Itgb2 (integrin subunit beta 2) - Rat Genome Database

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Gene: Itgb2 (integrin subunit beta 2) Rattus norvegicus
Analyze
Symbol: Itgb2
Name: integrin subunit beta 2
RGD ID: 1305581
Description: Contributes to cell adhesion molecule binding activity. Involved in several processes, including leukocyte migration involved in inflammatory response; positive regulation of angiogenesis; and positive regulation of nitric oxide biosynthetic process. Located in cell surface. Used to study nephritis and pneumonia. Biomarker of allergic rhinitis. Human ortholog(s) of this gene implicated in coronary restenosis; leukocyte adhesion deficiency; and leukocyte adhesion deficiency 1. Orthologous to human ITGB2 (integrin subunit beta 2); PARTICIPATES IN hypoxia inducible factor pathway; integrin mediated signaling pathway; Entamoebiasis pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Cd18; CD18 leukocyte adhesion molecule; integrin beta 2; integrin beta-2; integrin, beta 2; integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associated antigen 1; integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associated antigen 1); integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associated antigen 1, macrophage antigen 1 (mac-1) beta subunit); macrophage antigen 1 (mac-1) beta subunit; macrophage antigen 1 (mac-1) beta subunit); MGC116306
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82011,061,009 - 11,097,242 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2011,058,492 - 11,097,182 (-)EnsemblGRCr8
mRatBN7.22011,061,394 - 11,097,656 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2011,061,430 - 11,097,600 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2011,760,914 - 11,797,085 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02011,121,883 - 11,158,052 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02011,593,622 - 11,629,796 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02011,777,773 - 11,815,647 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2011,777,783 - 11,815,647 (-)Ensemblrn6Rnor6.0
Rnor_5.02013,944,190 - 13,981,048 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42011,446,521 - 11,485,009 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2012,564,941 - 12,601,097 (-)NCBICelera
RGSC_v3.12011,446,936 - 11,485,236 (-)NCBI
Cytogenetic Map20p12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(-)-Arctigenin  (ISO)
(1->4)-beta-D-glucan  (ISO)
(20S)-ginsenoside Rh1  (ISO)
(S)-ropivacaine  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-nitrotoluene  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
9-cis-retinoic acid  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
acteoside  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
alpha-Zearalanol  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
asbestos  (ISO)
atorvastatin calcium  (ISO)
atrazine  (EXP)
Azoxymethane  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
bromochloroacetic acid  (EXP)
buspirone  (EXP)
butanal  (ISO)
cadmium dichloride  (EXP,ISO)
Calcimycin  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
carnosic acid  (ISO)
cerivastatin  (ISO)
chlorogenic acid  (EXP)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (EXP)
cobalt dichloride  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
decabromodiphenyl ether  (EXP)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
diclofenac  (ISO)
dimethyl sulfoxide  (ISO)
dioxygen  (EXP)
diuron  (ISO)
doxorubicin  (ISO)
drometrizole  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
epoxiconazole  (ISO)
erianin  (ISO)
ethanol  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
Formylmethionyl-leucyl-phenylalanine methyl ester  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
ginsenoside C-K  (ISO)
ginsenoside Rb1  (EXP)
graphene oxide  (ISO)
griseofulvin  (ISO)
GSK-J4  (ISO)
Heliotrine  (EXP)
hydroquinone  (ISO)
indirubin  (ISO)
indometacin  (EXP,ISO)
iron atom  (ISO)
iron(0)  (ISO)
isoflavones  (ISO)
isotretinoin  (ISO)
josamycin  (ISO)
L-methionine  (ISO)
leukotriene B4  (EXP,ISO)
lidocaine  (ISO)
lipopolysaccharide  (EXP,ISO)
LY294002  (ISO)
methotrexate  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methylmercury(1+)  (ISO)
microcystin-LR  (EXP)
mycotoxin  (ISO)
N-[3-(aminomethyl)benzyl]acetamidine  (ISO)
N-formyl-L-methionyl-L-leucyl-L-phenylalanine  (ISO)
N-nitrosodimethylamine  (EXP)
naled  (ISO)
neoechinulin A  (ISO)
nickel atom  (ISO)
nitric oxide  (EXP,ISO)
notoginsenoside R1  (EXP,ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
oxycodone  (EXP)
ozone  (EXP,ISO)
paracetamol  (ISO)
pentanal  (ISO)
Pentoxifylline  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
plaunotol  (ISO)
probucol  (ISO)
progesterone  (ISO)
quercetin  (ISO)
resveratrol  (EXP,ISO)
Senkirkine  (EXP)
silicon dioxide  (ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
staurosporine  (ISO)
streptozocin  (EXP)
SU6656  (ISO)
sulfasalazine  (ISO)
sulforaphane  (ISO)
tamibarotene  (ISO)
testosterone  (EXP)
tetrachloromethane  (ISO)
theophylline  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
TMC-120A  (ISO)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (EXP,ISO)
triphenylstannane  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin D  (ISO)
wortmannin  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activated T cell proliferation  (ISO)
amyloid-beta clearance  (ISO)
cell adhesion  (IEA,ISO)
cell adhesion mediated by integrin  (IBA,IEA,ISO)
cell-cell adhesion  (IEA,IMP,ISO)
cell-cell adhesion mediated by integrin  (IEA,ISO)
cell-matrix adhesion  (IBA,IEA,ISO)
cellular extravasation  (IMP,ISO)
cellular response to low-density lipoprotein particle stimulus  (ISO)
endodermal cell differentiation  (IEA,ISO)
endothelial cell migration  (IMP)
heterotypic cell-cell adhesion  (IEA,ISO)
integrin-mediated signaling pathway  (IBA,IEA,ISO)
leukocyte activation  (IEA)
leukocyte adhesion to vascular endothelial cell  (IEA,ISO)
leukocyte cell-cell adhesion  (IBA,IEA,IMP,ISO)
leukocyte migration involved in inflammatory response  (IMP)
neuron cell-cell adhesion  (IEA,ISO)
neutrophil chemotaxis  (IBA,IEA,ISO)
neutrophil migration  (IEA,ISO)
obsolete positive regulation of NF-kappaB transcription factor activity  (IMP)
phagocytosis  (IEA,ISO)
phagocytosis, engulfment  (ISO)
positive regulation of angiogenesis  (IMP)
positive regulation of cell adhesion  (IEA)
positive regulation of leukocyte adhesion to vascular endothelial cell  (ISO)
positive regulation of neutrophil degranulation  (IEA,ISO)
positive regulation of nitric oxide biosynthetic process  (IMP)
positive regulation of phagocytosis  (ISO)
positive regulation of superoxide anion generation  (IEA,ISO)
receptor clustering  (IEA,ISO)
receptor internalization  (ISO)
receptor-mediated endocytosis  (ISO)
regulation of peptidyl-tyrosine phosphorylation  (ISO)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Altered gene expression in leukocyte transendothelial migration and cell communication pathways in periodontitis-affected gingival tissues. Abe D, etal., J Periodontal Res. 2011 Jun;46(3):345-53. doi: 10.1111/j.1600-0765.2011.01349.x. Epub 2011 Mar 7.
2. Point mutations impairing cell surface expression of the common beta subunit (CD18) in a patient with leukocyte adhesion molecule (Leu-CAM) deficiency. Arnaout MA, etal., J Clin Invest. 1990 Mar;85(3):977-81.
3. Soluble Jagged-1 inhibits neointima formation by attenuating Notch-Herp2 signaling. Caolo V, etal., Arterioscler Thromb Vasc Biol. 2011 May;31(5):1059-65. Epub 2011 Feb 17.
4. Regulation of LFA-1-dependent inflammatory cell recruitment by Cbl-b and 14-3-3 proteins. Choi EY, etal., Blood. 2008 Apr 1;111(7):3607-14. doi: 10.1182/blood-2007-07-103077. Epub 2008 Jan 31.
5. Increased expression of intercellular adhesion molecule-1 (ICAM-1) in a murine model of pulmonary eosinophilia and high IgE level. Chu HW, etal., Clin Exp Immunol. 1995 May;100(2):319-24.
6. Low-density array PCR analysis of reperfusion biopsies: an adjunct to histological analysis. Cravedi P, etal., Nephrol Dial Transplant. 2010 Dec;25(12):4077-86. Epub 2010 May 26.
7. Regulation of CD18 expression on neutrophils in response to fluid shear stress. Fukuda S and Schmid-Schonbein GW, Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13152-7. Epub 2003 Oct 31.
8. Inhibitory effect of olopatadine on antigen-induced eosinophil infiltration and the LFA-1 and Mac-1 expression in eosinophils. Fukuishi N, etal., Jpn J Pharmacol. 2002 Apr;88(4):463-6.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Characterization of three new membrane structures on rat NK cells which are involved in activation of the lytic machinery. Giezeman-Smits KM, etal., Immunobiology. 1997 Nov;197(5):429-43.
11. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
12. Mac-1 (CD11b/CD18) links inflammation and thrombosis after glomerular injury. Hirahashi J, etal., Circulation. 2009 Sep 29;120(13):1255-65. Epub 2009 Sep 14.
13. Unique CD18 mutations involving a deletion in the extracellular stalk region and a major truncation of the cytoplasmic domain in a patient with leukocyte adhesion deficiency type 1. Hixson P, etal., Blood. 2004 Feb 1;103(3):1105-13. Epub 2003 Sep 25.
14. Effects of monoclonal antibodies to adhesion molecules on eosinophilic myocarditis in Toxocara canis-infected CBA/J mice. Hokibara S, etal., Clin Exp Immunol. 1998 Nov;114(2):236-44.
15. Integrins: bidirectional, allosteric signaling machines. Hynes RO Cell 2002 Sep 20;110(6):673-87.
16. Treatment of established adjuvant arthritis in rats with monoclonal antibody to CD18 and very late activation antigen-4 integrins suppresses neutrophil and T-lymphocyte migration to the joints and improves clinical disease. Issekutz AC, etal., Immunology. 1996 Aug;88(4):569-76.
17. Loss of LFA-1, but not Mac-1, protects MRL/MpJ-Fas(lpr) mice from autoimmune disease. Kevil CG, etal., Am J Pathol. 2004 Aug;165(2):609-16.
18. [Circulating adhesion molecules (cICAM-1, lcVCAM-1) in patients with suspected inflammatory heart muscle disease]. Klein RM, etal., Z Kardiol. 1998 Feb;87(2):84-93.
19. Leukocyte recruitment in hepatic injury: selectin-mediated leukocyte rolling is a prerequisite for CD18-dependent firm adhesion. Klintman D, etal., J Hepatol. 2002 Jan;36(1):53-9.
20. Association of a CD18 gene polymorphism with a reduced risk of restenosis after coronary stenting. Koch W, etal., Am J Cardiol. 2001 Nov 15;88(10):1120-4.
21. CD18/ICAM-1-dependent oxidative NF-kappaB activation leading to nitric oxide production in rat Kupffer cells cocultured with syngeneic hepatoma cells. Kurose I, etal., J Clin Invest. 1997 Mar 1;99(5):867-78.
22. Differential requirement for CD18 in T-helper effector homing. Lee SH, etal., Nat Med. 2003 Oct;9(10):1281-6. doi: 10.1038/nm932. Epub 2003 Sep 14.
23. The role of adhesion molecules in the recruitment of hepatic natural killer cells (pit cells) in rat liver. Luo D, etal., Hepatology. 1996 Dec;24(6):1475-80.
24. Label-free proteomics reveals decreased expression of CD18 and AKNA in peripheral CD4+ T cells from patients with Vogt-Koyanagi-Harada syndrome. Mao L, etal., PLoS One. 2011 Jan 28;6(1):e14616.
25. A novel point mutation in CD18 causing the expression of dysfunctional CD11/CD18 leucocyte integrins in a patient with leucocyte adhesion deficiency (LAD). Mathew EC, etal., Clin Exp Immunol. 2000 Jul;121(1):133-8.
26. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
27. The ITGB2 immunomodulatory gene (CD18), enterocolitis, and Hirschsprung's disease. Moore SW, etal., J Pediatr Surg. 2008 Aug;43(8):1439-44.
28. Epstein-Barr virus infection induces an increase of T regulatory type 1 cells in Hodgkin lymphoma patients. Morales O, etal., Br J Haematol. 2014 Sep;166(6):875-90. doi: 10.1111/bjh.12980. Epub 2014 Jul 9.
29. Development of a cell-free binding assay for rat ICAM-1/LFA-1 interactions using a novel anti-rat LFA-1 monoclonal antibody and comparison with a cell-based assay. Mukasa R, etal., J Immunol Methods. 1999 Aug 31;228(1-2):69-79.
30. In vivo migration of lymphocytes in chronically rejecting rat kidney allografts. Muller V, etal., Transpl Int. 1999;12(2):145-51.
31. Lung injury after deposition of IgA immune complexes. Requirements for CD18 and L-arginine. Mulligan MS, etal., J Immunol. 1992 May 15;148(10):3086-92.
32. Kindlin 3 (FERMT3) is associated with unstable atherosclerotic plaques, anti-inflammatory type II macrophages and upregulation of beta-2 integrins in all major arterial beds. Oksala N, etal., Atherosclerosis. 2015 Sep;242(1):145-54. doi: 10.1016/j.atherosclerosis.2015.06.058. Epub 2015 Jul 13.
33. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
34. Characterization of 11 new cases of leukocyte adhesion deficiency type 1 with seven novel mutations in the ITGB2 gene. Parvaneh N, etal., J Clin Immunol. 2010 Sep;30(5):756-60. Epub 2010 Jun 12.
35. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
36. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
37. The differential roles of LFA-1 and Mac-1 in host defense against systemic infection with Streptococcus pneumoniae. Prince JE, etal., J Immunol. 2001 Jun 15;166(12):7362-9. doi: 10.4049/jimmunol.166.12.7362.
38. GOA pipeline RGD automated data pipeline
39. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
40. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
41. Reduction in inflammation following blockade of CD18 or CD29 adhesive pathways during the acute phase of a spirochetal-induced colitis in mice. Sacco RE, etal., Microb Pathog. 2000 Nov;29(5):289-99.
42. The role of alpha4 (CD49d) and beta2 (CD18) integrins in eosinophil and neutrophil migration to allergic lung inflammation in the Brown Norway rat. Schneider T, etal., Am J Respir Cell Mol Biol. 1999 Mar;20(3):448-57.
43. Tumor-specific CTL kill murine renal cancer cells using both perforin and Fas ligand-mediated lysis in vitro, but cause tumor regression in vivo in the absence of perforin. Seki N, etal., J Immunol. 2002 Apr 1;168(7):3484-92.
44. Tumour necrosis factor alpha secretion induces protease activation and acinar cell necrosis in acute experimental pancreatitis in mice. Sendler M, etal., Gut. 2012 Apr 5.
45. The effect of gentamicin-induced readthrough on a novel premature termination codon of CD18 leukocyte adhesion deficiency patients. Simon AJ, etal., PLoS One. 2010 Nov 16;5(11):e13659.
46. Antibody-induced modulation of the leukocyte CD11b integrin prevents mild but not major renal ischaemic injury. Tajra LC, etal., Nephrol Dial Transplant. 2000 Oct;15(10):1556-61.
47. The integrins. Takada Y, etal., Genome Biol. 2007;8(5):215.
48. Characterization of the rat leukocyte integrin, CD11/CD18, by the use of LFA-1 subunit-specific monoclonal antibodies. Tamatani T, etal., Eur J Immunol. 1991 Mar;21(3):627-33.
49. Reduced brain injury in CD18-deficient mice after experimental intracerebral hemorrhage. Titova E, etal., J Neurosci Res. 2008 Nov 1;86(14):3240-5.
50. Gene expression in macrophage-rich inflammatory cell infiltrates in human atherosclerotic lesions as studied by laser microdissection and DNA array: overexpression of HMG-CoA reductase, colony stimulating factor receptors, CD11A/CD18 integrins, and interleukin receptors. Tuomisto TT, etal., Arterioscler Thromb Vasc Biol. 2003 Dec;23(12):2235-40. Epub 2003 Oct 23.
51. Ageing prolongs inflammatory marker expression in regenerating rat skeletal muscles after injury. van der Poel C, etal., J Inflamm (Lond). 2011 Dec 29;8(1):41.
52. The critical role of intercellular adhesion molecule-1 in Masugi nephritis in rats. Wada J, etal., Nephron. 1996;73(2):264-72.
53. Extracellular adherence protein of Staphylococcus aureus suppresses disease by inhibiting T-cell recruitment in a mouse model of psoriasis. Wang H, etal., J Invest Dermatol. 2010 Mar;130(3):743-54. Epub 2009 Oct 8.
54. Essential role of ICAM-1/CD18 in mediating EPC recruitment, angiogenesis, and repair to the infarcted myocardium. Wu Y, etal., Circ Res. 2006 Aug 4;99(3):315-22. Epub 2006 Jul 6.
55. A prospective evaluation of the CD14 and CD18 gene polymorphisms and risk of stroke. Zee RY, etal., Stroke. 2002 Apr;33(4):892-5.
56. Integrated Analysis of Multiple Microarray Studies to Identify Core Gene-Expression Signatures Involved in Tubulointerstitial Injury in Diabetic Nephropathy. Zhou H, etal., Biomed Res Int. 2022 May 10;2022:9554658. doi: 10.1155/2022/9554658. eCollection 2022.
Additional References at PubMed
PMID:10528208   PMID:10601245   PMID:12477932   PMID:12496435   PMID:12652296   PMID:12885943   PMID:15210787   PMID:15249579   PMID:15457581   PMID:16093349   PMID:16937496   PMID:17023661  
PMID:18759008   PMID:18981818   PMID:19029120   PMID:19234460   PMID:19299737   PMID:19342649   PMID:19703720   PMID:19946888   PMID:20183869   PMID:20199584   PMID:20458337   PMID:20563599  
PMID:21180156   PMID:21193407   PMID:21207857   PMID:22778269   PMID:22871113   PMID:23154389   PMID:23382219   PMID:23395392   PMID:23620790   PMID:23830386   PMID:23981064   PMID:24458438  
PMID:24769233   PMID:25453580   PMID:28807980  


Genomics

Comparative Map Data
Itgb2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82011,061,009 - 11,097,242 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2011,058,492 - 11,097,182 (-)EnsemblGRCr8
mRatBN7.22011,061,394 - 11,097,656 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2011,061,430 - 11,097,600 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2011,760,914 - 11,797,085 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02011,121,883 - 11,158,052 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02011,593,622 - 11,629,796 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02011,777,773 - 11,815,647 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2011,777,783 - 11,815,647 (-)Ensemblrn6Rnor6.0
Rnor_5.02013,944,190 - 13,981,048 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42011,446,521 - 11,485,009 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2012,564,941 - 12,601,097 (-)NCBICelera
RGSC_v3.12011,446,936 - 11,485,236 (-)NCBI
Cytogenetic Map20p12NCBI
ITGB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382144,885,953 - 44,928,815 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2144,885,948 - 44,932,079 (-)Ensemblhg38GRCh38
GRCh372146,305,868 - 46,348,730 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362145,130,296 - 45,165,303 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342145,130,313 - 45,165,232NCBI
Celera2131,412,498 - 31,455,256 (-)NCBICelera
Cytogenetic Map21q22.3NCBI
HuRef2131,679,225 - 31,721,357 (-)NCBIHuRef
CHM1_12145,866,651 - 45,909,349 (-)NCBICHM1_1
T2T-CHM13v2.02143,246,634 - 43,289,593 (-)NCBIT2T-CHM13v2.0
Itgb2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391077,366,164 - 77,401,542 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1077,366,086 - 77,401,542 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381077,530,329 - 77,565,708 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1077,530,252 - 77,565,708 (+)Ensemblmm10GRCm38
MGSCv371076,993,093 - 77,028,419 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361076,985,685 - 77,009,099 (+)NCBIMGSCv36mm8
Celera1078,572,639 - 78,608,564 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Itgb2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540741,777,777 - 41,800,201 (-)Ensembl
ChiLan1.0NW_00495540741,779,849 - 41,805,637 (-)NCBIChiLan1.0ChiLan1.0
ITGB2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22240,933,241 - 40,976,107 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12135,804,383 - 35,839,245 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02131,181,228 - 31,216,033 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12144,470,999 - 44,505,963 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2144,470,999 - 44,505,963 (-)EnsemblpanPan2panpan1.1
ITGB2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13138,520,733 - 38,547,003 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3138,521,103 - 38,547,018 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3137,718,851 - 37,741,911 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03138,125,566 - 38,152,274 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3138,125,550 - 38,148,633 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13137,988,075 - 38,014,617 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03137,949,217 - 37,972,818 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03138,463,168 - 38,490,402 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Itgb2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497137,819,024 - 37,843,866 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367781,286,341 - 1,311,194 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049367781,286,475 - 1,311,184 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ITGB2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13207,512,950 - 207,544,107 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.113207,514,281 - 207,544,108 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213217,446,055 - 217,475,887 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ITGB2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1288,597,554 - 88,644,890 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl288,597,556 - 88,624,025 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605416,774,420 - 16,821,705 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Itgb2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474530,452,576 - 30,470,611 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474530,452,576 - 30,479,036 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Itgb2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v118872,085 - 909,423 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Itgb2
366 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:97
Count of miRNA genes:71
Interacting mature miRNAs:88
Transcripts:ENSRNOT00000001639
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)20418947649189476Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20126925056Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20133724594Rat
7387283Uae44Urinary albumin excretion QTL 440.1712urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)20126128279Rat
4889870Pur30Proteinuria QTL 30190.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20804392029865039Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600300Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20153308346533083Rat
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124164241Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20134066551Rat
631265Iresp1Immunoglobin response QTL18.3blood anti-double stranded DNA antibody amount (VT:0004762)serum anti-DNA antibody level (CMO:0001533)20904109911115921Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129193376Rat
4889857Pur27Proteinuria QTL 2712.20.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20127341128Rat
1598870Bp289Blood pressure QTL 2892.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)20821635953216359Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129193376Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129193376Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129193376Rat
1581577Pur15Proteinuria QTL 154.380.0002urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)20804392015089182Rat
1598858Cm61Cardiac mass QTL 613.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)20821635953216359Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129193376Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20114100378Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127341128Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127341128Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578510Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600300Rat

Markers in Region
Itgb2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22011,061,745 - 11,061,853 (+)MAPPERmRatBN7.2
Rnor_6.02011,778,099 - 11,778,206NCBIRnor6.0
Rnor_5.02013,944,516 - 13,944,623UniSTSRnor5.0
RGSC_v3.42011,446,847 - 11,446,954UniSTSRGSC3.4
Celera2012,565,267 - 12,565,374UniSTS
Cytogenetic Map20p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 65 161 91 90 59 92 59 6 354 190 11 140 81 92 31 13 13

Sequence


Ensembl Acc Id: ENSRNOT00000001639   ⟹   ENSRNOP00000001639
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2011,061,019 - 11,097,182 (-)Ensembl
mRatBN7.2 Ensembl2011,061,430 - 11,097,600 (-)Ensembl
Rnor_6.0 Ensembl2011,777,783 - 11,815,647 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000101048   ⟹   ENSRNOP00000081713
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2011,061,430 - 11,067,731 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000119404   ⟹   ENSRNOP00000082439
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2011,061,019 - 11,080,250 (-)Ensembl
mRatBN7.2 Ensembl2011,061,430 - 11,080,548 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000152597   ⟹   ENSRNOP00000099004
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2011,058,492 - 11,080,250 (-)Ensembl
RefSeq Acc Id: NM_001037780   ⟹   NP_001032869
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82011,061,009 - 11,097,182 (-)NCBI
mRatBN7.22011,061,420 - 11,097,600 (-)NCBI
Rnor_6.02011,777,773 - 11,815,647 (-)NCBI
Rnor_5.02013,944,190 - 13,981,048 (-)NCBI
RGSC_v3.42011,446,521 - 11,485,009 (-)RGD
Celera2012,564,941 - 12,601,097 (-)RGD
Sequence:
RefSeq Acc Id: XM_039098729   ⟹   XP_038954657
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82011,061,009 - 11,097,242 (-)NCBI
mRatBN7.22011,061,394 - 11,097,656 (-)NCBI
RefSeq Acc Id: XM_039098730   ⟹   XP_038954658
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82011,061,009 - 11,097,205 (-)NCBI
mRatBN7.22011,061,394 - 11,097,608 (-)NCBI
RefSeq Acc Id: XM_063279156   ⟹   XP_063135226
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82011,061,009 - 11,096,160 (-)NCBI
RefSeq Acc Id: NP_001032869   ⟸   NM_001037780
- Peptide Label: precursor
- UniProtKB: B2RYB8 (UniProtKB/TrEMBL),   F7F4S8 (UniProtKB/TrEMBL),   A0A9K3Y824 (UniProtKB/TrEMBL),   A6JK86 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000001639   ⟸   ENSRNOT00000001639
RefSeq Acc Id: XP_038954657   ⟸   XM_039098729
- Peptide Label: isoform X1
- UniProtKB: F7F4S8 (UniProtKB/TrEMBL),   B2RYB8 (UniProtKB/TrEMBL),   A0A9K3Y824 (UniProtKB/TrEMBL),   A6JK86 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038954658   ⟸   XM_039098730
- Peptide Label: isoform X1
- UniProtKB: F7F4S8 (UniProtKB/TrEMBL),   B2RYB8 (UniProtKB/TrEMBL),   A0A9K3Y824 (UniProtKB/TrEMBL),   A6JK86 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000081713   ⟸   ENSRNOT00000101048
Ensembl Acc Id: ENSRNOP00000082439   ⟸   ENSRNOT00000119404
RefSeq Acc Id: XP_063135226   ⟸   XM_063279156
- Peptide Label: isoform X1
- UniProtKB: A0A9K3Y824 (UniProtKB/TrEMBL),   B2RYB8 (UniProtKB/TrEMBL),   F7F4S8 (UniProtKB/TrEMBL),   A6JK86 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000099004   ⟸   ENSRNOT00000152597
Protein Domains
Integrin beta subunit cytoplasmic   Integrin beta subunit tail   Integrin beta subunit VWA   PSI

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B2RYB8-F1-model_v2 AlphaFold B2RYB8 1-768 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701505
Promoter ID:EPDNEW_R12029
Type:initiation region
Name:Itgb2_1
Description:integrin subunit beta 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02011,815,664 - 11,815,724EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305581 AgrOrtholog
BioCyc Gene G2FUF-4238 BioCyc
Ensembl Genes ENSRNOG00000001224 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000001639 ENTREZGENE
  ENSRNOT00000001639.8 UniProtKB/TrEMBL
  ENSRNOT00000119404 ENTREZGENE
  ENSRNOT00000119404.2 UniProtKB/TrEMBL
  ENSRNOT00000152597.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.410 UniProtKB/TrEMBL
  4.10.1240.30 UniProtKB/TrEMBL
  6.20.50.10 UniProtKB/TrEMBL
  Cytochrome c1, transmembrane anchor, C-terminal UniProtKB/TrEMBL
  Laminin UniProtKB/TrEMBL
  ligand-binding face of the semaphorins, domain 2 UniProtKB/TrEMBL
  ntegrin, alpha v. Chain A, domain 3 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7124173 IMAGE-MGC_LOAD
  IMAGE:7932515 IMAGE-MGC_LOAD
InterPro EGF_integrin_2 UniProtKB/TrEMBL
  Integin_beta_N UniProtKB/TrEMBL
  Integrin_bsu UniProtKB/TrEMBL
  Integrin_bsu-2_C UniProtKB/TrEMBL
  Integrin_bsu_cyt UniProtKB/TrEMBL
  Integrin_bsu_N UniProtKB/TrEMBL
  Integrin_bsu_tail UniProtKB/TrEMBL
  Integrin_bsu_tail_dom_sf UniProtKB/TrEMBL
  Integrin_dom UniProtKB/TrEMBL
  Integrin_I-EGF_CS UniProtKB/TrEMBL
  Plexin-like_fold UniProtKB/TrEMBL
  vWFA_dom_sf UniProtKB/TrEMBL
KEGG Report rno:309684 UniProtKB/TrEMBL
MGC_CLONE MGC:188433 IMAGE-MGC_LOAD
  MGC:94072 IMAGE-MGC_LOAD
NCBI Gene 309684 ENTREZGENE
PANTHER Integrin_beta_C UniProtKB/TrEMBL
  PTHR10082:SF15 UniProtKB/TrEMBL
Pfam EGF_integrin UniProtKB/TrEMBL
  Integrin_b_cyt UniProtKB/TrEMBL
  Integrin_B_tail UniProtKB/TrEMBL
  Integrin_beta UniProtKB/TrEMBL
  PSI_integrin UniProtKB/TrEMBL
PhenoGen Itgb2 PhenoGen
PIRSF Integrin_B UniProtKB/TrEMBL
PRINTS INTEGRINB UniProtKB/TrEMBL
PROSITE I_EGF_2 UniProtKB/TrEMBL
  INTEGRIN_BETA UniProtKB/TrEMBL
RatGTEx ENSRNOG00000001224 RatGTEx
SMART INB UniProtKB/TrEMBL
  Integrin_b_cyt UniProtKB/TrEMBL
  Integrin_B_tail UniProtKB/TrEMBL
  PSI UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/TrEMBL
  Integrin_bsu_tail UniProtKB/TrEMBL
  Plexin repeat UniProtKB/TrEMBL
  SSF53300 UniProtKB/TrEMBL
  SSF69179 UniProtKB/TrEMBL
UniProt A0A8I5ZTY9_RAT UniProtKB/TrEMBL
  A0A9K3Y824 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LCE4_RAT UniProtKB/TrEMBL
  A6JK86 ENTREZGENE, UniProtKB/TrEMBL
  B2RYB8 ENTREZGENE, UniProtKB/TrEMBL
  F7F4S8 ENTREZGENE
  Q4KLK5_RAT UniProtKB/TrEMBL
UniProt Secondary F7F4S8 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-18 Itgb2  integrin subunit beta 2  Itgb2  integrin, beta 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-12-15 Itgb2  integrin, beta 2  Itgb2  integrin beta 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Itgb2  integrin beta 2  Itgb2_predicted  integrin beta 2 (predicted)  Symbol and Name updated 1559027 APPROVED