Parl (presenilin associated, rhomboid-like) - Rat Genome Database

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Gene: Parl (presenilin associated, rhomboid-like) Rattus norvegicus
Analyze
Symbol: Parl
Name: presenilin associated, rhomboid-like
RGD ID: 1306191
Description: Predicted to enable serine-type endopeptidase activity. Involved in neuron differentiation and response to nutrient levels. Predicted to be located in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in Leber hereditary optic neuropathy; coronary artery disease; hyperinsulinism; myopia; and type 2 diabetes mellitus. Orthologous to human PARL (presenilin associated rhomboid like); PARTICIPATES IN mitochondrial autophagy pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC287979; MGC125008; mitochondrial intramembrane-cleaving protease PARL; presenilin-associated rhomboid-like protein, mitochondrial; presenilins-associated rhomboid-like protein, mitochondrial; Psarl
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81194,097,559 - 94,124,915 (+)NCBIGRCr8
mRatBN7.21180,594,059 - 80,620,506 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1180,593,192 - 80,620,506 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1189,317,103 - 89,343,416 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01181,970,532 - 81,996,820 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01181,031,594 - 81,057,895 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01184,517,368 - 84,544,463 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1184,517,368 - 84,544,462 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01187,581,642 - 87,607,939 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41182,836,666 - 82,864,977 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11182,894,267 - 82,922,572 (+)NCBI
Celera1179,434,291 - 79,460,794 (+)NCBICelera
Cytogenetic Map11q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Identification and replication of three novel myopia common susceptibility gene loci on chromosome 3q26 using linkage and linkage disequilibrium mapping. Andrew T, etal., PLoS Genet. 2008 Oct;4(10):e1000220. doi: 10.1371/journal.pgen.1000220. Epub 2008 Oct 10.
2. In utero exposure to prepregnancy maternal obesity and postweaning high-fat diet impair regulators of mitochondrial dynamics in rat placenta and offspring. Borengasser SJ, etal., Physiol Genomics. 2014 Dec 1;46(23):841-50. doi: 10.1152/physiolgenomics.00059.2014. Epub 2014 Oct 21.
3. Rhomboid family gene expression profiling in breast normal tissue and tumor samples. Canzoneri R, etal., Tumour Biol. 2014 Feb;35(2):1451-8. doi: 10.1007/s13277-013-1199-8. Epub 2013 Nov 2.
4. Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling. Cipolat S, etal., Cell. 2006 Jul 14;126(1):163-75.
5. Regulation of skeletal muscle oxidative capacity and insulin signaling by the mitochondrial rhomboid protease PARL. Civitarese AE, etal., Cell Metab. 2010 May 5;11(5):412-26. doi: 10.1016/j.cmet.2010.04.004.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. The Leu262Val polymorphism of presenilin associated rhomboid like protein (PARL) is associated with earlier onset of type 2 diabetes and increased urinary microalbumin creatinine ratio in an Irish case-control population. Hatunic M, etal., Diabetes Res Clin Pract. 2009 Mar;83(3):316-9. doi: 10.1016/j.diabres.2008.12.004. Epub 2009 Jan 29.
8. Genome-wide linkage scan and association study of PARL to the expression of LHON families in Thailand. Phasukkijwatana N, etal., Hum Genet. 2010 Jul;128(1):39-49. doi: 10.1007/s00439-010-0821-8. Epub 2010 Apr 21.
9. Association of PARL rs3732581 genetic variant with insulin levels, metabolic syndrome and coronary artery disease. Powell BL, etal., Hum Genet. 2008 Oct;124(3):263-70. doi: 10.1007/s00439-008-0552-2. Epub 2008 Aug 30.
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
13. Self-regulated cleavage of the mitochondrial intramembrane-cleaving protease PARL yields Pbeta, a nuclear-targeted peptide. Sík A, etal., J Biol Chem. 2004 Apr 9;279(15):15323-9. Epub 2004 Jan 19.
14. Variation in gene expression of presenilins-associated rhomboid-like protein and mitochondrial function in skeletal muscle of insulin-resistant rats. Tang H, etal., Endocrine. 2009 Dec;36(3):524-9. doi: 10.1007/s12020-009-9270-3. Epub 2009 Oct 27.
15. The mitochondrial rhomboid protease PSARL is a new candidate gene for type 2 diabetes. Walder K, etal., Diabetologia. 2005 Mar;48(3):459-68. Epub 2005 Feb 24.
16. Hypoxia activation of mitophagy and its role in disease pathogenesis. Wu H and Chen Q, Antioxid Redox Signal. 2015 Apr 20;22(12):1032-46. doi: 10.1089/ars.2014.6204. Epub 2015 Feb 10.
17. The role of PARL and HtrA2 in striatal neuronal injury after transient global cerebral ischemia. Yoshioka H, etal., J Cereb Blood Flow Metab. 2013 Nov;33(11):1658-65. doi: 10.1038/jcbfm.2013.139. Epub 2013 Aug 7.
18. No association between the SNPs (rs3749446 and rs1402000) in the PARL gene and LHON in Chinese patients with m.11778G>A. Zhang AM, etal., Hum Genet. 2010 Oct;128(4):465-8. doi: 10.1007/s00439-010-0875-7. Epub 2010 Aug 14.
Additional References at PubMed
PMID:15489334   PMID:18614015   PMID:21138942   PMID:21355049   PMID:21426348   PMID:22354088  


Genomics

Comparative Map Data
Parl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81194,097,559 - 94,124,915 (+)NCBIGRCr8
mRatBN7.21180,594,059 - 80,620,506 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1180,593,192 - 80,620,506 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1189,317,103 - 89,343,416 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01181,970,532 - 81,996,820 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01181,031,594 - 81,057,895 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01184,517,368 - 84,544,463 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1184,517,368 - 84,544,462 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01187,581,642 - 87,607,939 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41182,836,666 - 82,864,977 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11182,894,267 - 82,922,572 (+)NCBI
Celera1179,434,291 - 79,460,794 (+)NCBICelera
Cytogenetic Map11q23NCBI
PARL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383183,826,489 - 183,884,880 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3183,829,271 - 183,884,933 (-)EnsemblGRCh38hg38GRCh38
GRCh373183,547,059 - 183,602,668 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363185,029,867 - 185,085,387 (-)NCBINCBI36Build 36hg18NCBI36
Build 343185,029,881 - 185,085,356NCBI
Celera3181,990,550 - 182,046,014 (-)NCBICelera
Cytogenetic Map3q27.1NCBI
HuRef3180,956,508 - 181,012,355 (-)NCBIHuRef
CHM1_13183,511,499 - 183,567,008 (-)NCBICHM1_1
T2T-CHM13v2.03186,635,981 - 186,694,605 (-)NCBIT2T-CHM13v2.0
Parl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391620,098,570 - 20,121,090 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1620,098,568 - 20,121,137 (-)EnsemblGRCm39 Ensembl
GRCm381620,279,820 - 20,302,395 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1620,279,818 - 20,302,387 (-)EnsemblGRCm38mm10GRCm38
MGSCv371620,279,893 - 20,302,435 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361620,193,363 - 20,215,905 (-)NCBIMGSCv36mm8
Celera1620,843,305 - 20,865,847 (-)NCBICelera
Cytogenetic Map16A3NCBI
cM Map1612.4NCBI
Parl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542023,548,672 - 23,582,137 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542023,549,125 - 23,581,782 (+)NCBIChiLan1.0ChiLan1.0
PARL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22181,697,652 - 181,757,265 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13181,703,277 - 181,761,981 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03180,862,434 - 180,921,197 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13189,032,605 - 189,088,091 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3189,032,816 - 189,088,036 (-)Ensemblpanpan1.1panPan2
PARL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13416,790,049 - 16,837,557 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3416,781,139 - 16,837,545 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3420,877,392 - 20,924,904 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03416,697,285 - 16,744,859 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3416,697,285 - 16,744,840 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13416,735,526 - 16,783,030 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03416,731,170 - 16,778,655 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03416,960,810 - 17,008,629 (-)NCBIUU_Cfam_GSD_1.0
Parl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602119,853,920 - 119,901,118 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365785,945,635 - 5,993,143 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365785,945,765 - 5,992,972 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PARL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13121,758,738 - 121,813,638 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113121,758,734 - 121,813,679 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213131,193,528 - 131,248,518 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PARL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1155,536,556 - 5,589,522 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl155,536,610 - 5,590,825 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606314,318,952 - 14,371,951 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Parl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473072,642,925 - 72,683,820 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473072,642,828 - 72,683,820 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Parl
84 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:146
Count of miRNA genes:106
Interacting mature miRNAs:113
Transcripts:ENSRNOT00000030837, ENSRNOT00000071076
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)115980279482566553Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
634339Niddm50Non-insulin dependent diabetes mellitus QTL 503.32blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)116642214886241447Rat
1549848Bvd6Brain ventricular dilatation QTL 63.10.0001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116611332182169223Rat
10450831Scl80Serum cholesterol level QTL 804.70.01blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)117695713183051965Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116034659086241447Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114094618882566702Rat
1354656Bvd3Brain ventricular dilatation QTL 33.640.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116944607082846715Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)114428575982566702Rat
1354593Stl12Serum triglyceride level QTL 123.36blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)116642214886241447Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115445753486241447Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)115513672982993457Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)115635142486241447Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)115980279482566545Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000030837   ⟹   ENSRNOP00000029124
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1180,594,064 - 80,620,506 (+)Ensembl
Rnor_6.0 Ensembl1184,517,368 - 84,544,462 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000071076   ⟹   ENSRNOP00000064548
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1180,594,109 - 80,620,501 (+)Ensembl
Rnor_6.0 Ensembl1184,517,410 - 84,544,318 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000107477   ⟹   ENSRNOP00000087363
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1180,594,473 - 80,620,506 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000114687   ⟹   ENSRNOP00000093736
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1180,593,192 - 80,620,506 (+)Ensembl
RefSeq Acc Id: NM_001035249   ⟹   NP_001030326
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81194,098,487 - 94,124,906 (+)NCBI
mRatBN7.21180,594,077 - 80,620,497 (+)NCBI
Rnor_6.01184,517,368 - 84,544,463 (+)NCBI
Rnor_5.01187,581,642 - 87,607,939 (+)NCBI
RGSC_v3.41182,836,666 - 82,864,977 (+)RGD
Celera1179,434,291 - 79,460,794 (+)RGD
Sequence:
RefSeq Acc Id: XM_039088087   ⟹   XP_038944015
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81194,097,559 - 94,124,915 (+)NCBI
mRatBN7.21180,594,070 - 80,620,506 (+)NCBI
RefSeq Acc Id: XM_039088088   ⟹   XP_038944016
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81194,097,559 - 94,124,723 (+)NCBI
mRatBN7.21180,594,059 - 80,620,506 (+)NCBI
RefSeq Acc Id: XM_039088089   ⟹   XP_038944017
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81194,097,559 - 94,124,723 (+)NCBI
mRatBN7.21180,594,060 - 80,620,506 (+)NCBI
RefSeq Acc Id: XM_063270328   ⟹   XP_063126398
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81194,108,895 - 94,124,915 (+)NCBI
RefSeq Acc Id: NP_001030326   ⟸   NM_001035249
- Peptide Label: precursor
- UniProtKB: Q5I0L2 (UniProtKB/Swiss-Prot),   Q3B8P0 (UniProtKB/Swiss-Prot),   B0BMU4 (UniProtKB/TrEMBL),   F1LPN4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000064548   ⟸   ENSRNOT00000071076
Ensembl Acc Id: ENSRNOP00000029124   ⟸   ENSRNOT00000030837
RefSeq Acc Id: XP_038944016   ⟸   XM_039088088
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038944017   ⟸   XM_039088089
- Peptide Label: isoform X3
- UniProtKB: A0A8I6GKF1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038944015   ⟸   XM_039088087
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GKF1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000093736   ⟸   ENSRNOT00000114687
Ensembl Acc Id: ENSRNOP00000087363   ⟸   ENSRNOT00000107477
RefSeq Acc Id: XP_063126398   ⟸   XM_063270328
- Peptide Label: isoform X4
Protein Domains
Peptidase S54 rhomboid

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q3B8P0-F1-model_v2 AlphaFold Q3B8P0 1-377 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698288
Promoter ID:EPDNEW_R8809
Type:initiation region
Name:Parl_1
Description:presenilin associated, rhomboid-like
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01184,517,397 - 84,517,457EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306191 AgrOrtholog
BioCyc Gene G2FUF-20718 BioCyc
Ensembl Genes ENSRNOG00000023271 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000030837.8 UniProtKB/TrEMBL
  ENSRNOT00000071076.3 UniProtKB/TrEMBL
  ENSRNOT00000107477.1 UniProtKB/TrEMBL
  ENSRNOT00000114687.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1540.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7322400 IMAGE-MGC_LOAD
  IMAGE:8374563 IMAGE-MGC_LOAD
InterPro Peptidase_S54_rhomboid_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rhomboid-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rhomboid_protease_S54 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:287979 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:108980 IMAGE-MGC_LOAD
  MGC:187258 IMAGE-MGC_LOAD
NCBI Gene 287979 ENTREZGENE
PANTHER PRESENILINS-ASSOCIATED RHOMBOID-LIKE PROTEIN, MITOCHONDRIAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RHOMBOID PROTEASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Rhomboid UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Parl PhenoGen
RatGTEx ENSRNOG00000023271 RatGTEx
Superfamily-SCOP SSF144091 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6GF25_RAT UniProtKB/TrEMBL
  A0A8I6GKF1 ENTREZGENE, UniProtKB/TrEMBL
  B0BMU4 ENTREZGENE, UniProtKB/TrEMBL
  F1LPN4 ENTREZGENE, UniProtKB/TrEMBL
  M0R589_RAT UniProtKB/TrEMBL
  PARL_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q5I0L2 ENTREZGENE
UniProt Secondary Q5I0L2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-04 Parl  presenilin associated, rhomboid-like  Psarl  presenilin associated, rhomboid-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Psarl  presenilin associated, rhomboid-like  Psarl_predicted  presenilin associated, rhomboid-like (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Psarl_predicted  presenilin associated, rhomboid-like (predicted)      Symbol and Name status set to approved 70820 APPROVED