Cyp2w1 (cytochrome P450, family 2, subfamily w, polypeptide 1) - Rat Genome Database

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Gene: Cyp2w1 (cytochrome P450, family 2, subfamily w, polypeptide 1) Rattus norvegicus
Analyze
Symbol: Cyp2w1
Name: cytochrome P450, family 2, subfamily w, polypeptide 1
RGD ID: 1305193
Description: Predicted to enable heme binding activity; monooxygenase activity; and retinoid binding activity. Predicted to be involved in several processes, including aflatoxin metabolic process; retinoic acid catabolic process; and xenobiotic metabolic process. Predicted to be located in cell surface and endoplasmic reticulum lumen. Predicted to be active in cytoplasm. Orthologous to human CYP2W1 (cytochrome P450 family 2 subfamily W member 1); INTERACTS WITH bisphenol A; 2,3,7,8-tetrachlorodibenzodioxine (ortholog); 4,4'-sulfonyldiphenol (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cytochrome P450 2W1; LOC288517
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81220,405,400 - 20,410,282 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1220,405,400 - 20,410,282 (-)EnsemblGRCr8
mRatBN7.21215,291,552 - 15,296,421 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1215,291,704 - 15,296,421 (-)EnsemblmRatBN7.2
Rnor_6.01217,382,749 - 17,387,909 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1217,383,159 - 17,387,879 (-)Ensemblrn6Rnor6.0
Rnor_5.01219,367,866 - 19,374,746 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41215,792,480 - 15,797,202 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1217,045,261 - 17,050,420 (-)NCBICelera
RGSC_v3.11215,822,407 - 15,827,127 (-)NCBI
Cytogenetic Map12q11NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
3. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:16426568   PMID:16551781   PMID:20805301   PMID:22591743   PMID:26936974  


Genomics

Comparative Map Data
Cyp2w1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81220,405,400 - 20,410,282 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1220,405,400 - 20,410,282 (-)EnsemblGRCr8
mRatBN7.21215,291,552 - 15,296,421 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1215,291,704 - 15,296,421 (-)EnsemblmRatBN7.2
Rnor_6.01217,382,749 - 17,387,909 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1217,383,159 - 17,387,879 (-)Ensemblrn6Rnor6.0
Rnor_5.01219,367,866 - 19,374,746 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41215,792,480 - 15,797,202 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1217,045,261 - 17,050,420 (-)NCBICelera
RGSC_v3.11215,822,407 - 15,827,127 (-)NCBI
Cytogenetic Map12q11NCBI
CYP2W1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387983,181 - 989,640 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7983,181 - 989,640 (+)Ensemblhg38GRCh38
GRCh3771,022,817 - 1,029,276 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367989,361 - 995,802 (+)NCBIBuild 36Build 36hg18NCBI36
Build 347796,234 - 802,517NCBI
Celera7990,578 - 996,997 (+)NCBICelera
Cytogenetic Map7p22.3NCBI
HuRef7939,494 - 945,913 (+)NCBIHuRef
CHM1_171,021,926 - 1,028,345 (+)NCBICHM1_1
T2T-CHM13v2.071,088,177 - 1,094,636 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v271,077,465 - 1,083,884 (+)NCBI
Cyp2w1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395139,338,371 - 139,345,362 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5139,338,372 - 139,342,788 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm385139,352,616 - 139,359,607 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5139,352,617 - 139,357,033 (+)Ensemblmm10GRCm38
MGSCv375139,828,571 - 139,832,987 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv365139,606,259 - 139,610,675 (+)NCBIMGSCv36mm8
Celera5136,406,834 - 136,411,079 (+)NCBICelera
Cytogenetic Map5G2NCBI
cM Map578.44NCBI
LOC102016571
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554608,705,068 - 8,712,121 (+)Ensembl
ChiLan1.0NW_0049554608,705,068 - 8,711,266 (+)NCBIChiLan1.0ChiLan1.0
CYP2W1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v265,928,225 - 5,935,241 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1754,252,914 - 54,259,930 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v071,140,855 - 1,147,788 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.171,353,510 - 1,369,487 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl71,353,510 - 1,362,781 (+)EnsemblpanPan2panpan1.1
CYP2W1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1615,883,248 - 15,889,508 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl615,881,636 - 15,889,186 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha617,354,512 - 17,362,330 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0616,012,124 - 16,019,942 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl616,012,367 - 16,019,917 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1615,814,985 - 15,822,771 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0615,741,518 - 15,749,310 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0616,029,717 - 16,037,535 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
LOC101970215
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344143,793,867 - 143,807,376 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367541,203,017 - 1,208,131 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049367541,203,004 - 1,208,131 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CYP2W1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3642,471 - 648,909 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.13641,997 - 649,313 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23744,864 - 752,709 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CYP2W1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12820,580,272 - 20,592,771 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2820,582,287 - 20,591,497 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660901,103,793 - 1,111,633 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101698313
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474026,544,715 - 26,549,433 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474026,545,725 - 26,551,906 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
LOC116885802
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11613,842,914 - 13,848,038 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cyp2w1
22 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:108
Count of miRNA genes:90
Interacting mature miRNAs:95
Transcripts:ENSRNOT00000031264
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312418Kidm41Kidney mass QTL 413.70.0001kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)12592191825247790Rat
61443Btemp2Thermal response to stress QTL 23.30.000094body temperature trait (VT:0005535)core body temperature (CMO:0001036)122013902826430640Rat
70213Niddm27Non-insulin dependent diabetes mellitus QTL 273.72blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121120049452308831Rat
2306789Ean6Experimental allergic neuritis QTL 64.9nervous system integrity trait (VT:0010566)experimental autoimmune neuritis severity score (CMO:0001528)12129775522Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12348941648489416Rat
1331739Hrtrt14Heart rate QTL 143.56232heart pumping trait (VT:2000009)heart rate (CMO:0000002)12138687564Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121847304152308831Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049752308831Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)121526424852308831Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12133700600Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)121174352852308831Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
2293684Bmd26Bone mineral density QTL 264.40.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)12138635130Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12128133365Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)121223300030490641Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121746497946784661Rat
1300174Bw15Body weight QTL 152.93body mass (VT:0001259)body weight loss (CMO:0001399)12128606299Rat
1331786Kidm11Kidney mass QTL 113.571kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)121618743852308831Rat
1331787Rf41Renal function QTL 412.998kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)12133700556Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121613502952308831Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121618743851213550Rat
1331763Wbc2White blood cell count QTL 23.162leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)121120049452308831Rat
61416Pia4Pristane induced arthritis QTL 48.4joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)121874946936488809Rat
7204484Bp358Blood pressure QTL 3580.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)12124849755Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)61120049452308831Rat
7387292Kidm42Kidney mass QTL 423.030.0004kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)12141361854Rat
61421Cia12Collagen induced arthritis QTL 124.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121874946934312613Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12274769447747694Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121847304152308831Rat
2303568Bw88Body weight QTL 883body mass (VT:0001259)body weight (CMO:0000012)12128606299Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12308718048087180Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
7243862Mcs30Mammary carcinoma susceptibility QTL 308.62mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)12563330650633306Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121613502952308831Rat
2293086Iddm30Insulin dependent diabetes mellitus QTL 303.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12790162533938215Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
1331755Bp219Blood pressure QTL 2193.041arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121618743833700556Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
14 6 42 45 41 38 9 23 9 6 135 86 25 21 40 29 4 4

Sequence


Ensembl Acc Id: ENSRNOT00000091003   ⟹   ENSRNOP00000075407
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1220,405,400 - 20,410,282 (-)Ensembl
mRatBN7.2 Ensembl1215,291,704 - 15,296,421 (-)Ensembl
Rnor_6.0 Ensembl1217,383,159 - 17,387,879 (-)Ensembl
RefSeq Acc Id: NM_001427669   ⟹   NP_001414598
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81220,405,400 - 20,410,282 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001414598 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL89769 (Get FASTA)   NCBI Sequence Viewer  
  EDL89770 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000075407
  ENSRNOP00000075407.2
Ensembl Acc Id: ENSRNOP00000075407   ⟸   ENSRNOT00000091003
RefSeq Acc Id: NP_001414598   ⟸   NM_001427669
- UniProtKB: A0A0G2KAI3 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2KAI3-F1-model_v2 AlphaFold A0A0G2KAI3 1-492 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305193 AgrOrtholog
BioCyc Gene G2FUF-19889 BioCyc
Ensembl Genes ENSRNOG00000051770 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000091003 ENTREZGENE
  ENSRNOT00000091003.3 UniProtKB/TrEMBL
Gene3D-CATH 1.10.630.10 UniProtKB/TrEMBL
InterPro Cyt_P450 UniProtKB/TrEMBL
  Cyt_P450_CS UniProtKB/TrEMBL
  Cyt_P450_E_grp-I UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/TrEMBL
  Cytochrome_P450_fam2 UniProtKB/TrEMBL
NCBI Gene 288517 ENTREZGENE
PANTHER CYTOCHROME P450 2W1 UniProtKB/TrEMBL
  CYTOCHROME P450 508A4-RELATED UniProtKB/TrEMBL
Pfam p450 UniProtKB/TrEMBL
PharmGKB CYP2W1 RGD
PhenoGen Cyp2w1 PhenoGen
PRINTS EP450I UniProtKB/TrEMBL
  P450 UniProtKB/TrEMBL
PROSITE CYTOCHROME_P450 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000051770 RatGTEx
Superfamily-SCOP SSF48264 UniProtKB/TrEMBL
UniProt A0A0G2KAI3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-04-19 Cyp2w1  cytochrome P450, family 2, subfamily w, polypeptide 1  Cyp2w1  cytochrome P450, family 2, subfamily W, polypeptide 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Cyp2w1  cytochrome P450, family 2, subfamily W, polypeptide 1   Cyp2w1_predicted  cytochrome P450, family 2, subfamily W, polypeptide 1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Cyp2w1_predicted  cytochrome P450, family 2, subfamily W, polypeptide 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED