Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dimethylhydrazine | multiple interactions | ISO | Parp3 (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of PARP3 mRNA | CTD | PMID:22206623 | 17beta-estradiol | affects expression | ISO | PARP3 (Homo sapiens) | 6480464 | Estradiol affects the expression of PARP3 mRNA | CTD | PMID:22574217 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of PARP3 mRNA | CTD | PMID:22298810 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Parp3 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of PARP3 mRNA | CTD | PMID:21570461 | 2,4-dinitrotoluene | affects expression | EXP | | 6480464 | 2 and 4-dinitrotoluene affects the expression of PARP3 mRNA | CTD | PMID:21346803 | 3-chloropropane-1,2-diol | increases expression | EXP | | 6480464 | alpha-Chlorohydrin results in increased expression of PARP3 protein | CTD | PMID:34915118 | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | PARP3 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PARP3 mRNA | CTD | PMID:28628672 | 4,4'-sulfonyldiphenol | increases expression | ISO | Parp3 (Mus musculus) | 6480464 | bisphenol S results in increased expression of PARP3 mRNA | CTD | PMID:30951980 | 4,4'-sulfonyldiphenol | affects methylation | ISO | Parp3 (Mus musculus) | 6480464 | bisphenol S affects the methylation of PARP3 gene | CTD | PMID:31683443 | 4,4'-sulfonyldiphenol | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of PARP3 mRNA | CTD | PMID:36041667 | 4-hydroxyphenyl retinamide | decreases expression | ISO | Parp3 (Mus musculus) | 6480464 | Fenretinide results in decreased expression of PARP3 mRNA | CTD | PMID:28973697 | 6-propyl-2-thiouracil | decreases expression | EXP | | 6480464 | Propylthiouracil results in decreased expression of PARP3 mRNA | CTD | PMID:24780913 | acetamide | increases expression | EXP | | 6480464 | acetamide results in increased expression of PARP3 mRNA | CTD | PMID:31881176 | all-trans-retinoic acid | decreases expression | ISO | PARP3 (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of PARP3 mRNA | CTD | PMID:33167477 | atrazine | decreases expression | EXP | | 6480464 | Atrazine results in decreased expression of PARP3 mRNA | CTD | PMID:36841081 | benzo[a]pyrene | increases methylation | ISO | PARP3 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of PARP3 5' UTR | CTD | PMID:27901495 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of PARP3 mRNA | CTD | PMID:25181051 | bisphenol A | decreases expression | ISO | PARP3 (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of PARP3 mRNA | CTD | PMID:36232920 | bisphenol A | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of PARP3 mRNA | CTD | PMID:36041667 | bisphenol A | decreases expression | ISO | Parp3 (Mus musculus) | 6480464 | bisphenol A results in decreased expression of PARP3 mRNA | CTD | PMID:33221593 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of PARP3 mRNA | CTD | PMID:34947998 | bisphenol A | increases expression | ISO | Parp3 (Mus musculus) | 6480464 | bisphenol A results in increased expression of PARP3 mRNA | CTD | PMID:30245210 and PMID:30951980 | bisphenol A | multiple interactions | ISO | PARP3 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PARP3 mRNA | CTD | PMID:28628672 | bisphenol F | increases expression | ISO | Parp3 (Mus musculus) | 6480464 | bisphenol F results in increased expression of PARP3 mRNA | CTD | PMID:30951980 | bisphenol F | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of PARP3 mRNA | CTD | PMID:36041667 | carbon nanotube | decreases expression | ISO | Parp3 (Mus musculus) | 6480464 | Nanotubes and Carbon analog results in decreased expression of PARP3 mRNA | CTD | PMID:25620056 | carbon nanotube | increases expression | ISO | Parp3 (Mus musculus) | 6480464 | Nanotubes and Carbon results in increased expression of PARP3 mRNA | CTD | PMID:25554681 | CGP 52608 | multiple interactions | ISO | PARP3 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to PARP3 gene] | CTD | PMID:28238834 | chloroprene | decreases expression | ISO | Parp3 (Mus musculus) | 6480464 | Chloroprene results in decreased expression of PARP3 mRNA | CTD | PMID:23125180 | cisplatin | increases expression | ISO | PARP3 (Homo sapiens) | 6480464 | Cisplatin results in increased expression of PARP3 mRNA | CTD | PMID:27392435 and PMID:27594783 | cisplatin | multiple interactions | ISO | PARP3 (Homo sapiens) | 6480464 | [Cisplatin co-treated with jinfukang] results in increased expression of PARP3 mRNA | CTD | PMID:27392435 | copper atom | multiple interactions | ISO | PARP3 (Homo sapiens) | 6480464 | [Chelating Agents binds to Copper] which results in decreased expression of PARP3 mRNA | CTD | PMID:30911355 | copper(0) | multiple interactions | ISO | PARP3 (Homo sapiens) | 6480464 | [Chelating Agents binds to Copper] which results in decreased expression of PARP3 mRNA | CTD | PMID:30911355 | Cuprizon | increases expression | EXP | | 6480464 | Cuprizone results in increased expression of PARP3 mRNA | CTD | PMID:26577399 | dexamethasone | multiple interactions | ISO | PARP3 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PARP3 mRNA | CTD | PMID:28628672 | fenamidone | increases expression | ISO | Parp3 (Mus musculus) | 6480464 | fenamidone results in increased expression of PARP3 mRNA | CTD | PMID:27029645 | flutamide | decreases expression | EXP | | 6480464 | Flutamide results in decreased expression of PARP3 mRNA | CTD | PMID:24793618 | folic acid | multiple interactions | ISO | Parp3 (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of PARP3 mRNA | CTD | PMID:22206623 | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of PARP3 mRNA | CTD | PMID:33387578 | indometacin | multiple interactions | ISO | PARP3 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PARP3 mRNA | CTD | PMID:28628672 | methylphenidate | increases expression | ISO | Parp3 (Mus musculus) | 6480464 | Methylphenidate results in increased expression of PARP3 mRNA | CTD | PMID:22470460 | ozone | multiple interactions | ISO | Parp3 (Mus musculus) | 6480464 | [Air Pollutants results in increased abundance of Ozone] which results in increased expression of PARP3 mRNA | CTD | PMID:34911549 | paracetamol | affects expression | ISO | Parp3 (Mus musculus) | 6480464 | Acetaminophen affects the expression of PARP3 mRNA | CTD | PMID:17562736 | pentachlorophenol | increases expression | ISO | Parp3 (Mus musculus) | 6480464 | Pentachlorophenol results in increased expression of PARP3 mRNA | CTD | PMID:23892564 | perfluorohexanesulfonic acid | increases expression | ISO | Parp3 (Mus musculus) | 6480464 | perfluorohexanesulfonic acid results in increased expression of PARP3 mRNA | CTD | PMID:37995155 | pirinixic acid | multiple interactions | ISO | PARP3 (Homo sapiens) | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PARP3 mRNA | CTD | PMID:19710929 | silicon dioxide | decreases methylation | ISO | PARP3 (Homo sapiens) | 6480464 | Silicon Dioxide results in decreased methylation of PARP3 gene | CTD | PMID:34973136 | succimer | multiple interactions | ISO | Parp3 (Mus musculus) | 6480464 | [Succimer binds to Magnetite Nanoparticles] which results in increased expression of PARP3 mRNA | CTD | PMID:21641980 | sunitinib | decreases expression | ISO | PARP3 (Homo sapiens) | 6480464 | Sunitinib results in decreased expression of PARP3 mRNA | CTD | PMID:31533062 | tetrachloroethene | decreases expression | ISO | Parp3 (Mus musculus) | 6480464 | Tetrachloroethylene results in decreased expression of PARP3 mRNA | CTD | PMID:28973375 | tetrachloromethane | increases expression | ISO | Parp3 (Mus musculus) | 6480464 | Carbon Tetrachloride results in increased expression of PARP3 mRNA | CTD | PMID:27339419 and PMID:31919559 | thioacetamide | affects expression | EXP | | 6480464 | Thioacetamide affects the expression of PARP3 mRNA | CTD | PMID:34492290 | titanium dioxide | increases expression | ISO | Parp3 (Mus musculus) | 6480464 | titanium dioxide results in increased expression of PARP3 mRNA | CTD | PMID:27760801 | tungsten | decreases expression | ISO | Parp3 (Mus musculus) | 6480464 | Tungsten results in decreased expression of PARP3 mRNA | CTD | PMID:30912803 | valproic acid | decreases expression | ISO | PARP3 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of PARP3 mRNA | CTD | PMID:29154799 | vancomycin | decreases expression | ISO | Parp3 (Mus musculus) | 6480464 | Vancomycin results in decreased expression of PARP3 mRNA | CTD | PMID:18930951 | vinclozolin | decreases expression | EXP | | 6480464 | vinclozolin results in decreased expression of PARP3 mRNA | CTD | PMID:23034163 | |