SLC24A4 (solute carrier family 24 member 4) - Rat Genome Database

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Gene: SLC24A4 (solute carrier family 24 member 4) Pan paniscus
Analyze
Symbol: SLC24A4
Name: solute carrier family 24 member 4
RGD ID: 11983154
Description: ENCODES a protein that exhibits antiporter activity (inferred); calcium channel activity (inferred); calcium, potassium:sodium antiporter activity (inferred); INVOLVED IN drinking behavior (ortholog); intracellular calcium ion homeostasis (ortholog); olfactory nerve maturation (ortholog); PARTICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; ASSOCIATED WITH achondrogenesis type IA (ortholog); amelogenesis imperfecta (ortholog); amelogenesis imperfecta hypomaturation type 2A5 (ortholog); FOUND IN apical plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: sodium/potassium/calcium exchanger 4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21593,480,347 - 93,659,175 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11492,696,423 - 92,875,680 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01472,956,230 - 73,128,851 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11492,299,467 - 92,471,426 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1492,299,507 - 92,468,939 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
SLC24A4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21593,480,347 - 93,659,175 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11492,696,423 - 92,875,680 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01472,956,230 - 73,128,851 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11492,299,467 - 92,471,426 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1492,299,507 - 92,468,939 (+)Ensemblpanpan1.1panPan2
SLC24A4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381492,322,581 - 92,501,481 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1492,322,581 - 92,501,481 (+)EnsemblGRCh38hg38GRCh38
GRCh371492,788,925 - 92,967,825 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361491,858,678 - 92,032,349 (+)NCBINCBI36Build 36hg18NCBI36
Celera1472,841,198 - 73,019,912 (+)NCBICelera
Cytogenetic Map14q32.12NCBI
HuRef1472,971,235 - 73,150,009 (+)NCBIHuRef
CHM1_11492,727,545 - 92,906,261 (+)NCBICHM1_1
T2T-CHM13v2.01486,552,327 - 86,731,081 (+)NCBIT2T-CHM13v2.0
Slc24a4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912102,094,986 - 102,239,562 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12102,094,992 - 102,233,350 (+)EnsemblGRCm39 Ensembl
GRCm3812102,128,727 - 102,267,133 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12102,128,733 - 102,267,091 (+)EnsemblGRCm38mm10GRCm38
MGSCv3712103,367,629 - 103,504,959 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612102,530,469 - 102,667,799 (+)NCBIMGSCv36mm8
Celera12103,346,630 - 103,484,305 (+)NCBICelera
Cytogenetic Map12ENCBI
cM Map1251.42NCBI
Slc24a4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86127,044,470 - 127,184,684 (+)NCBIGRCr8
mRatBN7.26121,279,590 - 121,419,811 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6121,280,031 - 121,414,949 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6121,421,469 - 121,560,529 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06121,716,729 - 121,855,788 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06121,053,045 - 121,191,790 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06126,015,799 - 126,158,727 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6126,018,841 - 126,153,867 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06135,226,112 - 135,364,945 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46126,403,837 - 126,538,501 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16126,300,244 - 126,541,897 (+)NCBI
Celera6118,769,531 - 118,903,571 (+)NCBICelera
Cytogenetic Map6q32NCBI
Slc24a4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543814,609,424 - 14,759,673 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543814,609,779 - 14,765,516 (+)NCBIChiLan1.0ChiLan1.0
SLC24A4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.181,570,833 - 1,685,135 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl81,517,560 - 1,680,208 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha81,539,853 - 1,708,276 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.081,570,067 - 1,738,485 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl81,567,138 - 1,740,126 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.181,507,888 - 1,676,257 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.081,464,369 - 1,626,873 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.081,585,200 - 1,753,590 (+)NCBIUU_Cfam_GSD_1.0
Slc24a4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864012,828,736 - 12,951,485 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936733515,510 - 639,705 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936733515,546 - 639,699 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC24A4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7113,836,230 - 114,014,949 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.17113,836,207 - 114,014,952 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27120,439,442 - 120,621,231 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SLC24A4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12470,068,924 - 70,242,148 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2470,179,850 - 70,239,517 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605357,318,844 - 57,493,322 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc24a4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247348,911,455 - 9,063,063 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247348,911,376 - 9,069,054 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000060200   ⟹   ENSPPAP00000037300
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1492,299,507 - 92,468,939 (+)Ensembl
RefSeq Acc Id: XM_003832780   ⟹   XP_003832828
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21593,480,896 - 93,659,175 (+)NCBI
NHGRI_mPanPan11492,697,501 - 92,875,680 (+)NCBI
Mhudiblu_PPA_v01472,957,377 - 73,128,851 (+)NCBI
PanPan1.11492,299,467 - 92,471,426 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008958211   ⟹   XP_008956459
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21593,480,897 - 93,659,175 (+)NCBI
NHGRI_mPanPan11492,697,501 - 92,875,680 (+)NCBI
Mhudiblu_PPA_v01472,957,377 - 73,128,851 (+)NCBI
PanPan1.11492,299,467 - 92,471,426 (+)NCBI
Sequence:
RefSeq Acc Id: XM_034938033   ⟹   XP_034793924
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21593,480,347 - 93,659,175 (+)NCBI
NHGRI_mPanPan11492,696,423 - 92,875,680 (+)NCBI
Mhudiblu_PPA_v01472,956,230 - 73,128,851 (+)NCBI
RefSeq Acc Id: XM_034938034   ⟹   XP_034793925
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21593,480,895 - 93,659,175 (+)NCBI
NHGRI_mPanPan11492,697,501 - 92,875,680 (+)NCBI
Mhudiblu_PPA_v01472,957,377 - 73,128,851 (+)NCBI
RefSeq Acc Id: XM_034938035   ⟹   XP_034793926
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21593,480,896 - 93,659,175 (+)NCBI
NHGRI_mPanPan11492,697,501 - 92,875,680 (+)NCBI
Mhudiblu_PPA_v01472,957,377 - 73,128,851 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_003832828   ⟸   XM_003832780
- Peptide Label: isoform X1
- UniProtKB: A0A2R9C5V7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008956459   ⟸   XM_008958211
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_034793924   ⟸   XM_034938033
- Peptide Label: isoform X1
- UniProtKB: A0A2R9C5V7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034793925   ⟸   XM_034938034
- Peptide Label: isoform X2
RefSeq Acc Id: XP_034793926   ⟸   XM_034938035
- Peptide Label: isoform X4
RefSeq Acc Id: ENSPPAP00000037300   ⟸   ENSPPAT00000060200
Protein Domains
Sodium/calcium exchanger membrane region


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000041402 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000060200.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1420.30 UniProtKB/TrEMBL
InterPro K/Na/Ca-exchanger UniProtKB/TrEMBL
  NaCa_Exmemb UniProtKB/TrEMBL
  NCX_ion-bd_dom_sf UniProtKB/TrEMBL
KEGG Report pps:100978136 UniProtKB/TrEMBL
NCBI Gene SLC24A4 ENTREZGENE
PANTHER PTHR10846 UniProtKB/TrEMBL
  PTHR10846:SF21 UniProtKB/TrEMBL
Pfam Na_Ca_ex UniProtKB/TrEMBL
UniProt A0A2R9C5V7 ENTREZGENE, UniProtKB/TrEMBL