Stac (SH3 and cysteine rich domain)

Gene: Stac (SH3 and cysteine rich domain) Rattus norvegicus

Analyze

Symbol:

Stac

Name:

SH3 and cysteine rich domain

RGD ID:

1305745

Description:

Predicted to enable transmembrane transporter binding activity. Predicted to be involved in positive regulation of protein localization to plasma membrane and skeletal muscle contraction. Predicted to act upstream of or within cellular response to heat and muscle contraction. Predicted to be located in T-tubule and cytoplasmic side of plasma membrane. Orthologous to human STAC (SH3 and cysteine rich domain); INTERACTS WITH 6-propyl-2-thiouracil; amitrole; atrazine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC363152; SH3 and cysteine-rich domain-containing protein; src homology three (SH3) and cysteine rich domain

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	STAC (SH3 and cysteine rich domain)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Stac (src homology three (SH3) and cysteine rich domain)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Stac (SH3 and cysteine rich domain)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	STAC (SH3 and cysteine rich domain)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	STAC (SH3 and cysteine rich domain)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Stac (SH3 and cysteine rich domain)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	STAC (SH3 and cysteine rich domain)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	STAC (SH3 and cysteine rich domain)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Stac (SH3 and cysteine rich domain)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	STAC (SH3 and cysteine rich domain)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Stac (src homology three (SH3) and cysteine rich domain)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	stac (SH3 and cysteine rich domain)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	F19C7.8	Alliance	DIOPT (OrthoFinder\|PANTHER)
Drosophila melanogaster (fruit fly):	CG43729	Alliance	DIOPT (OrthoInspector\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	stac	Alliance	DIOPT (OrthoFinder\|PANTHER)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	120,409,165 - 120,531,394 (-)	NCBI		GRCr8
mRatBN7.2	8	111,530,800 - 111,653,228 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	111,530,800 - 111,654,008 (-)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	8	119,820,664 - 119,941,867 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	119,821,901 - 119,889,661 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	119,168,403 - 119,287,773 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	115,961,972 - 116,076,186 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	115,981,426 - 116,112,914 (-)	NCBI
Celera	8	110,812,081 - 110,932,713 (-)	NCBI		Celera
Cytogenetic Map	8	q32	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

allergic contact dermatitis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(S)-nicotine (ISO)

2-methylcholine (ISO)

6-propyl-2-thiouracil (EXP,ISO)

aflatoxin B1 (ISO)

Aflatoxin B2 alpha (ISO)

amitrole (EXP)

atrazine (EXP)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

butanal (ISO)

calcitriol (ISO)

carbamazepine (ISO)

CGP 52608 (ISO)

ciguatoxin CTX1B (ISO)

cisplatin (ISO)

clotrimazole (EXP)

copper atom (EXP)

copper(0) (EXP)

cyclosporin A (ISO)

diiodine (ISO)

endosulfan (EXP)

folic acid (ISO)

melphalan (ISO)

nickel sulfate (ISO)

nicotine (ISO)

nitrofen (EXP)

paracetamol (ISO)

perfluorononanoic acid (ISO)

phenobarbital (EXP)

silver atom (ISO)

silver(0) (ISO)

sodium arsenite (ISO)

sulfadimethoxine (EXP)

temozolomide (ISO)

testosterone (EXP)

trichloroethene (EXP)

trichostatin A (ISO)

valproic acid (ISO)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to heat (ISO)

muscle contraction (ISO)

positive regulation of protein localization to plasma membrane (IBA,ISO)

skeletal muscle contraction (IBA)

Cellular Component

cytoplasmic side of plasma membrane (ISO)

T-tubule (ISO)

Molecular Function

metal ion binding (IEA)

protein binding (ISO)

transmembrane transporter binding (IBA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	GOA pipeline	RGD automated data pipeline
4.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:18755693	PMID:23818578	PMID:27149520	PMID:28235806	PMID:29467163

Genomics

Comparative Map Data

Stac
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	120,409,165 - 120,531,394 (-)	NCBI		GRCr8
mRatBN7.2	8	111,530,800 - 111,653,228 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	111,530,800 - 111,654,008 (-)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	8	119,820,664 - 119,941,867 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	119,821,901 - 119,889,661 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	119,168,403 - 119,287,773 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	115,961,972 - 116,076,186 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	115,981,426 - 116,112,914 (-)	NCBI
Celera	8	110,812,081 - 110,932,713 (-)	NCBI		Celera
Cytogenetic Map	8	q32	NCBI

STAC
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	36,380,504 - 36,548,007 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	36,380,503 - 36,548,007 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	3	36,421,996 - 36,589,499 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	36,397,101 - 36,564,500 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	3	36,397,100 - 36,564,500	NCBI
Celera	3	36,365,008 - 36,532,250 (+)	NCBI		Celera
Cytogenetic Map	3	p22.3-p22.2	NCBI
HuRef	3	36,362,945 - 36,530,233 (+)	NCBI		HuRef
CHM1_1	3	36,371,843 - 36,539,723 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	3	36,381,995 - 36,549,211 (+)	NCBI		T2T-CHM13v2.0

Stac
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	111,386,476 - 111,519,673 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	111,390,505 - 111,519,416 (-)	Ensembl		GRCm39 Ensembl
GRCm38	9	111,561,437 - 111,690,588 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	111,561,437 - 111,690,348 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	111,463,938 - 111,592,720 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	9	111,406,250 - 111,535,105 (-)	NCBI		MGSCv36	mm8
Celera	9	111,283,101 - 111,415,949 (-)	NCBI		Celera
Cytogenetic Map	9	F3	NCBI
cM Map	9	61.81	NCBI

Stac
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955421	3,325,199 - 3,471,742 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955421	3,325,199 - 3,471,748 (+)	NCBI	ChiLan1.0	ChiLan1.0

STAC
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	36,342,972 - 36,515,560 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	36,347,739 - 36,520,324 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	36,287,485 - 36,457,151 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	36,578,543 - 36,747,971 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	36,578,543 - 36,747,971 (+)	Ensembl	panpan1.1		panPan2

STAC
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	23	6,372,337 - 6,524,334 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	23	6,372,257 - 6,519,748 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	23	6,412,243 - 6,563,487 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	23	6,656,701 - 6,808,405 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	23	6,656,464 - 6,808,400 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	23	6,476,557 - 6,627,887 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	23	6,619,492 - 6,770,889 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	23	6,609,913 - 6,761,385 (+)	NCBI		UU_Cfam_GSD_1.0

Stac
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	192,917,038 - 193,055,723 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936473	26,055,124 - 26,195,392 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936473	26,055,630 - 26,194,296 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

STAC
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	21,429,653 - 21,549,314 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	21,429,570 - 21,548,784 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	23,304,681 - 23,428,311 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

STAC
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	15	80,742,955 - 80,906,053 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	15	80,801,748 - 80,906,044 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666041	54,220,717 - 54,389,378 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Stac
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624788	14,360,738 - 14,539,934 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624788	14,360,682 - 14,540,035 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Stac
1167 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	86
Count of miRNA genes:	77
Interacting mature miRNAs:	81
Transcripts:	ENSRNOT00000011780
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
631650	Stl6	Serum triglyceride level QTL 6	4	0.0019	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	8	10378157	112202585	Rat
1554321	Bmd3	Bone mineral density QTL 3	7.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	40952565	123900184	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	46531639	119088626	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	8	46531639	119088626	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	absolute change in systolic blood pressure (CMO:0000607)	8	46531639	119088626	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	46531639	119088626	Rat
2303171	Bp331	Blood pressure QTL 331	5.57	0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	61290298	119084929	Rat
631210	Bw3	Body weight QTL3	5.9		mesenteric fat pad mass (VT:0010427)	mesenteric fat pad weight to body weight ratio (CMO:0000654)	8	69349194	112783834	Rat
1300171	Bp184	Blood pressure QTL 184	3.66		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	8	70513503	118219066	Rat
8694446	Bw170	Body weight QTL 170	12.07	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	8	71888757	116888757	Rat
9590292	Uminl3	Urine mineral level QTL 3	3.62	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	8	71888757	116888757	Rat
8694200	Abfw4	Abdominal fat weight QTL 4	9.07	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	8	71888757	116888757	Rat
8694392	Bw161	Body weight QTL 161	8.06	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	8	71888757	116888757	Rat
1549909	Stresp11	Stress response QTL 11	6.83	0.0019	stress-related behavior trait (VT:0010451)	number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)	8	73473045	118473045	Rat
2300181	Bmd55	Bone mineral density QTL 55	5.7	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	76468691	121468691	Rat
61437	Cia6	Collagen induced arthritis QTL 6			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	8	82460758	122812818	Rat
2313400	Anxrr25	Anxiety related response QTL 25			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	8	89265192	114019816	Rat
738011	Anxrr9	Anxiety related response QTL 9	6.1		exploratory behavior trait (VT:0010471)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	8	93535351	123900184	Rat
1358893	Bp263	Blood pressure QTL 263	5.01		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	93965141	123900184	Rat
1358903	Bp252	Blood pressure QTL 252	7	0.0001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	93965141	123900184	Rat
738014	Anxrr15	Anxiety related response QTL 15	3.6	0.005	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	8	95718998	123900184	Rat
2300182	Bmd56	Bone mineral density QTL 56	5.4		femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	95718998	123900184	Rat
724539	Cm19	Cardiac mass QTL 19	2.6		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	8	100149864	120994388	Rat

Markers in Region

D8Got209

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	112,029,138 - 112,029,299 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	120,318,398 - 120,318,558	NCBI	Rnor6.0
Rnor_5.0	8	119,658,215 - 119,658,375	UniSTS	Rnor5.0
RGSC_v3.4	8	116,669,299 - 116,669,460	RGD	RGSC3.4
RGSC_v3.4	8	116,669,300 - 116,669,460	UniSTS	RGSC3.4
RGSC_v3.1	8	116,688,755 - 116,688,915	RGD
Celera	8	111,305,443 - 111,305,603	UniSTS
RH 3.4 Map	8	1190.7	UniSTS
RH 3.4 Map	8	1190.7	RGD
RH 2.0 Map	8	953.2	RGD
Cytogenetic Map	8	q32	UniSTS

D9Bwg1012e

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	112,034,646 - 112,034,895 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	120,323,906 - 120,324,154	NCBI	Rnor6.0
Rnor_5.0	8	119,663,723 - 119,663,971	UniSTS	Rnor5.0
RGSC_v3.4	8	116,674,808 - 116,675,056	UniSTS	RGSC3.4
Celera	8	111,310,312 - 111,310,560	UniSTS
Cytogenetic Map	8	q32	UniSTS

AU049174

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	111,539,360 - 111,539,591 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	119,829,225 - 119,829,453	NCBI	Rnor6.0
Rnor_5.0	8	119,176,964 - 119,177,192	UniSTS	Rnor5.0
RGSC_v3.4	8	115,969,296 - 115,969,524	UniSTS	RGSC3.4
Celera	8	110,820,642 - 110,820,868	UniSTS
Cytogenetic Map	8	q32	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium									6
Low	3	29	17	4	5	4	5	6	66	33	38	8	5
Below cutoff		14	12	9	8	9	3	5	2	2	2	1	3

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001108784	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_001076458	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017596138	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017596139	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017603726	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017603727	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473954	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000011780 ⟹ ENSRNOP00000011780

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	111,530,800 - 111,654,008 (-)	Ensembl
Rnor_6.0 Ensembl	8	119,821,901 - 119,889,661 (-)	Ensembl

RefSeq Acc Id:

NM_001108784 ⟹ NP_001102254

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	120,409,165 - 120,531,320 (-)	NCBI

RefSeq Acc Id:

XM_017596138 ⟹ XP_017451627

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	120,409,165 - 120,531,394 (-)	NCBI
mRatBN7.2	8	111,530,800 - 111,653,228 (-)	NCBI
Rnor_6.0	8	119,820,664 - 119,941,867 (-)	NCBI

Sequence:

show sequence

CTCCCGTCCTCGGAGGGGCCAGCCCGGGCCCACCCGCCCGCTGCGGTGGGCGGCAGTCACGACT
AGAGGCGCGCAATCTCCAGCGAGGTGGCCACAGGCGCTGCGCGGGGCGGGGCGGAGGCCCGGGA
GGTGGGCTGGACCTGGCCAGGCGAGGCCCCAGGGCGCACGCCGCCGCCTGGCACGATGGACATC
CCGGGGACACGGCACTGAGCGAGCGAGCAAGAAGTCGAGCGAACCTGCGGTTCCCCCAGAAGCC
CAACACAGTTCCCGCGGCCAAGATGATCCCTCCAAGTGGCGCCCGCGAGGACAGCGGAGACGGA
CTGACCCGGGAGGCAACCGGCACAGAGCAGCCGCCCTCTCCTGCGTCCACCAGCAGCCTGGAAT
CCAAGACCAAGAGCTTGCGGAGCAAAAGTGCCGACAACTTCTTCCCAAGGACCAACAGTGATGT
GAAACCACAAGCAGACCTGCTGGCCAAGGCTAGCCCAGGCCCCAGCCCAATACCCATCCCTGGA
AGCCCAGCATCCATGCCCACCAAGGCTGGCCTGCACCCCGGCAGCAACAGCAAGGTCCACGCCT
TTCAGGAGCATGTCTTTAAGAAGCCCACCTTCTGTGATGTCTGCAACCACATGATCGTGGGAAC
ACATGCTAAGCACGGACTACGCTGTGGAGCCTGCAAGATGAGCATTCATCACAAGTGTGCAGAC
GGCCTGGCACCCCAGCGGTGCATGGGCAAGTTGCCAAAAGGATTCCGGCGTTACTACAGCTCCC
CCTTGCTCATTCACGAACAGTTTGGATGCATTAAAGAAGTTATGCCCATTGCTTGTGGCAATAA
AGTGGACCCAGTGTATGAAGCCCTCCGATTTGGCACATCCCTGGCCCAGAGAACAAAGAAGAGC
AGCTCAGGCAGTGGTTCTGACTCACCCCCCAGAACCTCGACTTCAGAGCTGGTAGAGGTTCCTG
AAGAGGCTGATGGGCCAGGAGACTCGTCTGACATCAGGCCACGGAGCAACAGTGTGTTTACATA
TCCGGAAAATGGCACCGATGACTTCAGAGATCAAGTAAAGACCATAAACCACCAGGGACCTCTT
TCCAAAGACCCATTACAGATGAACACCTACGTTGCCTTGTACAGATTTATACCACAGGAGAATG
AAGACTTGGAAATGAGGCCAGGAGACATGATCACTCTCCTAGAAGACTCCAATGAAGACTGGTG
GAAAGGAAAGATTCAGGACAGGGTTGGTTTCTTTCCAGCCAACTTTGTTCAGAGAGTAGAAGAG
CATGAGAAGATTTATAGGTGTGTCCGGACCTTCATTGGCTGCAAGGACCAGGGGCAGATAACAC
TGAAAGAGAATCAGATCTGTGTGACCTCTGAGGAAGAACGGGACGGCTTCATCAGAGTCCTCAG
TGGGAAGAAGAGAGGCCTCGTCCCATTGGATGTACTGGTAGACGTGTGACTGTAGCAGACCCTC
CCAGTGCAGGAGGCCAGCGCTGCTGATCTCTCTGTGTCCACCCAGAGGAGCAGCTGCACTGATG
GGTGCCCAGAAAACAGGGAGACTTGAAGATTTGAGAGTGTGCTAGCAATCTGGAAGCAGGCCAA
CTGCACAGCACACCAAGGCTGCCTGAGAGCAGCATCCCAGAGCTGAGGGCTGCTAGCGGGAGTA
GGTGGGCTGTAGCTAAGGCTGCCCCAGGACTCAGCTCCCTTCCTGCTCACCTGTGCAAGGCTGG
AGTCTGCTCCAGGTCATGGTGTGCTCCTGATGAGAAGTTTGGAGCAGAGTAGCCAAGCGTTACT
CTGGTTCTGGATTACTGGTCCCCGTGCTGGCCAATCAACCTCATCACGACTCTTGCAAAGAATC
AAGAAATCCAACCTCCCCGCTCCCAACACCCCAGGGCTCACTCCAGCTCCTGCTCAGTTTGTGT
CTTGGCTGGCAGGACTATCCTTTCTTTCTCTCCCATTCTTCAAGCACATCCTAGGCAGGGCCAA
ACCAGCAAGGTACCGAATGCAAAGATCTGACTTACCTACAGATTTCGAAGGAGGGCAGCCTTGC
TACTTCAGCGACTCGAAAGTGACAGGGCAAGGTCCAAGGCACAGAATCAAGTAGCAGCAAGTAG
TGGGTGTGGGGACAAGGAAGGAGTCCTTATACATTGGGATCGTACAGCCATTTTAGTTGGGTGG
TTTTTTTCCCCCAGAGCAGGTGGGGCTGGGAGTGGGAAGTAGGAAAGAGTCTCCGTTTTCATTT
CATATCCTCTTTATCAGGAGCAGCCCTTCTCCGTTTGTGCAACCTGTAGGACTGCACTGTGGTG
GACGAGTCCACCGTGCAGGGATCCAGGGGAGAGGGGAACACCACTGAGGAAAACATCTTAGTAT
AAATGTGGCCAACTTAGACTCCATTCTTCTCCAGGGCAATGGTTTCCGCTCCCACAGGTGTGAA
GTGAAAAGGACAGGAAATGCTTCTTTGTCTTTGTGCAGAGGAAGCTTGGGGCTTTGCTCACACC
ACCTGGGGATATTGCTCTCCACCTCTACCAATGTTTACAAGAACATACCACACTGCGATGCCTT
CCTCCCAGACCCTGTCCCAGCATTCAGACCTGCTTCCTGGCAGTCACTGACATGTCTAAATGAT
GTGACTTTGGGATTCTTCGTTGCTTTGATTTATTTTGCCACTGAGCAATAAAATCATTAGAACC
ATCTCA

hide sequence

RefSeq Acc Id:

XM_017596139 ⟹ XP_017451628

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	120,409,165 - 120,531,376 (-)	NCBI
mRatBN7.2	8	111,530,800 - 111,653,225 (-)	NCBI
Rnor_6.0	8	119,820,664 - 119,941,556 (-)	NCBI

Sequence:

show sequence

GGAGACGGACTGACCCGGGAGGCAACCGGCACAGAGCAGCCGCCCTCTCCTGCGTCCACCAGCA
GCCTGGAATCCAAGGAACACATGCTAAGCACGGACTACGCTGTGGAGCCTGCAAGATGAGCATT
CATCACAAGTGTGCAGACGGCCTGGCACCCCAGCGGTGCATGGGCAAGTTGCCAAAAGGATTCC
GGCGTTACTACAGCTCCCCCTTGCTCATTCACGAACAGTTTGGATGCATTAAAGAAGTTATGCC
CATTGCTTGTGGCAATAAAGTGGACCCAGTGTATGAAGCCCTCCGATTTGGCACATCCCTGGCC
CAGAGAACAAAGAAGAGCAGCTCAGGCAGTGGTTCTGACTCACCCCCCAGAACCTCGACTTCAG
AGCTGGTAGAGGTTCCTGAAGAGGCTGATGGGCCAGGAGACTCGTCTGACATCAGGCCACGGAG
CAACAGTGTGTTTACATATCCGGAAAATGGCACCGATGACTTCAGAGATCAAGTAAAGACCATA
AACCACCAGGGACCTCTTTCCAAAGACCCATTACAGATGAACACCTACGTTGCCTTGTACAGAT
TTATACCACAGGAGAATGAAGACTTGGAAATGAGGCCAGGAGACATGATCACTCTCCTAGAAGA
CTCCAATGAAGACTGGTGGAAAGGAAAGATTCAGGACAGGGTTGGTTTCTTTCCAGCCAACTTT
GTTCAGAGAGTAGAAGAGCATGAGAAGATTTATAGGTGTGTCCGGACCTTCATTGGCTGCAAGG
ACCAGGGGCAGATAACACTGAAAGAGAATCAGATCTGTGTGACCTCTGAGGAAGAACGGGACGG
CTTCATCAGAGTCCTCAGTGGGAAGAAGAGAGGCCTCGTCCCATTGGATGTACTGGTAGACGTG
TGACTGTAGCAGACCCTCCCAGTGCAGGAGGCCAGCGCTGCTGATCTCTCTGTGTCCACCCAGA
GGAGCAGCTGCACTGATGGGTGCCCAGAAAACAGGGAGACTTGAAGATTTGAGAGTGTGCTAGC
AATCTGGAAGCAGGCCAACTGCACAGCACACCAAGGCTGCCTGAGAGCAGCATCCCAGAGCTGA
GGGCTGCTAGCGGGAGTAGGTGGGCTGTAGCTAAGGCTGCCCCAGGACTCAGCTCCCTTCCTGC
TCACCTGTGCAAGGCTGGAGTCTGCTCCAGGTCATGGTGTGCTCCTGATGAGAAGTTTGGAGCA
GAGTAGCCAAGCGTTACTCTGGTTCTGGATTACTGGTCCCCGTGCTGGCCAATCAACCTCATCA
CGACTCTTGCAAAGAATCAAGAAATCCAACCTCCCCGCTCCCAACACCCCAGGGCTCACTCCAG
CTCCTGCTCAGTTTGTGTCTTGGCTGGCAGGACTATCCTTTCTTTCTCTCCCATTCTTCAAGCA
CATCCTAGGCAGGGCCAAACCAGCAAGGTACCGAATGCAAAGATCTGACTTACCTACAGATTTC
GAAGGAGGGCAGCCTTGCTACTTCAGCGACTCGAAAGTGACAGGGCAAGGTCCAAGGCACAGAA
TCAAGTAGCAGCAAGTAGTGGGTGTGGGGACAAGGAAGGAGTCCTTATACATTGGGATCGTACA
GCCATTTTAGTTGGGTGGTTTTTTTCCCCCAGAGCAGGTGGGGCTGGGAGTGGGAAGTAGGAAA
GAGTCTCCGTTTTCATTTCATATCCTCTTTATCAGGAGCAGCCCTTCTCCGTTTGTGCAACCTG
TAGGACTGCACTGTGGTGGACGAGTCCACCGTGCAGGGATCCAGGGGAGAGGGGAACACCACTG
AGGAAAACATCTTAGTATAAATGTGGCCAACTTAGACTCCATTCTTCTCCAGGGCAATGGTTTC
CGCTCCCACAGGTGTGAAGTGAAAAGGACAGGAAATGCTTCTTTGTCTTTGTGCAGAGGAAGCT
TGGGGCTTTGCTCACACCACCTGGGGATATTGCTCTCCACCTCTACCAATGTTTACAAGAACAT
ACCACACTGCGATGCCTTCCTCCCAGACCCTGTCCCAGCATTCAGACCTGCTTCCTGGCAGTCA
CTGACATGTCTAAATGATGTGACTTTGGGATTCTTCGTTGCTTTGATTTATTTTGCCACTGAGC
AATAAAATCATTAGAACCATCTCA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001102254	(Get FASTA)	NCBI Sequence Viewer
	XP_017451627	(Get FASTA)	NCBI Sequence Viewer
	XP_017451628	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL77031	(Get FASTA)	NCBI Sequence Viewer
	EDL77032	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000011780.8

RefSeq Acc Id:

XP_017451627 ⟸ XM_017596138

- Peptide Label:

isoform X1

- Sequence:

show sequence

MIPPSGAREDSGDGLTREATGTEQPPSPASTSSLESKTKSLRSKSADNFFPRTNSDVKPQADLL
AKASPGPSPIPIPGSPASMPTKAGLHPGSNSKVHAFQEHVFKKPTFCDVCNHMIVGTHAKHGLR
CGACKMSIHHKCADGLAPQRCMGKLPKGFRRYYSSPLLIHEQFGCIKEVMPIACGNKVDPVYEA
LRFGTSLAQRTKKSSSGSGSDSPPRTSTSELVEVPEEADGPGDSSDIRPRSNSVFTYPENGTDD
FRDQVKTINHQGPLSKDPLQMNTYVALYRFIPQENEDLEMRPGDMITLLEDSNEDWWKGKIQDR
VGFFPANFVQRVEEHEKIYRCVRTFIGCKDQGQITLKENQICVTSEEERDGFIRVLSGKKRGLV
PLDVLVDV

hide sequence

RefSeq Acc Id:

XP_017451628 ⟸ XM_017596139

- Peptide Label:

isoform X2

- Sequence:

show sequence

MSIHHKCADGLAPQRCMGKLPKGFRRYYSSPLLIHEQFGCIKEVMPIACGNKVDPVYEALRFGT
SLAQRTKKSSSGSGSDSPPRTSTSELVEVPEEADGPGDSSDIRPRSNSVFTYPENGTDDFRDQV
KTINHQGPLSKDPLQMNTYVALYRFIPQENEDLEMRPGDMITLLEDSNEDWWKGKIQDRVGFFP
ANFVQRVEEHEKIYRCVRTFIGCKDQGQITLKENQICVTSEEERDGFIRVLSGKKRGLVPLDVL
VDV

hide sequence

RefSeq Acc Id:

ENSRNOP00000011780 ⟸ ENSRNOT00000011780

RefSeq Acc Id:	NP_001102254 ⟸ NM_001108784
- UniProtKB:	A6I3J5 (UniProtKB/TrEMBL), F1M107 (UniProtKB/TrEMBL)

Protein Domains

Phorbol-ester/DAG-type SH3

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-F1M107-F1-model_v2	AlphaFold	F1M107	1-367	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1305745	AgrOrtholog
BioCyc Gene	G2FUF-29016	BioCyc
Ensembl Genes	ENSRNOG00000008865	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000011780.8	UniProtKB/TrEMBL
Gene3D-CATH	3.30.60.20	UniProtKB/TrEMBL
	SH3 Domains	UniProtKB/TrEMBL
InterPro	C1-like_sf	UniProtKB/TrEMBL
	Prot_Kinase_C-like_PE/DAG-bd	UniProtKB/TrEMBL
	SH3-like_dom	UniProtKB/TrEMBL
	SH3_domain	UniProtKB/TrEMBL
	STAC1/2/3	UniProtKB/TrEMBL
	STAC1_SH3	UniProtKB/TrEMBL
NCBI Gene	363152	ENTREZGENE
PANTHER	PTHR15135	UniProtKB/TrEMBL
	PTHR15135:SF3	UniProtKB/TrEMBL
Pfam	C1_1	UniProtKB/TrEMBL
	SH3_2	UniProtKB/TrEMBL
	SH3_9	UniProtKB/TrEMBL
	STAC2_u1	UniProtKB/TrEMBL
PhenoGen	Stac	PhenoGen
PRINTS	SH3DOMAIN	UniProtKB/TrEMBL
	SPECTRNALPHA	UniProtKB/TrEMBL
PROSITE	SH3	UniProtKB/TrEMBL
	ZF_DAG_PE_1	UniProtKB/TrEMBL
	ZF_DAG_PE_2	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000008865	RatGTEx
SMART	SH3	UniProtKB/TrEMBL
	SM00109	UniProtKB/TrEMBL
Superfamily-SCOP	SH3	UniProtKB/TrEMBL
	SSF57889	UniProtKB/TrEMBL
UniProt	A6I3J5	ENTREZGENE, UniProtKB/TrEMBL
	F1M107	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-10-23	Stac	SH3 and cysteine rich domain	Stac	src homology three (SH3) and cysteine rich domain	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Stac	src homology three (SH3) and cysteine rich domain	Stac_predicted	src homology three (SH3) and cysteine rich domain (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Stac_predicted	src homology three (SH3) and cysteine rich domain (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD