Sorcs1<sup>em1Mcwi</sup> (sortilin-related VPS10 domain containing receptor 1; zinc finger nuclease induced mutant 1, Medical College of Wisconsin) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Sorcs1em1Mcwi (sortilin-related VPS10 domain containing receptor 1; zinc finger nuclease induced mutant 1, Medical College of Wisconsin) Rattus norvegicus
Analyze
Symbol: Sorcs1em1Mcwi
Name: sortilin-related VPS10 domain containing receptor 1; zinc finger nuclease induced mutant 1, Medical College of Wisconsin
RGD ID: 4139864
Description: This allele was made by zinc finger nuclease mutagenesis. The resulting mutation is a 14-bp frameshift deletion mutation in exon 20 (del 1109-1122).
ASSOCIATED WITH proteinuria
Type: allele  of Sorcs1  
Previously known as: Sorcs1^[em1Mcwi]; Sorcs1em1Mcwi
Is Marker For: Strains:   FHH-Chr 1BN-Sorcs1em1Mcwi   FHH-Chr 1BN-Sorcs1em1Mcwi-/-  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Cytogenetic Map1 RGD


Disease Annotations     Click to see Annotation Detail View
proteinuria  (IMP)

References

References - curated
# Reference Title Reference Citation
1. Knockout rats via embryo microinjection of zinc-finger nucleases. Geurts AM, etal., Science. 2009 Jul 24;325(5939):433.
2. SORCS1 contributes to the development of renal disease in rats and humans. Lazar J, etal., Physiol Genomics. 2013 Aug 15;45(16):720-8. doi: 10.1152/physiolgenomics.00089.2013. Epub 2013 Jun 18.
3. PhysGen Knockouts PhysGen Knockout strains

Genomics

Allelic Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Assembly
Sorcs1em1Mcwi-var1 chr1 249207764 249207777 CCGGGTCAATGTAT - deletion mRatBN7.2

Related Rat Strains
The following Strains have been annotated to Sorcs1em1Mcwi
FHH-Chr 1BN-Sorcs1em1Mcwi-/-     FHH-Chr 1BN-Sorcs1em1Mcwi    


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_001070775 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles


Additional Information