Arhgap32 (Rho GTPase activating protein 32) - Rat Genome Database

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Gene: Arhgap32 (Rho GTPase activating protein 32) Rattus norvegicus
Analyze
Symbol: Arhgap32
Name: Rho GTPase activating protein 32
RGD ID: 1305267
Description: Predicted to enable GTPase activator activity. Involved in cerebellum development; positive regulation of axon extension; and positive regulation of neuron migration. Predicted to be located in postsynaptic density. Predicted to be active in several cellular components, including Golgi apparatus; actin cytoskeleton; and nuclear lumen. Orthologous to human ARHGAP32 (Rho GTPase activating protein 32); INTERACTS WITH 2,6-dinitrotoluene; 4-amino-2,6-dinitrotoluene; amitrole.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Grit; p250GAP; Rho GTPase-activating protein; rho GTPase-activating protein 32; RhoGAP involved in beta-catenin-N-cadherin and NMDA receptor signaling; Rics
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8838,679,368 - 38,939,960 (+)NCBIGRCr8
mRatBN7.2830,421,269 - 30,681,653 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl830,421,515 - 30,678,454 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0833,131,874 - 33,392,198 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl833,239,139 - 33,392,305 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0833,168,863 - 33,409,157 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4831,859,986 - 32,032,203 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1832,005,344 - 32,040,895 (+)NCBI
Celera831,879,179 - 32,135,024 (+)NCBICelera
Cytogenetic Map8q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
actin cytoskeleton  (IBA,ISO)
cell cortex  (IBA,ISO)
fibrillar center  (IBA,ISO)
glutamatergic synapse  (IDA,IEP)
Golgi apparatus  (IBA,ISO)
nucleoplasm  (IBA,ISO)
postsynaptic density  (IDA,IEP,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. p250GAP is a novel player in the Cdh1-APC/Smurf1 pathway of axon growth regulation. Kannan M, etal., PLoS One. 2012;7(11):e50735. doi: 10.1371/journal.pone.0050735. Epub 2012 Nov 30.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. RICS, a novel GTPase-activating protein for Cdc42 and Rac1, is involved in the beta-catenin-N-cadherin and N-methyl-D-aspartate receptor signaling. Okabe T, etal., J Biol Chem. 2003 Mar 14;278(11):9920-7. doi: 10.1074/jbc.M208872200. Epub 2003 Jan 16.
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12454018   PMID:12477932   PMID:22250289   PMID:27609886  


Genomics

Comparative Map Data
Arhgap32
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8838,679,368 - 38,939,960 (+)NCBIGRCr8
mRatBN7.2830,421,269 - 30,681,653 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl830,421,515 - 30,678,454 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0833,131,874 - 33,392,198 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl833,239,139 - 33,392,305 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0833,168,863 - 33,409,157 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4831,859,986 - 32,032,203 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1832,005,344 - 32,040,895 (+)NCBI
Celera831,879,179 - 32,135,024 (+)NCBICelera
Cytogenetic Map8q21NCBI
ARHGAP32
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811128,965,060 - 129,279,632 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11128,965,060 - 129,279,324 (-)EnsemblGRCh38hg38GRCh38
GRCh3711128,834,955 - 129,149,413 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611128,343,052 - 128,399,222 (-)NCBINCBI36Build 36hg18NCBI36
Celera11126,003,454 - 126,230,572 (-)NCBICelera
Cytogenetic Map11q24.3NCBI
HuRef11124,785,776 - 125,014,078 (-)NCBIHuRef
CHM1_111128,721,150 - 128,948,156 (-)NCBICHM1_1
T2T-CHM13v2.011128,999,975 - 129,315,124 (-)NCBIT2T-CHM13v2.0
Arhgap32
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39931,927,921 - 32,176,061 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl932,027,432 - 32,179,742 (+)EnsemblGRCm39 Ensembl
GRCm38932,016,625 - 32,268,443 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl932,116,136 - 32,268,446 (+)EnsemblGRCm38mm10GRCm38
MGSCv37931,923,721 - 32,072,084 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36931,957,765 - 32,010,849 (+)NCBIMGSCv36mm8
Celera929,377,749 - 29,526,489 (+)NCBICelera
Cytogenetic Map9A4NCBI
cM Map917.48NCBI
Arhgap32
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541229,910,395 - 30,203,340 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541229,910,395 - 30,113,959 (-)NCBIChiLan1.0ChiLan1.0
ARHGAP32
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29129,648,795 - 129,966,615 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111130,756,565 - 131,074,151 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011123,780,028 - 124,096,494 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111127,680,804 - 127,882,212 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11127,684,622 - 127,909,822 (-)Ensemblpanpan1.1panPan2
ARHGAP32
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.155,398,833 - 5,690,041 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl55,380,831 - 5,686,840 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha55,460,004 - 5,750,414 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.055,358,554 - 5,649,847 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl55,340,445 - 5,646,077 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.155,419,701 - 5,709,873 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.055,402,897 - 5,693,910 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.055,430,554 - 5,721,803 (+)NCBIUU_Cfam_GSD_1.0
Arhgap32
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947111,157,285 - 111,454,036 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365723,118,670 - 3,294,109 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365723,100,695 - 3,293,077 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARHGAP32
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl955,906,954 - 56,177,551 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1955,903,365 - 56,177,639 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2961,997,185 - 62,009,623 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ARHGAP32
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11120,108,671 - 120,333,200 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1120,112,042 - 120,329,370 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660435,674,740 - 5,987,192 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Arhgap32
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248123,282,299 - 3,597,436 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248123,278,564 - 3,474,004 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Arhgap32
1978 total Variants
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir1rno-miR-1-3pMirtarbaseexternal_infoGFP reporter assay//Immunocytochemistry//LuciferasNon-Functional MTI16260724
Mir132rno-miR-132-3pMirtarbaseexternal_infoGFP reporter assay//Immunocytochemistry//LuciferasFunctional MTI16260724

Predicted Target Of
Summary Value
Count of predictions:39
Count of miRNA genes:38
Interacting mature miRNAs:39
Transcripts:ENSRNOT00000011589
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)8209764047097640Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)8209764047097640Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)8209764047097640Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)8209764047097640Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)8470581049705810Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)8470581049705810Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)8470581049705810Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)8767057852670578Rat
1354595Despr4Despair related QTL 42.160.0036locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)8768895552688955Rat
1354627Despr14Despair related QTL 140.0056locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)8768895552688955Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)8873663553736635Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)8873663553736635Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)8971222053356647Rat
1357398Slep3Serum leptin concentration QTL 33.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)8971246341866876Rat
2302367Slep5Serum leptin concentration QTL 53.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)8971246341866876Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
1558646Swd5Spike wave discharge measurement QTL 53.450.00036brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)81490675159906751Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)81629044461290444Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)81898416884531599Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)82266233067662330Rat
2303564Gluco43Glucose level QTL 433blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)82613018771130187Rat
2303572Insul13Insulin level QTL 132blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)82613018771130187Rat
1359021Bp271Blood pressure QTL 2711.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82664491246711092Rat
631648Stl5Serum triglyceride level QTL 540.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)82720571554998217Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)82720571599103503Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82720571599103503Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)82720571599103503Rat
724540Uae8Urinary albumin excretion QTL 85urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)82815732330848259Rat
1331804Cm30Cardiac mass QTL 303.77443heart mass (VT:0007028)heart wet weight (CMO:0000069)82824291253961020Rat
1300146Rf17Renal function QTL 172.9renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)82824291273242912Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)82824291299525068Rat
2302278Gluco36Glucose level QTL 364.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)82950266550095447Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)82950266570386295Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)83018886794457446Rat

Markers in Region
D8Arb24  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0833,155,333 - 33,155,515NCBIRnor6.0
RGSC_v3.4831,766,837 - 31,767,074RGDRGSC3.4
RGSC_v3.4831,766,838 - 31,767,074UniSTSRGSC3.4
RGSC_v3.1831,775,603 - 31,775,840RGD
Celera831,902,370 - 31,902,558UniSTS
FHH x ACI Map824.3UniSTS
FHH x ACI Map824.3RGD
Cytogenetic Map8q21UniSTS
D8Got32  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2830,636,183 - 30,636,392 (+)MAPPERmRatBN7.2
Rnor_6.0833,346,763 - 33,346,971NCBIRnor6.0
Rnor_5.0833,364,604 - 33,364,812UniSTSRnor5.0
RGSC_v3.4831,989,626 - 31,989,835RGDRGSC3.4
RGSC_v3.4831,989,627 - 31,989,835UniSTSRGSC3.4
RGSC_v3.1831,998,393 - 31,998,601RGD
Celera832,089,521 - 32,089,729UniSTS
RH 3.4 Map8215.8UniSTS
RH 3.4 Map8215.8RGD
RH 2.0 Map8177.2RGD
Cytogenetic Map8q21UniSTS
D8Got40  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2830,669,201 - 30,669,418 (+)MAPPERmRatBN7.2
Rnor_6.0833,379,781 - 33,379,997NCBIRnor6.0
Rnor_5.0833,397,622 - 33,397,838UniSTSRnor5.0
RGSC_v3.4832,022,952 - 32,023,169RGDRGSC3.4
RGSC_v3.4832,022,953 - 32,023,169UniSTSRGSC3.4
RGSC_v3.1832,031,719 - 32,031,935RGD
Celera832,122,608 - 32,122,823UniSTS
RH 3.4 Map8247.9UniSTS
RH 3.4 Map8247.9RGD
Cytogenetic Map8q21UniSTS
STS-Z40721  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.06136,105,776 - 136,105,891NCBIRnor5.0
RGSC_v3.46127,295,586 - 127,295,700UniSTSRGSC3.4
Celera6119,647,373 - 119,647,487UniSTS
Celera831,896,807 - 31,896,836UniSTS
Cytogenetic Map8q21UniSTS
Cytogenetic Map6q13UniSTS
Cytogenetic Map6q32UniSTS
BF405189  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2830,666,387 - 30,666,503 (+)MAPPERmRatBN7.2
Rnor_6.0833,376,967 - 33,377,082NCBIRnor6.0
Rnor_5.0833,394,808 - 33,394,923UniSTSRnor5.0
RGSC_v3.4832,020,139 - 32,020,254UniSTSRGSC3.4
Celera832,119,794 - 32,119,909UniSTS
RH 3.4 Map8215.6UniSTS
Cytogenetic Map8q21UniSTS
PMC139861P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2830,677,681 - 30,678,317 (+)MAPPERmRatBN7.2
Rnor_6.0833,388,261 - 33,388,896NCBIRnor6.0
Rnor_5.0833,406,102 - 33,406,737UniSTSRnor5.0
RGSC_v3.4832,031,433 - 32,032,068UniSTSRGSC3.4
Celera832,131,087 - 32,131,722UniSTS
Cytogenetic Map8q21UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 2 9 2 2 74 24 35 11
Low 41 48 39 19 39 8 11 11 6 8
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001427098 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006226357 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006226361 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006226362 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006242777 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008766074 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008776684 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017595996 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017595997 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017595999 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017603599 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017603600 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017603601 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039082294 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063265400 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063265401 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063265402 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063265404 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063265405 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063265406 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC127149 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC168683 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000011589   ⟹   ENSRNOP00000011589
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl830,527,720 - 30,678,446 (+)Ensembl
Rnor_6.0 Ensembl833,239,139 - 33,392,305 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000099034   ⟹   ENSRNOP00000089744
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl830,421,515 - 30,678,446 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000100925   ⟹   ENSRNOP00000077564
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl830,437,555 - 30,678,454 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000119263   ⟹   ENSRNOP00000088168
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl830,527,720 - 30,678,446 (+)Ensembl
RefSeq Acc Id: NM_001427098   ⟹   NP_001414027
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8838,695,725 - 38,939,960 (+)NCBI
RefSeq Acc Id: XM_006242777   ⟹   XP_006242839
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8838,843,689 - 38,936,555 (+)NCBI
mRatBN7.2830,585,583 - 30,678,446 (+)NCBI
Rnor_6.0833,296,824 - 33,389,025 (+)NCBI
Rnor_5.0833,168,863 - 33,409,157 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008766074   ⟹   XP_008764296
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8838,778,613 - 38,936,555 (+)NCBI
mRatBN7.2830,521,794 - 30,681,653 (+)NCBI
Rnor_6.0833,239,338 - 33,388,875 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017595996   ⟹   XP_017451485
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8838,778,613 - 38,936,555 (+)NCBI
mRatBN7.2830,521,793 - 30,681,653 (+)NCBI
Rnor_6.0833,237,246 - 33,388,875 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017595997   ⟹   XP_017451486
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8838,701,585 - 38,936,555 (+)NCBI
mRatBN7.2830,540,892 - 30,678,446 (+)NCBI
Rnor_6.0833,237,246 - 33,389,025 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017595999   ⟹   XP_017451488
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8838,679,369 - 38,936,555 (+)NCBI
mRatBN7.2830,421,269 - 30,678,446 (+)NCBI
Rnor_6.0833,131,874 - 33,389,025 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039082294   ⟹   XP_038938222
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8838,865,061 - 38,936,555 (+)NCBI
mRatBN7.2830,606,994 - 30,678,446 (+)NCBI
RefSeq Acc Id: XM_063265400   ⟹   XP_063121470
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8838,701,585 - 38,936,555 (+)NCBI
RefSeq Acc Id: XM_063265401   ⟹   XP_063121471
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8838,701,585 - 38,936,555 (+)NCBI
RefSeq Acc Id: XM_063265402   ⟹   XP_063121472
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8838,778,613 - 38,936,555 (+)NCBI
RefSeq Acc Id: XM_063265404   ⟹   XP_063121474
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8838,701,585 - 38,936,555 (+)NCBI
RefSeq Acc Id: XM_063265405   ⟹   XP_063121475
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8838,679,368 - 38,936,555 (+)NCBI
RefSeq Acc Id: XM_063265406   ⟹   XP_063121476
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8838,701,585 - 38,929,334 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_006242839   ⟸   XM_006242777
- Peptide Label: isoform X10
- UniProtKB: A0A8I6GFW8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008764296   ⟸   XM_008766074
- Peptide Label: isoform X7
- UniProtKB: A0A8I6GFW8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017451488   ⟸   XM_017595999
- Peptide Label: isoform X8
- UniProtKB: A0A8I6GIC6 (UniProtKB/TrEMBL),   A0A8I6GFW8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017451486   ⟸   XM_017595997
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_017451485   ⟸   XM_017595996
- Peptide Label: isoform X4
- UniProtKB: A0A8I6GFW8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000011589   ⟸   ENSRNOT00000011589
RefSeq Acc Id: XP_038938222   ⟸   XM_039082294
- Peptide Label: isoform X11
- UniProtKB: B5DEI5 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000089744   ⟸   ENSRNOT00000099034
RefSeq Acc Id: ENSRNOP00000077564   ⟸   ENSRNOT00000100925
RefSeq Acc Id: ENSRNOP00000088168   ⟸   ENSRNOT00000119263
RefSeq Acc Id: XP_063121475   ⟸   XM_063265405
- Peptide Label: isoform X9
- UniProtKB: A0A8I5Y6H2 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001414027   ⟸   NM_001427098
- UniProtKB: A0A8I6GIC6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063121470   ⟸   XM_063265400
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063121471   ⟸   XM_063265401
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063121474   ⟸   XM_063265404
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063121476   ⟸   XM_063265406
- Peptide Label: isoform X12
RefSeq Acc Id: XP_063121472   ⟸   XM_063265402
- Peptide Label: isoform X3
- UniProtKB: F1MAK3 (UniProtKB/TrEMBL)
Protein Domains
Rho-GAP   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1MAK3-F1-model_v2 AlphaFold F1MAK3 1-2101 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305267 AgrOrtholog
BioCyc Gene G2FUF-31242 BioCyc
Ensembl Genes ENSRNOG00000008709 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000011589.7 UniProtKB/TrEMBL
  ENSRNOT00000099034.1 UniProtKB/TrEMBL
  ENSRNOT00000100925.1 UniProtKB/TrEMBL
  ENSRNOT00000119263.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.555.10 UniProtKB/TrEMBL
  3.30.1520.10 UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
InterPro PX_ARHGAP32 UniProtKB/TrEMBL
  PX_dom_sf UniProtKB/TrEMBL
  Rho_GTPase_activation_prot UniProtKB/TrEMBL
  RhoGAP_dom UniProtKB/TrEMBL
  SH3-like_dom UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
NCBI Gene 315530 ENTREZGENE
PANTHER CDC42 GTPASE-ACTIVATING PROTEIN UniProtKB/TrEMBL
  RHO GTPASE-ACTIVATING PROTEIN 32 UniProtKB/TrEMBL
Pfam RhoGAP UniProtKB/TrEMBL
  SH3_9 UniProtKB/TrEMBL
PhenoGen Arhgap32 PhenoGen
PROSITE RHOGAP UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000008709 RatGTEx
SMART RhoGAP UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
Superfamily-SCOP 64268 UniProtKB/TrEMBL
  Rho_GAP UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
UniProt A0A8I5Y6H2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GFW8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GIC6 ENTREZGENE, UniProtKB/TrEMBL
  B5DEI5 ENTREZGENE, UniProtKB/TrEMBL
  F1MAK3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-01 Arhgap32  Rho GTPase activating protein 32  Rics  Rho GTPase-activating protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-17 Rics  Rho GTPase-activating protein  Grit  Rho GTPase-activating protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-07 Grit  Rho GTPase-activating protein  RICS_predicted  RhoGAP involved in beta-catenin-N-cadherin and NMDA receptor signaling (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-12 RICS_predicted  RhoGAP involved in beta-catenin-N-cadherin and NMDA receptor signaling (predicted)      Symbol and Name status set to approved 70820 APPROVED