Sorcs1 (sortilin-related VPS10 domain containing receptor 1) - Rat Genome Database

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Pathways
Gene: Sorcs1 (sortilin-related VPS10 domain containing receptor 1) Rattus norvegicus
Analyze
Symbol: Sorcs1
Name: sortilin-related VPS10 domain containing receptor 1
RGD ID: 1305910
Description: Predicted to be involved in post-Golgi vesicle-mediated transport. Predicted to be active in Golgi apparatus and membrane. Used to study proteinuria. Orthologous to human SORCS1 (sortilin related VPS10 domain containing receptor 1); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC309533; VPS10 domain receptor protein SORCS 1; VPS10 domain-containing receptor SorCS1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Sorcs1em1Mcwi
Genetic Models: FHH-Chr 1BN-Sorcs1em1Mcwi-/- ; FHH-Chr 1BN-Sorcs1em1Mcwi
Candidate Gene For: Niddm65
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81259,022,007 - 259,535,731 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1259,021,631 - 259,535,685 (-)EnsemblGRCr8
mRatBN7.21249,080,662 - 249,594,520 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1249,081,355 - 249,594,507 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1257,225,370 - 257,730,896 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01263,918,158 - 264,423,716 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01256,561,905 - 257,073,670 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01269,965,824 - 270,473,097 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1269,973,351 - 270,472,866 (-)Ensemblrn6Rnor6.0
Rnor_5.01277,404,996 - 277,912,261 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41255,767,411 - 256,279,565 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1244,828,397 - 245,333,325 (-)NCBICelera
RGSC_v3.11256,033,640 - 256,545,663 (-)NCBI
Cytogenetic Map1q55NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
Golgi apparatus  (IBA)
membrane  (IBA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. SORCS1 contributes to the development of renal disease in rats and humans. Lazar J, etal., Physiol Genomics. 2013 Aug 15;45(16):720-8. doi: 10.1152/physiolgenomics.00089.2013. Epub 2013 Jun 18.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:12482870   PMID:31658245   PMID:31857633  


Genomics

Comparative Map Data
Sorcs1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81259,022,007 - 259,535,731 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1259,021,631 - 259,535,685 (-)EnsemblGRCr8
mRatBN7.21249,080,662 - 249,594,520 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1249,081,355 - 249,594,507 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1257,225,370 - 257,730,896 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01263,918,158 - 264,423,716 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01256,561,905 - 257,073,670 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01269,965,824 - 270,473,097 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1269,973,351 - 270,472,866 (-)Ensemblrn6Rnor6.0
Rnor_5.01277,404,996 - 277,912,261 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41255,767,411 - 256,279,565 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1244,828,397 - 245,333,325 (-)NCBICelera
RGSC_v3.11256,033,640 - 256,545,663 (-)NCBI
Cytogenetic Map1q55NCBI
SORCS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810106,573,663 - 107,181,138 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10106,573,663 - 107,164,706 (-)Ensemblhg38GRCh38
GRCh3710108,333,421 - 108,924,464 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3610108,323,411 - 108,914,282 (-)NCBIBuild 36Build 36hg18NCBI36
Build 3410108,323,410 - 108,914,282NCBI
Celera10102,072,553 - 102,663,374 (-)NCBICelera
Cytogenetic Map10q25.1NCBI
HuRef10101,965,988 - 102,556,901 (-)NCBIHuRef
CHM1_110108,615,122 - 109,206,295 (-)NCBICHM1_1
T2T-CHM13v2.010107,460,647 - 108,068,078 (-)NCBIT2T-CHM13v2.0
Sorcs1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391950,131,733 - 50,668,030 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1950,131,737 - 50,667,084 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381950,143,295 - 50,679,129 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1950,143,299 - 50,678,646 (-)Ensemblmm10GRCm38
MGSCv371950,222,150 - 50,753,102 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361950,204,284 - 50,731,796 (-)NCBIMGSCv36mm8
Celera1950,907,555 - 51,438,064 (-)NCBICelera
Cytogenetic Map19D1NCBI
cM Map1945.05NCBI
Sorcs1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554853,719,008 - 4,218,699 (+)Ensembl
ChiLan1.0NW_0049554853,719,006 - 4,222,143 (+)NCBIChiLan1.0ChiLan1.0
SORCS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28118,454,472 - 119,044,048 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110118,459,805 - 119,049,387 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v010103,164,581 - 103,753,754 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110106,623,481 - 107,211,230 (-)NCBIPanPan1.1PanPan1.1panPan2
SORCS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12818,619,015 - 18,933,785 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2818,622,234 - 18,797,249 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2818,745,291 - 19,221,898 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02819,098,613 - 19,608,198 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2819,067,554 - 19,609,122 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12818,630,873 - 19,139,229 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02818,678,797 - 19,178,427 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02818,811,161 - 19,310,390 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Sorcs1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721327,085,308 - 27,300,512 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493677628,537 - 241,135 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493677627,519 - 240,225 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SORCS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14117,479,787 - 118,009,583 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.114117,479,817 - 118,009,485 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214127,817,702 - 128,359,641 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SORCS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1999,581,375 - 100,171,637 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604860,747,868 - 61,334,611 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sorcs1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248315,435,192 - 5,736,481 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248315,433,671 - 5,901,911 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Sorcs1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1249,612,314 - 50,119,457 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Sorcs1
2852 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:247
Count of miRNA genes:165
Interacting mature miRNAs:179
Transcripts:ENSRNOT00000015979
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1208479811269633915Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1224633915269633915Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1232312773270518180Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1186658830266453731Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1226175591270518180Rat
1578775Iddm21Insulin dependent diabetes mellitus QTL 214.13blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1245782829270518180Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1205233991267096252Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1218829748263829748Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1186658830266453731Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
631837Niddm35Non-insulin dependent diabetes mellitus QTL 350.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1248619887269633915Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
631836Stl31Serum triglyceride level QTL 314.645e-06blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1247133834270518180Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1194786607262083703Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1600390Niddm64Non-insulin dependent diabetes mellitus QTL 640.003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1257624997270518180Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
1300108Rf8Renal function QTL 83.75renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1237995023269633915Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1233480549270108840Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1234540191270518180Rat
7387289Uae45Urinary albumin excretion QTL 452.860.0021urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1233204160270518180Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1233480549270108840Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1207163993269633915Rat
1598839Rf56Renal function QTL 56renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1255849111270518180Rat
1581544Rf52Renal function QTL 520.05urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)1241569529269633915Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
724538Kidm1Kidney mass QTL 13.2kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1223134011262090599Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
631536Lnnr2Liver neoplastic nodule remodeling QTL 22.90.0005liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)1243953669270518180Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1225108840270108840Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1185857683270518180Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1226175591270518180Rat
631669Iddm9Insulin dependent diabetes mellitus QTL 92.80.039blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1233349180270518180Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1228174566270518180Rat
724533Rf51Renal function QTL 515.30.0002kidney plasma flow trait (VT:0005524)renal plasma flow (CMO:0001914)1228180370266453608Rat

Markers in Region
D1Got243  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21249,464,806 - 249,465,102 (+)MAPPERmRatBN7.2
Rnor_6.01270,343,685 - 270,343,980NCBIRnor6.0
Rnor_5.01277,782,857 - 277,783,152UniSTSRnor5.0
RGSC_v3.41256,147,163 - 256,147,458UniSTSRGSC3.4
RGSC_v3.11256,413,080 - 256,413,374RGD
RH 3.4 Map11647.6UniSTS
RH 3.4 Map11647.6RGD
Cytogenetic Map1q55UniSTS
D1Swe6  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21249,556,757 - 249,557,041 (+)MAPPERmRatBN7.2
Rnor_6.01270,435,354 - 270,435,635NCBIRnor6.0
Rnor_5.01277,874,526 - 277,874,807UniSTSRnor5.0
RGSC_v3.41256,242,053 - 256,242,334UniSTSRGSC3.4
Celera1245,295,908 - 245,296,189UniSTS
Cytogenetic Map1q55UniSTS
D1Swe5  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21249,396,204 - 249,396,498 (+)MAPPERmRatBN7.2
Rnor_6.01270,282,616 - 270,282,909NCBIRnor6.0
Rnor_5.01277,721,788 - 277,722,081UniSTSRnor5.0
RGSC_v3.41256,078,665 - 256,078,958UniSTSRGSC3.4
Celera1245,135,983 - 245,136,276UniSTS
Cytogenetic Map1q55UniSTS
AU047999  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21249,246,112 - 249,246,400 (+)MAPPERmRatBN7.2
Rnor_6.01270,132,136 - 270,132,423NCBIRnor6.0
Rnor_5.01277,571,308 - 277,571,595UniSTSRnor5.0
RGSC_v3.41255,928,594 - 255,928,881UniSTSRGSC3.4
Cytogenetic Map1q55UniSTS
RH128986  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21249,085,276 - 249,085,472 (+)MAPPERmRatBN7.2
Rnor_6.01269,970,439 - 269,970,634NCBIRnor6.0
Rnor_5.01277,409,611 - 277,409,806UniSTSRnor5.0
RGSC_v3.41255,764,499 - 255,764,694UniSTSRGSC3.4
Celera1244,825,485 - 244,825,680UniSTS
RH 3.4 Map11647.7UniSTS
Cytogenetic Map1q55UniSTS
RH142862  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21249,589,323 - 249,589,454 (+)MAPPERmRatBN7.2
Rnor_6.01270,467,911 - 270,468,041NCBIRnor6.0
Rnor_5.01277,907,083 - 277,907,213UniSTSRnor5.0
RGSC_v3.41256,274,610 - 256,274,740UniSTSRGSC3.4
Celera1245,328,375 - 245,328,505UniSTS
RH 3.4 Map11652.0UniSTS
Cytogenetic Map1q55UniSTS
RH144267  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81259,165,619 - 259,165,827 (+)Marker Load Pipeline
mRatBN7.21249,224,379 - 249,224,588 (+)MAPPERmRatBN7.2
Rnor_6.01270,110,403 - 270,110,611NCBIRnor6.0
Rnor_5.01277,549,575 - 277,549,783UniSTSRnor5.0
RGSC_v3.41255,906,861 - 255,907,069UniSTSRGSC3.4
Celera1244,964,441 - 244,964,649UniSTS
RH 3.4 Map11649.4UniSTS
Cytogenetic Map1q55UniSTS
AW530705  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21249,577,642 - 249,577,799 (+)MAPPERmRatBN7.2
Rnor_6.01270,456,233 - 270,456,389NCBIRnor6.0
Rnor_5.01277,895,405 - 277,895,561UniSTSRnor5.0
RGSC_v3.41256,262,932 - 256,263,088UniSTSRGSC3.4
Celera1245,316,793 - 245,316,949UniSTS
RH 3.4 Map11650.3UniSTS
Cytogenetic Map1q55UniSTS
BF401123  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21249,515,864 - 249,516,027 (+)MAPPERmRatBN7.2
Rnor_6.01270,393,697 - 270,393,859NCBIRnor6.0
Rnor_5.01277,832,869 - 277,833,031UniSTSRnor5.0
RGSC_v3.41256,200,300 - 256,200,462UniSTSRGSC3.4
Celera1245,254,983 - 245,255,145UniSTS
RH 3.4 Map11648.7UniSTS
Cytogenetic Map1q55UniSTS
BE107951  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21249,228,447 - 249,228,631 (+)MAPPERmRatBN7.2
Rnor_6.01270,114,471 - 270,114,654NCBIRnor6.0
Rnor_5.01277,553,643 - 277,553,826UniSTSRnor5.0
RGSC_v3.41255,910,929 - 255,911,112UniSTSRGSC3.4
Celera1244,968,509 - 244,968,692UniSTS
RH 3.4 Map11648.7UniSTS
Cytogenetic Map1q55UniSTS
RH137888  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21249,399,008 - 249,399,151 (+)MAPPERmRatBN7.2
Rnor_6.01270,285,420 - 270,285,562NCBIRnor6.0
Rnor_5.01277,724,592 - 277,724,734UniSTSRnor5.0
RGSC_v3.41256,081,469 - 256,081,611UniSTSRGSC3.4
Celera1245,138,790 - 245,138,932UniSTS
RH 3.4 Map11648.7UniSTS
Cytogenetic Map1q55UniSTS
RH140348  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21249,080,890 - 249,081,010 (+)MAPPERmRatBN7.2
Rnor_6.01269,966,053 - 269,966,172NCBIRnor6.0
Rnor_5.01277,405,225 - 277,405,344UniSTSRnor5.0
RGSC_v3.41255,760,113 - 255,760,232UniSTSRGSC3.4
Celera1244,821,099 - 244,821,218UniSTS
RH 3.4 Map11648.3UniSTS
Cytogenetic Map1q55UniSTS
D1Hmgc19  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21249,583,745 - 249,583,894 (+)MAPPERmRatBN7.2
Rnor_6.01270,462,331 - 270,462,479NCBIRnor6.0
Rnor_5.01277,901,503 - 277,901,651UniSTSRnor5.0
Celera1245,322,849 - 245,322,997UniSTS
Cytogenetic Map1q55UniSTS


Genetic Models
This gene Sorcs1 is modified in the following models/strains:


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 10 65 161 79 78 47 27 47 6 269 123 10 140 75 89 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001191563 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001438076 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001438077 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006231519 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006231520 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006231521 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006231522 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006231523 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006231525 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008760442 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039080712 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039080717 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039080722 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039080727 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063265314 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH473986 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000015979   ⟹   ENSRNOP00000015979
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1259,028,864 - 259,535,685 (-)Ensembl
mRatBN7.2 Ensembl1249,088,189 - 249,594,507 (-)Ensembl
Rnor_6.0 Ensembl1269,973,351 - 270,472,866 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000098704   ⟹   ENSRNOP00000091270
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1259,021,738 - 259,535,685 (-)Ensembl
mRatBN7.2 Ensembl1249,088,357 - 249,594,507 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000099121   ⟹   ENSRNOP00000090827
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1259,028,830 - 259,535,685 (-)Ensembl
mRatBN7.2 Ensembl1249,081,355 - 249,594,507 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000108738   ⟹   ENSRNOP00000078816
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1259,021,631 - 259,535,685 (-)Ensembl
mRatBN7.2 Ensembl1249,081,355 - 249,594,507 (-)Ensembl
RefSeq Acc Id: NM_001191563   ⟹   NP_001178492
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81259,029,432 - 259,535,486 (-)NCBI
mRatBN7.21249,088,189 - 249,594,279 (-)NCBI
Rnor_6.01269,973,351 - 270,472,866 (-)NCBI
Rnor_5.01277,404,996 - 277,912,261 (-)NCBI
Celera1244,828,397 - 245,333,325 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006231519   ⟹   XP_006231581
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81259,022,007 - 259,535,634 (-)NCBI
mRatBN7.21249,080,662 - 249,594,424 (-)NCBI
Rnor_6.01269,966,589 - 270,472,968 (-)NCBI
Rnor_5.01277,404,996 - 277,912,261 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006231520   ⟹   XP_006231582
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81259,026,343 - 259,535,731 (-)NCBI
mRatBN7.21249,085,100 - 249,594,424 (-)NCBI
Rnor_6.01269,970,262 - 270,472,968 (-)NCBI
Rnor_5.01277,404,996 - 277,912,261 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006231521   ⟹   XP_006231583
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81259,022,007 - 259,535,664 (-)NCBI
mRatBN7.21249,080,662 - 249,594,424 (-)NCBI
Rnor_6.01269,965,824 - 270,472,968 (-)NCBI
Rnor_5.01277,404,996 - 277,912,261 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006231522   ⟹   XP_006231584
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81259,029,786 - 259,535,634 (-)NCBI
mRatBN7.21249,088,615 - 249,594,424 (-)NCBI
Rnor_6.01269,973,829 - 270,472,968 (-)NCBI
Rnor_5.01277,404,996 - 277,912,261 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006231523   ⟹   XP_006231585
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81259,026,343 - 259,535,634 (-)NCBI
mRatBN7.21249,085,100 - 249,594,424 (-)NCBI
Rnor_6.01269,970,262 - 270,472,968 (-)NCBI
Rnor_5.01277,404,996 - 277,912,261 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006231525   ⟹   XP_006231587
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81259,026,343 - 259,535,723 (-)NCBI
mRatBN7.21249,085,100 - 249,594,520 (-)NCBI
Rnor_6.01269,970,262 - 270,473,097 (-)NCBI
Rnor_5.01277,404,996 - 277,912,261 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039080712   ⟹   XP_038936640
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81259,026,343 - 259,535,634 (-)NCBI
mRatBN7.21249,085,100 - 249,594,424 (-)NCBI
RefSeq Acc Id: XM_039080717   ⟹   XP_038936645
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81259,026,343 - 259,426,479 (-)NCBI
mRatBN7.21249,085,100 - 249,485,297 (-)NCBI
RefSeq Acc Id: XM_039080722   ⟹   XP_038936650
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81259,026,343 - 259,137,681 (-)NCBI
mRatBN7.21249,085,100 - 249,198,037 (-)NCBI
RefSeq Acc Id: XM_039080727   ⟹   XP_038936655
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81259,026,343 - 259,140,298 (-)NCBI
mRatBN7.21249,085,100 - 249,199,057 (-)NCBI
RefSeq Acc Id: XM_063265314   ⟹   XP_063121384
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81259,026,343 - 259,535,634 (-)NCBI
RefSeq Acc Id: NP_001178492   ⟸   NM_001191563
- Peptide Label: precursor
- UniProtKB: F1LUZ4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006231583   ⟸   XM_006231521
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_006231581   ⟸   XM_006231519
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AEA1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006231587   ⟸   XM_006231525
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_006231585   ⟸   XM_006231523
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_006231582   ⟸   XM_006231520
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006231584   ⟸   XM_006231522
- Peptide Label: isoform X4
- UniProtKB: A0A8I6AF53 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000015979   ⟸   ENSRNOT00000015979
RefSeq Acc Id: XP_038936640   ⟸   XM_039080712
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038936645   ⟸   XM_039080717
- Peptide Label: isoform X8
- UniProtKB: A6JHS6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038936655   ⟸   XM_039080727
- Peptide Label: isoform X10
RefSeq Acc Id: XP_038936650   ⟸   XM_039080722
- Peptide Label: isoform X9
Ensembl Acc Id: ENSRNOP00000090827   ⟸   ENSRNOT00000099121
Ensembl Acc Id: ENSRNOP00000078816   ⟸   ENSRNOT00000108738
Ensembl Acc Id: ENSRNOP00000091270   ⟸   ENSRNOT00000098704
RefSeq Acc Id: XP_063121384   ⟸   XM_063265314
- Peptide Label: isoform X11
Protein Domains
PKD

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LUZ4-F1-model_v2 AlphaFold F1LUZ4 1-1168 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305910 AgrOrtholog
BioCyc Gene G2FUF-55424 BioCyc
Ensembl Genes ENSRNOG00000011313 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000015979 ENTREZGENE
  ENSRNOT00000015979.6 UniProtKB/TrEMBL
  ENSRNOT00000098704 ENTREZGENE
  ENSRNOT00000098704.2 UniProtKB/TrEMBL
  ENSRNOT00000099121 ENTREZGENE
  ENSRNOT00000099121.2 UniProtKB/TrEMBL
  ENSRNOT00000108738 ENTREZGENE
  ENSRNOT00000108738.2 UniProtKB/TrEMBL
Gene3D-CATH 2.10.70.80 UniProtKB/TrEMBL
  2.120.10.10 UniProtKB/TrEMBL
  2.130.10.10 UniProtKB/TrEMBL
  2.60.40.10 UniProtKB/TrEMBL
  3.30.60.270 UniProtKB/TrEMBL
InterPro Ig-like_fold UniProtKB/TrEMBL
  PKD_dom UniProtKB/TrEMBL
  PKD_dom_sf UniProtKB/TrEMBL
  Sortilin_C UniProtKB/TrEMBL
  Sortilin_N UniProtKB/TrEMBL
  VPS10 UniProtKB/TrEMBL
  VPS10-sortilin UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom UniProtKB/TrEMBL
KEGG Report rno:309533 UniProtKB/TrEMBL
NCBI Gene 309533 ENTREZGENE
PANTHER SORTILIN RELATED UniProtKB/TrEMBL
  VPS10 DOMAIN-CONTAINING RECEPTOR SORCS1 UniProtKB/TrEMBL
Pfam PKD UniProtKB/TrEMBL
  Sortilin-Vps10 UniProtKB/TrEMBL
  Sortilin_C UniProtKB/TrEMBL
PhenoGen Sorcs1 PhenoGen
PROSITE PKD UniProtKB/TrEMBL
RatGTEx ENSRNOG00000011313 RatGTEx
SMART VPS10 UniProtKB/TrEMBL
Superfamily-SCOP Oligoxyloglucan reducing end-specific cellobiohydrolase UniProtKB/TrEMBL
  PKD UniProtKB/TrEMBL
UniProt A0A8I5ZLQ5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AEA1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AF53 ENTREZGENE, UniProtKB/TrEMBL
  A6JHS6 ENTREZGENE, UniProtKB/TrEMBL
  F1LUZ4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-18 Sorcs1  sortilin-related VPS10 domain containing receptor 1  Sorcs1  VPS10 domain receptor protein SORCS 1   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Sorcs1  VPS10 domain receptor protein SORCS 1   Sorcs1_predicted  VPS10 domain receptor protein SORCS 1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Sorcs1_predicted  VPS10 domain receptor protein SORCS 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED