Slc24a4 (solute carrier family 24 member 4) - Rat Genome Database

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Gene: Slc24a4 (solute carrier family 24 member 4) Rattus norvegicus
Analyze
Symbol: Slc24a4
Name: solute carrier family 24 member 4
RGD ID: 1305926
Description: Predicted to enable calcium ion transmembrane transporter activity; calcium-dependent protein binding activity; and calmodulin binding activity. Predicted to be involved in several processes, including cellular response to high light intensity; cone photoresponse recovery; and monoatomic cation transmembrane transport. Predicted to act upstream of or within positive regulation of gene expression. Predicted to be located in several cellular components, including cone photoreceptor outer segment; cytoplasm; and vesicle. Predicted to be active in apical plasma membrane. Human ortholog(s) of this gene implicated in amelogenesis imperfecta hypomaturation type 2A5 and pigmentation disease. Orthologous to human SLC24A4 (solute carrier family 24 member 4); PARTICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC314396; Nckx4; sodium/potassium/calcium exchanger 4; solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Slc24a4Tn(sb-T2/Bart3)2.145Mcwi
Genetic Models: F344-Slc24a4Tn(sb-T2/Bart3)2.145Mcwi
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86127,044,470 - 127,184,684 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6127,044,470 - 127,184,684 (+)EnsemblGRCr8
mRatBN7.26121,279,590 - 121,419,811 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6121,280,031 - 121,414,949 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx6121,421,469 - 121,560,529 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06121,716,729 - 121,855,788 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06121,053,045 - 121,191,790 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.06126,015,799 - 126,158,727 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6126,018,841 - 126,153,867 (+)Ensemblrn6Rnor6.0
Rnor_5.06135,226,112 - 135,364,945 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46126,403,837 - 126,538,501 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera6118,769,531 - 118,903,571 (+)NCBICelera
RGSC_v3.16126,300,244 - 126,541,897 (+)NCBI
Cytogenetic Map6q32NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
apical plasma membrane  (IEA,ISO)
cell periphery  (IEA)
cone photoreceptor outer segment  (IEA,ISO)
cytoplasm  (IEA,ISO)
membrane  (IEA,ISO)
plasma membrane  (IBA,IEA,ISO)
vesicle  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Novel role for K+-dependent Na+/Ca2+ exchangers in regulation of cytoplasmic free Ca2+ and contractility in arterial smooth muscle. Dong H, etal., Am J Physiol Heart Circ Physiol. 2006 Sep;291(3):H1226-35. Epub 2006 Apr 14.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Preferential expression of plasmalemmal K-dependent Na+/Ca2+ exchangers in neurons versus astrocytes. Kiedrowski L, etal., Neuroreport 2002 Aug 27;13(12):1529-32.
4. Na+/Ca2+ exchangers: three mammalian gene families control Ca2+ transport. Lytton J Biochem J. 2007 Sep 15;406(3):365-82.
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:12477932   PMID:22057188   PMID:23375655   PMID:24621671   PMID:26247047   PMID:26631410  


Genomics

Comparative Map Data
Slc24a4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86127,044,470 - 127,184,684 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6127,044,470 - 127,184,684 (+)EnsemblGRCr8
mRatBN7.26121,279,590 - 121,419,811 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6121,280,031 - 121,414,949 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx6121,421,469 - 121,560,529 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06121,716,729 - 121,855,788 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06121,053,045 - 121,191,790 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.06126,015,799 - 126,158,727 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6126,018,841 - 126,153,867 (+)Ensemblrn6Rnor6.0
Rnor_5.06135,226,112 - 135,364,945 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46126,403,837 - 126,538,501 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera6118,769,531 - 118,903,571 (+)NCBICelera
RGSC_v3.16126,300,244 - 126,541,897 (+)NCBI
Cytogenetic Map6q32NCBI
SLC24A4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381492,322,581 - 92,501,481 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1492,322,581 - 92,501,481 (+)Ensemblhg38GRCh38
GRCh371492,788,925 - 92,967,825 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361491,858,678 - 92,032,349 (+)NCBIBuild 36Build 36hg18NCBI36
Celera1472,841,198 - 73,019,912 (+)NCBICelera
Cytogenetic Map14q32.12NCBI
HuRef1472,971,235 - 73,150,009 (+)NCBIHuRef
CHM1_11492,727,545 - 92,906,261 (+)NCBICHM1_1
T2T-CHM13v2.01486,552,327 - 86,731,081 (+)NCBIT2T-CHM13v2.0
Slc24a4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912102,094,986 - 102,239,562 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12102,094,992 - 102,233,350 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3812102,128,727 - 102,267,133 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12102,128,733 - 102,267,091 (+)Ensemblmm10GRCm38
MGSCv3712103,367,629 - 103,504,959 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3612102,530,469 - 102,667,799 (+)NCBIMGSCv36mm8
Celera12103,346,630 - 103,484,305 (+)NCBICelera
Cytogenetic Map12ENCBI
cM Map1251.42NCBI
Slc24a4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543814,609,424 - 14,759,673 (+)Ensembl
ChiLan1.0NW_00495543814,609,779 - 14,765,516 (+)NCBIChiLan1.0ChiLan1.0
SLC24A4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21593,480,347 - 93,659,175 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11492,696,423 - 92,875,680 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01472,956,230 - 73,128,851 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11492,299,467 - 92,471,426 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1492,299,507 - 92,468,939 (+)EnsemblpanPan2panpan1.1
SLC24A4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.181,570,833 - 1,685,135 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl81,517,560 - 1,680,208 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha81,539,853 - 1,708,276 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.081,570,067 - 1,738,485 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl81,567,138 - 1,740,126 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.181,507,888 - 1,676,257 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.081,464,369 - 1,626,873 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.081,585,200 - 1,753,590 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Slc24a4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864012,828,736 - 12,951,485 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936733515,510 - 639,705 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936733515,546 - 639,699 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC24A4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7113,836,230 - 114,014,949 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.17113,836,207 - 114,014,952 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27120,439,442 - 120,621,231 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SLC24A4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12470,068,924 - 70,242,148 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2470,179,850 - 70,239,517 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605357,318,844 - 57,493,322 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc24a4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247348,911,455 - 9,063,063 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247348,911,376 - 9,069,054 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Slc24a4
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v17113,417,757 - 113,553,212 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Slc24a4
568 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:221
Count of miRNA genes:153
Interacting mature miRNAs:177
Transcripts:ENSRNOT00000008886
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4145118Mcs26Mammary carcinoma susceptibility QTL 260.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6112483610147156653Rat
1331797Bp213Blood pressure QTL 2133.291arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)6114241077147156653Rat
2293088Iddm28Insulin dependent diabetes mellitus QTL 285.21blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)668767270135411972Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)688019181136741135Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)690871046135871046Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)693560258136550638Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)698944780143944780Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)6100704576136029228Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6110921244147156653Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)679198463144254945Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6106095977147156653Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)693778632138778632Rat
61329Eae9Experimental allergic encephalomyelitis QTL 93.7body mass (VT:0001259)change in body weight (CMO:0002045)684490437129490437Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)690871046135871046Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)693560258136550638Rat
737976Pia24Pristane induced arthritis QTL 24joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)6118366855147156653Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6101593607138161926Rat
1298087Iddm18Insulin dependent diabetes mellitus QTL 180.0001urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)6122236101147156653Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)693560258136550638Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)6101593607146593607Rat
2293085Iddm29Insulin dependent diabetes mellitus QTL 297.66blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)6121444670147156653Rat

Markers in Region
D6Hmgc16  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr86127,150,625 - 127,150,772 (+)Marker Load Pipeline
mRatBN7.26121,385,749 - 121,385,896 (+)MAPPERmRatBN7.2
Rnor_6.06126,124,502 - 126,124,648NCBIRnor6.0
Rnor_5.06135,336,598 - 135,336,744UniSTSRnor5.0
Celera6118,874,890 - 118,875,036UniSTS
Cytogenetic Map6q32UniSTS
RH132681  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26121,414,524 - 121,414,743 (+)MAPPERmRatBN7.2
Rnor_6.06126,153,443 - 126,153,661NCBIRnor6.0
Rnor_5.06135,364,508 - 135,364,726UniSTSRnor5.0
RGSC_v3.46126,538,108 - 126,538,326UniSTSRGSC3.4
Celera6118,903,178 - 118,903,396UniSTS
RH 3.4 Map14378.58UniSTS
Cytogenetic Map6q32UniSTS
RH143188  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26121,278,955 - 121,279,129 (+)MAPPERmRatBN7.2
Rnor_6.06126,017,781 - 126,017,954NCBIRnor6.0
Rnor_5.06135,228,511 - 135,228,684UniSTSRnor5.0
RGSC_v3.46126,402,762 - 126,402,935UniSTSRGSC3.4
Celera6118,768,456 - 118,768,629UniSTS
RH 3.4 Map6848.5UniSTS
Cytogenetic Map6q32UniSTS
BF392535  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26121,356,840 - 121,356,933 (+)MAPPERmRatBN7.2
Rnor_6.06126,095,845 - 126,095,937NCBIRnor6.0
Rnor_5.06135,307,941 - 135,308,033UniSTSRnor5.0
RGSC_v3.46126,480,627 - 126,480,719UniSTSRGSC3.4
Celera6118,845,981 - 118,846,073UniSTS
RH 3.4 Map6854.0UniSTS
Cytogenetic Map6q32UniSTS
RH138594  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26121,278,913 - 121,279,064 (+)MAPPERmRatBN7.2
Rnor_6.06126,017,739 - 126,017,889NCBIRnor6.0
Rnor_5.06135,228,469 - 135,228,619UniSTSRnor5.0
RGSC_v3.46126,402,720 - 126,402,870UniSTSRGSC3.4
Celera6118,768,414 - 118,768,564UniSTS
Cytogenetic Map6q32UniSTS
UniSTS:224816  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26121,303,322 - 121,303,428 (+)MAPPERmRatBN7.2
Rnor_6.06126,042,199 - 126,042,304NCBIRnor6.0
Rnor_5.06135,254,295 - 135,254,400UniSTSRnor5.0
RGSC_v3.46126,427,109 - 126,427,214UniSTSRGSC3.4
Celera6118,792,339 - 118,792,444UniSTS
Cytogenetic Map6q32UniSTS


Genetic Models
This gene Slc24a4 is modified in the following models/strains:
F344-Slc24a4Tn(sb-T2/Bart3)2.145Mcwi    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
9 7 66 159 60 59 28 66 28 6 276 162 9 132 72 84 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000008886   ⟹   ENSRNOP00000008886
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6127,066,631 - 127,179,824 (+)Ensembl
mRatBN7.2 Ensembl6121,301,755 - 121,414,949 (+)Ensembl
Rnor_6.0 Ensembl6126,040,631 - 126,153,867 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000088089   ⟹   ENSRNOP00000071582
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6121,280,031 - 121,414,918 (+)Ensembl
Rnor_6.0 Ensembl6126,018,856 - 126,153,836 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000089840   ⟹   ENSRNOP00000072760
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6127,044,470 - 127,184,684 (+)Ensembl
mRatBN7.2 Ensembl6121,280,031 - 121,414,918 (+)Ensembl
Rnor_6.0 Ensembl6126,018,841 - 126,153,437 (+)Ensembl
RefSeq Acc Id: NM_001401345   ⟹   NP_001388274
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86127,044,470 - 127,184,684 (+)NCBI
mRatBN7.26121,279,590 - 121,419,811 (+)NCBI
RefSeq Acc Id: NM_001401346   ⟹   NP_001388275
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86127,044,470 - 127,184,684 (+)NCBI
mRatBN7.26121,279,590 - 121,419,811 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001388274 (Get FASTA)   NCBI Sequence Viewer  
  NP_001388275 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI68870 (Get FASTA)   NCBI Sequence Viewer  
  EDL81742 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000008886.8
  ENSRNOP00000072760
  ENSRNOP00000072760.1
Ensembl Acc Id: ENSRNOP00000008886   ⟸   ENSRNOT00000008886
Ensembl Acc Id: ENSRNOP00000072760   ⟸   ENSRNOT00000089840
Ensembl Acc Id: ENSRNOP00000071582   ⟸   ENSRNOT00000088089
RefSeq Acc Id: NP_001388274   ⟸   NM_001401345
- Peptide Label: isoform 1
- UniProtKB: A0A0G2K3S9 (UniProtKB/TrEMBL),   A0A8J8XAJ2 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001388275   ⟸   NM_001401346
- Peptide Label: isoform 2
- UniProtKB: A0A8J8XAJ2 (UniProtKB/TrEMBL)
Protein Domains
Sodium/calcium exchanger membrane region

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K3S9-F1-model_v2 AlphaFold A0A0G2K3S9 1-622 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305926 AgrOrtholog
BioCyc Gene G2FUF-36455 BioCyc
Ensembl Genes ENSRNOG00000006729 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000008886.8 UniProtKB/TrEMBL
  ENSRNOT00000089840 ENTREZGENE
  ENSRNOT00000089840.3 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1420.30 UniProtKB/TrEMBL
InterPro K-dep_Na/Ca-exchanger-like UniProtKB/TrEMBL
  NaCa_Exmemb UniProtKB/TrEMBL
  NCX_ion-bd_dom_sf UniProtKB/TrEMBL
NCBI Gene 314396 ENTREZGENE
PANTHER PTHR10846 UniProtKB/TrEMBL
  PTHR10846:SF21 UniProtKB/TrEMBL
Pfam Na_Ca_ex UniProtKB/TrEMBL
PhenoGen Slc24a4 PhenoGen
RatGTEx ENSRNOG00000006729 RatGTEx
UniProt A0A0G2K3S9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8J8XAJ2 ENTREZGENE
  D3ZCC3_RAT UniProtKB/TrEMBL
UniProt Secondary A0A8J8XAJ2 UniProtKB/TrEMBL
  B5DF00 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-18 Slc24a4  solute carrier family 24 (sodium/potassium/calcium exchanger), member 4  Slc24a4_predicted  solute carrier family 24 (sodium/potassium/calcium exchanger), member 4 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-12 Slc24a4_predicted  solute carrier family 24 (sodium/potassium/calcium exchanger), member 4 (predicted)      Symbol and Name status set to approved 70820 APPROVED