Tjp1 (tight junction protein 1) - Rat Genome Database

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Gene: Tjp1 (tight junction protein 1) Rattus norvegicus
Analyze
Symbol: Tjp1
Name: tight junction protein 1
RGD ID: 1306305
Description: Enables beta-catenin binding activity and transmembrane transporter binding activity. Involved in several processes, including cellular response to glucose stimulus; negative regulation of vascular permeability; and response to lipopolysaccharide. Located in bicellular tight junction and gap junction. Biomarker of several diseases, including brain ischemia; metabolic dysfunction and alcohol associated liver disease; peptic esophagitis; perinatal necrotizing enterocolitis; and uveitis. Orthologous to human TJP1 (tight junction protein 1); PARTICIPATES IN E-cadherin signaling pathway; INTERACTS WITH (+)-pilocarpine; (R)-carnitine; (S)-nicotine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: tight junction protein ZO-1; ZO-1; zona occludens 1; zona occludens protein 1; zonula occludens protein 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81128,260,330 - 128,505,018 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1128,260,330 - 128,505,158 (-)EnsemblGRCr8
mRatBN7.21118,849,838 - 119,094,492 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1118,849,838 - 119,094,432 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1126,838,905 - 126,903,927 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01134,010,313 - 134,075,335 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01126,827,729 - 126,892,646 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01126,146,489 - 126,515,359 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1126,146,489 - 126,227,469 (-)Ensemblrn6Rnor6.0
Rnor_5.01127,243,076 - 127,607,938 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41119,684,774 - 119,750,532 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1111,069,963 - 111,134,894 (-)NCBICelera
RGSC_v3.11119,763,121 - 119,845,891 (-)NCBI
Cytogenetic Map1q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(-)-anisomycin  (ISO)
(20S)-ginsenoside Rg3  (ISO)
(R)-carnitine  (EXP)
(S)-colchicine  (ISO)
(S)-nicotine  (EXP,ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-(5-isoquinolinesulfonyl)-2-methylpiperazine  (EXP)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP)
17beta-estradiol 17-glucosiduronic acid  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP,ISO)
2,4-D  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-amino-2-deoxy-D-galactopyranose  (EXP)
2-hydroxypropanoic acid  (ISO)
2-methoxy-17beta-estradiol  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxynon-2-enal  (ISO)
5-(2-methylpiperazine-1-sulfonyl)isoquinoline  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
6-O-alpha-D-glucopyranosyl-D-fructofuranose  (ISO)
6-propyl-2-thiouracil  (EXP)
7,8-dihydroxycoumarin  (ISO)
acadesine  (ISO)
acetaldehyde  (ISO)
acetic acid [2-[[(5-nitro-2-thiazolyl)amino]-oxomethyl]phenyl] ester  (ISO)
acrylamide  (EXP)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha,alpha-trehalose  (ISO)
alpha-D-galactose  (ISO)
alternariol  (ISO)
Altertoxin II  (ISO)
Ammothamnine  (EXP)
ampicillin  (ISO)
anthocyanin  (EXP)
antirheumatic drug  (ISO)
apocynin  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
biochanin A  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
Brodifacoum  (EXP)
bucladesine  (EXP)
Butylbenzyl phthalate  (ISO)
butyric acid  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calciol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carrageenan  (ISO)
chelerythrine  (ISO)
chlorogenic acid  (EXP)
chlorothalonil  (ISO)
chlorpyrifos  (EXP,ISO)
choline  (ISO)
cisplatin  (ISO)
clopidogrel  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
corn oil  (EXP)
cortisol  (ISO)
costunolide  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
CU-CPT22  (ISO)
curcumin  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cyfluthrin  (ISO)
D-glucose  (ISO)
decabromodiphenyl ether  (ISO)
Deoxycorticosterone acetate  (ISO)
deoxynivalenol  (ISO)
Deoxyschizandrin  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
Di-n-octyl phthalate  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
dieldrin  (EXP)
diethyl phthalate  (ISO)
diiodine  (ISO)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethyl sulfoxide  (ISO)
dioxygen  (ISO)
dizocilpine maleate  (ISO)
dodecanoic acid  (ISO)
doramapimod  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
enzyme inhibitor  (ISO)
ethanol  (EXP,IEP,ISO)
ethylene glycol  (EXP)
etomidate  (ISO)
fasudil  (EXP,ISO)
ferrostatin-1  (ISO)
ferulic acid  (ISO)
Fexaramine  (ISO)
flavonoids  (ISO)
folic acid  (ISO)
folpet  (ISO)
FR900359  (ISO)
fucoxanthin  (ISO)
furan  (ISO)
galactose  (ISO)
gamma-hexachlorocyclohexane  (EXP,ISO)
gamma-linolenic acid  (ISO)
genistein  (EXP)
Ginkgoic acid  (ISO)
Ginkgolide A  (ISO)
ginsenoside Re  (ISO)
glucose  (ISO)
glycyrrhizinic acid  (EXP,ISO)
glyphosate  (EXP)
Goe 6976  (EXP)
Harpagoside  (ISO)
hexadecanoic acid  (ISO)
homocysteine  (ISO)
hydrogen peroxide  (ISO)
hydrogen sulfide  (ISO)
hydroquinone  (EXP)
imidacloprid  (EXP)
indometacin  (EXP,ISO)
irinotecan  (ISO)
isovitexin  (EXP)
ivermectin  (ISO)
kaempferol  (EXP,ISO)
ketoconazole  (EXP)
kynurenic acid  (ISO)
L-ascorbic acid  (EXP)
L-methionine  (ISO)
lactulose  (EXP)
lead diacetate  (ISO)
lead(0)  (EXP,ISO)
levamisole  (ISO)
lipopolysaccharide  (EXP,ISO)
lithium atom  (EXP)
lithium chloride  (ISO)
lithium hydride  (EXP)
lithocholic acid  (ISO)
losartan  (EXP)
luteolin  (ISO)
LY294002  (ISO)
lycopene  (ISO)
malaoxon  (EXP)
malathion  (EXP)
melatonin  (ISO)
menadione  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
mesalamine  (ISO)
methamphetamine  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
methoxychlor  (EXP)
methylglyoxal  (ISO)
methylmercury chloride  (EXP,ISO)
metronidazole  (ISO)
microcystin-LR  (EXP,ISO)
mifepristone  (ISO)
Mitoquinone  (ISO)
MK-2206  (ISO)
ML-7  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
Monobutylphthalate  (EXP,ISO)
mycophenolic acid  (ISO)
myricetin  (EXP)
N(6),N(6)-dimethyladenine  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-acetylsphingosine  (ISO)
N-methyl-D-aspartic acid  (ISO)
Neoisoliquiritin  (ISO)
neomycin  (ISO)
nicotine  (EXP,ISO)
nitric oxide  (EXP,ISO)
nobiletin  (ISO)
Nonylphenol  (EXP)
obeticholic acid  (ISO)
ochratoxin A  (ISO)
octhilinone  (ISO)
okadaic acid  (ISO)
oleanolic acid  (ISO)
Olmesartan medoxomil  (ISO)
oroxylin A  (EXP)
oxaliplatin  (EXP)
oxamic acid  (ISO)
oxybenzone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parthenolide  (ISO)
patulin  (ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (EXP)
phenol  (ISO)
phosgene  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
poly(I:C)  (ISO)
potassium dichromate  (ISO)
potassium iodide  (EXP)
PRIM-O-GLUCOSYLCIMIFUGIN  (ISO)
probenecid  (ISO)
procymidone  (ISO)
Prothioconazole-desthio  (ISO)
puerarin  (ISO)
quercetin  (EXP,ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rifampicin  (ISO)
ritonavir  (EXP)
rotenone  (EXP,ISO)
rottlerin  (ISO)
Salidroside  (ISO)
salubrinal  (ISO)
sanguinarine  (ISO)
saquinavir  (EXP)
SB 203580  (ISO)
SB 431542  (ISO)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
selenium atom  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sodium fluoride  (ISO)
sodium propionate  (ISO)
sodium sulfide (anhydrous)  (ISO)
sorafenib  (ISO)
staurosporine  (EXP)
streptozocin  (ISO)
sulfasalazine  (EXP)
tamoxifen  (ISO)
tectorigenin  (ISO)
telmisartan  (ISO)
tert-butyl hydroperoxide  (EXP)
tetrachloromethane  (ISO)
thalidomide  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
tributylstannane  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclocarban  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
troglitazone  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
vitamin E  (EXP)
vorinostat  (EXP,ISO)
vortioxetine  (ISO)
wortmannin  (ISO)
zafirlukast  (ISO)
zardaverine  (EXP)
zileuton  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Matrix metalloproteinases inhibition provides neuroprotection against hypoxia-ischemia in the developing brain. Chen W, etal., J Neurochem. 2009 Nov;111(3):726-36. Epub 2009 Aug 27.
2. Catenins in the rat epididymis: their expression and regulation in adulthood and during postnatal development. DeBellefeuille S, etal., Endocrinology. 2003 Nov;144(11):5040-9. doi: 10.1210/en.2002-0139. Epub 2003 Aug 13.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Mechanoelectrical remodeling and arrhythmias during progression of hypertrophy. Jin H, etal., FASEB J. 2010 Feb;24(2):451-63. Epub 2009 Oct 13.
6. Changes in hepatic cell junctions structure during experimental necrotizing enterocolitis: effect of EGF treatment. Khailova L, etal., Pediatr Res. 2009 Aug;66(2):140-4.
7. Administration of S-nitrosoglutathione after traumatic brain injury protects the neurovascular unit and reduces secondary injury in a rat model of controlled cortical impact. Khan M, etal., J Neuroinflammation. 2009 Nov 4;6:32.
8. Connexin45 interacts with zonula occludens-1 in osteoblastic cells. Laing JG, etal., Cell Commun Adhes 2001;8(4-6):209-12.
9. Interleukin-6, desmosome and tight junction protein expression levels in reflux esophagitis-affected mucosa. Li FY and Li Y, World J Gastroenterol. 2009 Aug 7;15(29):3621-30.
10. Altered distribution of tight junction proteins after intestinal ischaemia/reperfusion injury in rats. Li Q, etal., J Cell Mol Med. 2009 Sep;13(9B):4061-76. Epub 2009 Nov 19.
11. Ginkgolic acid (GA) suppresses gastric cancer growth by inducing apoptosis and suppressing STAT3/JAK2 signaling regulated by ROS. Liang JR and Yang H, Biomed Pharmacother. 2020 May;125:109585. doi: 10.1016/j.biopha.2019.109585. Epub 2020 Feb 25.
12. Bile duct ligation in the rat causes upregulation of ZO-2 and decreased colocalization of claudins with ZO-1 and occludin. Maly IP and Landmann L, Histochem Cell Biol. 2008 Mar;129(3):289-99. Epub 2008 Jan 15.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Zonula occludens-1, occludin, and E-cadherin protein expression in biliary tract cancers. Nemeth Z, etal., Pathol Oncol Res. 2009 Sep;15(3):533-9. Epub .
15. At low doses ethanol maintains blood-brain barrier (BBB) integrity after hypoxia and reoxygenation: a brain slice study. Peng C, etal., Neurol Res. 2013 Oct;35(8):790-7. doi: 10.1179/1743132813Y.0000000198. Epub 2013 Apr 12.
16. Puerarin ameliorates experimental alcoholic liver injury by inhibition of endotoxin gut leakage, Kupffer cell activation, and endotoxin receptors expression. Peng JH, etal., J Pharmacol Exp Ther. 2013 Mar;344(3):646-54. doi: 10.1124/jpet.112.201137. Epub 2012 Dec 31.
17. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
18. Different effects of ZO-1, ZO-2 and ZO-3 silencing on kidney collecting duct principal cell proliferation and adhesion. Qiao X, etal., Cell Cycle. 2014;13(19):3059-75. doi: 10.4161/15384101.2014.949091.
19. [Effects of electromagnetic pulse on blood-brain barrier permeability and tight junction proteins in rats] Qiu LB, etal., Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2009 Sep;27(9):539-43.
20. Astragaloside IV attenuates cerebral ischemia-reperfusion-induced increase in permeability of the blood-brain barrier in rats. Qu YZ, etal., Eur J Pharmacol. 2009 Mar 15;606(1-3):137-41. Epub 2009 Jan 25.
21. GOA pipeline RGD automated data pipeline
22. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. ZO-1 expression and phosphorylation in diabetic nephropathy. Rincon-Choles H, etal., Diabetes. 2006 Apr;55(4):894-900.
25. Transforming growth factor-beta signaling alters substrate permeability and tight junction protein expression at the blood-brain barrier during inflammatory pain. Ronaldson PT, etal., J Cereb Blood Flow Metab. 2009 Jun;29(6):1084-98. Epub 2009 Mar 25.
26. Glibenclamide reduces inflammation, vasogenic edema, and caspase-3 activation after subarachnoid hemorrhage. Simard JM, etal., J Cereb Blood Flow Metab. 2009 Feb;29(2):317-30. Epub 2008 Oct 15.
27. Connexin 43 interacts with zona occludens-1 and -2 proteins in a cell cycle stage-specific manner. Singh D, etal., J Biol Chem. 2005 Aug 26;280(34):30416-21. Epub 2005 Jun 26.
28. Focal adhesion kinase is a blood-testis barrier regulator. Siu ER, etal., Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9298-303. doi: 10.1073/pnas.0813113106. Epub 2009 May 21.
29. P-glycoprotein regulates blood-testis barrier dynamics via its effects on the occludin/zonula occludens 1 (ZO-1) protein complex mediated by focal adhesion kinase (FAK). Su L, etal., Proc Natl Acad Sci U S A. 2011 Dec 6;108(49):19623-8. doi: 10.1073/pnas.1111414108. Epub 2011 Nov 21.
30. Prophylactic effect of rebamipide on aspirin-induced gastric lesions and disruption of tight junctional protein zonula occludens-1 distribution. Suzuki T, etal., J Pharmacol Sci. 2008 Mar;106(3):469-77.
31. Phosphorylation regulates connexin43/ZO-1 binding and release, an important step in gap junction turnover. Thévenin AF, etal., Mol Biol Cell. 2017 Dec 1;28(25):3595-3608. doi: 10.1091/mbc.E16-07-0496. Epub 2017 Oct 11.
32. The corneal endothelium in an endotoxin-induced uveitis model: correlation between in vivo confocal microscopy and immunohistochemistry. Trinh L, etal., Mol Vis. 2008 Jun 16;14:1149-56.
33. Localization of claudin-5 and ZO-1 in rat spleen sinus endothelial cells. Uehara K and Uehara A, Histochem Cell Biol. 2008 Jan;129(1):95-103. Epub 2007 Sep 25.
34. Age-dependent responses of glial cells and leptomeninges during systemic inflammation. Wu Z, etal., Neurobiol Dis. 2008 Dec;32(3):543-51. Epub 2008 Sep 21.
35. Differential interactions between transforming growth factor-beta3/TbetaR1, TAB1, and CD2AP disrupt blood-testis barrier and Sertoli-germ cell adhesion. Xia W, etal., J Biol Chem. 2006 Jun 16;281(24):16799-813. Epub 2006 Apr 13.
36. Effects of chronic ethanol ingestion on tight junction proteins and barrier function of alveolar epithelium in the rat. Zhang YL, etal., Shock. 2007 Aug;28(2):245-52.
Additional References at PubMed
PMID:8636221   PMID:9531559   PMID:9582296   PMID:10395790   PMID:10873669   PMID:11025210   PMID:11090614   PMID:11689568   PMID:11706048   PMID:11731229   PMID:11734628   PMID:12060405  
PMID:12064589   PMID:12068294   PMID:12203721   PMID:12507281   PMID:12633933   PMID:12673830   PMID:12717711   PMID:12832289   PMID:14622136   PMID:14685273   PMID:14699011   PMID:14757759  
PMID:15052661   PMID:15084279   PMID:15173637   PMID:15492000   PMID:15702233   PMID:15728677   PMID:15775979   PMID:15788452   PMID:15950600   PMID:16105026   PMID:16199027   PMID:16275913  
PMID:16364283   PMID:16427635   PMID:16510873   PMID:16520537   PMID:16931598   PMID:17000770   PMID:17122142   PMID:17130295   PMID:17138661   PMID:17397395   PMID:17541973   PMID:17666436  
PMID:18183615   PMID:18308723   PMID:18423437   PMID:18603586   PMID:18706176   PMID:18823282   PMID:18855986   PMID:18922801   PMID:19017651   PMID:19129494   PMID:19213829   PMID:19507189  
PMID:19590046   PMID:20080746   PMID:20089884   PMID:20473291   PMID:20551175   PMID:20599605   PMID:20868367   PMID:20970449   PMID:21131473   PMID:21285373   PMID:21318404   PMID:21334421  
PMID:21336719   PMID:21411630   PMID:21454477   PMID:21725876   PMID:21884682   PMID:21947081   PMID:22006950   PMID:22512338   PMID:22559818   PMID:22611033   PMID:22855531   PMID:22946046  
PMID:23434913   PMID:23610556   PMID:23801859   PMID:23824537   PMID:23863479   PMID:23885123   PMID:23963446   PMID:23979167   PMID:24008412   PMID:24098443   PMID:24191021   PMID:24339795  
PMID:24580804   PMID:24854121   PMID:24889144   PMID:25468996   PMID:25512490   PMID:25753039   PMID:26464396   PMID:26609154   PMID:26977812   PMID:27037668   PMID:27452368   PMID:28169360  
PMID:29258088   PMID:29524637   PMID:29749551   PMID:29803674   PMID:30734065   PMID:31506421   PMID:31540688   PMID:31795317   PMID:31975378   PMID:32716860   PMID:32807750   PMID:33343804  
PMID:34552687   PMID:34800366  


Genomics

Comparative Map Data
Tjp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81128,260,330 - 128,505,018 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1128,260,330 - 128,505,158 (-)EnsemblGRCr8
mRatBN7.21118,849,838 - 119,094,492 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1118,849,838 - 119,094,432 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1126,838,905 - 126,903,927 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01134,010,313 - 134,075,335 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01126,827,729 - 126,892,646 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01126,146,489 - 126,515,359 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1126,146,489 - 126,227,469 (-)Ensemblrn6Rnor6.0
Rnor_5.01127,243,076 - 127,607,938 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41119,684,774 - 119,750,532 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1111,069,963 - 111,134,894 (-)NCBICelera
RGSC_v3.11119,763,121 - 119,845,891 (-)NCBI
Cytogenetic Map1q22NCBI
TJP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381529,699,367 - 29,969,049 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1529,699,367 - 29,968,915 (-)Ensemblhg38GRCh38
GRCh371529,991,571 - 30,261,252 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361527,779,648 - 27,901,998 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341527,779,650 - 27,901,998NCBI
Celera157,633,694 - 7,756,038 (-)NCBICelera
Cytogenetic Map15q13.1NCBI
HuRef157,657,688 - 7,779,970 (-)NCBIHuRef
CHM1_11529,958,950 - 30,081,290 (-)NCBICHM1_1
T2T-CHM13v2.01527,490,136 - 27,760,675 (-)NCBIT2T-CHM13v2.0
Tjp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39764,945,913 - 65,177,629 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl764,945,913 - 65,177,529 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38765,296,165 - 65,527,850 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl765,296,165 - 65,527,781 (-)Ensemblmm10GRCm38
MGSCv37772,441,051 - 72,516,130 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36765,175,118 - 65,250,189 (-)NCBIMGSCv36mm8
Celera762,713,602 - 62,789,529 (-)NCBICelera
Cytogenetic Map7CNCBI
cM Map735.02NCBI
Tjp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541628,654,905 - 28,870,555 (+)Ensembl
ChiLan1.0NW_00495541628,640,807 - 28,869,717 (+)NCBIChiLan1.0ChiLan1.0
TJP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2166,352,353 - 6,620,446 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1159,994,935 - 10,263,190 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v015981,198 - 1,249,292 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11526,479,294 - 26,598,886 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1526,344,878 - 26,598,878 (+)EnsemblpanPan2panpan1.1
TJP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1338,997,122 - 39,076,617 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl338,997,076 - 39,241,574 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha341,683,799 - 41,794,039 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0339,375,018 - 39,624,615 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl339,375,026 - 39,624,599 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1338,917,559 - 39,028,158 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0339,155,559 - 39,266,003 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0339,363,904 - 39,474,165 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tjp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640144,288,679 - 144,519,613 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364831,814,894 - 2,030,946 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364831,814,870 - 2,045,802 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TJP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1144,930,370 - 145,195,836 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11144,930,387 - 145,195,857 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21161,175,436 - 161,284,250 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TJP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12652,623,751 - 52,750,037 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2652,622,743 - 52,749,950 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604887,901,251 - 88,170,935 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tjp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247682,828,324 - 3,034,302 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247682,826,848 - 3,034,195 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Tjp1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12134,928,827 - 135,162,015 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Tjp1
1870 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:139
Count of miRNA genes:119
Interacting mature miRNAs:128
Transcripts:ENSRNOT00000014988
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631496Bp97Blood pressure QTL 973.08arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1115183611176289080Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1102780511182384005Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1101228864146228864Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1111949780210707719Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
631684Bp117Blood pressure QTL 1178.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1120082258165082258Rat
9590300Scort16Serum corticosterone level QTL 164.390.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1112521556157521556Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1128019551173019551Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
61399Tcat1Tongue tumor resistance QTL 13.3tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 5 mm (CMO:0001879)1108680016153680016Rat
631569Bp93Blood pressure QTL 930.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1115183611131244255Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)191302413136302413Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)1102359314153680016Rat
152025232Bw192Body weight QTL 1923.93body mass (VT:0001259)1127329268206393015Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)199645382182701046Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1111949780210707719Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1109493780193400781Rat
8694370Bw154Body weight QTL 1548.910.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)1112521556157521556Rat
2317833Alcrsp19Alcohol response QTL 1912.40.001response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1110389869155389869Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1124975316152612788Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
1354623Rf46Renal function QTL 463.8blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)1111949780160574007Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of, or within a discrete space in an open field apparatus (CMO:0001514)192683681137683681Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
1641897Alcrsp1Alcohol response QTL 1response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1110389869155389869Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)192683681137683681Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)197582336142582336Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1116099376191260518Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1101594089146594089Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1100345976145345976Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)196717367160111531Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat
61370Mcs3Mammary carcinoma susceptibility QTL 32.15mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1111404407142582336Rat

Markers in Region
TJP1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21118,849,893 - 118,850,058 (+)MAPPERmRatBN7.2
Rnor_6.01126,146,545 - 126,146,709NCBIRnor6.0
Rnor_5.01127,243,132 - 127,243,296UniSTSRnor5.0
RGSC_v3.41119,684,830 - 119,684,994UniSTSRGSC3.4
Celera1111,070,019 - 111,070,183UniSTS
Cytogenetic Map1q22UniSTS
TJP1  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81128,260,488 - 128,260,590 (+)Marker Load Pipeline
mRatBN7.21118,849,996 - 118,850,097 (+)MAPPERmRatBN7.2
Rnor_6.01126,146,648 - 126,146,748NCBIRnor6.0
Rnor_5.01127,243,235 - 127,243,335UniSTSRnor5.0
RGSC_v3.41119,684,933 - 119,685,033UniSTSRGSC3.4
Celera1111,070,122 - 111,070,222UniSTS
Cytogenetic Map1q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 89 59 6 353 189 11 142 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001106266 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001437492 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001437493 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001437494 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001437495 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001437496 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001437497 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001437499 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001437500 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006229330 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006229331 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006229332 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006229333 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017588930 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017588931 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017588932 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017588933 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017588934 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017588935 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017588936 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105265 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105279 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105288 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105296 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105302 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105314 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105325 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105332 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105338 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105346 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284350 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284353 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284358 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284360 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284361 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284364 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284370 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005501920 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH473980 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000014988   ⟹   ENSRNOP00000014988
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1128,260,330 - 128,309,617 (-)Ensembl
mRatBN7.2 Ensembl1118,849,838 - 118,899,126 (-)Ensembl
Rnor_6.0 Ensembl1126,146,489 - 126,211,439 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000087332   ⟹   ENSRNOP00000072324
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1128,260,730 - 128,326,311 (-)Ensembl
mRatBN7.2 Ensembl1118,849,841 - 118,915,820 (-)Ensembl
Rnor_6.0 Ensembl1126,147,386 - 126,227,469 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000096674   ⟹   ENSRNOP00000093370
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1128,260,330 - 128,505,107 (-)Ensembl
mRatBN7.2 Ensembl1118,849,841 - 119,094,432 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000112594   ⟹   ENSRNOP00000078542
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1128,260,330 - 128,342,169 (-)Ensembl
mRatBN7.2 Ensembl1118,849,841 - 118,931,543 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000146483   ⟹   ENSRNOP00000109784
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1128,260,730 - 128,505,158 (-)Ensembl
RefSeq Acc Id: NM_001106266   ⟹   NP_001099736
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81128,260,330 - 128,325,360 (-)NCBI
mRatBN7.21118,849,838 - 118,914,869 (-)NCBI
Rnor_6.01126,146,489 - 126,211,439 (-)NCBI
Rnor_5.01127,243,076 - 127,607,938 (-)NCBI
RGSC_v3.41119,684,774 - 119,750,532 (-)RGD
Celera1111,069,963 - 111,134,894 (-)RGD
Sequence:
RefSeq Acc Id: XM_017588935   ⟹   XP_017444424
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81128,260,332 - 128,505,018 (-)NCBI
mRatBN7.21118,849,840 - 119,094,477 (-)NCBI
Rnor_6.01126,146,491 - 126,403,469 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039105261   ⟹   XP_038961189
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81128,260,332 - 128,505,018 (-)NCBI
mRatBN7.21118,849,840 - 119,094,492 (-)NCBI
RefSeq Acc Id: XM_039105265   ⟹   XP_038961193
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81128,260,332 - 128,505,018 (-)NCBI
mRatBN7.21118,849,840 - 119,094,492 (-)NCBI
RefSeq Acc Id: XM_039105279   ⟹   XP_038961207
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81128,260,332 - 128,505,018 (-)NCBI
mRatBN7.21118,849,840 - 119,094,492 (-)NCBI
RefSeq Acc Id: XM_039105288   ⟹   XP_038961216
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81128,260,332 - 128,505,018 (-)NCBI
mRatBN7.21118,849,840 - 119,094,492 (-)NCBI
RefSeq Acc Id: XM_039105296   ⟹   XP_038961224
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81128,260,332 - 128,505,018 (-)NCBI
mRatBN7.21118,849,844 - 119,094,477 (-)NCBI
RefSeq Acc Id: XM_039105302   ⟹   XP_038961230
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81128,260,332 - 128,501,457 (-)NCBI
mRatBN7.21118,849,840 - 119,090,974 (-)NCBI
RefSeq Acc Id: XM_039105314   ⟹   XP_038961242
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81128,260,332 - 128,504,978 (-)NCBI
mRatBN7.21118,849,840 - 119,094,492 (-)NCBI
RefSeq Acc Id: XM_039105325   ⟹   XP_038961253
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81128,260,332 - 128,342,499 (-)NCBI
mRatBN7.21118,849,840 - 118,931,943 (-)NCBI
RefSeq Acc Id: XM_039105332   ⟹   XP_038961260
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81128,260,332 - 128,364,184 (-)NCBI
mRatBN7.21118,849,840 - 118,953,602 (-)NCBI
RefSeq Acc Id: XM_039105338   ⟹   XP_038961266
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81128,260,332 - 128,504,978 (-)NCBI
mRatBN7.21118,849,840 - 119,094,492 (-)NCBI
RefSeq Acc Id: XM_039105346   ⟹   XP_038961274
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81128,260,332 - 128,504,978 (-)NCBI
mRatBN7.21118,849,840 - 119,094,492 (-)NCBI
RefSeq Acc Id: XM_063284350   ⟹   XP_063140420
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81128,260,332 - 128,342,499 (-)NCBI
RefSeq Acc Id: XM_063284353   ⟹   XP_063140423
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81128,260,332 - 128,504,978 (-)NCBI
RefSeq Acc Id: XM_063284358   ⟹   XP_063140428
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81128,260,332 - 128,342,499 (-)NCBI
RefSeq Acc Id: XM_063284360   ⟹   XP_063140430
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81128,260,332 - 128,342,499 (-)NCBI
RefSeq Acc Id: XM_063284361   ⟹   XP_063140431
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81128,260,332 - 128,342,499 (-)NCBI
RefSeq Acc Id: XM_063284364   ⟹   XP_063140434
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81128,260,332 - 128,342,499 (-)NCBI
RefSeq Acc Id: XM_063284370   ⟹   XP_063140440
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81128,260,332 - 128,342,499 (-)NCBI
RefSeq Acc Id: XR_005501920
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81128,260,332 - 128,505,018 (-)NCBI
mRatBN7.21118,849,840 - 119,094,492 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001099736 (Get FASTA)   NCBI Sequence Viewer  
  NP_001424421 (Get FASTA)   NCBI Sequence Viewer  
  NP_001424422 (Get FASTA)   NCBI Sequence Viewer  
  NP_001424423 (Get FASTA)   NCBI Sequence Viewer  
  NP_001424424 (Get FASTA)   NCBI Sequence Viewer  
  NP_001424425 (Get FASTA)   NCBI Sequence Viewer  
  NP_001424426 (Get FASTA)   NCBI Sequence Viewer  
  NP_001424428 (Get FASTA)   NCBI Sequence Viewer  
  NP_001424429 (Get FASTA)   NCBI Sequence Viewer  
  XP_017444424 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961189 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961193 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961207 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961216 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961224 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961230 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961242 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961253 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961260 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961266 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961274 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140420 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140423 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140428 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140430 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140431 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140434 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140440 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein A0A0G2K2P5 (Get FASTA)   NCBI Sequence Viewer  
  EDM08402 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000078542
  ENSRNOP00000078542.1
  ENSRNOP00000093370
  ENSRNOP00000109784
RefSeq Acc Id: NP_001099736   ⟸   NM_001106266
- Sequence:
RefSeq Acc Id: XP_017444424   ⟸   XM_017588935
- Peptide Label: isoform X3
- UniProtKB: A0A8I6AFQ2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000014988   ⟸   ENSRNOT00000014988
Ensembl Acc Id: ENSRNOP00000072324   ⟸   ENSRNOT00000087332
RefSeq Acc Id: XP_038961274   ⟸   XM_039105346
- Peptide Label: isoform X14
- UniProtKB: A0A8I6AFQ2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038961266   ⟸   XM_039105338
- Peptide Label: isoform X11
- UniProtKB: A0A8I6AFQ2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038961242   ⟸   XM_039105314
- Peptide Label: isoform X8
- UniProtKB: A0A8I6AFQ2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038961216   ⟸   XM_039105288
- Peptide Label: isoform X5
- UniProtKB: A6JBM5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038961207   ⟸   XM_039105279
- Peptide Label: isoform X4
- UniProtKB: A6JBM5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038961193   ⟸   XM_039105265
- Peptide Label: isoform X2
- UniProtKB: A6JBM5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038961189   ⟸   XM_039105261
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AFQ2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038961230   ⟸   XM_039105302
- Peptide Label: isoform X7
- UniProtKB: A0A8L2R644 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038961260   ⟸   XM_039105332
- Peptide Label: isoform X10
- UniProtKB: A0A8L2R644 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038961253   ⟸   XM_039105325
- Peptide Label: isoform X9
- UniProtKB: A0A8L2R644 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038961224   ⟸   XM_039105296
- Peptide Label: isoform X6
Ensembl Acc Id: ENSRNOP00000078542   ⟸   ENSRNOT00000112594
Ensembl Acc Id: ENSRNOP00000093370   ⟸   ENSRNOT00000096674
RefSeq Acc Id: XP_063140423   ⟸   XM_063284353
- Peptide Label: isoform X13
- UniProtKB: A0A8I6AFQ2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063140440   ⟸   XM_063284370
- Peptide Label: isoform X19
RefSeq Acc Id: XP_063140434   ⟸   XM_063284364
- Peptide Label: isoform X18
RefSeq Acc Id: XP_063140431   ⟸   XM_063284361
- Peptide Label: isoform X17
- UniProtKB: A0A8I6AFQ2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063140430   ⟸   XM_063284360
- Peptide Label: isoform X16
RefSeq Acc Id: XP_063140428   ⟸   XM_063284358
- Peptide Label: isoform X15
RefSeq Acc Id: XP_063140420   ⟸   XM_063284350
- Peptide Label: isoform X12
Ensembl Acc Id: ENSRNOP00000109784   ⟸   ENSRNOT00000146483
Protein Domains
Guanylate kinase-like   PDZ   SH3   ZU5

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K2P5-F1-model_v2 AlphaFold A0A0G2K2P5 1-1765 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306305 AgrOrtholog
BioCyc Gene G2FUF-59045 BioCyc
Ensembl Genes ENSRNOG00000011077 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000096674 ENTREZGENE
  ENSRNOT00000112594 ENTREZGENE
  ENSRNOT00000112594.1 UniProtKB/Swiss-Prot
  ENSRNOT00000146483 ENTREZGENE
Gene3D-CATH 2.30.42.10 UniProtKB/Swiss-Prot
  2.60.220.30 UniProtKB/Swiss-Prot
  3.40.50.300 UniProtKB/Swiss-Prot
  SH3 Domains UniProtKB/Swiss-Prot
InterPro GK/Ca_channel_bsu UniProtKB/Swiss-Prot
  Guanylate_kin-like_dom UniProtKB/Swiss-Prot
  IPR005417 UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
  PDZ UniProtKB/Swiss-Prot
  PDZ_sf UniProtKB/Swiss-Prot
  SH3-like_dom_sf UniProtKB/Swiss-Prot
  SH3_domain UniProtKB/Swiss-Prot
  ZO-1 UniProtKB/Swiss-Prot
  ZO-1_SH3 UniProtKB/Swiss-Prot
  ZU5_dom UniProtKB/Swiss-Prot
NCBI Gene 292994 ENTREZGENE
PANTHER PTHR13865:SF25 UniProtKB/Swiss-Prot
  TIGHT JUNCTION PROTEIN UniProtKB/Swiss-Prot
Pfam Guanylate_kin UniProtKB/Swiss-Prot
  PDZ UniProtKB/Swiss-Prot
  SH3_2 UniProtKB/Swiss-Prot
  ZU5 UniProtKB/Swiss-Prot
PhenoGen Tjp1 PhenoGen
PRINTS ZONOCCLUDNS UniProtKB/Swiss-Prot
  ZONOCCLUDNS1 UniProtKB/Swiss-Prot
PROSITE GUANYLATE_KINASE_2 UniProtKB/Swiss-Prot
  PDZ UniProtKB/Swiss-Prot
  SH3 UniProtKB/Swiss-Prot
  ZU5 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000011077 RatGTEx
SMART GuKc UniProtKB/Swiss-Prot
  PDZ UniProtKB/Swiss-Prot
  ZU5 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50044 UniProtKB/Swiss-Prot
  SSF50156 UniProtKB/Swiss-Prot
  SSF52540 UniProtKB/Swiss-Prot
UniProt A0A0G2K2P5 ENTREZGENE
  A0A8I6AFQ2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2R644 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0M3R2_RAT UniProtKB/TrEMBL
  A6JBM5 ENTREZGENE, UniProtKB/TrEMBL
  F1M4A0_RAT UniProtKB/TrEMBL
  ZO1_RAT UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Tjp1  tight junction protein 1   Tjp1_predicted  tight junction protein 1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Tjp1_predicted  tight junction protein 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED