Ap2a1 (adaptor related protein complex 2 subunit alpha 1) - Rat Genome Database

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Gene: Ap2a1 (adaptor related protein complex 2 subunit alpha 1) Rattus norvegicus
Analyze
Symbol: Ap2a1
Name: adaptor related protein complex 2 subunit alpha 1
RGD ID: 1306254
Description: Predicted to enable clathrin adaptor activity; low-density lipoprotein particle receptor binding activity; and protein kinase binding activity. Involved in positive regulation of neuron projection development and positive regulation of receptor-mediated endocytosis. Located in apical plasma membrane; basolateral plasma membrane; and clathrin-coated vesicle. Part of protein-containing complex. Is active in synaptic vesicle. Orthologous to human AP2A1 (adaptor related protein complex 2 subunit alpha 1); PARTICIPATES IN Arf family mediated signaling pathway; clathrin-dependent synaptic vesicle endocytosis; endocytosis pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: adaptor protein complex AP-2, alpha 1 subunit; adaptor-related protein complex 2, alpha 1 subunit; alpha-adaptin A; AP-2 complex subunit alpha-1; LOC308578
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81104,520,789 - 104,550,655 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1104,520,792 - 104,550,655 (-)EnsemblGRCr8
mRatBN7.2195,384,306 - 95,414,170 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl195,384,309 - 95,414,147 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1100,769,699 - 100,799,574 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01109,242,364 - 109,272,239 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01102,532,757 - 102,562,632 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01100,896,582 - 100,926,443 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1100,896,947 - 100,926,335 (-)Ensemblrn6Rnor6.0
Rnor_5.01101,961,206 - 101,990,841 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4195,373,135 - 95,403,376 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera189,646,459 - 89,675,632 (-)NCBICelera
RGSC_v3.1195,451,977 - 95,481,455 (-)NCBI
Cytogenetic Map1q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
alpha-pinene  (ISO)
amitrole  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
C60 fullerene  (EXP)
cadmium dichloride  (ISO)
chlordecone  (ISO)
cobalt atom  (EXP)
dexamethasone  (ISO)
dibutyl phthalate  (EXP)
dioxygen  (ISO)
ethanol  (ISO)
fenthion  (ISO)
folic acid  (ISO)
FR900359  (ISO)
furfural  (ISO)
indometacin  (ISO)
iron atom  (EXP)
iron(0)  (EXP)
ivermectin  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
methapyrilene  (ISO)
methidathion  (ISO)
methimazole  (EXP)
N-ethyl-N-nitrosourea  (ISO)
nickel atom  (EXP)
ozone  (ISO)
paracetamol  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
propiconazole  (EXP)
resveratrol  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sulfadimethoxine  (EXP)
tamoxifen  (ISO)
tetrahydropalmatine  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
triptonide  (ISO)
tungsten  (EXP,ISO)
zinc protoporphyrin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The interaction of epsin and Eps15 with the clathrin adaptor AP-2 is inhibited by mitotic phosphorylation and enhanced by stimulation-dependent dephosphorylation in nerve terminals. Chen H, etal., J Biol Chem. 1999 Feb 5;274(6):3257-60.
2. Otoferlin couples to clathrin-mediated endocytosis in mature cochlear inner hair cells. Duncker SV, etal., J Neurosci. 2013 May 29;33(22):9508-19. doi: 10.1523/JNEUROSCI.5689-12.2013.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. The role of endocytic l1 trafficking in polarized adhesion and migration of nerve growth cones. Kamiguchi H and Yoshihara F, J Neurosci. 2001 Dec 1;21(23):9194-203.
6. HIP1 and HIP12 display differential binding to F-actin, AP2, and clathrin. Identification of a novel interaction with clathrin light chain. Legendre-Guillemin V, etal., J Biol Chem 2002 May 31;277(22):19897-904.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Co-localization of rab4 with endocytosis-related proteins in the rat parotid glands. Nashida T, etal., Arch Histol Cytol. 2003 Mar;66(1):45-52.
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Comprehensive gene review and curation RGD comprehensive gene curation
15. Association of insulin-like growth factor 1 receptor with EHD1 and SNAP29. Rotem-Yehudar R, etal., J Biol Chem. 2001 Aug 31;276(35):33054-60. Epub 2001 Jun 21.
16. Synaptic vesicle endocytosis. Saheki Y and De Camilli P, Cold Spring Harb Perspect Biol. 2012 Sep 1;4(9):a005645. doi: 10.1101/cshperspect.a005645.
17. Hidden proteome of synaptic vesicles in the mammalian brain. Taoufiq Z, etal., Proc Natl Acad Sci U S A. 2020 Dec 29;117(52):33586-33596. doi: 10.1073/pnas.2011870117. Epub 2020 Dec 21.
18. Enthoprotin: a novel clathrin-associated protein identified through subcellular proteomics. Wasiak S, etal., J Cell Biol 2002 Sep 2;158(5):855-62. Epub 2002 Sep 03.
Additional References at PubMed
PMID:9259551   PMID:9694653   PMID:11382783   PMID:11879655   PMID:12234931   PMID:16903783   PMID:19946888   PMID:21307259   PMID:21499258   PMID:21700703   PMID:22262466   PMID:23509262  
PMID:23676497   PMID:24251095   PMID:24305805   PMID:26005850   PMID:26771574   PMID:31505169   PMID:37127089  


Genomics

Comparative Map Data
Ap2a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81104,520,789 - 104,550,655 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1104,520,792 - 104,550,655 (-)EnsemblGRCr8
mRatBN7.2195,384,306 - 95,414,170 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl195,384,309 - 95,414,147 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1100,769,699 - 100,799,574 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01109,242,364 - 109,272,239 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01102,532,757 - 102,562,632 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01100,896,582 - 100,926,443 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1100,896,947 - 100,926,335 (-)Ensemblrn6Rnor6.0
Rnor_5.01101,961,206 - 101,990,841 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4195,373,135 - 95,403,376 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera189,646,459 - 89,675,632 (-)NCBICelera
RGSC_v3.1195,451,977 - 95,481,455 (-)NCBI
Cytogenetic Map1q22NCBI
AP2A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381949,767,001 - 49,807,114 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1949,766,990 - 49,807,114 (+)Ensemblhg38GRCh38
GRCh371950,270,258 - 50,310,371 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361954,961,992 - 55,002,181 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341954,961,991 - 55,002,181NCBI
Celera1947,139,637 - 47,179,822 (+)NCBICelera
Cytogenetic Map19q13.33NCBI
HuRef1946,646,519 - 46,686,682 (+)NCBIHuRef
CHM1_11950,271,982 - 50,312,188 (+)NCBICHM1_1
T2T-CHM13v2.01952,767,146 - 52,807,252 (+)NCBIT2T-CHM13v2.0
Ap2a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39744,549,797 - 44,578,914 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl744,549,797 - 44,578,920 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38744,900,373 - 44,929,490 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl744,900,373 - 44,929,496 (-)Ensemblmm10GRCm38
MGSCv37752,155,743 - 52,184,860 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36744,768,425 - 44,797,510 (-)NCBIMGSCv36mm8
Celera740,350,575 - 40,379,662 (-)NCBICelera
Cytogenetic Map7B3NCBI
cM Map729.01NCBI
Ap2a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555591,117,636 - 1,143,409 (-)Ensembl
ChiLan1.0NW_0049555591,117,380 - 1,143,403 (-)NCBIChiLan1.0ChiLan1.0
AP2A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22055,881,843 - 55,922,688 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11957,802,612 - 57,843,456 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01946,779,196 - 46,820,055 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11955,696,819 - 55,736,570 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1955,694,070 - 55,736,570 (+)EnsemblpanPan2panpan1.1
AP2A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11106,752,326 - 106,784,803 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1106,751,800 - 106,784,663 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1106,335,247 - 106,367,722 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01107,273,281 - 107,305,783 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1107,272,755 - 107,305,845 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11106,945,343 - 106,977,824 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01106,587,348 - 106,619,846 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01107,427,815 - 107,460,313 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ap2a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934921,944,676 - 21,978,793 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366643,562,798 - 3,599,791 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366643,562,800 - 3,596,983 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AP2A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl654,786,511 - 54,823,904 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1654,786,537 - 54,823,906 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2650,515,632 - 50,553,005 (+)NCBISscrofa10.2Sscrofa10.2susScr3
AP2A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1642,933,303 - 42,968,963 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl642,953,693 - 42,969,427 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607322,903,648 - 22,943,697 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ap2a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248324,513,977 - 4,540,277 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248324,513,977 - 4,540,080 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Ap2a1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12154,613,708 - 154,642,809 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ap2a1
518 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:77
Count of miRNA genes:69
Interacting mature miRNAs:75
Transcripts:ENSRNOT00000020304
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1102780511182384005Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)192963855109494029Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1101228864146228864Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)191302413136302413Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)1102359314153680016Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)199645382182701046Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of, or within a discrete space in an open field apparatus (CMO:0001514)192683681137683681Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)192683681137683681Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)197582336142582336Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1101594089146594089Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1100345976145345976Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)196717367160111531Rat

Markers in Region
Ap2a1  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81104,520,811 - 104,520,989 (+)Marker Load Pipeline
mRatBN7.2195,384,325 - 95,384,502 (+)MAPPERmRatBN7.2
Rnor_6.01100,896,605 - 100,896,781NCBIRnor6.0
Rnor_5.01101,961,224 - 101,961,399UniSTSRnor5.0
RGSC_v3.4195,373,155 - 95,373,937UniSTSRGSC3.4
Celera189,646,048 - 89,646,293UniSTS
Cytogenetic Map1q22UniSTS
AW530045  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2195,384,078 - 95,384,282 (+)MAPPERmRatBN7.2
Rnor_6.01100,896,358 - 100,896,561NCBIRnor6.0
Rnor_5.01101,960,977 - 101,961,180UniSTSRnor5.0
RGSC_v3.4195,372,908 - 95,373,111UniSTSRGSC3.4
Celera189,645,801 - 89,646,004UniSTS
RH 3.4 Map1908.59UniSTS
Cytogenetic Map1q22UniSTS
MARC_23449-23450:1027106382:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2195,390,394 - 95,390,879 (+)MAPPERmRatBN7.2
Rnor_6.01100,902,674 - 100,903,158NCBIRnor6.0
Rnor_5.01101,967,292 - 101,967,776UniSTSRnor5.0
RGSC_v3.4195,379,830 - 95,380,314UniSTSRGSC3.4
Celera189,652,186 - 89,652,670UniSTS
Cytogenetic Map1q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
23 13 84 214 91 90 59 159 59 6 489 286 21 192 113 124 31 34 34

Sequence


Ensembl Acc Id: ENSRNOT00000020304   ⟹   ENSRNOP00000020304
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1104,520,792 - 104,550,655 (-)Ensembl
mRatBN7.2 Ensembl195,384,311 - 95,414,147 (-)Ensembl
Rnor_6.0 Ensembl1100,896,947 - 100,926,335 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097722   ⟹   ENSRNOP00000087357
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1104,520,792 - 104,538,461 (-)Ensembl
mRatBN7.2 Ensembl195,384,309 - 95,403,110 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000101662   ⟹   ENSRNOP00000086051
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1104,520,792 - 104,538,461 (-)Ensembl
mRatBN7.2 Ensembl195,384,309 - 95,403,110 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000114111   ⟹   ENSRNOP00000083087
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1104,520,792 - 104,538,461 (-)Ensembl
mRatBN7.2 Ensembl195,384,309 - 95,403,110 (-)Ensembl
RefSeq Acc Id: NM_001395092   ⟹   NP_001382021
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81104,520,792 - 104,550,655 (-)NCBI
mRatBN7.2195,384,306 - 95,414,170 (-)NCBI
RefSeq Acc Id: NM_001395093   ⟹   NP_001382022
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81104,520,792 - 104,550,655 (-)NCBI
mRatBN7.2195,384,306 - 95,414,170 (-)NCBI
RefSeq Acc Id: XM_063261974   ⟹   XP_063118044
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81104,523,088 - 104,550,608 (-)NCBI
RefSeq Acc Id: XM_063261976   ⟹   XP_063118046
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81104,520,789 - 104,550,608 (-)NCBI
RefSeq Acc Id: XM_063261978   ⟹   XP_063118048
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81104,520,789 - 104,550,608 (-)NCBI
Ensembl Acc Id: ENSRNOP00000020304   ⟸   ENSRNOT00000020304
Ensembl Acc Id: ENSRNOP00000083087   ⟸   ENSRNOT00000114111
Ensembl Acc Id: ENSRNOP00000087357   ⟸   ENSRNOT00000097722
Ensembl Acc Id: ENSRNOP00000086051   ⟸   ENSRNOT00000101662
RefSeq Acc Id: NP_001382022   ⟸   NM_001395093
- Peptide Label: isoform 2
- UniProtKB: D3ZUY8 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001382021   ⟸   NM_001395092
- Peptide Label: isoform 1
- UniProtKB: A6JAU3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063118048   ⟸   XM_063261978
- Peptide Label: isoform X3
- UniProtKB: D3ZUY8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063118046   ⟸   XM_063261976
- Peptide Label: isoform X2
- UniProtKB: A6JAU3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063118044   ⟸   XM_063261974
- Peptide Label: isoform X1
- UniProtKB: D3ZUY8 (UniProtKB/TrEMBL)
Protein Domains
Clathrin adaptor alpha/beta/gamma-adaptin appendage

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZUY8-F1-model_v2 AlphaFold D3ZUY8 1-977 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306254 AgrOrtholog
BioCyc Gene G2FUF-59743 BioCyc
Ensembl Genes ENSRNOG00000026243 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000020304 ENTREZGENE
  ENSRNOT00000020304.8 UniProtKB/TrEMBL
  ENSRNOT00000097722 ENTREZGENE
  ENSRNOT00000097722.2 UniProtKB/TrEMBL
  ENSRNOT00000101662 ENTREZGENE
  ENSRNOT00000101662.2 UniProtKB/TrEMBL
  ENSRNOT00000114111.2 UniProtKB/TrEMBL
Gene3D-CATH 1.25.10.10 UniProtKB/TrEMBL
  2.60.40.1230 UniProtKB/TrEMBL
  3.30.310.10 UniProtKB/TrEMBL
InterPro Adaptor_Complx_Large_Subunit UniProtKB/TrEMBL
  AP2_complex_asu UniProtKB/TrEMBL
  ARM-like UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/TrEMBL
  Calthrin/coatomer_app_sub_C UniProtKB/TrEMBL
  Clathrin/coatomer_adapt-like_N UniProtKB/TrEMBL
  Clathrin/coatomer_app_Ig-like UniProtKB/TrEMBL
  Clathrin_a-adaptin_app_sub_C UniProtKB/TrEMBL
  Clathrin_a/b/g-adaptin_app_Ig UniProtKB/TrEMBL
  TBP_dom_sf UniProtKB/TrEMBL
NCBI Gene 308578 ENTREZGENE
PANTHER ADAPTIN, ALPHA/GAMMA/EPSILON UniProtKB/TrEMBL
Pfam Adaptin_N UniProtKB/TrEMBL
  Alpha_adaptin_C UniProtKB/TrEMBL
  Alpha_adaptinC2 UniProtKB/TrEMBL
PhenoGen Ap2a1 PhenoGen
PIRSF AP2_complex_alpha UniProtKB/TrEMBL
RatGTEx ENSRNOG00000026243 RatGTEx
SMART Alpha_adaptinC2 UniProtKB/TrEMBL
Superfamily-SCOP AP2_adap_app UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/TrEMBL
  Clath_adapt UniProtKB/TrEMBL
UniProt A0A8I5ZVC3_RAT UniProtKB/TrEMBL
  A0A8I6A4J2_RAT UniProtKB/TrEMBL
  A0A8I6A5N8_RAT UniProtKB/TrEMBL
  A6JAU3 ENTREZGENE, UniProtKB/TrEMBL
  D3ZUY8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-03 Ap2a1  adaptor related protein complex 2 subunit alpha 1  Ap2a1  adaptor-related protein complex 2, alpha 1 subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Ap2a1  adaptor-related protein complex 2, alpha 1 subunit  Ap2a1  adaptor protein complex AP-2, alpha 1 subunit   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Ap2a1  adaptor protein complex AP-2, alpha 1 subunit   Ap2a1_predicted  adaptor protein complex AP-2, alpha 1 subunit (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Ap2a1_predicted  adaptor protein complex AP-2, alpha 1 subunit (predicted)      Symbol and Name status set to approved 70820 APPROVED