Sorcs1 (sortilin-related VPS10 domain containing receptor 1) - Rat Genome Database

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Gene: Sorcs1 (sortilin-related VPS10 domain containing receptor 1) Mus musculus
Analyze
Symbol: Sorcs1
Name: sortilin-related VPS10 domain containing receptor 1
RGD ID: 1314225
MGI Page MGI
Description: Predicted to be involved in post-Golgi vesicle-mediated transport. Predicted to be located in membrane. Predicted to be active in Golgi apparatus. Is expressed in several structures, including frenulum; genitourinary system; nervous system; sensory organ; and visual system. Orthologous to human SORCS1 (sortilin related VPS10 domain containing receptor 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: mSorCS; Sorcs; VPS10 domain receptor protein SORCS 1; VPS10 domain-containing receptor SorCS1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391950,131,733 - 50,668,030 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1950,131,737 - 50,667,084 (-)EnsemblGRCm39 Ensembl
GRCm381950,143,295 - 50,679,129 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1950,143,299 - 50,678,646 (-)EnsemblGRCm38mm10GRCm38
MGSCv371950,222,150 - 50,753,102 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361950,204,284 - 50,731,796 (-)NCBIMGSCv36mm8
Celera1950,907,555 - 51,438,064 (-)NCBICelera
Cytogenetic Map19D1NCBI
cM Map1945.05NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
Golgi apparatus  (IBA)
membrane  (IBA,ISO)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. SORCS1 contributes to the development of renal disease in rats and humans. Lazar J, etal., Physiol Genomics. 2013 Aug 15;45(16):720-8. doi: 10.1152/physiolgenomics.00089.2013. Epub 2013 Jun 18.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. Mouse MP Annotation Import Pipeline RGD automated import pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10545116   PMID:10600506   PMID:10760602   PMID:11042159   PMID:11076861   PMID:11201086   PMID:11217851   PMID:12477932   PMID:15009648   PMID:15489334  
PMID:16141072   PMID:16141073   PMID:16682971   PMID:16919269   PMID:17426289   PMID:18315530   PMID:20881129   PMID:21267068   PMID:21873635   PMID:24128306   PMID:24715575   PMID:25157818  
PMID:26119586   PMID:26291160   PMID:26916443   PMID:29440124   PMID:31095505   PMID:31658245   PMID:32325033  


Genomics

Comparative Map Data
Sorcs1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391950,131,733 - 50,668,030 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1950,131,737 - 50,667,084 (-)EnsemblGRCm39 Ensembl
GRCm381950,143,295 - 50,679,129 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1950,143,299 - 50,678,646 (-)EnsemblGRCm38mm10GRCm38
MGSCv371950,222,150 - 50,753,102 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361950,204,284 - 50,731,796 (-)NCBIMGSCv36mm8
Celera1950,907,555 - 51,438,064 (-)NCBICelera
Cytogenetic Map19D1NCBI
cM Map1945.05NCBI
SORCS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810106,573,663 - 107,181,138 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10106,573,663 - 107,164,706 (-)EnsemblGRCh38hg38GRCh38
GRCh3710108,333,421 - 108,924,464 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3610108,323,411 - 108,914,282 (-)NCBINCBI36Build 36hg18NCBI36
Build 3410108,323,410 - 108,914,282NCBI
Celera10102,072,553 - 102,663,374 (-)NCBICelera
Cytogenetic Map10q25.1NCBI
HuRef10101,965,988 - 102,556,901 (-)NCBIHuRef
CHM1_110108,615,122 - 109,206,295 (-)NCBICHM1_1
T2T-CHM13v2.010107,460,647 - 108,068,078 (-)NCBIT2T-CHM13v2.0
Sorcs1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81259,022,007 - 259,535,731 (-)NCBIGRCr8
mRatBN7.21249,080,662 - 249,594,520 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1249,081,355 - 249,594,507 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1257,225,370 - 257,730,896 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01263,918,158 - 264,423,716 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01256,561,905 - 257,073,670 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01269,965,824 - 270,473,097 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1269,973,351 - 270,472,866 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01277,404,996 - 277,912,261 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41255,767,411 - 256,279,565 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11256,033,640 - 256,545,663 (-)NCBI
Celera1244,828,397 - 245,333,325 (-)NCBICelera
Cytogenetic Map1q55NCBI
Sorcs1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554853,719,008 - 4,218,699 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554853,719,006 - 4,222,143 (+)NCBIChiLan1.0ChiLan1.0
SORCS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28118,454,472 - 119,044,048 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110118,459,805 - 119,049,387 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v010103,164,581 - 103,753,754 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110106,623,481 - 107,211,230 (-)NCBIpanpan1.1PanPan1.1panPan2
SORCS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12818,619,015 - 18,933,785 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2818,622,234 - 18,797,249 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2818,745,291 - 19,221,898 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02819,098,613 - 19,608,198 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2819,067,554 - 19,609,122 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12818,630,873 - 19,139,229 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02818,678,797 - 19,178,427 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02818,811,161 - 19,310,390 (-)NCBIUU_Cfam_GSD_1.0
Sorcs1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721327,085,308 - 27,300,512 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493677628,537 - 241,135 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493677627,519 - 240,225 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SORCS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14117,479,787 - 118,009,583 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114117,479,817 - 118,009,485 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214127,817,702 - 128,359,641 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SORCS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1999,581,375 - 100,171,637 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604860,747,868 - 61,334,611 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sorcs1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248315,435,192 - 5,736,481 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248315,433,671 - 5,901,911 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Sorcs1
21571 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1932
Count of miRNA genes:774
Interacting mature miRNAs:1021
Transcripts:ENSMUST00000072685, ENSMUST00000111756, ENSMUST00000164039, ENSMUST00000168357
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302063Eae19_mexperimental allergic encephalomyelitis 19 (mouse)Not determined191829516252295381Mouse
1302004Lfp2_mlong free running period 2 (mouse)Not determined191829516252295381Mouse
4142343Moen2_mmodifier of engrailed QTL 2 (mouse)Not determined192023431454234461Mouse
10412251Mnp_mmodifier of Niemann Pick type C1 (mouse)Not determined192023431454234461Mouse
4141659Pbwg20_mpostnatal body weight growth 20 (mouse)Not determined192137870555378928Mouse
1558876W3q14_mweight 3 weeks QTL 14 (mouse)Not determined192231332653911504Mouse
12790634Ebm1_mEpidermolysis Bullosa modifier 1 (mouse)192498843958988439Mouse
1301451Ath16_matherosclerosis 16 (mouse)Not determined192542691759427005Mouse
13506250Renmq1_mrenal mercury accumulation QTL 1 (mouse)192738559461385705Mouse
4141138Femwf11_mfemur work to failure 11 (mouse)Not determined2814034861420004Mouse
1300683Fembm7_mfemoral bone morphometry 7 (mouse)Not determined193014122461420004Mouse
1301942Pas13_mpulmonary adenoma susceptibility 13 (mouse)Not determined193014123161420004Mouse
1301410Cd8mts6_mCD8 memory T cell subset 6 (mouse)Not determined193014123161420004Mouse
1300856Nobq2_mNew Zealand obese QTL 2 (mouse)Not determined193089788061420004Mouse
1301741Lith2_mlithogenic gene 2 (mouse)Not determined193299215861420004Mouse
1301639Stnn_mstriatal neuron number (mouse)Not determined193395195261420004Mouse
4141019Tgq29_mtriglyceride QTL 29 (mouse)Not determined3459678661420004Mouse
1302170Tanidd1_mtally ho associated non-insulin dependednt diabetes mellitus 1 (mouse)Not determined193675259761420004Mouse
4141650Chldq9_mcholesterol and HDL QTL 9 (mouse)Not determined193788298261420004Mouse
1301466T2dm2_mtype 2 diabetes mellitus 2 (mouse)Not determined193837605061420004Mouse
1302104Lfp1_mlong free running period 1 (mouse)Not determined193918406461420004Mouse
10043896Bw21_mbody weight QTL 21 (mouse)Not determined193959606661420004Mouse
1300585Pgia12_mproteoglycan induced arthritis 12 (mouse)Not determined194258685961420004Mouse
4141412Acsns1_mAngiostrongylus costaricensis nematode susceptibility 1 (mouse)Not determined4789788055026545Mouse

Markers in Region
22.MMHAP15FRH7.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381950,492,849 - 50,493,010UniSTSGRCm38
MGSCv371950,567,339 - 50,567,500UniSTSGRCm37
Celera1951,253,563 - 51,253,724UniSTS
Cytogenetic Map19D2UniSTS
cM Map1951.0UniSTS
Whitehead_YAC19 UniSTS
D13Mit221  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381950,603,245 - 50,603,362UniSTSGRCm38
MGSCv371950,677,735 - 50,677,852UniSTSGRCm37
Celera1951,357,425 - 51,357,533UniSTS
Cytogenetic Map19D2UniSTS
cM Map1330.0UniSTS
cM Map19 UniSTS
Whitehead Genetic1315.3UniSTS
D19Mit25  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381950,418,177 - 50,418,326UniSTSGRCm38
MGSCv371950,492,667 - 50,492,816UniSTSGRCm37
Celera1951,178,870 - 51,179,019UniSTS
Cytogenetic Map19D2UniSTS
cM Map1950.0UniSTS
Whitehead Genetic1937.2UniSTS
Whitehead/MRC_RH19522.15UniSTS
Whitehead_YAC19 UniSTS
D19Dcr14  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381950,249,163 - 50,249,260UniSTSGRCm38
MGSCv371950,323,653 - 50,323,750UniSTSGRCm37
Celera1951,008,959 - 51,009,056UniSTS
Cytogenetic Map19D2UniSTS
cM Map19 UniSTS
Sorcs1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map19D2UniSTS
cM Map1951.0UniSTS
cM Map1951.0UniSTS
Sorcs1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map19D2UniSTS
cM Map1951.0UniSTS
Sorcs1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map19D2UniSTS
Sorcs1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map19D2UniSTS
Sorcs1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map19D2UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001252501 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001290356 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001360457 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_021377 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006527243 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006527244 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017318265 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030251008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030251009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC100726 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC101735 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC101745 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC122294 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC131103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC158463 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF137367 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF195056 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF284755 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK030440 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK046724 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK054036 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC007486 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BE655207 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CF746738 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466534 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ479927 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000072685   ⟹   ENSMUSP00000072472
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1950,131,739 - 50,667,084 (-)Ensembl
GRCm38.p6 Ensembl1950,143,301 - 50,678,646 (-)Ensembl
RefSeq Acc Id: ENSMUST00000111756   ⟹   ENSMUSP00000107386
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1950,141,130 - 50,666,923 (-)Ensembl
GRCm38.p6 Ensembl1950,152,692 - 50,678,485 (-)Ensembl
RefSeq Acc Id: ENSMUST00000164039   ⟹   ENSMUSP00000132615
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1950,136,098 - 50,667,084 (-)Ensembl
GRCm38.p6 Ensembl1950,147,660 - 50,678,646 (-)Ensembl
RefSeq Acc Id: ENSMUST00000168357   ⟹   ENSMUSP00000129190
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1950,139,405 - 50,241,116 (-)Ensembl
GRCm38.p6 Ensembl1950,150,967 - 50,252,678 (-)Ensembl
RefSeq Acc Id: ENSMUST00000209413   ⟹   ENSMUSP00000147463
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1950,131,737 - 50,667,084 (-)Ensembl
GRCm38.p6 Ensembl1950,143,299 - 50,678,646 (-)Ensembl
RefSeq Acc Id: ENSMUST00000209783   ⟹   ENSMUSP00000148254
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1950,141,391 - 50,666,923 (-)Ensembl
GRCm38.p6 Ensembl1950,152,953 - 50,678,485 (-)Ensembl
RefSeq Acc Id: ENSMUST00000211008   ⟹   ENSMUSP00000147456
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1950,141,130 - 50,666,923 (-)Ensembl
GRCm38.p6 Ensembl1950,152,692 - 50,678,485 (-)Ensembl
RefSeq Acc Id: ENSMUST00000211687   ⟹   ENSMUSP00000147591
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1950,136,098 - 50,666,923 (-)Ensembl
GRCm38.p6 Ensembl1950,147,660 - 50,678,485 (-)Ensembl
RefSeq Acc Id: NM_001252501   ⟹   NP_001239430
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391950,131,737 - 50,667,165 (-)NCBI
GRCm381950,143,301 - 50,678,646 (-)NCBI
Celera1950,903,195 - 51,438,098 (-)ENTREZGENE
cM Map19 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001290356   ⟹   NP_001277285
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391950,141,391 - 50,667,165 (-)NCBI
GRCm381950,152,953 - 50,678,646 (-)NCBI
Celera1950,903,195 - 51,438,098 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001360457   ⟹   NP_001347386
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391950,136,098 - 50,667,165 (-)NCBI
GRCm381950,147,660 - 50,678,646 (-)NCBI
Sequence:
RefSeq Acc Id: NM_021377   ⟹   NP_067352
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391950,136,098 - 50,667,165 (-)NCBI
GRCm381950,147,660 - 50,678,646 (-)NCBI
MGSCv371950,222,150 - 50,753,102 (-)RGD
Celera1950,903,195 - 51,438,098 (-)ENTREZGENE
cM Map19 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006527243   ⟹   XP_006527306
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391950,138,546 - 50,667,113 (-)NCBI
GRCm381950,147,660 - 50,475,452 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006527244   ⟹   XP_006527307
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391950,139,351 - 50,668,030 (-)NCBI
GRCm381950,150,919 - 50,679,128 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017318265   ⟹   XP_017173754
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391950,131,733 - 50,667,113 (-)NCBI
GRCm381950,143,295 - 50,475,452 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030251008   ⟹   XP_030106868
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391950,131,733 - 50,668,030 (-)NCBI
GRCm381950,143,295 - 50,679,129 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030251009   ⟹   XP_030106869
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391950,131,733 - 50,667,113 (-)NCBI
GRCm381950,143,295 - 50,475,452 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_067352   ⟸   NM_021377
- Peptide Label: isoform 1 precursor
- UniProtKB: A0A1B0GRN1 (UniProtKB/TrEMBL),   E9PYT6 (UniProtKB/TrEMBL),   Q1HL25 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001239430   ⟸   NM_001252501
- Peptide Label: isoform 2 precursor
- UniProtKB: A0A1B0GRC4 (UniProtKB/TrEMBL),   E9QQ02 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006527307   ⟸   XM_006527244
- Peptide Label: isoform X5
- UniProtKB: A0A1B0GRB7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006527306   ⟸   XM_006527243
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: NP_001277285   ⟸   NM_001290356
- Peptide Label: isoform 3 precursor
- UniProtKB: A0A1B0GT94 (UniProtKB/TrEMBL),   Q1HL23 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017173754   ⟸   XM_017318265
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_030106868   ⟸   XM_030251008
- Peptide Label: isoform X1
- UniProtKB: A0A1B0GRB7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_030106869   ⟸   XM_030251009
- Peptide Label: isoform X2
RefSeq Acc Id: NP_001347386   ⟸   NM_001360457
- Peptide Label: isoform 4 precursor
- UniProtKB: A0A1B0GRB7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSMUSP00000107386   ⟸   ENSMUST00000111756
RefSeq Acc Id: ENSMUSP00000132615   ⟸   ENSMUST00000164039
RefSeq Acc Id: ENSMUSP00000147591   ⟸   ENSMUST00000211687
RefSeq Acc Id: ENSMUSP00000147456   ⟸   ENSMUST00000211008
RefSeq Acc Id: ENSMUSP00000072472   ⟸   ENSMUST00000072685
RefSeq Acc Id: ENSMUSP00000129190   ⟸   ENSMUST00000168357
RefSeq Acc Id: ENSMUSP00000148254   ⟸   ENSMUST00000209783
RefSeq Acc Id: ENSMUSP00000147463   ⟸   ENSMUST00000209413
Protein Domains
PKD

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JLC4-F1-model_v2 AlphaFold Q9JLC4 1-1167 view protein structure

Promoters
RGD ID:13679758
Promoter ID:EPDNEW_M24028
Type:multiple initiation site
Name:Sorcs1_1
Description:Mus musculus sortilin-related VPS10 domain containing receptor1 , transcript variant 3, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381950,678,656 - 50,678,716EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1929666 AgrOrtholog
Ensembl Genes ENSMUSG00000043531 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000072685.13 UniProtKB/TrEMBL
  ENSMUST00000111756.4 UniProtKB/TrEMBL
  ENSMUST00000164039.9 UniProtKB/TrEMBL
  ENSMUST00000168357.9 UniProtKB/TrEMBL
  ENSMUST00000209413 ENTREZGENE
  ENSMUST00000209413.2 UniProtKB/TrEMBL
  ENSMUST00000209783 ENTREZGENE
  ENSMUST00000209783.2 UniProtKB/TrEMBL
  ENSMUST00000211008.2 UniProtKB/TrEMBL
  ENSMUST00000211687 ENTREZGENE
  ENSMUST00000211687.2 UniProtKB/TrEMBL
Gene3D-CATH 2.10.70.80 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.120.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.130.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.60.270 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PKD_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PKD_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sortilin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sortilin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VPS10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:58178 UniProtKB/TrEMBL
MGD MGI:1929666 ENTREZGENE
NCBI Gene 58178 ENTREZGENE
PANTHER SORTILIN RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VPS10 DOMAIN-CONTAINING RECEPTOR SORCS1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PKD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sortilin-Vps10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sortilin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Sorcs1 PhenoGen
PROSITE PKD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART VPS10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Oligoxyloglucan reducing end-specific cellobiohydrolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49299 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1B0GRB7 ENTREZGENE, UniProtKB/TrEMBL
  A0A1B0GRC4 ENTREZGENE, UniProtKB/TrEMBL
  A0A1B0GRN1 ENTREZGENE, UniProtKB/TrEMBL
  A0A1B0GT94 ENTREZGENE, UniProtKB/TrEMBL
  E9PYT6 ENTREZGENE, UniProtKB/TrEMBL
  E9Q203_MOUSE UniProtKB/TrEMBL
  E9QQ02 ENTREZGENE, UniProtKB/TrEMBL
  E9QQ63_MOUSE UniProtKB/TrEMBL
  Q1HL23 ENTREZGENE, UniProtKB/TrEMBL
  Q1HL24_MOUSE UniProtKB/TrEMBL
  Q1HL25 ENTREZGENE, UniProtKB/TrEMBL
  Q8BQQ0_MOUSE UniProtKB/TrEMBL
  Q8BSV0_MOUSE UniProtKB/TrEMBL
  Q9JLC4 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q8VI45 UniProtKB/Swiss-Prot
  Q922I1 UniProtKB/Swiss-Prot
  Q9QY21 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-05-05 Sorcs1  sortilin-related VPS10 domain containing receptor 1    VPS10 domain receptor protein SORCS 1  Symbol and/or name change 5135510 APPROVED