675,846,090 - 75,847,587 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera671,812,955 - 71,818,504 (+)NCBICelera
RGSC_v3.1675,849,225 - 75,850,715 (+)NCBI
Cytogenetic Map6q23NCBI
INSM2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381435,534,164 - 35,537,054 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1435,534,164 - 35,537,054 (+)Ensemblhg38GRCh38
GRCh371436,003,370 - 36,006,260 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361435,072,999 - 35,076,011 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341435,072,998 - 35,076,011NCBI
Celera1415,867,108 - 15,870,120 (+)NCBICelera
Cytogenetic Map14q13.2NCBI
HuRef1416,117,138 - 16,120,150 (+)NCBIHuRef
CHM1_11436,002,929 - 36,005,941 (+)NCBICHM1_1
T2T-CHM13v2.01429,721,890 - 29,724,780 (+)NCBIT2T-CHM13v2.0
Insm2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391255,646,212 - 55,648,818 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1255,646,212 - 55,648,871 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381255,598,917 - 55,602,018 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1255,599,427 - 55,602,086 (+)Ensemblmm10GRCm38
MGSCv371256,699,904 - 56,703,005 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361256,517,603 - 56,519,084 (+)NCBIMGSCv36mm8
Celera1256,748,546 - 56,751,647 (+)NCBICelera
Cytogenetic Map12C1NCBI
cM Map1224.05NCBI
Insm2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540925,584,904 - 25,585,998 (-)Ensembl
ChiLan1.0NW_00495540925,584,543 - 25,586,025 (-)NCBIChiLan1.0ChiLan1.0
INSM2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21536,848,522 - 36,851,469 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11436,065,025 - 36,067,972 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01416,287,866 - 16,290,884 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11434,468,831 - 34,470,476 (+)NCBIPanPan1.1PanPan1.1panPan2
INSM2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1814,217,694 - 14,220,661 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl814,217,785 - 14,219,458 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha814,013,937 - 14,016,656 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0814,324,080 - 14,326,798 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl814,324,080 - 14,325,753 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1814,025,158 - 14,027,875 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0814,090,754 - 14,093,472 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0814,380,468 - 14,383,186 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Insm2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864046,139,681 - 46,142,555 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364949,645,673 - 9,647,361 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364949,645,568 - 9,648,449 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
INSM2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl764,374,823 - 64,376,495 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1764,372,361 - 64,378,366 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2769,282,117 - 69,285,979 (-)NCBISscrofa10.2Sscrofa10.2susScr3
INSM2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12412,340,659 - 12,343,663 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2412,340,864 - 12,342,570 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660531,305,073 - 1,308,143 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Insm2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248381,271,100 - 1,272,764 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248381,269,909 - 1,272,849 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Insm2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1768,840,950 - 68,842,531 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Insm2
42 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:73
Count of miRNA genes:63
Interacting mature miRNAs:66
Transcripts:ENSRNOT00000010188
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590290Uminl2Urine mineral level QTL 23.960.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)64451097489510974Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)671278722116278722Rat
70176Mcsm1Mammary carcinoma susceptibility modifier QTL 1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)664367996109367996Rat
2293088Iddm28Insulin dependent diabetes mellitus QTL 285.21blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)668767270135411972Rat
1558641Cm47Cardiac mass QTL 472.90.001heart mass (VT:0007028)heart wet weight (CMO:0000069)66345744194939581Rat
4889933Bss88Bone structure and strength QTL 883.8tibia size trait (VT:0100001)tibia total bone volume (CMO:0001724)65368492198684921Rat
737827Hcar11Hepatocarcinoma resistance QTL 114.4liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)646050607116278722Rat
634307Bp141Blood pressure QTL 1414arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)64095756485957564Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)64604735391047353Rat
1331743Uae28Urinary albumin excretion QTL 284.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)64515378690153786Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62661831486868070Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)620859430113082285Rat
9590140Scort4Serum corticosterone level QTL 414.490.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)64451097489510974Rat
2301964Bp323Blood pressure QTL 3234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6186868070Rat
9590306Scort18Serum corticosterone level QTL 182.880.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)64451097489510974Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62661831486868070Rat
4889848Pur25Proteinuria QTL 25140.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)66303731995934232Rat
6893340Cm77Cardiac mass QTL 770.260.57heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)63902865986867923Rat
5684963Bss99Bone structure and strength QTL 993.1tibia area (VT:1000281)tibia area measurement (CMO:0001382)65368492198684921Rat
5684992Bmd83Bone mineral density QTL 824.8tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)65368492198684921Rat
1576302Schws4Schwannoma susceptibility QTL 40.0078nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)678204640123204640Rat
1300075Glom7Glomerulus QTL 75.60.0000002kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)676937178121937178Rat
1300143Rf14Renal function QTL 142.92renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)64016318385163183Rat
6893332Cm74Cardiac mass QTL 740.40.64heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)66345744194939581Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
11 10 25 135 48 46 22 72 22 3 184 115 2 125 29 53 24 14 14

Sequence


Ensembl Acc Id: ENSRNOT00000010188   ⟹   ENSRNOP00000010188
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl676,383,446 - 76,384,933 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000149150   ⟹   ENSRNOP00000111664
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl678,705,641 - 78,717,027 (+)Ensembl
RefSeq Acc Id: NM_001398789   ⟹   NP_001385718
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8678,708,983 - 78,711,575 (+)NCBI
mRatBN7.2672,973,861 - 72,976,453 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001385718 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM03430 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000111664
  ENSRNOP00000111664.1
Ensembl Acc Id: ENSRNOP00000010188   ⟸   ENSRNOT00000010188
RefSeq Acc Id: NP_001385718   ⟸   NM_001398789
- UniProtKB: A6HBM5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000111664   ⟸   ENSRNOT00000149150
Protein Domains
C2H2-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZKF8-F1-model_v2 AlphaFold D3ZKF8 1-495 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306949 AgrOrtholog
BioCyc Gene G2FUF-37484 BioCyc
Ensembl Genes ENSRNOG00000007754 Ensembl
  ENSRNOG00000083293 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000149150 ENTREZGENE
  ENSRNOT00000149150.1 UniProtKB/TrEMBL
Gene3D-CATH Classic Zinc Finger UniProtKB/TrEMBL
InterPro INSM1/2 UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
  Znf_C2H2_type UniProtKB/TrEMBL
NCBI Gene 314131 ENTREZGENE
PANTHER INSULINOMA-ASSOCIATED 1 UniProtKB/TrEMBL
  INSULINOMA-ASSOCIATED PROTEIN 2 UniProtKB/TrEMBL
Pfam zf-C2H2 UniProtKB/TrEMBL
PhenoGen Insm2 PhenoGen
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000007754 RatGTEx
  ENSRNOG00000083293 RatGTEx
SMART ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP beta-beta-alpha zinc fingers UniProtKB/TrEMBL
UniProt A0ABK0LYX5_RAT UniProtKB/TrEMBL
  A6HBM5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-11 Insm2  INSM transcriptional repressor 2  Insm2  insulinoma-associated 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Insm2  insulinoma-associated 2   Insm2_predicted  insulinoma-associated 2 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Insm2_predicted  insulinoma-associated 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED